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21. 发明授权

US07612316B2 Focus detection device and fluorescent observation device using the same 有权
标题翻译：聚焦检测装置及使用其的荧光观察装置
公开(公告)号：US07612316B2
公开(公告)日：2009-11-03
申请号：US11876676
申请日：2007-10-22
申请人： Masayoshi Karasawa , Atsuhiro Tsuchiya , Takashi Yoneyama , Kenichi Koyama
发明人： Masayoshi Karasawa , Atsuhiro Tsuchiya , Takashi Yoneyama , Kenichi Koyama
IPC分类号： G02B7/04
CPC分类号： G02B21/0088 , G02B21/16 , G02B21/244 , G02B21/245
摘要： A focus detection device which is applied to a fluorescent observation device for observing a fluorescent image to be emitted from an observation sample on the basis of an evanescent light, includes an image pickup unit which detects a contrast of the fluorescent image by imaging the fluorescent image, and a detector which detects a focus on the basis of the detection result.
摘要翻译：应用于荧光观察装置的焦点检测装置包括通过对荧光图像进行成像来检测荧光图像的对比度的图像拾取单元，该荧光观察装置用于观察从观察样本发射的荧光图像以及基于检测结果检测焦点的检测器。

22. 发明授权

US07304282B2 Focus detection device and fluorescent observation device using the same 有权
标题翻译：聚焦检测装置及使用其的荧光观察装置
公开(公告)号：US07304282B2
公开(公告)日：2007-12-04
申请号：US11328028
申请日：2006-01-09
申请人： Masayoshi Karasawa , Atsuhiro Tsuchiya , Takashi Yoneyama , Kenichi Koyama
发明人： Masayoshi Karasawa , Atsuhiro Tsuchiya , Takashi Yoneyama , Kenichi Koyama
IPC分类号： G02B7/04
CPC分类号： G02B21/0088 , G02B21/16 , G02B21/244 , G02B21/245
摘要： A focus detection device which is applied to a fluorescent observation device for observing a fluorescent image to be emitted from an observation sample on the basis of an evanescent light, includes an image pickup unit which detects a contrast of the fluorescent image by imaging the fluorescent image, and a detector which detects a focus on the basis of the detection result.
摘要翻译：应用于荧光观察装置的焦点检测装置包括通过对荧光图像进行成像来检测荧光图像的对比度的图像拾取单元，该荧光观察装置用于观察从观察样本发射的荧光图像以及基于检测结果检测焦点的检测器。

23. 发明申请

US20050237604A1 In-vivo examination apparatus 有权
标题翻译：体内检查装置
公开(公告)号：US20050237604A1
公开(公告)日：2005-10-27
申请号：US11095518
申请日：2005-04-01
申请人： Yoshihiro Kawano , Susumu Honda , Kenichi Koyama , Atsuhiro Tsuchiya , Kazuhiko Osa
发明人： Yoshihiro Kawano , Susumu Honda , Kenichi Koyama , Atsuhiro Tsuchiya , Kazuhiko Osa
IPC分类号： A61B19/00 , G02B21/00 , G02B21/08 , G02B21/26
CPC分类号： G02B21/26 , A61B90/20 , A61B90/50 , G02B21/0012 , G02B21/082 , G02B21/24
摘要： An in-vivo examination apparatus in which the examination angle can be changed while keeping an examination site in focus to carry out accurate in-vivo examination is provided. The in-vivo examination apparatus includes a stage on which a living organism is mounted, a measurement head that irradiates the living organism on the stage with light emitted from a light source and detects light returning from the living organism, and a rotation mechanism that rotates the measurement head about a fixed point on the stage.
摘要翻译：提供一种体内检查装置，其中可以在保持检查部位聚焦的同时改变检查角度，以进行准确的体内检查。体内检查装置包括安装有活体的台，测量头，用从光源发出的光照射舞台上的活体，并检测从活体返回的光;旋转机构，其旋转测量头围绕舞台上的一个固定点。

24. 发明授权

US06226118B1 Optical microscope 失效
公开(公告)号：US06226118B1
公开(公告)日：2001-05-01
申请号：US09098064
申请日：1998-06-16
申请人： Kenichi Koyama , Atsuhiro Tsuchiya , Masaru Fujiwara , Sadashi Adachi
发明人： Kenichi Koyama , Atsuhiro Tsuchiya , Masaru Fujiwara , Sadashi Adachi
IPC分类号： G02B2100
CPC分类号： G02B7/16
摘要： An optical microscope has a revolver for selectively inserting a plurality of objective lenses including a low-magnification (very-low-magnification) objective lens on an optical axis for observation light. In fluorescence observation using the low-magnification objective lens, the effective diameter of an observation optical system is set larger than that of an illumination optical system. With this arrangement, fluorescence observation using the low-magnification objective lens can be stably performed. A cube unit having a plurality of cubes corresponding to the respective microscopic methods is arranged in the optical microscope. An auxiliary lens serving as a very-low-magnification objective lens is mounted in this cube unit. The auxiliary lens can be automatically used in observation using the very-low-magnification objective lens. With this arrangement, a compact optical microscope excellent in operability can be realized.

