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    • 22. 发明专利
    • AT202567T
    • 2001-07-15
    • AT95909996
    • 1995-02-27
    • OTSUKA PHARMA CO LTD
    • KUROKI YASUHISAMIYATA KAZUYOSHITSUDA YOSHIHIKOINOUE YASUHIDEKANAYA JUNSATO KEIGO
    • C07F9/6512A61K31/675
    • The invention provides a phosphonic diester derivative of the formula: wherein R , R , R and R are the same or different and each represents a hydrogen atom, a lower alkyl group, a halogen atom, a nitro group, a lower alkoxy group, a cyano group, a phenylsulfonylamino group, a benzoylamino group, an amino group or a halogen-substituted lower alkyl group, R represents a phenyl group, a lower alkyl group, a phenyl(lower)alkyl group optionally substituted by halogen on the phenyl ring, a lower alkenyl group, a carboxy(lower)alkyl group, a (lower)alkoxy-carbonyl(lower)alkyl group, a (lower)alkoxy(lower)alkyl group, a lower alkynyl group, a benzoyl(lower)alkyl group, an amino group, a di(lower)alkanoylamino group, a benzylideneamino group optionally having lower alkoxy on the phenyl ring or a pyridylmethylideneamino group, R represents a lower alkyl group, R represents a lower alkoxy group, a hydroxyl group, a phenyl group, a phenyl(lower)alkoxy group optionally having halogen on the phenyl ring or a phenyl(lower)alkylamino group, X and X independently represent an oxygen atom or a sulfur atom, A represents an oxygen atom or a single bond, and Z represents a lower alkylene group. The derivatives according to the invention are useful as therapeutic or preventive compositions for hyperlipidemia, hypertension, and diabetes.