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1. 发明申请

WO9854211A2 CYCLODEPSIPEPTIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译： CYCLODEPSIPEPTIDES和含有它们的药物组合物
公开(公告)号：WO9854211A2
公开(公告)日：1998-12-03
申请号：PCT/JP9802380
申请日：1998-05-29
申请人： MEIJI MILK PROD CO LTD , TSUNOO AKINOBU , KAMIJO MASAYUKI
发明人： TSUNOO AKINOBU , KAMIJO MASAYUKI
IPC分类号： A61K38/00 , A61P9/04 , A61P9/06 , A61P9/08 , C07D273/00 , C07D498/14 , C07K11/02 , A61K31/395 , A61K38/15
CPC分类号： C07D273/00 , A61K38/00 , C07K11/02 , Y02P20/55
摘要： This invention relates to the cyclodepsipeptide represented by formula (1), wherein R , R and R are a hydrogen atom or a methyl group, R and R lower alkyl groups, and R a lower alkyl group or an aralkyl group. R and R are a hydrogen, an alkyl group of 1 to 8 carbons or an aralkyl group (but not R =R =H), A and B are individually an ethylene group or a methylene group that is substituted by a lower alkyl group, X and Y represent -O- and -N(R )- in which R is a hydrogen atom or a methyl group, R and R of X, and/or R and R being capable of forming a nitrogen-containing ring together with the contiguous carbon and nitrogen atoms. This invention also provides a medicine containing this compound as an effective ingredient. These compounds have strong cardiotonic, antiarrhythnic and vasodilating effects without an arrhythmic side effect.
摘要翻译：本发明涉及由式（1）表示的环缩酚肽，其中R 1a，R 1b和R 1c是氢原子或甲基，R 2和R 4低级烷基，和R 3是低级烷基或芳烷基。 R 5和R 6是氢，1至8个碳原子的烷基或芳烷基（但不是R 5 = R 6 = H），A和B分别是亚乙基或被低级烷基取代的亚甲基，X和Y表示-O-和-N（R 1d） - ，其中R 1d是氢原子或甲基，R 2和R X 1和/或R 4和R 1c能够与连续的碳原子和氮原子一起形成含氮环。本发明还提供含有该化合物作为有效成分的药物。这些化合物具有强烈的强心药，抗心律失常药和血管舒张作用，无副作用。

2. 发明申请

WO0002578A8 REMEDIES FOR APOPTOSIS-ASSOCIATED DISEASES 审中-公开
标题翻译：用于治疗相关疾病的补救措施
公开(公告)号：WO0002578A8
公开(公告)日：2001-03-15
申请号：PCT/JP9903740
申请日：1999-07-09
申请人： MEIJI MILK PROD CO LTD , MURAMATSU TAKASHI , IKEMATSU SHINYA , YOSHIDA YOSHIHIRO , KADOMATSU KENJI , ODA MUNEHIRO , SAKUMA SADATOSHI , ASHIDA KIN YA , KINO KOHSUKE
发明人： MURAMATSU TAKASHI , IKEMATSU SHINYA , YOSHIDA YOSHIHIRO , KADOMATSU KENJI , ODA MUNEHIRO , SAKUMA SADATOSHI , ASHIDA KIN-YA , KINO KOHSUKE
IPC分类号： A61K38/18 , A61K38/17
CPC分类号： A61K38/18
摘要： It is found out that a protein belonging to the midkine (MK) family inhibits the induction of apoptosis caused by anticancer agents, ultraviolet irradiation and ischemic stress. This finding makes it possible to provide novel drugs containing the protein belonging to the MK family as the active ingredient for treating and preventing any diseases caused by apoptosis, for example, heart diseases, renal diseases, nervous diseases or liver diseases.
摘要翻译：发现属于中期因子（MK）家族的蛋白质抑制由抗癌剂引起的凋亡诱导，紫外线照射和缺血应激。该发现使得可以提供含有属于MK家族的蛋白质的新药物作为治疗和预防由凋亡引起的任何疾病，例如心脏病，肾脏疾病，神经疾病或肝脏疾病的活性成分。

