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21. 发明申请

WO2009128644A3 GENOME-SCALE BUTANOL-PRODUCING MICROORGANISM METABOLIC NETWORK MODEL AND METHODS USING THE SAME FOR ANALYSIS OF METABOLIC CHARACTERISTICS OF BUTANOL-PRODUCING MICROORGANISMS AND FOR SCREENING DELETION TARGETS 审中-公开
标题翻译：基因组规模的丁醇生产微生物代谢网络模型及其方法用于分析丁醇生产微生物的代谢特征和筛选减少目标
公开(公告)号：WO2009128644A3
公开(公告)日：2010-01-21
申请号：PCT/KR2009001923
申请日：2009-04-14
申请人： KOREA ADVANCED INST SCI & TECH , BIOFUELCHEM CO , GS CALTEX CORP , LEE SANG YUP , LEE JOUNG MIN , YUN HONG SEOK , JUNG KWANG SEOP
发明人： LEE SANG YUP , LEE JOUNG MIN , YUN HONG SEOK , JUNG KWANG SEOP
IPC分类号： C12Q1/32
CPC分类号： G01N33/569 , C12Q1/32 , C12Q1/527
摘要： The present invention relates to a metabolic network model for analysis of metabolic characteristics of butanol-producing microorganisms and methods using the same for analysis of metabolic characteristics of butanol-producing microorganisms and for screening deletion targets; and, more particularly, to establishing a metabolic network model of butanol-producing microorganisms using gene-protein-biochemical reaction associations and methods for analysis of metabolic characteristics such as a metabolic flow, etc., using the established model and for screening deletion targets with a simulation based on the metabolic flow analysis to improve the productivity of a specific metabolic product during the deletion. A metabolic network model according to the invention is useful for analysis of metabolic characteristics such as a metabolic flow, etc. of butanol-producing microorganisms and for screening a deletion target enzyme or a gene therefor to increase the production of a specific metabolic product. Moreover, unlike conventional methods, a deletion target screening method according to the invention makes it possible to predict deletion targets in an efficient manner, to save time and costs and to provide mutant microorganisms capable of producing a specific metabolic product at a high efficiency.
摘要翻译：本发明涉及用于分析丁醇生产微生物的代谢特征的代谢网络模型和使用其的丁醇生产微生物的代谢特征分析和筛选缺失目标的方法; 并且更具体地，涉及使用基因 - 蛋白质 - 生物化学反应关联建立丁醇生产微生物的代谢网络模型以及使用所建立的模型分析代谢流动等代谢特征的方法，并且用基于代谢流分析的模拟以提高缺失期间特定代谢产物的生产力。根据本发明的代谢网络模型可用于分析丁醇生产微生物的代谢特征如代谢流等，并用于筛选缺失目标酶或其基因以增加特定代谢产物的产生。此外，与常规方法不同，根据本发明的缺失靶标筛选方法使得有可能以有效的方式预测缺失靶标，节省时间和成本并且提供能够高效生产特定代谢产物的突变微生物。

22. 发明申请

WO2009125924A2 MUTANT MICROORGANISM WITH HIGH ABILITY OF PRODUCING PUTRESCINE AND PREPARATION OF PUTRESCINE USING SAME 审中-公开
标题翻译：具有生产PUTRESCINE的高生产能力和使用相同的PUTRESCINE的制备的突变微生物
公开(公告)号：WO2009125924A2
公开(公告)日：2009-10-15
申请号：PCT/KR2009001103
申请日：2009-03-05
申请人： KOREA ADVANCED INST SCI & TECH , LEE SANG YUP , QIAN ZHI GANG , XIA XIAOXIA , JEON YONG JAE
发明人： LEE SANG YUP , QIAN ZHI GANG , XIA XIAOXIA , JEON YONG JAE
IPC分类号： C12N15/00
CPC分类号： C12P13/001
摘要： The present invention relates to a mutant microorganism having a high ability of producing putrescine in which genes associated with the decomposition or use pathway of putrescine are weakened or deleted, in a microorganism having a putrescine production metabolic pathway, and to a method for preparing putrescine with a high yield rate by culturing the mutant microorganism under an anaerobic condition. The mutant microorganism having a high ability of producing putrescine according to the present invention is useful for the high-yield production of putrescine and has broad industrial application.
摘要翻译：本发明涉及在具有腐胺生产代谢途径的微生物中具有高腐蚀性的与腐胺的分解或使用途径相关的基因被腐蚀或缺失的腐胺的能力强的突变体微生物，以及一种制备腐胺的方法通过在厌氧条件下培养突变体微生物获得高产率。根据本发明的腐胺生产能力高的突变微生物可用于高产量腐胺的制备，具有广泛的工业应用。

