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21. 发明授权

US5863519A Composition and method of MRI using both a positive and a negative contrast agent 失效
标题翻译：使用正和负造影剂的MRI的组成和方法
公开(公告)号：US5863519A
公开(公告)日：1999-01-26
申请号：US602289
申请日：1996-02-16
申请人： Klaes Golman , Goran Pettersson , Arne Berg , Jo Klaveness , P.ang.l Rongved , Peter Leander , Ib Leunbach , Wolfgang Gunther
发明人： Klaes Golman , Goran Pettersson , Arne Berg , Jo Klaveness , P.ang.l Rongved , Peter Leander , Ib Leunbach , Wolfgang Gunther
IPC分类号： A61K49/06 , A61K49/18 , A61B5/055
CPC分类号： A61K49/08 , A61K49/18 , A61K49/1818 , A61K49/1863
摘要： There is provided a contrast medium composition comprising: (a) a first contrast agent comprising a physiologically tolerable manganese compound together with an uptake promoter, having a manganese concentration of at least 0.3 mM or being in a dosage unit form containing at least 300 .mu.mol manganese, wherein the uptake promoter comprises a physiologically tolerable reducing compound containing an .alpha.-hydroxy ketone group or a physiologically tolerable acid containing .alpha.- and/or .beta.- hydroxy or amino groups, or a salt thereof, and/or vitamin D; together with (b) a second contrast agent.Such compositions are particularly suitable for imaging of the liver.
摘要翻译：提供造影剂组合物，其包含：（a）第一造影剂，其包含生理上可耐受的锰化合物以及吸收促进剂，其锰浓度至少为0.3mM或以含有至少300μmol的剂量单位形式锰，其中所述摄取促进剂包含含有α-羟基酮基或含有α-和/或β-羟基或氨基或其盐和/或维生素D的生理上可耐受的酸的生理上可耐受的还原化合物; （b）第二种造影剂。这样的组合物特别适用于肝脏的成像。

22. 发明授权

US4573181A X-Ray fluorescence analyzers 失效
标题翻译： X射线荧光分析仪
公开(公告)号：US4573181A
公开(公告)日：1986-02-25
申请号：US455842
申请日：1983-01-05
申请人： Thomas Gronberg , Torsten Almen , Klaes Golman , Soren Mattsson , Staffan Sjoberg
发明人： Thomas Gronberg , Torsten Almen , Klaes Golman , Soren Mattsson , Staffan Sjoberg
IPC分类号： G01N23/223 , H01J37/252 , G01N23/22
CPC分类号： G01N23/223 , G01N2223/076
摘要： An apparatus for determining the content of an element having an atomic number higher than 47, in a sample volume, in particular for determining the concentration of an X-ray contrast agent in vivo, employs a radiation source for such excitation of the element in the sample volume with collimated radiation that the element emits its characteristic X-ray radiation. An NaI(T1) scintillation detector is directed towards the sample volume for receiving X-ray radiation therefrom at an angle of from 90.degree. to 135.degree. in relation to the excitation radiation. Both the energy of Copton-scattered photons in the sample and the difference between this energy and 28.5 KeV must be clearly distinguished from the characteristic energy of the element concerned. A first single-channel analyzer registers the number of pulses of the detector within a predetermined energy interval about the energy value for the characteristic X-ray radiation of the element concerned, and two further single-channel analyzers register the number of pulses at the limits of the interval mentioned. A calculating unit in the form of computer determines the background radiation in the interval mentioned using the two latter pulse numbers, and determines the content of the element concerned from the difference between the pulse number of the first analyzer and the pulse number representing the background radiation.
摘要翻译：用于确定样品体积中具有高于47的原子序数的元素的含量的装置，特别是用于确定体内X射线造影剂的浓度的装置，采用这种激发元素的辐射源具有准直辐射的样品体积，该元件发射其特征X射线辐射。 NaI（T1）闪烁检测器指向样品体积，以相对于激发辐射以90°至135°的角度从其接收X射线辐射。样品中康普顿散射光子的能量和该能量与28.5KeV之间的差异必须与相关元件的特征能量明确区分开。第一个单通道分析仪将关于有关元件的特征X射线辐射的能量值的检测器的脉冲数量记录在预定的能量间隔内，另外两个单通道分析器将限制的脉冲数的间隔时间。以计算机形式的计算单元确定使用后两个脉冲数的所述间隔中的背景辐射，并且根据第一分析仪的脉冲数与表示背景辐射的脉冲数之间的差确定相关元素的内容。

