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    • 1. 发明授权
    • Microscope apparatus and microscope observation method
    • 显微镜仪器和显微镜观察法
    • US08730315B2
    • 2014-05-20
    • US12908307
    • 2010-10-20
    • Takashi Yoneyama
    • Takashi Yoneyama
    • H04N7/18H04N5/30
    • G02B21/367
    • The number of seams between magnified images in a created virtual slide is reduced to make the virtual slide clear and sharp. Provided is a microscope apparatus including an objective lens that collects light from a sample on a slide; a focus position detecting section that detects a focus position of the objective lens with respect to the sample; a focus state adjustment section that adjusts a focus state with respect to the sample based on a detection result from the focus position detecting section; and a magnified-image acquisition section that acquires a magnified image of each part of the sample, in which, if the focus position detected by the focus position detecting section is changed by more than a predetermined threshold with respect to a focus state in which an adjacent magnified image was obtained, the focus state adjustment section limits the adjustment in the focus state to the predetermined threshold or less.
    • 创建的虚拟幻灯片中放大图像之间的接缝数量减少,使虚拟幻灯片清晰锐利。 本发明提供一种显微镜装置,其包括从载玻片上的样品收集光的物镜; 焦点位置检测部分,其检测物镜相对于样本的聚焦位置; 焦点状态调整部,其基于来自所述焦点位置检测部的检测结果来调整相对于所述样本的聚焦状态; 以及放大图像获取部分,其获取样本的每个部分的放大图像,其中如果由聚焦位置检测部分检测到的对焦位置相对于聚焦状态改变了超过预定阈值,其中 获得相邻的放大图像,聚焦状态调整部将聚焦状态的调整限制为规定的阈值以下。
    • 2. 发明申请
    • Microscope apparatus and image acquisition method
    • 显微镜装置和图像采集方法
    • US20110316999A1
    • 2011-12-29
    • US13160201
    • 2011-06-14
    • Takashi YoneyamaChika Nakajima
    • Takashi YoneyamaChika Nakajima
    • H04N7/18G06K9/34G06K9/40
    • H04N7/183G02B21/241G02B21/367
    • Provided is a microscope apparatus including a macro-image, acquisition section that acquires a macro image of a glass slide having a specimen mounted thereon; an extraction section that extracts the specimen in the acquired macro image; a block setting section that sets, when the extracted specimen is scattered to form a plurality of lumps, a plurality of blocks that include the lumps of the specimen; an area dividing section that divides an area that includes the specimen in each of the blocks into a plurality of small regions; and a micro-image acquisition section that acquires, for each of the small regions, a micro image while performing an automatic focusing operation for the specimen in the small region, in which the micro-image acquisition section searches for an autofocusing in-focus position in each of the blocks set by the block setting section.
    • 本发明提供一种显微镜装置,其包括宏观图像,获取部件,其获取安装有样本的载玻片的宏观图像; 提取部,其提取所获取的宏图像中的样本; 块设置部分,当提取的样本被散射以形成多个块时,设置包括样本块的多个块; 区域分割部,其将包含在各块中的检体的区域分割为多个小区域; 以及微图像获取部,其对于每个所述小区域,在对所述微图像获取部搜索自动聚焦对焦位置的小区域中的样本进行自动聚焦操作时,获取微图像 在块设置部分设置的每个块中。
    • 3. 发明申请
    • Virtual-Slide Creating Device
    • 虚拟幻灯片创建设备
    • US20110221881A1
    • 2011-09-15
    • US13042178
    • 2011-03-07
    • Tetsuya ShirotaTakashi YoneyamaChika NakajimaYasuaki Natori
    • Tetsuya ShirotaTakashi YoneyamaChika NakajimaYasuaki Natori
    • H04N7/18
    • G02B21/367G02B21/26
    • It is possible to create a virtual slide of a subject of observation in a simple configuration without setting a movement pattern in advance. Provided is a virtual-slide creating device including a stage on which a sample is mounted; an objective lens that collects light from the sample; a relative movement mechanism that moves at least one of these components relative to each other in a direction crossing the optical axis of the objective lens; a position detecting unit that obtains relative position information of the stage and the objective lens; an image capturing unit that acquires a partial enlarged image of the sample; a display unit that displays the enlarged image acquired; an image saving unit that saves an enlarged image acquired by the image capturing unit each time at least one of the stage and the objective lens is moved relative to each other by a predetermined distance, based on the relative position information obtained; and an image processing unit that creates a virtual slide by forming an array of saved enlarged images based on the relative position information detected.