23. 发明申请

WO2011084002A3 METHOD FOR PRODUCING ORGANIC ACIDS FROM BIOMASS 审中-公开
标题翻译：从生物量生产有机酸的方法
公开(公告)号：WO2011084002A3
公开(公告)日：2012-01-12
申请号：PCT/KR2011000103
申请日：2011-01-07
申请人： KOREA ADVANCED INST SCI & TECH , CHANG HO NAM , LEE SANG YUP , YANG SEUNG MAN , KIM NAG JONG , KANG JONG WON , JEONG CHANGMOON , CHOI JIN DAL RAE
发明人： CHANG HO NAM , LEE SANG YUP , YANG SEUNG MAN , KIM NAG JONG , KANG JONG WON , JEONG CHANGMOON , CHOI JIN DAL RAE
IPC分类号： C12P7/04 , B09B3/00
CPC分类号： C12P7/6409 , C12P7/40
摘要： The present invention relates to a method for producing organic acids from biomass, and more specifically relates to a method for producing various organic acids (volatile fatty acids) from land-based, freshwater-based, marine or biodegradable organic mixed biomass by using a high-density cell culture method, and then concentrating and distilling the same. The method for producing organic acids from biomass comprises the steps of: (a) producing organic acids by fermenting biomass; (b) concentrating the organic acids so produced by at least 30%; and (c) recovering the organic acids by fractional distillation of the concentrated organic acid. A method for isolating organic acids produced economically from biomass according to the present invention can be used to advantage in converting organic acids into fuel or compounds such as alcohols, esters and alkanes in addition to the economic use of organic acids.
摘要翻译：本发明涉及从生物质生产有机酸的方法，更具体地涉及一种通过使用高的从陆基，淡水，海洋或可生物降解的有机混合生物质生产各种有机酸（挥发性脂肪酸）的方法浓缩细胞培养法，然后浓缩蒸馏。从生物质生产有机酸的方法包括以下步骤：（a）通过发酵生物质生产有机酸; （b）将如此生产的有机酸浓缩至少30％; 和（c）通过浓缩有机酸的分馏回收有机酸。根据本发明的从生物质经济地分离有机酸的方法除了经济地使用有机酸之外，还可用于将有机酸转化成燃料或化合物如醇，酯和烷烃。

24. 发明申请

WO2011155799A2 MUTANT MICROORGANISM HAVING A HYDROCARBON-GENERATING ABILITY AND METHOD FOR PRODUCING HYDROCARBON USING SAME 审中-公开
标题翻译：具有烃生产能力的突变微生物和使用其生产烃类的方法
公开(公告)号：WO2011155799A2
公开(公告)日：2011-12-15
申请号：PCT/KR2011004289
申请日：2011-06-10
申请人： KOREA ADVANCED INST SCI & TECH , LEE SANG YUP , CHOI YONG JUN
发明人： LEE SANG YUP , CHOI YONG JUN
IPC分类号： C12N1/21 , C12N15/52 , C12P5/00
CPC分类号： C12P5/00 , C07K14/245 , C12N9/001 , C12N9/18 , C12N9/88 , C12N9/93 , C12N15/52 , C12N15/70 , C12P5/005 , C12P5/02 , C12P5/026
摘要： The present invention relates to a mutant microorganism having the ability to generate hydrocarbon containing alkanes and to a method for producing hydrocarbons containing alkanes using the same. More particularly, the present invention relates to a mutant microorganism in which genes that code for enzymes for converting fatty acyl-acps to free fatty acids, genes that code for enzymes for converting free fatty acids to fatty acyl-CoA, genes that code for enzymes for converting fatty acyl-CoA to fatty aldehydes, and genes that code for enzymes for converting fatty aldehydes to alkanes are introduced to the microorganisms improved to be appropriate for the production of hydrocarbons containing alkanes. The present invention also relates to a method for producing hydrocarbons containing alkanes. The mutant microorganism according to the present invention has a high possibility of being utilized in strain improvement resulting from an additional metabolic control, and therefore, can be valuably used in the industrial production of hydrocarbons containing alkanes.
摘要翻译：本发明涉及具有产生含烃烷烃的能力的突变微生物以及使用其的烷烃生产烃的方法。更具体地说，本发明涉及一种突变体微生物，其中编码用于将脂肪酰基 - 脯氨酸转化为游离脂肪酸的酶的基因，编码用于将游离脂肪酸转化成脂肪酰基-CoA的酶的基因，编码酶的基因用于将脂肪酰基辅酶A转化成脂肪醛，并且将用于将脂肪醛转化为烷烃的酶编码的基因被引入微生物以改进以适合于生产含烷烃的烃。本发明还涉及一种生产含烷烃的烃的方法。根据本发明的突变体微生物具有很高的可能性，用于由额外的代谢控制引起的应变改善，因此可以有价值地用于工业生产含烃烷烃。

