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21. 发明授权

US5681724A Parasitic helminth macrophage inhibitory factor nucleic acid molecules and uses thereof 失效
标题翻译：寄生蠕虫巨噬细胞抑制因子核酸分子及其用途
公开(公告)号：US5681724A
公开(公告)日：1997-10-28
申请号：US558735
申请日：1995-11-16
申请人： Cynthia Ann Tripp , Kevin S. Brandt , Nancy Wisnewski
发明人： Cynthia Ann Tripp , Kevin S. Brandt , Nancy Wisnewski
IPC分类号： G01N33/53 , A61K31/00 , A61K31/70 , A61K38/00 , A61K39/002 , A61P33/00 , A61P33/02 , A61P33/10 , C07K14/44 , C07K14/52 , C07K16/20 , C12N7/00 , C12N15/00 , C12N15/09 , C12P21/02 , C12R1/10 , H01G9/04 , H01G9/055 , C07H21/04
CPC分类号： H01G9/055 , C07K14/52 , C07K2319/00 , Y10S435/975
摘要： The present invention relates to parasitic helminth macrophage migration inhibitory factor (MIF) proteins; to parasitic helminth MIF nucleic acid molecules, including those that encode such MIF proteins; to antibodies raised against such MIF proteins; and to compounds that inhibit parasitic helminth MIF activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译：本发明涉及寄生蠕虫巨噬细胞迁移抑制因子（MIF）蛋白; 包括那些编码这种MIF蛋白的MIF核酸分子，针对这种MIF蛋白产生的抗体; 以及抑制寄生蠕虫MIF活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。

22. 发明授权

US07662622B2 Flea peritrophin nucleic acid molecules 失效
标题翻译：跳蚤培养蛋白核酸分子
公开(公告)号：US07662622B2
公开(公告)日：2010-02-16
申请号：US11778533
申请日：2007-07-16
申请人： Patrick J. Gaines , Nancy Wisnewski
发明人： Patrick J. Gaines , Nancy Wisnewski
IPC分类号： C12N15/00 , C12N15/12
CPC分类号： C07K14/4359 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C12N2799/021
摘要： The present invention relates to flea peritrophin proteins; to flea peritrophin nucleic acid molecules, including those that encode such flea peritrophin proteins; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain and use such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit flea peritrophin activity, as well as the use of such therapeutic compositions to treat animals.
摘要翻译：本发明涉及跳蚤培养蛋白; 跳蚤培养蛋白核酸分子，包括编码这种跳蚤培养蛋白的蛋白质; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。本发明还包括获得和使用这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这种抑制性化合物，特别是那些特异性抑制跳蚤营养不良蛋白活性的化合物的治疗组合物，以及这些治疗组合物用于治疗动物的用途。

23. 发明授权

US07476728B2 Flea GABA receptor subunit nucleic acid molecules 失效
标题翻译：跳蚤GABA受体亚基核酸分子
公开(公告)号：US07476728B2
公开(公告)日：2009-01-13
申请号：US10433140
申请日：2002-11-21
申请人： Nancy Wisnewski , Kevin S. Brandt
发明人： Nancy Wisnewski , Kevin S. Brandt
IPC分类号： C07H21/02
CPC分类号： C07K14/705 , A61K38/00 , G01N2500/04
摘要： The present invention relates to flea GABA receptor subunit nucleic acid molecules; to flea GABA receptor subunit proteins encoded by such nucleic acid molecules; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and inhibitory compounds, particularly those that specifically inhibit flea GABA receptor subunit activity, as well as the use of such therapeutic compositions to treat animals.
摘要翻译：本发明涉及跳蚤GABA受体亚基核酸分子; 由这种核酸分子编码的跳蚤GABA受体亚基蛋白; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和抑制性化合物，特别是那些特异性抑制跳蚤GABA受体亚基活性的化合物的治疗组合物，以及这些治疗组合物用于治疗动物的治疗组合物。

