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21. 发明申请

US20110189785A1 PROCESSING UNITS AND METHODS FOR THE PROCESSING OF LIQUID SAMPLES 失效
标题翻译：处理单元和液体样品加工方法
公开(公告)号：US20110189785A1
公开(公告)日：2011-08-04
申请号：US12850949
申请日：2010-08-05
申请人： Oliver Gutmann , Edwin Oosterbroek , Michael Glauser , Michael Andreas Heinrich , Jean-Pierre Bolliger , Emad Sarofim , Rainer D. Jaeggi
发明人： Oliver Gutmann , Edwin Oosterbroek , Michael Glauser , Michael Andreas Heinrich , Jean-Pierre Bolliger , Emad Sarofim , Rainer D. Jaeggi
IPC分类号： G01N21/00 , G01N33/00
CPC分类号： G01N35/1072 , B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L2200/027 , B01L2200/0621 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2300/14 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B01L2400/0677 , G01N2035/00158 , Y10T436/2575
摘要： A microfluidic processing unit for the automated processing of liquid samples and method thereof are disclosed. In one embodiment, the unit comprises first and second main channels connected to a pump for generating a negative or positive pressure therein; a sample channel which supplies a liquid sample is connectable to a sample vessel containing the liquid sample, the sample channel communicates with the first main channel and is equipped with an on/off valve; one or more reagent channels for supplying one or more reagents, the reagent channels being connectable to reagent vessels containing reagents for reacting with the liquid samples, each of the reagent channels communicating with the first or second main channel and being equipped with an on/off valve; and a reaction chamber for reacting a sample and reagent, the reaction chamber being connected to the first and second main channels via at least one on/off valve.
摘要翻译：公开了用于液体样品的自动处理的微流体处理单元及其方法。在一个实施例中，该单元包括连接到泵的用于在其中产生负压或正压的第一和第二主通道; 提供液体样品的样品通道可连接到包含液体样品的样品容器，样品通道与第一主通道连通并且配备有开关阀; 一个或多个用于供应一种或多种试剂的试剂通道，所述试剂通道可连接到含有用于与液体样品反应的试剂的试剂容器，每个试剂通道与第一或第二主通道连通并且装备有开/关阀; 以及用于使样品和试剂反应的反应室，所述反应室经由至少一个开/关阀连接到所述第一和第二主通道。

22. 发明授权

US08778696B2 Processing units and methods for the processing of liquid samples 失效
标题翻译：处理液体样品处理单元和方法
公开(公告)号：US08778696B2
公开(公告)日：2014-07-15
申请号：US12850949
申请日：2010-08-05
申请人： Oliver Gutmann , Edwin Oosterbroek , Michael Glauser , Michael Andreas Heinrich , Jean-Pierre Bolliger , Emad Sarofim , Rainer D. Jaeggi
发明人： Oliver Gutmann , Edwin Oosterbroek , Michael Glauser , Michael Andreas Heinrich , Jean-Pierre Bolliger , Emad Sarofim , Rainer D. Jaeggi
IPC分类号： G01N33/00 , B01L3/00
CPC分类号： G01N35/1072 , B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L2200/027 , B01L2200/0621 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2300/14 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B01L2400/0677 , G01N2035/00158 , Y10T436/2575
摘要： A microfluidic processing unit for the automated processing of liquid samples and method thereof are disclosed. In one embodiment, the unit comprises first and second main channels connected to a pump for generating a negative or positive pressure therein; a sample channel which supplies a liquid sample is connectable to a sample vessel containing the liquid sample, the sample channel communicates with the first main channel and is equipped with an on/off valve; one or more reagent channels for supplying one or more reagents, the reagent channels being connectable to reagent vessels containing reagents for reacting with the liquid samples, each of the reagent channels communicating with the first or second main channel and being equipped with an on/off valve; and a reaction chamber for reacting a sample and reagent, the reaction chamber being connected to the first and second main channels via at least one on/off valve.
摘要翻译：公开了用于液体样品的自动处理的微流体处理单元及其方法。在一个实施例中，该单元包括连接到泵的用于在其中产生负压或正压的第一和第二主通道; 提供液体样品的样品通道可连接到包含液体样品的样品容器，样品通道与第一主通道连通并且配备有开关阀; 用于供应一种或多种试剂的一个或多个试剂通道，所述试剂通道可连接到含有用于与液体样品反应的试剂的试剂容器，每个试剂通道与第一或第二主通道连通并且装备有开/关阀; 以及用于使样品和试剂反应的反应室，所述反应室经由至少一个开/关阀连接到所述第一和第二主通道。