25. 发明申请

WO2011037414A3 RECOMBINANT MUTANT MICROORGANISM WITH INCREASED ALCOHOL PRODUCTION ABILITY, AND PREPARATION METHOD OF ALCOHOL USING SAME 审中-公开
标题翻译：具有提高的酒精生产能力的重组突变微生物和使用其的醇的制备方法
公开(公告)号：WO2011037414A3
公开(公告)日：2011-10-27
申请号：PCT/KR2010006510
申请日：2010-09-21
申请人： KOREA ADVANCED INST SCI & TECH , BIOFUELCHEM CO , GS CALTEX CORP , LEE SANG YUP , JANG YU-SIN , LEE JOUNG MIN , IM JUNG AE , SONG HYOHAK
发明人： LEE SANG YUP , JANG YU-SIN , LEE JOUNG MIN , IM JUNG AE , SONG HYOHAK
IPC分类号： C12N1/21 , C12N15/52 , C12P7/06 , C12P7/16 , C12R1/145
CPC分类号： C12N9/13 , C12N9/0006 , C12N9/88 , C12N15/74 , C12P3/00 , C12P7/04 , C12P7/06 , C12P7/16 , C12P7/26 , C12P7/28 , C12P7/52 , C12P7/54 , C12P7/56 , Y02E50/10 , Y02E50/17
摘要： The present invention relates to a recombinant mutant microorganism with an increased alcohol production ability, and a preparation method of alcohol using the same, and more specifically, to a recombinant mutant microorganism which hardly produces acetone as a by-product and has an increased production ability of butanol, ethanol, isopropanol or an alcohol mixture capable of being used as fuel, and a preparation method of butanol, ethanol, isopropanol or an alcohol mixture using the same. The recombinant mutant microorganism with an increased production ability of butanol or an alcohol mixture and an acetone removing ability according to the present invention is characterized in that a gene encoding an enzyme involved in the production of butanol from butyryl-CoA or butylaldehyde and involved in the production of isopropanol from acetone is amplified or introduced into a host microorganism. Since the recombinant mutant microorganism according to the present invention hardly produces by-products such as acetone and the like by the manipulation of metabolic flow and can improve alcohol productivity, it is useful for the industrial production of butanol or an alcohol mixture comprising butanol and isopropanol.
摘要翻译：本发明涉及具有增加的醇生产能力的重组突变体微生物和使用其的醇的制备方法，更具体地，涉及难以产生丙酮作为副产物并且具有增加的生产能力的重组突变微生物丁醇，乙醇，异丙醇或可用作燃料的醇混合物，以及使用其的丁醇，乙醇，异丙醇或醇混合物的制备方法。根据本发明的丁醇或醇混合物的生产能力增加的重组突变微生物的特征在于编码参与从丁酰辅酶A或丁醛生产丁醇并涉及从丙酮生产异丙醇被扩增或引入宿主微生物。由于根据本发明的重组突变体微生物通过操作代谢流量几乎不产生诸如丙酮等副产物并且可以提高酒精生产率，因此可用于工业生产丁醇或包含丁醇和异丙醇的醇混合物。

