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21. 发明专利

CA2241679C PHOSPHONIC ACID DIESTER DERIVATIVES 未知
公开(公告)号：CA2241679C
公开(公告)日：2002-02-12
申请号：CA2241679
申请日：1996-12-24
申请人： OTSUKA PHARMA CO LTD
发明人： MIKI SHINYA , INOUE YASUHIDE , SATO KEIGO , MIYATA KAZUYOSHI , SHOJI YASUO , SAKAI YASUHIRO , TSUDA YOSHIHIKO
IPC分类号： C07F9/6509 , C07F9/6539 , C07F9/6553 , C07F9/6558 , C07F9/6561 , A61K31/67 , A61K31/675
摘要： A phosphonic diester derivative represented by the following formula (1): (see formula I) wherein R1 represents a cycloalkyl group; a phenyl group which may have 1 to 3 substituents selected from the group consisting of a lower alkoxy group, a lower alkyl group, a halogen atom, a halogen-substituted lower alkyl group, a lower alkanoyl group, a nitro group, a benzoyl group, a cyano group, an N-lower alkylcarbamoyl group, an N-phenyl-lower alkylcarbamoyl group, an N-(halogen- substituted phenyl)carbamoyl group and an N,N-di-lower alkylcarbamoyl group; a 1,3,4-thiadiazol-2-yl group having a halogen-substituted lower alkyl group as a substituent; a thiazolyl group; a pyridyl group which may be,substituted by a halogen atom; a benzothiazol-2-yl group having 1 to 2 lower alkoxy groups on the phenyl ring; or a 4,5-dihydrothieno[3,2-e]benzothiazol-2-yl group; R2 represents a hydrogen atom or a phenyl lower alkyl group; R3 and R4 each represents a lower alkyl group; and A represents a heterocyclic ring selected from the group consisting of a pyrazine ring, a thiophene ring and a phenyl-substituted thiazole ring; the derivative being of value as an agent for treating and preventing hyperlipidemia, diabetes and cataract, or as an antitumor agent.

22. 发明专利

AT202567T 未知
公开(公告)号：AT202567T
公开(公告)日：2001-07-15
申请号：AT95909996
申请日：1995-02-27
申请人： OTSUKA PHARMA CO LTD
发明人： KUROKI YASUHISA , MIYATA KAZUYOSHI , TSUDA YOSHIHIKO , INOUE YASUHIDE , KANAYA JUN , SATO KEIGO
IPC分类号： C07F9/6512 , A61K31/675
摘要： The invention provides a phosphonic diester derivative of the formula: wherein R , R , R and R are the same or different and each represents a hydrogen atom, a lower alkyl group, a halogen atom, a nitro group, a lower alkoxy group, a cyano group, a phenylsulfonylamino group, a benzoylamino group, an amino group or a halogen-substituted lower alkyl group, R represents a phenyl group, a lower alkyl group, a phenyl(lower)alkyl group optionally substituted by halogen on the phenyl ring, a lower alkenyl group, a carboxy(lower)alkyl group, a (lower)alkoxy-carbonyl(lower)alkyl group, a (lower)alkoxy(lower)alkyl group, a lower alkynyl group, a benzoyl(lower)alkyl group, an amino group, a di(lower)alkanoylamino group, a benzylideneamino group optionally having lower alkoxy on the phenyl ring or a pyridylmethylideneamino group, R represents a lower alkyl group, R represents a lower alkoxy group, a hydroxyl group, a phenyl group, a phenyl(lower)alkoxy group optionally having halogen on the phenyl ring or a phenyl(lower)alkylamino group, X and X independently represent an oxygen atom or a sulfur atom, A represents an oxygen atom or a single bond, and Z represents a lower alkylene group. The derivatives according to the invention are useful as therapeutic or preventive compositions for hyperlipidemia, hypertension, and diabetes.