23. 发明授权

US08372654B2 Method for investigating the fate of a test compound or the stateof a biological system by means of NMR of hyperpolarised NMR active nuclei 有权
标题翻译：通过超极化NMR活性核的NMR研究试验化合物的命运或生物体系的状态的方法
公开(公告)号：US08372654B2
公开(公告)日：2013-02-12
申请号：US10311108
申请日：2001-06-12
申请人： Neil Cook , Albie Santos , Nigel Bosworth , Jan Wolber , Mike Looker , Peter Knox , Jan Jenrik Ardenkjaer-Larsen , Klaes Golman
发明人： Neil Cook , Albie Santos , Nigel Bosworth , Jan Wolber , Mike Looker , Peter Knox , Jan Jenrik Ardenkjaer-Larsen , Klaes Golman
IPC分类号： G01N1/00
CPC分类号： G01R33/465 , A61K49/10 , G01N33/5088 , G01R33/5601 , G01R33/62 , Y10T436/24 , Y10T436/25
摘要： The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarization methods offering enhanced sensitivity of detection over conventional NMR for studying the fate of a test compound in a biological system. The methods are particularly suitable for studying metabolism and toxicity of drugs. The resulting NMR sensitivity increase is advantageous in two key aspects of NMR detection: test compounds can be detected at lower concentrations and substantial time saving can be achieved in cases where extensive averaging is conventionally employed to increase the signal to noise ratio of the corresponding NMR spectra. The methods can be used for studios that were not practical or not possible using conventional NMR.
摘要翻译：本发明涉及核磁共振（NMR）光谱和磁共振成像（MRI），特别是NMR光谱。它提供超极化方法，提供检测与常规NMR的灵敏度，以研究生物系统中测试化合物的命运。该方法特别适用于研究药物的代谢和毒性。所得的NMR灵敏度增加在NMR检测的两个关键方面是有利的：可以以较低的浓度检测测试化合物，并且在通常采用广泛平均以提高相应NMR光谱的信噪比的情况下可以实现显着的时间节省。该方法可用于使用常规NMR不实用或不可能的工作室。

24. 发明授权

US07557573B2 NMR-based methods for detecting ligands, where the ligand or target are hyperpolarized and the NMR-spectrum is compared with a reference spectrum of the ligand or target 有权
标题翻译：用于检测配体的基于NMR的方法，其中配体或靶是超极化的，并且将NMR光谱与配体或靶的参考光谱进行比较
公开(公告)号：US07557573B2
公开(公告)日：2009-07-07
申请号：US10537235
申请日：2003-11-27
申请人： Jan-Henrik Ardenkjaer-Larsen , Herbert Baumann , Graham John Cotton , Klaes Golman , Mark Howard , Mathilde H. Lerche , Rolf Servin , Mikkel Thaning , Jan Wolber
发明人： Jan-Henrik Ardenkjaer-Larsen , Herbert Baumann , Graham John Cotton , Klaes Golman , Mark Howard , Mathilde H. Lerche , Rolf Servin , Mikkel Thaning , Jan Wolber
IPC分类号： G01V3/00
CPC分类号： G01R33/465 , G01N24/08 , G01N24/088 , G01R33/282 , G01R33/62
摘要： The invention relates to NMR-based methods comprising hyperpolarised ligands or targets for use in NMR-based assays.
摘要翻译：本发明涉及包含用于基于NMR的测定中使用的超极化配体或靶的基于NMR的方法。