26. 发明申请

WO2011084002A2 METHOD FOR PRODUCING ORGANIC ACIDS FROM BIOMASS 审中-公开
标题翻译：从生物量生产有机酸的方法
公开(公告)号：WO2011084002A2
公开(公告)日：2011-07-14
申请号：PCT/KR2011000103
申请日：2011-01-07
申请人： KOREA ADVANCED INST SCI & TECH , CHANG HO NAM , LEE SANG YUP , YANG SEUNG MAN , KIM NAG JONG , KANG JONG WON , JEONG CHANGMOON , CHOI JIN DAL RAE
发明人： CHANG HO NAM , LEE SANG YUP , YANG SEUNG MAN , KIM NAG JONG , KANG JONG WON , JEONG CHANGMOON , CHOI JIN DAL RAE
IPC分类号： C12P7/04 , B09B3/00
CPC分类号： C12P7/6409 , C12P7/40
摘要： The present invention relates to a method for producing organic acids from biomass, and more specifically relates to a method for producing various organic acids (volatile fatty acids) from land-based, freshwater-based, marine or biodegradable organic mixed biomass by using a high-density cell culture method, and then concentrating and distilling the same. The method for producing organic acids from biomass comprises the steps of: (a) producing organic acids by fermenting biomass; (b) concentrating the organic acids so produced by at least 30%; and (c) recovering the organic acids by fractional distillation of the concentrated organic acid. A method for isolating organic acids produced economically from biomass according to the present invention can be used to advantage in converting organic acids into fuel or compounds such as alcohols, esters and alkanes in addition to the economic use of organic acids.
摘要翻译：本发明涉及从生物质生产有机酸的方法，更具体地涉及一种通过使用高的从陆基，淡水，海洋或可生物降解的有机混合生物质生产各种有机酸（挥发性脂肪酸）的方法浓缩细胞培养法，然后浓缩蒸馏。从生物质生产有机酸的方法包括以下步骤：（a）通过发酵生物质生产有机酸; （b）将如此生产的有机酸浓缩至少30％; 和（c）通过浓缩有机酸的分馏回收有机酸。根据本发明的从生物质经济地分离有机酸的方法除了经济地使用有机酸之外，还可用于将有机酸转化成燃料或化合物如醇，酯和烷烃。

27. 发明申请

WO2011021846A2 MULTI-SPOT METAL-DEPOSITED NUCLEIC ACID CHIP WITH NANOSTRUCTURE ARRAYS FOR DIAGNOSING CORNEAL DYSTROPHY, AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：纳米结构阵列用于诊断角膜营养不良的多点金属沉积的核酸芯片及其制备方法
公开(公告)号：WO2011021846A2
公开(公告)日：2011-02-24
申请号：PCT/KR2010005452
申请日：2010-08-18
申请人： KOREA ADVANCED INST SCI & TECH , AVELLINO CO LTD , LEE SANG YUP , YOO SO YOUNG , KIM DO KYUN , PARK TAE JUNG , YUN JUNG KUK , LEE GENE
发明人： LEE SANG YUP , YOO SO YOUNG , KIM DO KYUN , PARK TAE JUNG , YUN JUNG KUK , LEE GENE
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , B01J2219/00509 , B01J2219/00608 , B01J2219/00612 , B01J2219/00614 , B01J2219/00621 , B01J2219/00637 , B01J2219/00648 , B01J2219/00722 , B82Y30/00 , C12Q1/6883 , C12Q2600/158
摘要： The present invention relates to a multi-spot metal-deposited nucleic acid chip with nanostructure arrays for diagnosing corneal dystrophy, and more particularly, to a multi-spot metal-deposited nucleic acid chip with nanostructure arrays which uses the optical characteristics of localized surface plasmon resonance (LSPR), to a method for producing the chip, and to a multi-spot metal-deposited nucleic acid chip with nanostructure arrays for diagnosing BIGH3 gene mutations and various types of corneal dystrophies. According to the present invention, the metal-deposited nucleic acid chip with nanostructure arrays, and an analysis device including a light source, a detector, a spectrophotometer and a computer are combined to be used as a label-free biosensor based on the optical characteristics of LSPR. The multi-spot metal-deposited nucleic acid chip with nanostructure arrays for diagnosing BIGH3 gene mutations and corneal dystrophy according to the present invention diagnoses various types of corneal dystrophies, which are hereditary eye diseases, at the same time.
摘要翻译：具有纳米结构阵列的多点金属沉积核酸芯片技术领域本发明涉及用于诊断角膜营养不良的具有纳米结构阵列的多点金属沉积核酸芯片，并且更具体地涉及具有纳米结构阵列的多点金属沉积核酸芯片，其使用局部表面等离子体共振（LSPR），用于生产芯片的方法，以及具有纳米结构阵列的多点金属沉积核酸芯片，用于诊断BIGH3基因突变和各种类型的角膜营养不良。根据本发明，将具有纳米结构阵列的金属沉积核酸芯片和包括光源，检测器，分光光度计和计算机的分析装置组合以用作基于光学特性的无标记生物传感器的LSPR。根据本发明的用于诊断BIGH3基因突变和角膜营养不良的具有纳米结构阵列的多点金属沉积核酸芯片同时诊断作为遗传性眼病的各种类型的角膜营养不良。