25. 发明申请

US20080179491A1 FOCUS DETECTION DEVICE AND FLUORESCENT OBSERVATION DEVICE USING THE SAME 有权
标题翻译：聚焦检测装置和使用该荧光检测装置的荧光观察装置
公开(公告)号：US20080179491A1
公开(公告)日：2008-07-31
申请号：US11876676
申请日：2007-10-22
申请人： Masayoshi KARASAWA , Atsuhiro Tsuchiya , Takashi Yoneyama , Kenichi Koyama
发明人： Masayoshi KARASAWA , Atsuhiro Tsuchiya , Takashi Yoneyama , Kenichi Koyama
IPC分类号： G02B7/09
CPC分类号： G02B21/0088 , G02B21/16 , G02B21/244 , G02B21/245
摘要： A focus detection device which is applied to a fluorescent observation device for observing a fluorescent image to be emitted from an observation sample on the basis of an evanescent light, includes an image pickup unit which detects a contrast of the fluorescent image by imaging the fluorescent image, and a detector which detects a focus on the basis of the detection result.
摘要翻译：应用于荧光观察装置的焦点检测装置包括通过对荧光图像进行成像来检测荧光图像的对比度的图像拾取单元，该荧光观察装置用于观察从观察样本发射的荧光图像以及基于检测结果检测焦点的检测器。

26. 发明授权

US6043475A Focal point adjustment apparatus and method applied to microscopes 失效
标题翻译：焦点调节装置和方法应用于显微镜
公开(公告)号：US6043475A
公开(公告)日：2000-03-28
申请号：US839658
申请日：1997-04-15
申请人： Masakazu Shimada , Takashi Nagano , Takashi Yoneyama , Nobuyuki Nagasawa , Hideaki Endo , Jitsunari Kojima , Atsuhiro Tsuchiya , Yukiko Saeki
发明人： Masakazu Shimada , Takashi Nagano , Takashi Yoneyama , Nobuyuki Nagasawa , Hideaki Endo , Jitsunari Kojima , Atsuhiro Tsuchiya , Yukiko Saeki
IPC分类号： G02B21/24 , G02B7/04
CPC分类号： G02B21/241
摘要： A focal point adjustment apparatus applied to an optical apparatus with a projection optical system, comprises, an object lens, a stage on which a plate member on which a subject is put for measurement is placed, provision unit for providing the thickness of the plate member for measurement, determining unit for determining data on the distance between the object lens and the stage on the basis of the thickness of the plate member for measurement provided by the provision unit, and focusing unit for adjusting the distance between the object lens and the stage on the basis of the data on the distance between the object lens and the stage determined by the determining unit.
摘要翻译：一种应用于具有投影光学系统的光学装置的焦点调节装置，包括：物镜，放置有被测体放置用于测量的板构件的台，提供单元，用于提供板构件的厚度用于测量的确定单元，用于基于由提供单元提供的用于测量的板构件的厚度来确定物镜与台架之间的距离的数据;以及聚焦单元，用于调整物镜与舞台之间的距离基于由所述确定单元确定的所述物镜与所述台阶之间的距离的数据。

27. 发明申请

US20080204865A1 MICROSCOPE SYSTEM AND MICROSCOPE FOCUS MAINTAINING DEVICE FOR THE SAME 审中-公开
公开(公告)号：US20080204865A1
公开(公告)日：2008-08-28
申请号：US12105137
申请日：2008-04-17
申请人： Takashi YONEYAMA , Atsuhiro Tsuchiya , Kenichi Koyama
发明人： Takashi YONEYAMA , Atsuhiro Tsuchiya , Kenichi Koyama
IPC分类号： G02B21/02 , G02B21/06 , G02B21/26
CPC分类号： G02B21/367 , G02B21/16 , G02B21/245
摘要： A microscope system has a stage on which an observation sample, including an observation object and a transparent member, is to be placed. An objective lens is placed to face the observation sample placed on the stage, and a focusing unit moves at least one of the stage and the objective lens to perform a focusing operation. An autofocus unit controls a focusing driving unit by a so-called Through-the-Lens: TTL system. After autofocus is performed for the transparent member by the autofocus unit, the focusing driving unit makes at least one of the stage and the objective lens move by a predetermined constant amount.