24. 发明授权

US07348410B2 Flea head, nerve cord, hindgut and malpighian tubule proteins 失效
标题翻译：跳蚤头，神经线，后肠和小血管小管蛋白
公开(公告)号：US07348410B2
公开(公告)日：2008-03-25
申请号：US10978245
申请日：2004-10-29
申请人： Patrick J. Gaines , Nancy Wisnewski
发明人： Patrick J. Gaines , Nancy Wisnewski
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00 , G01N33/53
CPC分类号： C07K14/4359 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C12N2799/021
摘要： The present invention relates to flea head, nerve cord, hindgut and Malpighian tubule proteins; to flea head, nerve cord, hindgut and Malpighian tubule nucleic acid molecules, including those that encode such flea head, nerve cord, hindgut and Malpighian tubule proteins; to antibodies raised against such flea head, nerve cord, hindgut and Malpighian tubule proteins; and to compounds that inhibit flea head, nerve cord, hindgut and Malpighian tubule protein activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising proteins, nucleic acid molecules, or protective compounds derived from proteins of the present invention as well as the use of such therapeutic compositions to protect animals from flea infestation. Also included in the present invention is the use of flea head, nerve cord, hindgut and Malpighian tubule proteins to derive inhibitory compounds.
摘要翻译：本发明涉及跳蚤头，神经根，后肠和马鞭状小管蛋白; 跳蚤头，神经线，后肠和马鞭状小管核酸分子，包括编码这种跳蚤头，神经线，后肠和马鞭状小管蛋白的那些; 针对这种跳蚤头，神经线，后肠和马鞭状小管蛋白质产生的抗体; 以及抑制跳蚤头，神经丝，后肠和马鞭状小管蛋白活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含衍生自本发明蛋白质的蛋白质，核酸分子或保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。本发明还包括使用跳蚤头，神经根，后肠和马鞭状小管蛋白来衍生抑制性化合物。

25. 发明申请

US20070231894A1 FLEA ULTRASPIRACLE NUCLEIC ACID MOLECULES 失效
标题翻译： FLEA ULTRASPIRACLE核酸分子
公开(公告)号：US20070231894A1
公开(公告)日：2007-10-04
申请号：US11697551
申请日：2007-04-06
申请人： Nancy Wisnewski , Anna Becher , Eric Jarvis
发明人： Nancy Wisnewski , Anna Becher , Eric Jarvis
IPC分类号： C07H21/04 , C12N15/00 , C12N5/06
CPC分类号： C07K14/4359 , C07K14/721 , Y10S530/858
摘要： The present invention relates to flea ecdysone receptor and ultraspiracle proteins; to flea ecdysone receptor and ultraspiracle nucleic acid molecules, including those that encode such flea ecdysone receptor and ultraspiracle proteins; to antibodies raised against such flea ecdysone receptor and ultraspiracle proteins; and to compounds that inhibit flea ecdysone receptor and/or ultraspiracle activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising a protective compound derived from a protein of the present invention that inhibits the binding between ecdysone receptor and ecdysone as well as the use of such therapeutic compositions to protect animals from flea infestation.
摘要翻译：本发明涉及跳蚤蜕皮激素受体和超尖锐蛋白质; 跳蚤蜕皮激素受体和超尖锐核酸分子，包括那些编码这种跳蚤蜕皮激素受体和超尖锐蛋白质的分子; 针对这种跳蚤蜕皮激素受体和超尖锐蛋白的抗体; 以及抑制跳蚤蜕皮激素受体和/或超急性活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含抑制蜕皮激素受体和蜕皮激素之间结合的本发明蛋白质的保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。

26. 发明申请

US20060149048A1 Canine COX-2 nucleic acid molecules 失效
公开(公告)号：US20060149048A1
公开(公告)日：2006-07-06
申请号：US11372770
申请日：2006-03-10
申请人： Nancy Wisnewski , Kevin Brandt
发明人： Nancy Wisnewski , Kevin Brandt
IPC分类号： C07H21/04 , C12P21/06 , C12N9/02 , C12N5/06
CPC分类号： A61K31/7088 , C12N9/90
摘要： The present invention relates to canine COX-1 and COX-2 proteins; to canine COX-1 and COX-2 nucleic acid molecules, including those that encode such COX-1 and COX-2 proteins, respectively; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit COX-2 activity, as well as the use of such therapeutic compositions to treat animals.

