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1. 发明专利

JPH02302669A METHOD FOR DETECTING HEPATITIS B VIRUS ANTIBODY 失效
公开(公告)号：JPH02302669A
公开(公告)日：1990-12-14
申请号：JP12157789
申请日：1989-05-17
申请人： SHINO TEST CORP , MEIJI MILK PROD CO LTD
发明人： SUZUKI TAKASHI , NAITO MASAHIRO , ODA MUNEHIRO
IPC分类号： G01N33/576
摘要： PURPOSE:To detect an HBs (hepatitis B virus surface antigen) antibody with high sensitivity by using a cell holding at least one of the play S1, S2 regions and S-gene of a hepatitis B virus genom. CONSTITUTION:As a cell holding at least one of the play S1 region, play S2 region and S-gene of hepatitis B virus genom, for example, a cell in which at least one of the play S1, S2 regions and S-gene of the hepatitis B virus genom is artificially incorporated by gene engineering technique is designated. By culturing the cell line thus created artificially, for example, human liver cancerous cell, the HBs antigen is obtained in a cultured product such as a culture solution, a culture supernatant liquid, a culture filtrate or a culture cell and purified by an arbitrary method. By using the antibody detecting reagent to HBs containing HBs, a HBs antibody can be detected with high sensitivity.

2. 发明专利

JP2525195B2 失效
公开(公告)号：JP2525195B2
公开(公告)日：1996-08-14
申请号：JP16775387
申请日：1987-07-07
申请人： SHINO TEST CORP
发明人： HAMAOKA AKIRA , NAITO MASAHIRO , SUZUKI TAKASHI
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/535

3. 发明专利

JPH0584466B2 失效
公开(公告)号：JPH0584466B2
公开(公告)日：1993-12-02
申请号：JP4527686
申请日：1986-03-04
申请人： SHINO TEST CORP
发明人： SUZUKI TAKASHI , UCHIDA REIKO
IPC分类号： A61K35/16 , A61K35/14 , A61K35/24 , G01N33/50 , G01N33/68

4. 发明专利

JPH02296151A MICRO-TITER PLATE 失效
公开(公告)号：JPH02296151A
公开(公告)日：1990-12-06
申请号：JP11607689
申请日：1989-05-11
申请人： SHINO TEST CORP
发明人： NAITO MASAHIRO , SUZUKI TAKASHI , HAMAOKA AKIRA
IPC分类号： G01N33/543
摘要： PURPOSE:To make it possible to distinguish an agglutination image into an agglutinated part and a non-agglutinated part by forming a cylinder shaped recess or a conical recess at the center of the bottom surface of a well. CONSTITUTION:This plate 1 is used as a judging container when the measure ment of various antibody values, virus and the like in body fluid is judged with agglutinated image in immounological particle agglutination reaction. A cylinder-shaped or conical recess 3 is formed at the center of the bottom surface of a U-shaped or V-shaped well 2 wherein a sample under test or a reagent is contained, stored and reacted. At this time, particles are agglutinated, spread on the bottom surface of the well 2 and appear uniformly or the particles are concentrated at one point of the center of the well 2 without agglutination depending on whether antigen-antibody reaction takes place or not. When the excessive particles fall in the recess 3 formed in this way and the intermediate agglutinated image is formed, judgment of the agglutination or the non- agglutination can be clearly carried out, and the judgment becomes easy.

5. 发明专利

JPH02210262A METHOD FOR INDIRECTLY MEASURING FLOCCULATION REACTION 失效
公开(公告)号：JPH02210262A
公开(公告)日：1990-08-21
申请号：JP2971889
申请日：1989-02-10
申请人： SHINO TEST CORP
发明人： SUZUKI TAKASHI , HAMAOKA AKIRA , NAITO MASAHIRO
IPC分类号： G01N33/543 , G01N33/553
摘要： PURPOSE:To maintain measuring sensitivity and stability, to shorten the measuring time and to carry out measurement irrespective of the kinds by binding a material having affinity to a magnetic-particle carrier and simultaneously or subsequently exerting a magnetic force on the carrier. CONSTITUTION:The reaction of a material to be tested and the particle carrier bound with a material having affinity for the material to be tested is judged as the flocculation of the particle carrier. At this time, the material having affinity is bound to the magnetic-particle carrier, and simultaneously or subsequently a magnetic force is exerted on the carrier. Consequently, the settling velocity of the particle is accelerated, and the measuring time is remarkably shortened from several hours to several minutes. Furthermore, the time of the exertion of the magnetic force is limited to prevent the decreases in the measuring speed and stability of a flocculation image due to the effect of gravity on the high-specific-gravity particle.

6. 发明专利

JPH04216466A MAGNETISM GENERATOR AND IMMUNOASSAY 失效
公开(公告)号：JPH04216466A
公开(公告)日：1992-08-06
申请号：JP40337590
申请日：1990-12-18
申请人： SHINO TEST CORP , NITTETSU MINING CO LTD
发明人： HAMAOKA AKIRA , SUZUKI TAKASHI , NAITO MASAHIRO , MIYAMOTO NORITO
IPC分类号： G01N33/543 , G01N33/553
摘要： PURPOSE:To carry out measurement within a short time in immunoassay and to allow a magnetism generator used in measurement to simply correspond to many kinds of measuring containers. CONSTITUTION:In an apparatus or process allowing magnetic force to act on the magnetic particle carrier in immunoassay using said magnetic particle carrier, a magnet 1 is allowed to directly or indirectly act on a ferromagnetic body 2 to generate a magnetic field space of a uniform magnetic vector constituted of the magnetic lines of force temporarily discharged from the surface of the ferromagnetic body and the magnetic force of the magnetic field space is allowed to act on the magnetic particle carrier.