28. 发明申请

US20080123185A1 MICROSCOPE SYSTEM AND MICROSCOPE FOCUS MAINTAINING DEVICE FOR THE SAME 审中-公开
标题翻译： MICROSCOPE系统和MICROSCOPE聚焦装置相同
公开(公告)号：US20080123185A1
公开(公告)日：2008-05-29
申请号：US12018061
申请日：2008-01-22
申请人： Takashi YONEYAMA , Atsuhiro Tsuchiya , Kenichi Koyama
发明人： Takashi YONEYAMA , Atsuhiro Tsuchiya , Kenichi Koyama
IPC分类号： G02B21/00
CPC分类号： G02B21/367 , G02B21/16 , G02B21/245
摘要： A microscope system has a stage on which an observation sample, including an observation object and a transparent member, is to be placed. An objective lens is placed to face the observation sample placed on the stage, and a focusing unit moves at least one of the stage and the objective lens to perform a focusing operation. An autofocus unit controls a focusing driving unit by a so-called Through-the-Lens: TTL system. After autofocus is performed for the transparent member by the autofocus unit, the focusing driving unit makes at least one of the stage and the objective lens move by a predetermined constant amount.
摘要翻译：显微镜系统具有要放置观察对象和透明构件的观察样本的阶段。放置物镜以面对放置在舞台上的观察样本，并且聚焦单元移动舞台和物镜中的至少一个以执行聚焦操作。自动对焦单元通过所谓的透镜：TTL系统控制聚焦驱动单元。通过自动对焦单元对透明构件进行自动聚焦之后，聚焦驱动单元使舞台和物镜中的至少一个移动预定的恒定量。

29. 发明授权

US07268938B2 In-vivo examination apparatus 有权
标题翻译：体内检查装置
公开(公告)号：US07268938B2
公开(公告)日：2007-09-11
申请号：US11095518
申请日：2005-04-01
申请人： Yoshihiro Kawano , Kenichi Koyama , Atsuhiro Tsuchiya
发明人： Yoshihiro Kawano , Kenichi Koyama , Atsuhiro Tsuchiya
IPC分类号： G02B21/00 , G02B21/06
CPC分类号： G02B21/26 , A61B90/20 , A61B90/50 , G02B21/0012 , G02B21/082 , G02B21/24
摘要： An in-vivo examination apparatus in which the examination angle can be changed while keeping an examination site in focus to carry out accurate in-vivo examination is provided. The in-vivo examination apparatus includes a stage on which a living organism is mounted, a measurement head that irradiates the living organism on the stage with light emitted from a light source and detects light returning from the living organism, and a rotation mechanism that rotates the measurement head about a fixed point on the stage.
摘要翻译：提供一种体内检查装置，其中可以在保持检查部位聚焦的同时改变检查角度，以进行准确的体内检查。体内检查装置包括安装有活体的台，测量头，用从光源发出的光照射舞台上的活体，并检测从活体返回的光;旋转机构，其旋转测量头围绕舞台上的固定点。

30. 发明申请

US20050187441A1 Laser-scanning examination apparatus 审中-公开
标题翻译：激光扫描检查仪
公开(公告)号：US20050187441A1
公开(公告)日：2005-08-25
申请号：US11035075
申请日：2005-01-14
申请人： Kenji Kawasaki , Hiroshi Sasaki , Kenichi Koyama , Atsuhiro Tsuchiya , Yoshihiro Kawano
发明人： Kenji Kawasaki , Hiroshi Sasaki , Kenichi Koyama , Atsuhiro Tsuchiya , Yoshihiro Kawano
IPC分类号： A61B5/00 , G01N21/64 , G03C5/16
CPC分类号： G01N21/6458
摘要： A laser-scanning examination apparatus includes a laser light source; an optical fiber through which laser light generated in the laser light source is transmitted; a scan head including a casing for housing a laser scanning unit that scans the laser light transmitted by the optical fiber on a specimen, an objective unit for imaging the laser light scanned by the laser scanning unit onto the specimen; an optical detector for detecting returning light that returns from the specimen to the interior of the casing via the objective unit; a stage for mounting the specimen; and an arm that supports the scan head so that the position and orientation of the objective unit with respect to the stage can be adjusted. The optical detector is provided on an outer surface of the casing except for the surface located in the opposite direction from the direction in which the arm extends from the casing. The laser-scanning examination apparatus has a compact head unit and allows improved ease-of-use by securing a large space around the head unit.
摘要翻译：激光扫描检查装置包括激光光源; 在激光光源中产生的激光透过的光纤; 扫描头，包括用于容纳将由所述光纤透射的激光扫描在检体上的激光扫描单元的外壳，用于将由所述激光扫描单元扫描的激光成像到所述样本上的目标单元; 光检测器，用于检测经由所述物镜单元从所述样本返回到所述壳体内部的返回光; 安装样品的阶段; 以及支撑扫描头的臂，使得可以调节物镜单元相对于平台的位置和取向。光检测器设置在壳体的外表面上，除了位于与臂从壳体延伸的方向相反的方向上的表面之外。激光扫描检查装置具有紧凑的头部单元，并且通过确保头部单元周围的大空间来允许改进的易于使用。

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