27. 发明申请

US20050239103A1 Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof 失效
标题翻译：跳蚤头，神经线，后肠和恶臭小管核酸分子，蛋白质及其用途
公开(公告)号：US20050239103A1
公开(公告)日：2005-10-27
申请号：US10978245
申请日：2004-10-29
申请人： Kevin Brandt , Patrick Gaines , Dan Stinchcomb , Nancy Wisnewski
发明人： Kevin Brandt , Patrick Gaines , Dan Stinchcomb , Nancy Wisnewski
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P17/00 , A61P33/14 , A61P37/08 , C07H21/04 , C07K14/435 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/4359 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C12N2799/021
摘要： The present invention relates to flea head, nerve cord, hindgut and Malpighian tubule proteins; to flea head, nerve cord, hindgut and Malpighian tubule nucleic acid molecules, including those that encode such flea head, nerve cord, hindgut and Malpighian tubule proteins; to antibodies raised against such flea head, nerve cord, hindgut and Malpighian tubule proteins; and to compounds that inhibit flea head, nerve cord, hindgut and Malpighian tubule protein activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising proteins, nucleic acid molecules, or protective compounds derived from proteins of the present invention as well as the use of such therapeutic compositions to protect animals from flea infestation. Also included in the present invention is the use of flea head, nerve cord, hindgut and Malpighian tubule proteins to derive inhibitory compounds.
摘要翻译：本发明涉及跳蚤头，神经根，后肠和马鞭状小管蛋白; 跳蚤头，神经线，后肠和马鞭状小管核酸分子，包括编码这种跳蚤头，神经线，后肠和马鞭状小管蛋白的那些; 针对这种跳蚤头，神经线，后肠和马鞭状小管蛋白质产生的抗体; 以及抑制跳蚤头，神经线，后肠和马鞭状小管蛋白活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含衍生自本发明蛋白质的蛋白质，核酸分子或保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。本发明还包括使用跳蚤头，神经根，后肠和马鞭状小管蛋白来衍生抑制性化合物。

28. 发明授权

US06518266B1 1- Aryl-3-thioalkyl pyrazoles, the synthesis thereof and the use thereof as insecticides 有权
标题翻译： 1-芳基-3-硫烷基吡唑，其合成及其作为杀虫剂的用途
公开(公告)号：US06518266B1
公开(公告)日：2003-02-11
申请号：US09621456
申请日：2000-07-21
申请人： Daljit S. Dhanoa , Dario Doller , Sanath Meegalla , Richard M. Soll , Nancy Wisnewski , Gary Silver , Dan T. Stinchcomb , R. Lee Seward , Dimitris Agrafiotis , Deyou Sha
发明人： Daljit S. Dhanoa , Dario Doller , Sanath Meegalla , Richard M. Soll , Nancy Wisnewski , Gary Silver , Dan T. Stinchcomb , R. Lee Seward , Dimitris Agrafiotis , Deyou Sha
IPC分类号： C07D23124
CPC分类号： C07D403/04 , A01N43/56 , A01N43/82 , A01N55/00 , C07D231/18 , C07D231/20 , C07D231/44 , C07D231/52 , C07D409/04 , C07D413/04
摘要： The present invention is directed to novel pyrazole derivatives and their use as pesticidal agents. The pyrazole derivatives have Formula I: or a salt thereof, where R1 represents R5O, R5SO2, R5SO or R5S in which R5 is as defined herein; X is halo, cyano, C1-6 alkoxycarbonyl, C2-6 alkynyl, optionally substituted C6-14 aryl or an optionally substituted 5- to 7-membered heteroaromatic ring linked to thiazole via a carbon-carbon bond; R2 is hydrogen, amino, chloro, bromo, iodo, cyano, C1-6 alkoxy, C1-6 alkyl or C6-10 aryl; and R3-R7 each represent hydrogen, halogen, straight- or branched-chain C1-4 alkyl or C1-4 alkoxy, either of which is unsubstituted or substituted by one or more halogen atoms, straight- or branched-chain C1-4 alkylthio or C1-4 alkylsulphinyl, either of which is substituted by one or more halogen atoms, nitro, cyano, or straight- or branched-chain C1-4 alkylsulphonyl group which is unsubstituted or substituted by one or more halogen atoms.
摘要翻译：本发明涉及新颖的吡唑衍生物及其作为杀虫剂的用途。吡唑衍生物具有式I或其盐，其中R 1表示其中R 5如本文所定义的R5O，R5SO2，R5SO或R5S; X为卤素，氰基，C1-6烷氧基羰基，C2-6炔基，任选取代的C6-14 芳基或通过碳 - 碳键与噻唑连接的任选取代的5至7元杂芳环; R 2是氢，氨基，氯，溴，碘，氰基，C 1-6烷氧基，C 1-6烷基或C 6-10 芳基; 和R 3 -R 7各自表示氢，卤素，直链或支链C 1-4烷基或C 1-4烷氧基，其中任一个是未取代的或被一个或多个卤素原子，直链或支链C 1-4烷硫基或任选被一个或多个卤素原子取代的C 1-4烷基亚磺酰基，未被取代或被一个或多个卤素原子取代的硝基，氰基或直链或支链C 1-4烷基磺酰基。

