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    • 3. 发明申请
    • FLEA HEAD, NERVE CORD, HINDGUT AND MALPIGHIAN TUBULE NUCLEIC ACID MOLECULES, PROTEINS AND USES THEREOF
    • FLEA头,神经线,HINDGUT和MALPIGHIAN管核核酸分子,蛋白质及其用途
    • US20070270576A1
    • 2007-11-22
    • US11565729
    • 2006-12-01
    • Kevin BrandtPatrick GainesDan StinchcombNancy Wisnewski
    • Kevin BrandtPatrick GainesDan StinchcombNancy Wisnewski
    • C40B40/08C07H21/04C07K14/435
    • C07K14/4359
    • The present invention relates to flea head, nerve cord, hindgut and Malpighian tubule proteins; to flea head, nerve cord, hindgut and Malpighian tubule nucleic acid molecules, including those that encode such flea head, nerve cord, hindgut and Malpighian tubule proteins; to antibodies raised against such flea head, nerve cord, hindgut and Malpighian tubule proteins; and to compounds that inhibit flea head, nerve cord, hindgut and Malpighian tubule protein activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising proteins, nucleic acid molecules, antibodies, or protective compounds derived from proteins of the present invention as well as the use of such therapeutic compositions to protect animals from flea infestation. Also included in the present invention is the use of flea head, nerve cord, hindgut and Malpighian tubule proteins to derive inhibitory compounds.
    • 本发明涉及跳蚤头,神经根,后肠和马鞭状小管蛋白; 跳蚤头,神经线,后肠和马鞭状小管核酸分子,包括编码这种跳蚤头,神经线,后肠和马鞭状小管蛋白的那些; 针对这种跳蚤头,神经线,后肠和马鞭状小管蛋白质产生的抗体; 以及抑制跳蚤头,神经丝,后肠和马鞭状小管蛋白活性的化合物。 本发明还包括获得这些蛋白质,核酸分子,抗体和抑制性化合物的方法。 本发明还包括包含衍生自本发明蛋白质的蛋白质,核酸分子,抗体或保护性化合物的治疗组合物,以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。 本发明还包括使用跳蚤头,神经根,后肠和马鞭状小管蛋白来衍生抑制性化合物。