23. 发明授权

US08808647B2 Multi-well plate with tailored chambers 有权
标题翻译：多孔板与定制的房间
公开(公告)号：US08808647B2
公开(公告)日：2014-08-19
申请号：US12556925
申请日：2009-09-10
申请人： Claudio Cherubini , Nicole Gwerder , Martin Kopp , Edwin Oosterbroek , Emad Sarofim
发明人： Claudio Cherubini , Nicole Gwerder , Martin Kopp , Edwin Oosterbroek , Emad Sarofim
IPC分类号： B01L3/00
CPC分类号： B01L3/50851 , B01L2300/0829 , B01L2300/0851 , B01L2300/0858
摘要： Systems, methods and multi-well plates comprising an array of wells for thermal treatment of chemical or biological samples are disclosed. Each of the wells comprises a bottom opening, an upper opening, inner side walls extending from the bottom opening to the upper opening, a protrusion extending from the inner side walls into the well with a first cross-sectional area and located at a height from the bottom opening which is smaller than the height from the upper opening. A sample chamber with a second cross-sectional area is formed between the bottom opening and the protrusion. An upper chamber with a third cross-sectional area is formed between the protrusion and the upper opening, and in which the first cross-sectional area is smaller than the third cross-sectional area and smaller than or equal to the second cross-sectional area.
摘要翻译：公开了包括用于化学或生物样品的热处理的孔阵列的系统，方法和多孔板。每个孔包括底部开口，上部开口，从底部开口延伸到上部开口的内侧壁，从内侧壁延伸进入井的突起，其具有第一横截面积并且位于与底部开口小于从上部开口的高度。具有第二横截面积的样品室形成在底部开口和突起之间。在所述突起与所述上部开口之间形成具有第三横截面积的上部腔室，其中，所述第一横截面积小于所述第三横截面积，并且小于或等于所述第二横截面积。

24. 发明授权

US08420024B2 Bent microstructures for sampling, transporting or dispensing a fluid media 有权
公开(公告)号：US08420024B2
公开(公告)日：2013-04-16
申请号：US13439036
申请日：2012-04-04
申请人： Stephan Korner , Patrick Griss , Emad Sarofim , Carlo Effenhauser
发明人： Stephan Korner , Patrick Griss , Emad Sarofim , Carlo Effenhauser
IPC分类号： B01L3/00
CPC分类号： G01N1/20 , B01L3/0244 , B01L3/502707 , B01L3/502715 , B01L2200/025 , B01L2400/025 , B01L2400/0406 , Y10T29/49826 , Y10T436/110833 , Y10T436/2575
摘要： A device for sampling, transporting and/or disposal of fluid media in the nl and μl-range comprises a substrate with an open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open or closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.

25. 发明授权

US08369918B2 Body fluid sampling device 有权
标题翻译：体液取样装置
公开(公告)号：US08369918B2
公开(公告)日：2013-02-05
申请号：US13167243
申请日：2011-06-23
申请人： Irio G. Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , David Hasker , Volker Zimmer
发明人： Irio G. Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , David Hasker , Volker Zimmer
IPC分类号： A61B5/04
CPC分类号： A61B5/14532 , A61B5/1411 , A61B5/1486 , A61B5/150022 , A61B5/150251 , A61B5/150297 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/15107 , A61B5/15117
摘要： Body fluid sampling device comprising a sampling element having a fluid pathway (11) for receiving body fluid, at least a portion of the fluid pathway is open to the environment and further comprising a fluid receiving means (40) being spaced from the fluid pathway so that fluid in the pathway will not contact the fluid receiving means initially. The fluid receiving means has two or more test zones (45) for performing analytical reactions. Fluid from the channel is contacted with the fluid receiving means either by bringing the fluid receiving means and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving means.
摘要翻译：体液取样装置包括具有用于接收体液的流体通道（11）的采样元件，流体通路的至少一部分对环境开放，并且还包括与流体通道间隔开的流体接收装置（40）路径中的流体最初不会接触流体接收装置。流体接收装置具有用于进行分析反应的两个或更多个测试区（45）。来自通道的流体通过使流体接收装置和流体机械接触或者将流体从流路电输送到流体接收装置上而与流体接收装置接触。