    • 可以以简单的配置创建观察对象的虚拟幻灯片,而无需事先设置移动模式。 提供了一种虚拟幻灯片创建装置,其包括安装有样本的阶段; 从样品中收集光的物镜; 相对运动机构,其在与物镜的光轴交叉的方向上相对于彼此移动这些部件中的至少一个; 位置检测单元,其获得所述平台和所述物镜的相对位置信息; 获取所述样本的部分放大图像的图像捕获单元; 显示所获取的放大图像的显示单元; 图像保存单元,其基于所获得的相对位置信息,每次使所述舞台和所述物镜中的至少一个相对于彼此移动预定距离,从而保存由所述摄像单元获取的放大图像; 以及图像处理单元,其基于检测到的相对位置信息,通过形成保存的放大图像的阵列来创建虚拟幻灯片。
    • 4. 发明申请
    • Microscope Apparatus and Microscope Observation Method
    • 显微镜仪器和显微镜观察方法
    • US20110102571A1
    • 2011-05-05
    • US12908307
    • 2010-10-20
    • Takashi Yoneyama
    • Takashi Yoneyama
    • H04N7/18G02B21/00
    • G02B21/367
    • The number of seams between magnified images in a created virtual slide is reduced to make the virtual slide clear and sharp. Provided is a microscope apparatus including an objective lens that collects light from a sample on a slide; a focus position detecting section that detects a focus position of the objective lens with respect to the sample; a focus state adjustment section that adjusts a focus state with respect to the sample based on a detection result from the focus position detecting section; and a magnified-image acquisition section that acquires a magnified image of each part of the sample, in which, if the focus position detected by the focus position detecting section is changed by more than a predetermined threshold with respect to a focus state in which an adjacent magnified image was obtained, the focus state adjustment section limits the adjustment in the focus state to the predetermined threshold or less.
    • 创建的虚拟幻灯片中放大图像之间的接缝数量减少,使虚拟幻灯片清晰锐利。 本发明提供一种显微镜装置,其包括从载玻片上的样品收集光的物镜; 焦点位置检测部分,其检测物镜相对于样本的聚焦位置; 焦点状态调整部,其基于来自所述焦点位置检测部的检测结果来调整相对于所述样本的聚焦状态; 以及放大图像获取部分,其获取样本的每个部分的放大图像,其中如果由聚焦位置检测部分检测到的对焦位置相对于聚焦状态改变超过预定阈值,其中 获得相邻的放大图像,聚焦状态调整部将聚焦状态的调整限制为规定的阈值以下。
    • 5. 发明授权
    • Microscope system for obtaining high and low magnification images
    • 显微镜系统,用于获得高和低倍率的图像
    • US07756357B2
    • 2010-07-13
    • US10871817
    • 2004-06-17
    • Takashi Yoneyama
    • Takashi Yoneyama
    • G06K9/40G06K9/36G02B23/00
    • G06K9/00127
    • A host system defines a plurality of partial areas for a observation object which is a sample, obtains a partial image of an observation object in the partial area captured using a TV camera at the interval of the depth of focus of an objective lens in the depth-of-focus direction of the objective lens, generates from the partial images a focused partial image in which an object contained in the partial area is represented in a focusing state regardless of the difference in a position in the depth-of-focus direction, and generates and displays a focused image of an observation object by combining focused partial images generated in the respective partial area.