25. 发明申请

US20050136002A1 Use of particulate contrast agents in diagnostic imaging for studying physiological paramaters 审中-公开
标题翻译：在诊断成像中使用颗粒造影剂来研究生理参数
公开(公告)号：US20050136002A1
公开(公告)日：2005-06-23
申请号：US10945852
申请日：2004-09-21
申请人： Sigrid Fossheim , Jo Klaveness , Atle Bjornerud , Pal Rongved , Klaes Golman , Roald Skurtveit
发明人： Sigrid Fossheim , Jo Klaveness , Atle Bjornerud , Pal Rongved , Klaes Golman , Roald Skurtveit
IPC分类号： A61K9/127 , A61B5/00 , A61B5/055 , A61B8/00 , A61K9/14 , A61K9/50 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/00
CPC分类号： A61B5/01 , A61B5/055 , A61B5/416 , A61B5/4519 , A61B8/481 , A61K49/1812 , A61K49/223
摘要： The present invention relates to a method of imaging of an animate human or non-human animal body, which method comprises: administering parenterally to said body a particulate material comprising a matrix or membrane material and at least one contrast generating species, which matrix or membrane material is responsive to a pre-selected physiological parameter whereby to alter the contrast efficacy of said species in response to a change in the value of said parameter; generating image data of at least part of said body in which said species is present; and generating therefrom a signal indicative of the value or variation of said parameter in said part of said body. The invention also relates to contrast media for imaging a physioloogical parameter.
摘要翻译：本发明涉及一种对人或非动物体动物进行成像的方法，该方法包括：向所述身体肠胃外给予包含基质或膜材料和至少一种对比生成物质的颗粒材料，所述物质或基质或膜材料响应于预先选择的生理参数，从而响应于所述参数的值的变化来改变所述物种的对比效能; 生成存在所述物种的所述身体的至少一部分的图像数据; 以及由此生成指示所述身体的所述部分中的所述参数的值或变化的信号。本发明还涉及用于对生理参数进行成像的造影剂。

26. 发明授权

US6008644A Nuclear Polarization Enhanced Nuclear Magnetic Resonance Imaaging 失效
标题翻译：核极化增强核磁共振成像
公开(公告)号：US6008644A
公开(公告)日：1999-12-28
申请号：US888317
申请日：1997-07-03
申请人： Ib Leunbach , Ian Young , Gosta Ehnholm , Georg Hansson , Stefan Petersson , Lars-Goran Wistrand , Klaes Golman
发明人： Ib Leunbach , Ian Young , Gosta Ehnholm , Georg Hansson , Stefan Petersson , Lars-Goran Wistrand , Klaes Golman
IPC分类号： B82B1/00 , A61B5/055 , G01N24/12 , G01R33/28 , G01R33/62 , G01V3/00
CPC分类号： G01R33/5601 , G01R33/282 , G01R33/62
摘要： This invention relates to a method of electron spin resonance enhanced magnetic resonance imaging which relies on ex vivo dynamic nuclear polarisation of an MR imaging agent.
摘要翻译：本发明涉及依赖于MR成像剂的离体动态核极化的电子自旋共振增强磁共振成像方法。