26. 发明申请

US20110250695A1 METHOD, STRUCTURE, DEVICE, KIT AND SYSTEM FOR THE AUTOMATED ANALYSIS OF LIQUID SAMPLES 有权
标题翻译：液体样品自动分析的方法，结构，装置，工具包和系统
公开(公告)号：US20110250695A1
公开(公告)日：2011-10-13
申请号：US12903492
申请日：2010-10-13
申请人： Emad Sarofim , Edwin Oosterbroek , Claudio Cherubini , Nenad Milicevic
发明人： Emad Sarofim , Edwin Oosterbroek , Claudio Cherubini , Nenad Milicevic
IPC分类号： G01N35/00 , G01N33/00 , C12M1/34 , B01L3/00
CPC分类号： G01N35/00029 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/0673 , B01L2300/0829 , B01L2300/0864 , B01L2400/0409 , B01L2400/0677 , G01N21/07 , G01N2021/0325 , G01N2035/00099 , G01N2035/00495
摘要： A method for the automated analysis of liquid samples using at least one microfluidic structure is disclosed as well as microfluidic structures, a device having at least one of the microfluidic structures, a kit and a system including such microfluidic device. In one embodiment, the method may comprise: transferring said sample into a first fluid reservoir which is in fluid communication with a second fluid reservoir by a flow channel; spinning said microfluidic structure so as to transport said sample into one or more dead-end recesses or chambers; transferring a control fluid into the structure which generates a barrier to flow and diffusion of said sample contained in said one or more dead-end recesses or chambers; and analyzing said sample contained in said one or more dead-end recesses or chambers.
摘要翻译：公开了使用至少一个微流体结构自动分析液体样品的方法，以及微流体结构，具有至少一个微流体结构的装置，试剂盒和包括这种微流体装置的系统。在一个实施例中，该方法可以包括：将所述样品转移到通过流动通道与第二流体储存器流体连通的第一流体储存器中; 旋转所述微流体结构以将所述样品输送到一个或多个死端凹部或腔室中; 将控制流体转移到所述结构中，所述结构产生所述一个或多个死端凹部或室中容纳的所述样品的流动和扩散的阻挡层; 并分析包含在所述一个或多个死端凹部或腔室中的所述样品。

27. 发明申请

US20090291505A1 Analytical Device for Thermally Treating a Fluid and/or Monitoring a Property Thereof 审中-公开
标题翻译：用于热处理流体和/或监测流体的分析装置
公开(公告)号：US20090291505A1
公开(公告)日：2009-11-26
申请号：US12373519
申请日：2007-07-13
申请人： Emad Sarofim
发明人： Emad Sarofim
IPC分类号： G01N33/00 , G01N21/01 , B32B37/02
CPC分类号： B01L3/50851 , Y10T436/143333
摘要： A device having a protrusion in one of the large side walls of a chamber thereof is disclosed. The device can be used advantageously in reliable analyses in automate procedures.
摘要翻译：公开了一种在其室的大侧壁之一上具有突起的装置。该设备可以有效地用于自动化程序中的可靠分析。

