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21. 发明专利

JPH06329557A CARRIER FOR ADSORBING PHYSIOLOGICALLY ACTIVE SUBSTANCE 失效
公开(公告)号：JPH06329557A
公开(公告)日：1994-11-29
申请号：JP12001593
申请日：1993-05-21
申请人： MEIJI MILK PROD CO LTD
发明人： ODA MUNEHIRO , YOKOYAMA MINEHIKO , IKEGAMI HIDEJI , SAKUMA SADATOSHI , ITO HIROYUKI
IPC分类号： A61K9/107 , A61K47/02
摘要： PURPOSE:To obtain a carrier for adsorbing a physiologically active substance composed of fine particles of hydroxyapatite having the surface treated with albumin and/or a polyvalent organic acid. CONSTITUTION:The carrier for adsorbing a physiologically active substance contains fine particles of hydroxyapatite, having the surface treated with albumin (e.g. human blood serum albumin) and/or a polyvalent organic acid (e.g. citric acid) and having preferably

22. 发明专利

JPH06306082A ANTIBACTERIAL, ANTIFUNGAL AND ANTIVIRAL AGENT 失效
公开(公告)号：JPH06306082A
公开(公告)日：1994-11-01
申请号：JP9974293
申请日：1993-04-26
申请人： MEIJI MILK PROD CO LTD
发明人： ODA MUNEHIRO , ITO HIROYUKI , SUDO TETSUSHI , SAKUMA SADATOSHI , NOMIYA KENJI
IPC分类号： A01N59/16 , A61K31/28 , A61K33/38 , A61P31/04 , A61P31/12 , C07F1/10
摘要： PURPOSE:To obtain the composition having broad antimicrobial spectrum, excellent in durability and residual effects, etc., having high safety and useful as a antibacterial, antifungal and antiviral agent. CONSTITUTION:The objective complex is obtained by coordinating a thiol group- containing compound in silver ion. Furthermore, in the complex, the reaction molar ratio of the thiol group-containing compound to silver ion is preferably 0.1-4 and pair cation is preferably selected from K , Ca and Ba . Further, the complex is preferably obtained by reacting, e.g the thiol group-containing compound with silver ion in an aqueous solution and depositing the complex with an alcohol, etc.

23. 发明专利

JPH02302669A METHOD FOR DETECTING HEPATITIS B VIRUS ANTIBODY 失效
公开(公告)号：JPH02302669A
公开(公告)日：1990-12-14
申请号：JP12157789
申请日：1989-05-17
申请人： SHINO TEST CORP , MEIJI MILK PROD CO LTD
发明人： SUZUKI TAKASHI , NAITO MASAHIRO , ODA MUNEHIRO
IPC分类号： G01N33/576
摘要： PURPOSE:To detect an HBs (hepatitis B virus surface antigen) antibody with high sensitivity by using a cell holding at least one of the play S1, S2 regions and S-gene of a hepatitis B virus genom. CONSTITUTION:As a cell holding at least one of the play S1 region, play S2 region and S-gene of hepatitis B virus genom, for example, a cell in which at least one of the play S1, S2 regions and S-gene of the hepatitis B virus genom is artificially incorporated by gene engineering technique is designated. By culturing the cell line thus created artificially, for example, human liver cancerous cell, the HBs antigen is obtained in a cultured product such as a culture solution, a culture supernatant liquid, a culture filtrate or a culture cell and purified by an arbitrary method. By using the antibody detecting reagent to HBs containing HBs, a HBs antibody can be detected with high sensitivity.

24. 发明专利

JPH01197442A ANTITUMOR AGENT 失效
公开(公告)号：JPH01197442A
公开(公告)日：1989-08-09
申请号：JP2137188
申请日：1988-02-02
申请人： MEIJI MILK PROD CO LTD
发明人： TADA NOBUHIKO , ODA MUNEHIRO , KUROTSU TAKAHIRO , IKEGAMI HIDEJI
IPC分类号： A61K39/395 , A61P35/00
摘要： PURPOSE:To obtain an antitumor agent comprising monoclonal antibody A1, 287 against ganglioside GD2 of cell surface as an active ingredient. CONSTITUTION:An antibody-forming cell obtained by immunizing an A mouse against T cell leukemia cell strain EL4 derived from C57BL/6 mouse is fused with a mouse myeloma cell to give a hybridoma. Monoclonal antibody A1, 287 which has actions to extremely prolong life of cancerous mouse transplanted with mouse T cell leukemia cell strain or to completely reject tumor is obtained from monoclonal antibodies against ganglioside GD2 of cell surface produced by the hybridoma and an antitumor agent comprising the monoclonal antibody as an active ingredient is obtained. The antitumor agent is used for treating malignant lymphoma and a daily dose of intravenous drip is 50-1,000ml as a drip injection containing 0.1mug-100mg/ml, preferably 1mug-1mg/ml of the antibody.

25. 发明专利

JPS601877B2 失效
公开(公告)号：JPS601877B2
公开(公告)日：1985-01-17
申请号：JP303981
申请日：1981-01-14
申请人： MEIJI MILK PROD CO LTD
发明人： TSUCHA FUMYASU , MYAZAWA KYUSHICHI , KANBE MICHIO , ODA MUNEHIRO , EBISAWA NAOYUKI
IPC分类号： C08B37/00 , A61K31/715 , C12P19/04 , C12R1/225 , C12R1/46