27. 发明授权

US5958376A Iodinated X-ray contrast media 失效
标题翻译：碘化X射线造影剂
公开(公告)号：US5958376A
公开(公告)日：1999-09-28
申请号：US793927
申请日：1997-06-27
申请人： Anna Rydbeck , Torsten Almen , Mikkel Thaning , Sven Goran Andersson , Lars-Goran Wistrand , Klaes Golman
发明人： Anna Rydbeck , Torsten Almen , Mikkel Thaning , Sven Goran Andersson , Lars-Goran Wistrand , Klaes Golman
IPC分类号： A61K49/04 , C07C33/46 , C07C43/295 , C07C49/255 , C07C49/83 , C07C69/02 , C07C69/12 , C07C233/25 , C07C235/16 , C07C237/46 , C07C275/28 , C07C275/40 , C07C275/42 , C07C307/10 , C07C311/29 , C07C317/22 , C07C233/00 , C07C273/00
CPC分类号： C07C237/46 , A61K49/0433 , C07C233/25 , C07C235/16 , C07C275/42
摘要： The invention provides iodinated bis phenyl compounds, useful as X-ray contrast agents, of formula (I) (wherein each C.sub.6 R.sub.5 moiety may be the same or different; each denotes a hydrogen or iodine atom or a group M, two or three non-adjacent R groups on each C.sub.6 R.sub.5 moiety denoting iodine atoms and one, two or three R groups on each C.sub.6 R.sub.5 moiety denoting M groups; X denotes a group providing a 1, 2 or 3 atom chain linking the two C.sub.6 R.sub.5 groups, preferably where X is or contains in the bridging chain a carbonyloxy group each C.sub.6 R.sub.5 group being a triodophenyl group or a group in which each R is other than hydrogen; and each M is independently a non-ionic hydrophilic moiety, M preferably being a non-ionic hydrophilic moiety comprising a monohydroxy- or polyhydroxy-alkyl group) and isomers, especially stereoisomers and rotamers, thereof. ##STR1##
摘要翻译： PCT No.PCT / GB95 / 02264 Sec。 371日期：1997年6月27日 102（e）日期1997年6月27日PCT提交1995年9月22日PCT公布。公开号WO96 / 09285 日期：1996年3月28日本发明提供了可用作式（I）的X射线造影剂的碘化双苯基化合物（其中每个C 6 R 5部分可以相同或不同;各自表示氢或碘原子或基团M，每个C6R5部分上两个或三个不相邻的R基团，表示碘原子，每个C6R5部分上含有一个，两个或三个R基团，表示M基团; X表示提供连接两个C 6 R 5基团的1,2或3个原子链的基团，优选其中X是桥连环中或在桥连环中含有碳氧基，每个C 6 R 5基团是三苯基或每个R不是氢的基团;每个M独立地是非离子亲水部分，M优选是非离子亲水部分，包含单羟基或多羟基 - 烷基的离子亲水部分）和异构体，特别是立体异构体和旋转异构体。

28. 发明授权

US5817289A Non-cluster type bismuth compounds 失效
标题翻译：非簇型铋化合物
公开(公告)号：US5817289A
公开(公告)日：1998-10-06
申请号：US486225
申请日：1995-06-07
申请人： Jo Klaveness , Arne Berg , Torsten Almen , Klaes Golman , Michael Droege , S. B. Yu
发明人： Jo Klaveness , Arne Berg , Torsten Almen , Klaes Golman , Michael Droege , S. B. Yu
IPC分类号： A61K49/00 , A61K49/04 , C07F9/94 , A61K51/00 , A61M36/14
CPC分类号： A61K49/04 , A61K49/0433 , C07F9/94
摘要： The use in diagnostic imaging, in particular X-ray, MRI, ultrasound and scintigraphy, of contrast agents comprising bismuth clusters and/or organic bismuth compounds, and contrast media containing such bismuth compounds. The bismuth compounds are also useful in therapy, in particular as antimicrobial agents and antiulcer agents. Novel bismuth compounds are also disclosed.
摘要翻译：用于包含铋簇和/或有机铋化合物的造影剂的诊断成像，特别是X射线，MRI，超声和闪烁扫描，以及含有这种铋化合物的造影剂。铋化合物也可用于治疗，特别是抗微生物剂和抗溃疡剂。还公开了新颖的铋化合物。