28. 发明申请

US20060081600A1 Method and apparatus for performing rapid thermo cycling as well as micro fabricated system 审中-公开
标题翻译：执行快速热循环的方法和装置以及微制造系统
公开(公告)号：US20060081600A1
公开(公告)日：2006-04-20
申请号：US11226637
申请日：2005-09-13
申请人： Martin Kopp , Emad Sarofim
发明人： Martin Kopp , Emad Sarofim
IPC分类号： F27D11/04
CPC分类号： G05D23/19 , B01L7/52 , B01L2300/1822 , B01L2300/1833
摘要： A method to adjust a temperature of a fluid is disclosed, the method comprising the steps of providing a heat sink taking effect on the fluid, heating the fluid by Joule heating, and adjusting the heat provided by Joule heating in order to reach a desired temperature of the fluid. Furthermore, an apparatus to carry out the method is also disclosed. Therewith, a very efficient temperature change of the fluid can very quickly be obtained since the temperature of the surrounding is not substantially changed by heat diffusion. While a temperature increase is carried out by Joule heating, a temperature decrease is carried out by simply deactivating Joule heating. As soon as Joule heating is deactivated, the heat is extracted from the fluid by the heat sink, thereby initiating a high speed temperature change towards lower temperatures.
摘要翻译：公开了一种调节流体温度的方法，该方法包括以下步骤：提供散热器对流体的作用，通过焦耳加热加热流体，并调节由焦耳加热提供的热量以达到所需温度的流体。此外，还公开了一种执行该方法的装置。因此，由于通过热扩散基本上不改变周围的温度，所以可以非常快速地获得流体的非常有效的温度变化。当通过焦耳加热进行温度升高时，通过简单地停用焦耳加热来进行温度降低。一旦焦耳加热被停用，热量通过散热器从流体中提取，从而开始向较低温度的高速温度变化。

29. 发明授权

US06649896B2 Method and a device for measuring the spatially averaged intensity of a light beam and a method and a device for regulating a light source 有权
公开(公告)号：US06649896B2
公开(公告)日：2003-11-18
申请号：US10168790
申请日：2002-06-21
申请人： Lukas Birrer , Thomas Caratsch , Olivier Elsenhans , Emad Sarofim , Urban Schnell
发明人： Lukas Birrer , Thomas Caratsch , Olivier Elsenhans , Emad Sarofim , Urban Schnell
IPC分类号： H01L3100
CPC分类号： G01J1/4228 , G01J1/04 , G01J1/0429 , G01J1/1626 , G01J1/32 , G01J1/4257
摘要： A photoelectric module (1) comprises an electrically non-conducting support (2) and a photoelectric element including an array of spatially distributed photoelectric members applied to a surface of the support (2). High simplicity and efficiency is obtained by the double function of module (1) for light transmission or reflection, and spatially averaged light measurement. In a preferred application of module (1) a light source (8, LED) is energized by a driving circuit (9) controlled by an electronic circuit (11). The input of this circuit (11) is connected to the photoelectric module (1), the power delivered to the light source (8) and the intensity of the light beam emitted by the light source being regulated preferably to a constant value by the feedback loop consisting of module (1), electronic circuit (11) and driving circuit (9).

30. 发明授权

US08814808B2 Body fluid sampling device 有权
标题翻译：体液取样装置
公开(公告)号：US08814808B2
公开(公告)日：2014-08-26
申请号：US12879500
申请日：2010-09-10
申请人： Irio Guiseppe Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilifried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
发明人： Irio Guiseppe Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilifried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
IPC分类号： A61B5/151 , A61B5/15 , A61B5/145
CPC分类号： A61B5/1411 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150068 , A61B5/150282 , A61B5/150358 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/15045 , A61B5/150503 , A61B5/15151 , A61B5/15163
摘要： Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid. In one embodiment, the collection zone includes a plurality of holes, e.g., 3 or more holes, or 50 to 100 holes. The hole size may be small, e.g., having a diameter of 0.01 to 0.5 mm. The holes may or may not extend through the lancet. In some embodiments, the holes have a depth of 50 to 500 μm. In other embodiments, the collection zone is porous, or is a roughened area. The collection zone can take up a very small volume of body fluid, e.g., 3 to 10 nL, in a very short time period, e.g., less than 0.5 seconds. In other embodiments, the device further comprises a fluid receiving means spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially.
摘要翻译：体液取样装置包括具有用于接收体液的收集区的皮肤刺穿元件。在一个实施例中，收集区包括多个孔，例如3个或更多个孔，或50至100个孔。孔尺寸可以较小，例如具有0.01至0.5mm的直径。这些孔可以延伸穿过刺血针也可能不延伸穿过刺血针。在一些实施例中，孔的深度为50至500μm。在其它实施方案中，收集区是多孔的，或者是粗糙区域。收集区可以在非常短的时间段（例如小于0.5秒）内占据非常小体积的体液，例如3至10nL。在其他实施例中，该装置还包括与收集区间隔开的流体接收装置，使得收集区中的体液最初不会接触流体接收装置。

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