3. 发明公开

EP0774510A4 UNGULATE EG CELL 失效
标题翻译：鸡蛋一只，从Paarhufern
公开(公告)号：EP0774510A4
公开(公告)日：1997-12-10
申请号：EP95921970
申请日：1995-06-15
申请人： MEIJI MILK PROD CO LTD
发明人： HASHIMOTO KOICHIRO , MITANI TASUKU , TAKAHASHI NOBUKO , NAKAO HARUHIKO , KAWASE EIHACHIRO , MATSUI YASUHISA
IPC分类号： C12N5/074 , C12N15/877 , C12N5/06 , A01K67/027 , C12N15/87 , C12N15/88 , C12N15/89
CPC分类号： C12N15/8778 , C12N5/0611

4. 发明公开

EP0727427A4 ANTIBACTERIAL, ANTIFUNGAL AND ANTIVIRAL AGENT 失效
标题翻译： ANTIBACTERIELLES，抗真菌和抗介质
公开(公告)号：EP0727427A4
公开(公告)日：1997-10-15
申请号：EP94929019
申请日：1994-10-07
申请人： MEIJI MILK PROD CO LTD , TOYO INK MFG CO
发明人： ODA MUNEHIRO , ITOH HIROYUKI , SUDO TETSUSHI , SAKUMA SADATOSHI , NOMIYA KENJI , SUZUKI YASUNORI , JONOSHITA YUKIYOSHI , KIKUCHI AKIRA , TAKABATAKE YOSHIKO
IPC分类号： A01N31/02 , A01N31/08 , A01N31/16 , A01N37/36 , A01N37/40 , A01N37/44 , A01N43/40 , A01N43/52 , A01N43/54 , A01N43/713 , A01N43/90 , A01N47/28 , A01N59/16 , C07C323/52 , C07C323/62 , C07F1/10 , A01N25/08 , A01N37/10 , A61K31/28
CPC分类号： C07C323/62 , A01N31/02 , A01N31/08 , A01N31/16 , A01N37/36 , A01N37/40 , A01N37/44 , A01N43/40 , A01N43/52 , A01N43/54 , A01N43/713 , A01N43/90 , A01N47/28 , A01N59/16 , C07C323/52 , A01N61/00 , A01N43/78 , A01N37/06 , A01N2300/00
摘要： A complex comprising a coordination compound between a silver ion and a thiol compound; an antibacterial, antifungal and antiviral agent containing the same as the active ingredient; and an antibacterial, antifungal and antiviral composition containing the above agent and a vehicle or a filler. The agent has a wide antibacterial and antifungal spectrum and an antiviral activity, is well compatible with various vehicles and fillers, sustains its activity for long, and is reduced in peroral toxicity, skin irritation and mucosa irritation.

5. 发明公开

EP0205625A1 HEPATITIS B VIRUS VACCINE AND PROCESS FOR ITS PREPARATION. 失效
标题翻译： HEPATITIS-B-VIRUSIMPFSTOFF UND DESSEN HERSTELLUNG。
公开(公告)号：EP0205625A1
公开(公告)日：1986-12-30
申请号：EP86900287
申请日：1985-12-28
申请人： JAPAN FOUND CANCER , MEIJI MILK PROD CO LTD
发明人： KOIKE KATSUO , SUGANO HARUO , ODA MUNEHIRO , KATAYANAGI SHIGERU , FUJIMORI TAKAO
IPC分类号： A61K39/29 , C07K14/02 , C12P21/08 , C12R1/91
CPC分类号： C07K14/005 , C12N2730/10122
摘要： A composition of polypeptides (and/or glycopolypeptides wherein a sugar chain is bound to said polypeptide) composed of one or more of an adr-type hepatitis B virus surface antigen and/or intermediate surface antigen of said and/or large surface antigen of said virus, a process for its preparation, and a vaccine for hepatitis B virus containing said composition as an effective ingredient. The vaccine can be produced in a large amount by culturing variant strain huGK-14, thus being advantageously produced without resort to human blood.
摘要翻译：由所述的所述和/或大的表面抗原的一种或多种adr型乙型肝炎病毒表面抗原和/或中间表面抗原组成的多肽（和/或糖多肽，其中糖链与所述多肽结合）的组合物病毒，其制备方法和含有所述组合物作为有效成分的乙型肝炎病毒疫苗。可以通过培养变异菌株huGK-14来大量生产疫苗，因此有利地生产而不用诉诸于人的血液。