28. 发明申请

WO2009157739A3 BIOSENSOR USING CONDUCTIVE GRAPHENES AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：使用导电石墨的生物传感器及其制备方法
公开(公告)号：WO2009157739A3
公开(公告)日：2010-04-01
申请号：PCT/KR2009003482
申请日：2009-06-26
申请人： KOREA ADVANCED INST SCI & TECH , LEE SANG YUP , PARK TAE JUNG , HONG WON HI , JUNG HEE TAE , PARK HO SEOK , CHOI BONG GILL
发明人： LEE SANG YUP , PARK TAE JUNG , HONG WON HI , JUNG HEE TAE , PARK HO SEOK , CHOI BONG GILL
IPC分类号： C01B31/02
CPC分类号： G01N33/5438 , B82Y30/00 , B82Y40/00 , C01B32/194 , C12Q1/004
摘要： The present invention relates to a biosensor using conductive graphenes and a preparation method thereof, and more particularly, to a biosensor and a preparation method thereof, which uses a conductive graphene prepared using chemical functional groups or a conductive graphine to which a bioreceptor is attached, the bioreceptor being selectively combined to a target biomaterial on a laminated conductive graphene film repeatedly overlaid with the conductive graphenes in order to have a high surface density on a substrate. The conductive graphene biosensor according to the present invention has a large surface area and excellent electric conductivity, and thus can increase the immobilization rate of biological molecules, such as DNA, and enhance the detection sensitivity for biological molecules. In addition, by either directly detecting various target biomolecules or detecting electrochemical signals, the present invention can accurately detect reactions of biomaterials and bioreceptors on a large scale at once, and can introduce a detection method by which an accurate measurement, even of a small amount of source, can be obtained.
摘要翻译：本发明涉及一种使用导电石墨烯的生物传感器及其制备方法，更具体地说，涉及一种生物传感器及其制备方法，该生物传感器及其制备方法使用使用化学官能团或连接有生物受体的导电石墨制备的导电石墨烯，生物受体被选择性地组合到层叠的导电石墨烯膜上的目标生物材料上，所述层压导电石墨烯膜与导电石墨烯重复地重叠以在基底上具有高的表面密度。根据本发明的导电石墨烯生物传感器具有大的表面积和优异的导电性，因此可以增加DNA等生物分子的固定化率，提高生物分子的检测灵敏度。另外，通过直接检测各种目标生物分子或检测电化学信号，本发明可以一次性地大规模地精确地检测生物材料和生物感应器的反应，并且可以引入检测方法，通过该方法进行精确的测量，甚至少量的来源，可以获得。