7. 发明专利

JPS6469954A IMMUNOLOGICAL MEASURING METHOD 失效
公开(公告)号：JPS6469954A
公开(公告)日：1989-03-15
申请号：JP22656187
申请日：1987-09-11
申请人： SHINO TEST CORP , TOKUYAMA SODA KK
发明人： SUZUKI TAKASHI , NAITO MASAHIRO , TAKAHASHI NAOFUMI
IPC分类号： G01N33/543
摘要： PURPOSE:To judge the presence or absence of antigen or antibody in a sample based on the presence or absence of occurring aggregation reaction, by adding the sample to a measuring container, on the inner wall of which the antibody or the antigen that corresponds to the antigen or the antibody in the sample is fixed. CONSTITUTION:Antibody or antigen is fixed to the inner wall of a measuring container. A sample is added to the measuring container. Antigen or antibody included in the sample is made to react with the antibody or antigen, which is fixed in the measuring container. The sample including the unreacted antigen or antibody is made to remain without washing and removal of the sample including the unreacted antigen or antibody. Under this state, insoluble carrier particles, to which analogous body of the antibody, antigen or specific coupling is fixed, is added. Thus, the presence or absence of the antigen or antibody in the sample is judged based on the presence or absence of the occurring aggregation reaction.

8. 发明专利

JPS6412267A ENZYME LABELING SUGAR LIPID ANTIGEN AND ENZYME IMMUNITY MEASUREMENT USING IT 失效
公开(公告)号：JPS6412267A
公开(公告)日：1989-01-17
申请号：JP16775387
申请日：1987-07-07
申请人： SHINO TEST CORP
发明人： HAMAOKA AKIRA , NAITO MASAHIRO , SUZUKI TAKASHI
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/535
摘要： PURPOSE:To perform oxygen immunity measurement of a highly sensitive sugar chain antigen with a simple unit by attaching a sugar lipid antigen to oxygen without losing its antigen property and by obtaining oxygen labeling sugar lipid antigen. CONSTITUTION:Oxygen and sugar lipid antigen, where a hydrophobic group with alkyl chain was introduced, are attached hydrophobically and the alkyl chain is set to an alkyl group with two more carbons. Also, enzymes are peroxidase, glucose oxidase, alkaline phosfatase, or beta-galactoxidase. Also, sugar lipid antigens is ganglio, globo, isoglobo, lacto, or neolacto sugar lipid. Enzyme labeling sugar lipid antigen is obtained without losing antigen property of sugar lipid antigen while indexing competitive prevention by sugar chain antigen in the specimen liquid of reaction between an enzyme labeling sugar lipid antigen and a peculiar antibody for sugar chain of sugar lipid antigen which is fixed to an insoluble carrier. It allows for a simple and highly sensitive enzyme immunity measurement of sugar chain antigen by the competition method.

9. 发明专利

JPS62261960A LABELED IMMUNE CARRIER AND ITS USING METHOD 失效
公开(公告)号：JPS62261960A
公开(公告)日：1987-11-14
申请号：JP10383086
申请日：1986-05-08
申请人： SHINO TEST CORP
发明人： NAITO MASAHIRO , SUZUKI TAKASHI , HAMAOKA AKIRA , NAKAMURA TAKEKI
IPC分类号： G01N33/543 , C12Q1/00 , G01N33/535
摘要： PURPOSE:To manufacture a labeled immune carrier which obviates the deterioration in antibody activity and enzyme activity without directly conjugating the antibody and enzyme by conjugating both of the antibody and enzyme corresponding to a material to be examined to a pulverized particle carrier insoluble in water. CONSTITUTION:Both of the antibody and enzyme corresponding to the material to be examined are conjugated to the carrier consisting the pulverized particles (

10. 发明专利

JPS62203061A METHOD FOR STABILIZING CRP 失效
公开(公告)号：JPS62203061A
公开(公告)日：1987-09-07
申请号：JP4527686
申请日：1986-03-04
申请人： SHINO TEST CORP
发明人： SUZUKI TAKASHI , UCHIDA REIKO
IPC分类号： A61K35/16 , A61K35/14 , A61K35/24 , G01N33/50 , G01N33/68
摘要： PURPOSE:To make it possible to simply preserve a CRP standard solution for a long period of them, by adding an alkaline earth metal to purified CRP or a standard product of CRP containing the serum component of a human or other mammal. CONSTITUTION:An alkaline earth metal is added to purified CRP or a standard of CRP containing the serum component of a human or other mammal. As the alkaline earth metal, Ca, Ba and Mg can be used alone or as a mixture of two or more kinds of them and, further, can be used as a water-soluble salt such as chloride, acetate or nitrate. The use amount thereof is sufficient if at least 0.1-3mM is added and 1-2mM is added pref. An arbitrary component having buffering action or physiological saline may be added. Further, preservatives such as sodium azide or polyethylene glycol used in immunological nephelometry may be added.

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