6. 发明公开

EP0960887A4 T CELL EPITOPE PEPTIDE 失效
标题翻译： T细胞表位肽
公开(公告)号：EP0960887A4
公开(公告)日：2002-09-18
申请号：EP97927371
申请日：1997-06-12
申请人： MEIJI MILK PROD CO LTD
发明人： KINO KOHSUKE , DAIRIRI KAZUO
IPC分类号： A61K38/00 , A61K39/00 , A61K39/36 , C07K14/415 , C07K14/725 , A61K38/02 , C07K7/08 , G01N33/53
CPC分类号： C07K14/415 , A61K38/00 , A61K39/00 , A61K39/36
摘要： The T cell epitope site on a Japanese cypress (hinoki) pollen allergen molecule has been identified by stimulating a T cell line established from a patient suffering from Japanese cypress pollen allergy with an overlap peptide covering the primary structure of the Japanese cypress pollen allergen. The peptide is useful in the immunotherapy or diagnosis of spring tree pollinoses including Japanese cypress pollinosis having cross reactivity with Japanese cypress pollen.

7. 发明公开

EP0779359A4 METHOD OF CULTURING AVIAN CELLS AND CELL LINE OBTAINED THEREBY 失效
标题翻译：方法为培养细胞BIRD和GOT细胞系
公开(公告)号：EP0779359A4
公开(公告)日：1999-10-27
申请号：EP95929221
申请日：1995-08-24
申请人： MEIJI MILK PROD CO LTD
发明人： KUWANA TAKASHI , HASHIMOTO KOICHIRO , NAKANISHI AKIRA
IPC分类号： C12N5/02 , C12N5/074 , C12N5/06
CPC分类号： C12N5/0604 , C12N5/0611 , C12N2500/60 , C12N2502/13
摘要： A method of culturing avian cells in a medium with a pH value of 7.8 or above, whereby avian cells can be subcultured stably for long. Since avian cells have been incapable of subculture heretofore, it has been impossible to effect in vitro cell or gene manipulation therewith. Now that such a manipulation becomes possible by the invention method, the way is opened for the industrial utilization of avian cells in the creation of transgenic birds and the production of vaccines.

8. 发明公开

EP0873754A4 AMINO ACID COMPOSITIONS 失效
标题翻译： AMINOSÄURENZUSAMMENSETZUNGEN
公开(公告)号：EP0873754A4
公开(公告)日：1999-03-24
申请号：EP97900113
申请日：1997-01-09
申请人： RIKAGAKU KENKYUSHO , MEIJI MILK PROD CO LTD
发明人： ABE TAKASHI , TSUCHITA HIROSHI , IIDA KOJI
IPC分类号： A61K31/415 , A61K38/48 , A61K31/195 , A61K31/395 , A61K31/40
CPC分类号： A61K31/415 , A61K31/40 , A61K31/195 , A61K2300/00
摘要： Amino acid compositions containing the following amino acids each in the molar proportion as specified below: proline (12.6 - 23.4), alanine (8.4 - 15.6), glycine (13.3 - 24.9), valine (8.2 - 15.4), threonine (5.0 - 9.4), leucine (4.3 - 8.1), histidine (1.8 - 11.9), serine (1.7 - 3.3), lysine (6.0 - 11.2), isoleucine (3.1 - 5.9), glutamic acid (2.2 - 10.4), arginine (2.4 - 4.6), phenylalanine (2.6 - 5.0), tyrosine (4.2 - 7.8) and trypsin (1.5 - 2.9). These compositions are efficacious in supplementing amino acids in blood reduced in association with hard exercise and suppressing changes in blood amino acid levels, thus improving motor functions, relieving fatigue after exercise, and facilitating the recovery from fatigue.
摘要翻译：包含以下摩尔比的以下氨基酸的氨基酸组合物：脯氨酸（12.6至23.4），丙氨酸（8.4至15.6），甘氨酸（13.3至24.9），缬氨酸（8.2至15.4），苏氨酸（5.0至9.4），亮氨酸（4.3至8.1），组氨酸（1.8至11.9），丝氨酸（1.7至3.3），赖氨酸（6.0至11.2），异亮氨酸（3.1至5.9），谷氨酸（2.2至10.4），精氨酸（2.4至4.6）苯丙氨酸（2.6〜5.0），酪氨酸（4.2〜7.8）和胰蛋白酶（1.5〜2.9）。该组合物补充了在锻炼期间减少的血液氨基酸，并且显示出改善运动功能的效果，减少运动后的疲劳并帮助恢复疲劳。

