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1. 发明专利

CA2339350A1 HIGH LEVEL SECRETORY EXPRESSION SYSTEM OF INTACT MK FAMILY PROTEIN 未知
公开(公告)号：CA2339350A1
公开(公告)日：2000-02-24
申请号：CA2339350
申请日：1999-08-10
申请人： MEIJI MILK PROD CO LTD
发明人： ASAMI YUKIO , MURASUGI AKIRA , KUMAI HIDESHI , KIDO ISAO
IPC分类号： C07K14/475 , C12N1/19 , C12N15/70 , C12N15/81 , C12P21/02
摘要： A Pichia yeast, which has been transformed by an expression vector containin g an MK family protein gene ligated to an .alpha.1 factor signal sequence originating in Saccharomyces cerevisiae under the regulation of a methanol- inducible alcohol oxidase gene (AOX1) promoter originating in Pichia pastori s and a transcription termination factor, is cultured and a true MK family protein is thus secreted and expressed on a mass scale in the culture supernatant.

2. 发明专利

AU5067499A Mass secretion/expression system of true mk family protein 未知
公开(公告)号：AU5067499A
公开(公告)日：2000-03-06
申请号：AU5067499
申请日：1999-08-10
申请人： MEIJI MILK PROD CO LTD
发明人： MURASUGI AKIRA , ASAMI YUKIO , KIDO ISAO , KUMAI HIDESHI
IPC分类号： C07K14/475 , C12N1/19 , C12N15/70 , C12N15/81

3. 发明专利

JPH09289877A CALCIUM-REINFORCING AGENT 失效
公开(公告)号：JPH09289877A
公开(公告)日：1997-11-11
申请号：JP5548497
申请日：1997-02-25
申请人： MEIJI MILK PROD CO LTD
发明人： ODA MUNEHIRO , IKEGAMI HIDEJI , KIDO ISAO , SAKUMA SADATOSHI , ITO HIROYUKI , WAKUTA JUNICHIRO
IPC分类号： A23L2/52 , A23L1/304 , A23L13/60 , A23L17/00 , A61K33/06 , A61P19/10 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To obtain a calcium-reinforcing agent for food products and medicines which can stably disperse in water for a long period of time without sedimentation of the components by surface-treating hydroxy apatite with a solution containing citric acid or a citrate salt, or with a protein or a peptide. SOLUTION: Ultrafine particles of hydroxyapatite with a particle size of

4. 发明专利

JPH09248192A DNA CODING PROTEIN HAVING ABILITY TO PROLIFERATE AND DIFFERENTIATE THYMUS MACROPHAGE-BASED CELL AND CEREBRAL MICROGLIA CELL 失效
公开(公告)号：JPH09248192A
公开(公告)日：1997-09-22
申请号：JP21410696
申请日：1996-07-26
申请人： MEIJI MILK PROD CO LTD
发明人： KIKUCHI AIKO , KAMO ISAO , KIDO ISAO , ORIKI KAZUO , ODA MUNEHIRO , SAKUMA SADATOSHI
IPC分类号： C12N15/09 , C07H21/04 , C07K14/52 , C07K14/53 , C07K14/535 , C12P21/02 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To obtain a new DNA fragment having each specific base sequence and molecular weight, coding a protein having activity to proliferate, differentiate and induce thymus macrophage-based cells and cerebral microglia cells, and useful for e.g. cloning the corresponding DNA. SOLUTION: This new DNA fragment, which has a molecular weight (determined by SDS-polyacrylamide gel electrophoresis) of about 60000 dalton and codes a polypeptide derived from a protein having activity to proliferate differentiate and induce thymus macrophage-based cells and cerebral microglia cells singly, or a polypeptide having an amino acid sequence homologous with that of the above polypeptide, is useful for cloning the cDNA and genome DNA each corresponding to the protein bearing the above-mentioned activity. This DNA fragment is obtained by the following process: mRNA is isolated by conventional means from peritubular contractile cells capable of producing the protein, the corresponding cDNA is synthesized by using the mRNA, and then cloned by PCR process using a primer obtained with the cDNA as template.

5. 发明专利

JP2006246900A Calcium reinforcing agent 有权
标题翻译：钙增强剂
公开(公告)号：JP2006246900A
公开(公告)日：2006-09-21
申请号：JP2006160758
申请日：2006-06-09
申请人： Meiji Milk Prod Co Ltd , 明治乳業株式会社
发明人： ODA MUNEHIRO , IKEGAMI HIDEJI , KIDO ISAO , SAKUMA SADATOSHI , ITO HIROYUKI , WAKUTA JUNICHIRO
IPC分类号： A23L1/304 , A61K33/06 , A61P9/10 , A61P19/08 , A61P19/10
摘要： PROBLEM TO BE SOLVED: To provide a new calcium reinforcing agent capable of stably dispersing and suspending for a long period without precipitation of hydroxyapatite in the case of suspending in water, and useful as food and drink for reinforcing calcium (for instance, paste product, liquid product and solid product) or medical drug. SOLUTION: This calcium reinforcing agent is produced by subjecting hydroxyapatite ultrafine particles of ≤800 nm to surface treatment (for instance, ultrasonic treatment) using protein (casein, albumin or the like) or peptide (caseinphosphopeptide or the like), and if necessary reducing the product to powder or slurry. As it is clear from Fig. 1, disperse system is stable in hydroxyapatite ultrafine particle suspension. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供一种能够在水中悬浮的情况下长时间稳定地分散和悬浮而不沉淀羟基磷灰石的新型钙增强剂，并且可用作加强钙的食物和饮料（例如，糊状产品，液体产品和固体产品）或药物。解决方案：使用蛋白质（酪蛋白，白蛋白等）或肽（酪蛋白肽等）对≤800nm的羟基磷灰石超微粒子进行表面处理（例如超声波处理）来制造该钙增强剂，如果需要，将产品还原成粉末或浆料。如图所示。 1，分散系统在羟磷灰石超细颗粒悬浮液中稳定。版权所有（C）2006，JPO＆NCIPI

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