23. 发明专利

NO20005328D0 未知
公开(公告)号：NO20005328D0
公开(公告)日：2000-10-23
申请号：NO20005328
申请日：2000-10-23
申请人： OTSUKA PHARMA CO LTD
发明人： SAKAI YASUHIRO , MIYATA KAZUYOSHI , KAWAMURA KENICHI , TSUDA YOSHIHIKO , INOUE YASUHIDE
IPC分类号： A61K31/66 , A61K31/675 , A61P3/08 , A61P3/10 , A61P31/10 , C07F9/40 , C07F9/58 , C07F9/6509 , C07F
摘要： Novel phosphonic diester derivatives represented by general formula (1) or pharmacologically acceptable salts thereof which are useful as drugs, wherein R represents amino, N-(lower alkyl)amino, N-(lower alkenyl)amino, etc.; R and R represent each hydrogen, lower alkyl, halogeno, lower alkoxy etc.; R represents hydrogen, lower alkyl or phenyl(lower alkyl); R and R represent each lower alkyl; X, Y and Z are all carbon atoms, or one of X, Y and Z is a nitrogen atom while other two are carbon atoms; and Q represents a single bond or alkylene.

24. 发明专利

DE69425804D1 PHOSPHONSÄUREDIESTERDERIVATE 未知
公开(公告)号：DE69425804D1
公开(公告)日：2000-10-12
申请号：DE69425804
申请日：1994-05-31
申请人： OTSUKA PHARMA CO LTD
发明人： KUROGI YASUHISA , MIYATA KAZUYOSHI , NAKAMURA SHIZUO , KONDO MITSUYOSHI , IWAMOTO TAKESHI , NABA CHIEKO , TSUDA YOSHIHIKO , INOUE YASUHIDE , KANAYA JUN , SATO KEIGO
IPC分类号： C07F9/6512 , C07F9/6558 , A61K31/675
摘要： A phosphonic diester derivative represented by general formula (1) and useful as remedies for hyperlipidemia, hypertension, diabetes, and so forth. In said formula, A represents oxygen or sulfur; R , R , R and R represent each independently hydrogen, lower alkoxy, nitro, lower alkyl, halogenated lower alkyl or halogen; R represents phenyl, -B-R (wherein B represents oxygen or sulfur; and R represents hydrogen, lower alkyl, cycloalkyl, phenyl, phenylated lower alkyl wherein the phenyl may be halogenated, phenoxylated lower alkyl, lower-alkoxy carbonyl-subsituted lower alkyl, carboxylated lower alkyl or lower alkenyl) or -NR R (wherein R and R represent each independently hydrogen, lower alkyl, amino or cycloakyl, or R and R are combined together to form lower alkylene); and R and R represent each independently hydrogen or lower alkyl.

25. 发明专利

AT188704T 未知
公开(公告)号：AT188704T
公开(公告)日：2000-01-15
申请号：AT93910361
申请日：1993-05-20
申请人： OTSUKA PHARMA CO LTD
发明人： MIYATA KAZUYOSHI , SHOJI YASUO , TSUDA YOSHIHIKO , TSUTSUMI KAZUHIKO , INOUE YASUHIDE , NABA CHIEKO , KUROGI YASUHISA
IPC分类号： A61K31/675 , C07F9/6506 , C07F9/653 , C07F9/6541 , C07F9/6561
摘要： A phosphonic diester derivative represented by general formula (1). It has the effect of reducing blood sugar and lipid levels, and so forth, and is useful for treating diabetes, hyperlipidemia, and the like.