29. 发明授权

US5716598A Contrast medium for magnetic resonance imaging using physiologically tolerable manganese compound 失效
标题翻译：使用生理可耐受锰化合物的磁共振成像对比剂
公开(公告)号：US5716598A
公开(公告)日：1998-02-10
申请号：US465100
申请日：1995-06-05
申请人： Klaes Golman , Goran Pettersson , Arne Berg , Jo Klaveness , Pal Rongved , Peter Leander
发明人： Klaes Golman , Goran Pettersson , Arne Berg , Jo Klaveness , Pal Rongved , Peter Leander
IPC分类号： A61K49/06 , A61K49/18 , A61K49/00 , A61B5/055
CPC分类号： A61K49/06 , A61K49/18
摘要： There is provided a contrast medium composition for magnetic resonance imaging comprising a physiologically tolerable manganese compound, a physiologically tolerable reducing compound containing an .alpha.-hydroxy ketone group, or salt thereof and a physiologically tolerable carrier or excipient, having a manganese concentration of at least 0.3 mM or being in a dosage unit form containing at least 300 .mu.mol manganese. Such compositions are particularly suitable for imaging of the liver.
摘要翻译：提供了一种用于磁共振成像的造影剂组合物，其包含生理上可耐受的锰化合物，含有α-羟基酮基团的生理上可耐受的还原化合物或其盐和生理上可耐受的载体或赋形剂，其锰浓度为至少0.3 或含有至少300μmol锰的剂量单位形式。这样的组合物特别适用于肝脏的成像。

30. 发明授权

US5700448A Use of persistent free-radicals in magnetic resonance imaging 失效
标题翻译：在磁共振成像中使用持续自由基
公开(公告)号：US5700448A
公开(公告)日：1997-12-23
申请号：US415662
申请日：1995-04-03
申请人： Klaes Golman , Sven Andersson , Frode Rise , Lars-Goran Wistrand , Hakan Wikstrom
发明人： Klaes Golman , Sven Andersson , Frode Rise , Lars-Goran Wistrand , Hakan Wikstrom
IPC分类号： A61B5/055 , A61K20060101 , A61K49/00 , A61K49/20 , C07B60/00 , C07C43/20 , C07C45/67 , C07C45/70 , C07C46/00 , C07C49/747 , C07C49/753 , C07C50/28 , C07C69/92 , C07C233/69 , C07C235/48 , C07C255/32 , C07C255/36 , C07C255/41 , C07C309/66 , C07C317/22 , C07C317/24 , C07C323/20 , C07D209/36 , C07D209/48 , C07D215/24 , C07D311/82 , C07D339/06 , C07D471/04 , C07D493/04 , C07D495/04 , C07D497/04 , C07D519/00
CPC分类号： C07D209/48 , A61K49/20 , C07C233/69 , C07C255/36 , C07C255/41 , C07C309/66 , C07C317/22 , C07C323/20 , C07C45/673 , C07C45/70 , C07C46/00 , C07C49/747 , C07C49/753 , C07C50/28 , C07C69/92 , C07D209/36 , C07D215/24 , C07D311/82 , C07D339/06 , C07D471/04 , C07D493/04 , C07D495/04 , C07D497/04 , C07C2101/16 , Y10T436/24
摘要： The present invention relates to the use of persistent free radicals, in particular persistent free radicals having a carbon-based .pi.-bonded electronic system available for delocalization of the unpaired electrons as image enhancing agents in magnetic resonance imaging (MRI), in particular electron spin resonance enhanced magnetic resonance imaging (ESREMRI). The invention also relates to contrast media containing such radicals and to the use of such radicals and their non-radical precursors in the manufacture of MRI and ESREMRI contrast media.
摘要翻译：本发明涉及持久性自由基的使用，特别是具有可用于在磁共振成像（MRI）中作为图像增强剂的非配对电子的离域的碳基π键化电子系统的持久自由基，特别是电子自旋共振增强磁共振成像（ESREMRI）。本发明还涉及含有这种自由基的造影剂以及这种自由基及其非自由基前体在制造MRI和ESREMRI造影剂中的用途。

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