29. 发明授权

US06372887B1 Flea serine protease inhibitor proteins 失效
标题翻译：跳蚤丝氨酸蛋白酶抑制蛋白
公开(公告)号：US06372887B1
公开(公告)日：2002-04-16
申请号：US08745995
申请日：1996-11-07
申请人： Gary M. Silver , Nancy Wisnewski
发明人： Gary M. Silver , Nancy Wisnewski
IPC分类号： C07K1481
CPC分类号： C07K14/8121 , A61K38/00 , Y02A50/473
摘要： The present invention relates to flea serine protease inhibitor proteins; to flea serine protease inhibitor nucleic acid molecules, including those that encode such serine protease inhibitor proteins; to antibodies raised against such serine protease inhibitor proteins; and to compounds that inhibit flea serine protease inhibitor activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous ectoparasite infestation.
摘要翻译：本发明涉及跳蚤丝氨酸蛋白酶抑制蛋白; 跳蚤丝氨酸蛋白酶抑制剂核酸分子，包括编码这种丝氨酸蛋白酶抑制蛋白的那些; 针对这种丝氨酸蛋白酶抑制蛋白产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶抑制剂活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括含有这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及使用这种治疗组合物来保护动物免受血液外寄生虫侵袭。

30. 发明授权

US08268976B2 Flea GABA receptor subunit nucleic acid molecules 有权
标题翻译：跳蚤GABA受体亚基核酸分子
公开(公告)号：US08268976B2
公开(公告)日：2012-09-18
申请号：US12352535
申请日：2009-01-12
申请人： Nancy Wisnewski , Kevin S. Brandt
发明人： Nancy Wisnewski , Kevin S. Brandt
IPC分类号： C12N15/11 , C12N15/63
CPC分类号： C07K14/705 , A61K38/00 , G01N2500/04
摘要： The present invention relates to flea GABA receptor subunit nucleic acid molecules; to flea GABA receptor subunit proteins encoded by such nucleic acid molecules; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and inhibitory compounds, particularly those that specifically inhibit flea GABA receptor subunit activity, as well as the use of such therapeutic compositions to treat animals.
摘要翻译：本发明涉及跳蚤GABA受体亚基核酸分子; 由这种核酸分子编码的跳蚤GABA受体亚基蛋白; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和抑制性化合物，特别是那些特异性抑制跳蚤GABA受体亚基活性的化合物的治疗组合物，以及这些治疗组合物用于治疗动物的治疗组合物。

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