26. 发明专利

AU678276B2 Phosphonic diester derivative 未知
公开(公告)号：AU678276B2
公开(公告)日：1997-05-22
申请号：AU7276394
申请日：1994-08-08
申请人： OTSUKA PHARMA CO LTD
发明人： MIYATA KAZUYOSHI , KUROGI YASUHISA , TSUDA YOSHIHIKO , TSUTSUMI KAZUHIKO , IWAMOTO TAKESHI , NABA CHIEKO
IPC分类号： C07F9/655 , A61K31/665
摘要： A phosphonic diester derivative represented by general formula (1), wherein R , R and R are the same or different from one another and each represents hydrogen, lower alkyl, halogeno, cyano, hydroxy or lower alkoxy which may be substituted by halogen, phenyl or hydroxypiperidino; R represents hydrogen, lower alkoxy, halogeno or lower alkyl which may be substituted by halogeno or cyano; and R and R are the same or different from each other and each represents hydrogen or lower alkyl. This derivative is excellent in hypolipemic, hypotensive and hypoglycemic effects and is useful for treating and preventing hyperlipemia, hypertension and diabetes.

27. 发明专利

AU664337B2 Phosphonic diester derivative 未知
公开(公告)号：AU664337B2
公开(公告)日：1995-11-09
申请号：AU6855894
申请日：1994-05-31
申请人： OTSUKA PHARMA CO LTD
发明人： KUROGI YASUHISA , MIYATA KAZUYOSHI , NAKAMURA SHIZUO , KONDO MITSUYOSHI , IWAMOTO TAKESHI , NABA CHIEKO , TSUDA YOSHIHIKO , INOUE YASUHIDE , KANAYA JUN , SATO KEIGO
IPC分类号： C07F9/6512 , C07F9/6558 , A61K31/675
摘要： A phosphonic diester derivative represented by general formula (1) and useful as remedies for hyperlipidemia, hypertension, diabetes, and so forth. In said formula, A represents oxygen or sulfur; R , R , R and R represent each independently hydrogen, lower alkoxy, nitro, lower alkyl, halogenated lower alkyl or halogen; R represents phenyl, -B-R (wherein B represents oxygen or sulfur; and R represents hydrogen, lower alkyl, cycloalkyl, phenyl, phenylated lower alkyl wherein the phenyl may be halogenated, phenoxylated lower alkyl, lower-alkoxy carbonyl-subsituted lower alkyl, carboxylated lower alkyl or lower alkenyl) or -NR R (wherein R and R represent each independently hydrogen, lower alkyl, amino or cycloakyl, or R and R are combined together to form lower alkylene); and R and R represent each independently hydrogen or lower alkyl.

28. 发明专利

CA2142597A1 PHOSPHONIC DIESTER DERIVATIVES 未知
公开(公告)号：CA2142597A1
公开(公告)日：1995-01-05
申请号：CA2142597
申请日：1994-05-31
申请人： OTSUKA PHARMA CO LTD
发明人： KUROGI YASUHISA , MIYATA KAZUYOSHI , NAKAMURA SHIZUO , KONDO MITSUYOSHI , IWAMOTO TAKESHI , NABA CHIEKO , TSUDA YOSHIHIKO , INOUE YASUHIDE , KANAYA JUN , SATO KEIGO
IPC分类号： C07F9/6512 , C07F9/6558 , C07F9/547 , A61K31/675
摘要： A phosphonic diester derivative represented by general formula (I) and useful as remedies for hyperlipidemia, hypertension, diabetes, and so forth. In said formula, A represents oxygen or sulfer; R1, R2, R9 and R10 represent each independently hydrogen, lower alkoxy, nitro, lower alkyl, halogenated lower alkyl or halogen; R3 represents phenyl, -B-R6 (wherein B represents oxygen or sulfur; and R6 represents hydrogen, lower alkyl, cycloalkyl, phenyl, phenylated lower alkyl wherein the phenyl may be halogenated, phenoxylated lower alkyl, lower-alkoxy carbonyl-substituted lower alkyl, carboxylated lower alkyl or lower alkenyl) or -NR7R8 (wherein R7 and R8 represent each independently hydrogen, lower alkyl, amino or cycloalkyl, or R7 and R8 are combined together to form lower alkylene); and R4 and R5 represent each independently hydrogen or lower alkyl.