26. 发明专利

JPS59162880A Production of plasminogen activator 失效
标题翻译：生产激素的生成
公开(公告)号：JPS59162880A
公开(公告)日：1984-09-13
申请号：JP3748283
申请日：1983-03-09
申请人： Meiji Milk Prod Co Ltd
发明人： ODA MUNEHIRO , HAYAZAKI JIYUNICHI , MIYAHARA MICHINORI , YOSHIYAMA YOSHIHIRO , KANBE MICHIO , TSUCHIYA FUMIYASU
IPC分类号： C12N9/64
摘要： PURPOSE: To produce plasminogen activator, economically, by culturing plasminogen activator-producing cell in a synthetic medium added with transferrin, ethanolamine, and selenous acid.
CONSTITUTION: A serum-free synthetic medium is prepared by adding transferrin, ethanolamine, selenous acid, and preferably a proliferation promoting factor (QGF) to a base medium such as RPMI-1640 (product of GIBCO Corp.). Plasminogen activator-producing cell (e.g. cell strain QG-90) is cultured in the serum- free synthetic medium at about 30W40°C, and the produced plasminogen activator is separated from the cultured product and purified, e.g. by gel-filtration. The plasminogen activator is effective to activate plasminogen and produce plasmin for pharmaceutical use.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：经济地通过在加入转铁蛋白，乙醇胺和硒酸的合成培养基中培养产生纤溶酶原激活物的细胞来产生纤溶酶原激活物。构成：通过将铁蛋白，乙醇胺，硒酸，优选增殖促进因子（QGF）加入到诸如RPMI-1640（GIBCO Corp.的产品）的基础培养基中来制备无血清合成培养基。在约30-40℃，在无血清的合成培养基中培养产生纤溶酶原激活物的细胞（例如细胞株QG-90），并将所产生的纤溶酶原激活物从培养产物中分离并纯化，例如。通过凝胶过滤。纤溶酶原激活剂有效激活纤溶酶原并产生用于药物用途的纤溶酶。

27. 发明专利

JPS5814835B2 失效
公开(公告)号：JPS5814835B2
公开(公告)日：1983-03-22
申请号：JP988078
申请日：1978-02-02
申请人： MEIJI MILK PROD CO LTD
发明人： ODA MUNEHIRO , MATSUDA KOJIRO , KANBE MICHIO , TSUCHA FUMYASU , HIBINO KOICHI
IPC分类号： C02F3/12

28. 发明专利

JP2001269194A METHOD FOR PRODUCING HEPATITIS B VIRUS SURFACE ANTIGEN IN HIGH YIELDS ON CELL CULTURE 失效
公开(公告)号：JP2001269194A
公开(公告)日：2001-10-02
申请号：JP2000089517
申请日：2000-03-28
申请人： MEIJI MILK PROD CO LTD
发明人： KUROTSU TAKAHIRO , ODA MUNEHIRO , KOIKE KATSURO
IPC分类号： C12P21/02 , C12N5/10
摘要： PROBLEM TO BE SOLVED: To provide a method for producing an antigen in high yields by which the production of the antigen is increased and the antigen equal to natural type HBs antigen (derived from blood plasma) on the physicochemical and immunological characteristics of the antigen can be obtained when an established cell line derived from the human liver cancer tissue producing hepatitis B virus surface antigen (HBs antigen) is cultured to obtain the antigen from the cultured supernatant. SOLUTION: When the established cell line huGK-14 derived from the human liver cancer tissue producing HBs antigen is cultured to obtain the antigen from the cultured supernatant, an unusually high concentration of HBs antigen particles is productively secreted into the cultured supernatant by including dexamethasone and N,N-dimethylacetamide in the culture medium for production.

29. 发明专利

JPH10160735A SANDWICH MEASURING METHOD 失效
公开(公告)号：JPH10160735A
公开(公告)日：1998-06-19
申请号：JP1774997
申请日：1997-01-16
申请人： MEIJI MILK PROD CO LTD
发明人： YANO AKIRA , YOKOYAMA MINEHIKO , IKEMATSU SHINYA , ODA MUNEHIRO , MURAMATSU TAKASHI , MURAMATSU TOSHIKO
IPC分类号： G01N33/53 , G01N33/531 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To obtain a sandwich measuring method in which a high-sensitivity measuring system can be constructed by a method wherein two kinds of polychlonal antibodies are used as a first antibody and a second antibody for a sandwich method. SOLUTION: A sandwich method is constructed in such a way that human MK is used as an antigen and that a rabbit and a chicken are used an immune animals. When epitopes on MK molecules recognized by two kinds of polyclonal antibodies derived from the rabbit and the chicken are compared, the two kinds of polyclonal antibodies recognize respectively different epitope groups on identical antigen molecules. When the polyclonal antibodies are used as a first antibody and a second antibody for the sandwich method, it is possible to establish the sandwich method similar to that of monoclonal antibodies. In addition, an antigen is a protein which is originally owened by an animal species, different animal species are immunized, and polyclonal antibodies are obtained from them. In addition, two kinds of animal species which are immunized are not limited to the rabbit and the chicken, and a combination of animal species in which epitopes are not overlapped can be used arbitrarily.

30. 发明专利

JPH09289877A CALCIUM-REINFORCING AGENT 失效
公开(公告)号：JPH09289877A
公开(公告)日：1997-11-11
申请号：JP5548497
申请日：1997-02-25
申请人： MEIJI MILK PROD CO LTD
发明人： ODA MUNEHIRO , IKEGAMI HIDEJI , KIDO ISAO , SAKUMA SADATOSHI , ITO HIROYUKI , WAKUTA JUNICHIRO
IPC分类号： A23L2/52 , A23L1/304 , A23L13/60 , A23L17/00 , A61K33/06 , A61P19/10 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To obtain a calcium-reinforcing agent for food products and medicines which can stably disperse in water for a long period of time without sedimentation of the components by surface-treating hydroxy apatite with a solution containing citric acid or a citrate salt, or with a protein or a peptide. SOLUTION: Ultrafine particles of hydroxyapatite with a particle size of

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