9. 发明公开

EP0714662A4 ANTIALLERGIC AGENT 失效
标题翻译： ANTIALLALLERGIESCHE SUBSTANZ
公开(公告)号：EP0714662A4
公开(公告)日：1997-11-12
申请号：EP94921100
申请日：1994-07-15
申请人： MEIJI MILK PROD CO LTD
发明人： KINO KOHSUKE , KOMIYAMA NAOKI , SONE TOSHIO , KOHNO YOICHI
IPC分类号： A61K39/00 , A61K39/35 , C07K14/705 , A61K38/00 , A61K39/36
CPC分类号： C07K14/705 , A61K39/00 , A61K39/35
摘要： An antiallergic agent containing as the active ingredient a peptide containing a monovalent B cell epitope on an allergen molecule with which an IgE antibody specifically combines and having the effect of inhibiting the formation of a cross-linked structure by the combination of the allergen with the IgE antibody. This agent works on the basis of an entirely new mechanism of inhibiting antigen-specifically the cross-linking of the IgE antibody. It is useful for preventing and treating immediate allergic diseases such as food allergy, tick allergy, bronchial asthma, pollinosis, allergic rhinitis and allergic enterogastritis.
摘要翻译：一种抗变态反应剂，其含有IgE抗体与IgE抗体特异性结合的变应原分子上含有单价B细胞表位的肽，并具有抑制过敏原与IgE结合形成交联结构的作用抗体。该试剂基于全新的抑制抗原特异性IgE抗体交联的机制。对预防和治疗即食过敏，蜱过敏，支气管哮喘，花粉症，过敏性鼻炎和过敏性肠胃炎等即时过敏性疾病有用。

10. 发明公开

EP0603416A4 METHOD OF INTEGRATING GENE INTO CHROMOSOME OF -i(LACTOBACILLUS DELBRUECKII) SPECIES AND PRODUCT OF GENE INTEGRATION. 失效
标题翻译： METHOD FOR整合基因到染色体甲-i（LACTOKACILLUS德氏）种及产品，遗传融合。
公开(公告)号：EP0603416A4
公开(公告)日：1997-04-23
申请号：EP93914972
申请日：1993-07-08
申请人： MEIJI MILK PROD CO LTD
发明人： SASAKI TAKASHI , SASAKI YASUKO , ITO YOSHIYUKI , OTSU KUMI
IPC分类号： C12N15/09 , C12N1/21 , C12N9/04 , C12N15/74 , C12N15/90 , C12R1/225
CPC分类号： C12N9/0006 , C12N15/746 , C12N15/902
摘要： A product of gene integration prepared by integrating an arbitrary gene into a chromosomal DNA of a bacillus of Lactobacillus delbrueckii species through a method which comprises constructing an integration plasmid by combining pAM beta 1 plasmid with a target gene, subjecting the obtained plasmid to conjugation transfer and homologous recombination to thereby integrate only the target gene into the chromosomal DNA, and eliminating the DNA sequence of the pAM beta 1 as a vector. The product can be widely applied to the production of food, drug and feed.

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