29. 发明专利

CY1111503T1 ΥΔΑΤΙΚΟ ΔΙΑΛΥΜΑ ΟΞΑΝΕΞΙΔΙΝΗΣ, ΜΕΘΟΔΟΣ ΠΑΡΑΣΚΕΥΗΣ ΤΟΥ ΙΔΙΟΥ, ΚΑΙ ΑΠΟΛΥΜΑΝΤΙΚΟ 未知
公开(公告)号：CY1111503T1
公开(公告)日：2015-10-07
申请号：CY111100448
申请日：2011-05-09
申请人： OTSUKA PHARMA CO LTD
发明人： MIYATA KAZUYOSHI , INOUE YASUHIDE , HAGI AKIFUMI , KIKUCHI MOTOYA , OHNO HITOSHI , HASHIMOTO KINJI , OHGURO KINUE , SATO TETSUYA , TSUBOUCHI HIDETSUGU , ISHIKAWA HIROSHI , OKAMURA TAKASHI , IWATA KOUSHI
IPC分类号： A61K31/155 , A01N25/02 , A01N37/02 , A01N47/44 , A61K9/00 , A61K9/08 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/34 , A61L2/18 , A61P17/00 , A61P31/00
摘要： Ηπαρούσαεφεύρεσηπαρέχειένααπολυμαντικόπουπεριέχειολανεξιδίνησεσυγκέντρωσηπουεπαρκείγιαναεμφανίσειαποτελεσματικήβακτηριοκτόνοδράση, καιπουδενέχεισχεδόνκαμίαπαράπλευρηδράσηόπωςδερματικόερεθισμό. Συγκεκριμένα, ηπαρούσαεφεύρεσηπαρέχειένααπολυμαντικόπουπεριέχειέναυδατικόδιάλυμαπουπεριέχειολανεξιδίνηκαιτουλάχιστονισομοριακήποσότηταγλουκονικούοξέος, καιουσιαστικάδενπεριέχειούτεάλλοοξύεκτόςαπότογλουκονικόοξύούτεάλαςάλλουοξέοςεκτόςαπότογλουκονικόοξύ.

30. 发明专利

MY144306A AQUOUES SOLUTION OF OLANEXIDINE, METHOD OF PREPARING THE AQUEOUS SOLUTION, AND DISINFECTANT 未知
公开(公告)号：MY144306A
公开(公告)日：2011-08-29
申请号：MYPI20083048
申请日：2004-05-27
申请人： OTSUKA PHARMA CO LTD
发明人： MIYATA KAZUYOSHI , ISHIKAWA HIROSHI , OKAMURA TAKASHI , IWATA KOUSHI , INOUE YASUHIDE , HAGI AKIFUMI , KIKUCHI MOTOYA , OHNO HITOSHI , HASHIMOTO KINJI , OHGURO KINUE , SATO TETSUYA , TSUBOUCHI HIDETSUGU
IPC分类号： A01N47/44 , A61K31/155 , A61K9/00 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/12 , A61L2/18 , A61P17/00 , A61P31/00
摘要： THE PRESENT INVENTION PROVIDES A DISINFECTANT THAT CONTAINS OLANEXIDINE IN A CONCENTRATION SUFFICIENT TO EXHIBIT AN EFFECTIVE BACTERICIDAL EFFECT, AND THAT HAS HARDLY ANY SIDE EFFECTS SUCH AS SKIN IRRITATION. SPECIFICALLY, THE PRESENT INVENTION PROVIDES A DISINFECTANT CONTAINING AN AQUEOUS SOLUTION THAT CONTAINS OLANEXIDINE AND AT LEAST AN EQUIMOLAR AMOUNT OF GLUCONIC ACID, AND SUBSTANTIALLY CONTAINS NEITHER AN ACID OTHER THAN GLUCONIC ACID NOR A SALT OF THE ACID OTHER THAN GLUCONIC ACID.

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