29. 发明申请

WO2010033007A2 METHOD FOR SYNTHESIZING PROTEIN CONTAINING HIGH CONTENT OF SPECIFIC AMINO ACID THROUGH SIMULTANEOUS EXPRESSION WITH TRNA OF THE SPECIFIC AMINO ACID 审中-公开
标题翻译：通过与特异性氨基酸的TRNA同时表达含有特定氨基酸的高含量的蛋白质的方法
公开(公告)号：WO2010033007A2
公开(公告)日：2010-03-25
申请号：PCT/KR2009005394
申请日：2009-09-22
申请人： KOREA ADVANCED INST SCI & TECH , LEE SANG YUP , XIA XIAOXIA , QIAN ZHI GANG , BAEK JONG HWAN
发明人： LEE SANG YUP , XIA XIAOXIA , QIAN ZHI GANG , BAEK JONG HWAN
IPC分类号： C12N1/21
CPC分类号： C12N15/67 , C07K14/43518 , C07K14/43586
摘要： The present invention relates to a method for enhancing the expression of a target protein through the simultaneous expression of a gene encoding the target protein containing a high content of a specific amino acid, and of a sequence encoding tRNA of the specific amino acid. According to the present invention, the expression of a protein containing a high content of a specific amino acid can be remarkably improved through the simultaneous expression with tRNA of the specific amino acid. Thus, the method of the present invention is useful to increase productivity of a protein containing a high content of a specific amino acid such as a repeat protein.
摘要翻译：本发明涉及通过同时表达编码含有高含量的特定氨基酸的靶蛋白的基因和编码特定氨基酸的tRNA的序列来增强靶蛋白的表达的方法。根据本发明，通过与特定氨基酸的tRNA同时表达，可以显着提高含有特定氨基酸含量的蛋白质的表达。因此，本发明的方法可用于提高含有高含量的特定氨基酸如重复蛋白质的蛋白质的生产率。

30. 发明申请

WO2009128644A2 GENOME-SCALE BUTANOL-PRODUCING MICROORGANISM METABOLIC NETWORK MODEL AND METHODS USING THE SAME FOR ANALYSIS OF METABOLIC CHARACTERISTICS OF BUTANOL-PRODUCING MICROORGANISMS AND FOR SCREENING DELETION TARGETS 审中-公开
标题翻译：基因组大肠杆菌生产微生物代谢网络模型及其使用方法用于分析生产微生物的代谢特征和筛选目标的代谢特征
公开(公告)号：WO2009128644A2
公开(公告)日：2009-10-22
申请号：PCT/KR2009001923
申请日：2009-04-14
申请人： KOREA ADVANCED INST SCI & TECH , BIOFUELCHEM CO , GS CALTEX CORP , LEE SANG YUP , LEE JOUNG MIN , YUN HONG SEOK , JUNG KWANG SEOP
发明人： LEE SANG YUP , LEE JOUNG MIN , YUN HONG SEOK , JUNG KWANG SEOP
IPC分类号： C12Q1/32
CPC分类号： G01N33/569 , C12Q1/32 , C12Q1/527
摘要： The present invention relates to a metabolic network model for analysis of metabolic characteristics of butanol-producing microorganisms and methods using the same for analysis of metabolic characteristics of butanol-producing microorganisms and for screening deletion targets; and, more particularly, to establishing a metabolic network model of butanol-producing microorganisms using gene-protein-biochemical reaction associations and methods for analysis of metabolic characteristics such as a metabolic flow, etc., using the established model and for screening deletion targets with a simulation based on the metabolic flow analysis to improve the productivity of a specific metabolic product during the deletion. A metabolic network model according to the invention is useful for analysis of metabolic characteristics such as a metabolic flow, etc. of butanol-producing microorganisms and for screening a deletion target enzyme or a gene therefor to increase the production of a specific metabolic product. Moreover, unlike conventional methods, a deletion target screening method according to the invention makes it possible to predict deletion targets in an efficient manner, to save time and costs and to provide mutant microorganisms capable of producing a specific metabolic product at a high efficiency.
摘要翻译：本发明涉及用于分析产生丁醇的微生物的代谢特征的代谢网络模型，以及使用该代谢特征分析产生丁醇的微生物的代谢特征和筛选缺失目标的方法。更具体地，使用基因 - 蛋白质 - 生物化学反应关联建立丁醇生产微生物的代谢网络模型，以及使用建立的模型分析代谢流动等的代谢特征的方法，并用于筛选具有基于代谢流分析的模拟，以提高缺失期间特定代谢产物的生产力。根据本发明的代谢网络模型可用于分析产生丁醇的微生物的代谢流等的代谢特征，并且用于筛选缺失目标酶或其基因以增加特定代谢产物的产生。此外，与常规方法不同，根据本发明的缺失目标筛选方法使得有可能以有效的方式预测缺失目标，以节省时间和成本，并提供能够以高效率产生特定代谢产物的突变体微生物。

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