    • 主机系统定义用于作为样本的观察对象的多个部分区域,在深度为物镜的焦深的间隔处,使用TV摄像机获取的局部区域中的观察对象的部分图像 物镜的聚焦方向从部分图像生成聚焦部分图像,其中包含在部分区域中的物体在聚焦状态下被表示,而与聚焦方向上的位置的差异无关, 并且通过组合在各个部分区域中生成的聚焦部分图像来生成并显示观察对象的聚焦图像。
    • 7. 发明申请
    • Microscope system
    • 显微镜系统
    • US20050002587A1
    • 2005-01-06
    • US10871817
    • 2004-06-17
    • Takashi Yoneyama
    • Takashi Yoneyama
    • G06K9/00G06K9/36G06K9/40
    • G06K9/00127
    • A host system defines a plurality of partial areas for a observation object which is a sample, obtains a partial image of an observation object in the partial area captured using a TV camera at the interval of the depth of focus of an objective lens in the depth-of-focus direction of the objective lens, generates from the partial images a focused partial image in which an object contained in the partial area is represented in a focusing state regardless of the difference in a position in the depth-of-focus direction, and generates and displays a focused image of an observation object by combining focused partial images generated in the respective partial area.
    • 主机系统定义用于作为样本的观察对象的多个部分区域,在深度为物镜的焦深的间隔处,使用TV摄像机获取的局部区域中的观察对象的部分图像 物镜的聚焦方向从部分图像生成聚焦部分图像,其中包含在部分区域中的物体在聚焦状态下被表示,而不管聚焦方向上的位置的差异如何, 并且通过组合在各个部分区域中生成的聚焦部分图像来生成并显示观察对象的聚焦图像。
    • 9. 发明申请
    • MICROSCOPE SYSTEM
    • 微观系统
    • US20120293864A1
    • 2012-11-22
    • US13562855
    • 2012-07-31
    • Hideyuki KawanabeTetsuya ShirotaYasuko IshiiTakashi Yoneyama
    • Hideyuki KawanabeTetsuya ShirotaYasuko IshiiTakashi Yoneyama
    • G02B21/06
    • G01N21/6458G02B21/241G02B21/361G02B21/365
    • A microscope system that is capable of changing a status of observation of a sample comprises an instruction unit for giving instruction for driving one or more optical members including an objective lens or for changing a relative position of the sample and the objective lens; and an image capturing unit for capturing an observed image of the sample as a still image or a live image. The microscope system changes an order for performing operations in accordance with the instruction from the instruction unit, the operations including an operation of driving the one or more optical members or changing the relative position; an operation of switching the illumination light for the sample from being cut-off or reduced to being applied; and an operation of switching the image displayed in a display unit from the still image to the live image.
    • 能够改变样本的观察状态的显微镜系统包括指示单元,用于指示用于驱动包括物镜的一个或多个光学构件或用于改变样品和物镜的相对位置; 以及用于捕获作为静止图像或实况图像的样本的观察图像的图像捕获单元。 显微镜系统根据来自指示单元的指令改变执行操作的顺序,操作包括驱动一个或多个光学构件的操作或改变相对位置; 将样品的照明光切换或减少到施加的操作; 以及将从显示单元显示的图像从静止图像切换到实时图像的操作。
    • 10. 发明授权
    • Microscope system and method for synthesizing microscopic images
    • 显微镜系统和微观图像合成方法
    • US08014579B2
    • 2011-09-06
    • US11801694
    • 2007-05-10
    • Tetsuya ShirotaTakashi Yoneyama
    • Tetsuya ShirotaTakashi Yoneyama
    • G06K9/00
    • G02B21/367
    • An observation state obtainment unit obtains an observation state of a microscope at the time of obtaining the microscopic image of a specimen obtained by using the microscope. A motion image data generation unit generates data of a motion image from the microscopic images of a time series. A correlation addition unit adds, to data of the motion image, information that correlates microscopic images constituting the motion image with an observation state of the microscope at the time of obtaining the microscopic images. A record unit records data of the motion image and an observation state of the microscope correlated with the data.
    • 观察状态获取单元获得通过使用显微镜获得的样本的显微镜图像时的显微镜的观察状态。 运动图像数据生成单元从时间序列的显微镜图像生成运动图像的数据。 相关附加单元将运动图像的数据添加到将构成运动图像的显微图像与获得显微镜图像时的显微镜的观察状态相关联的信息。 记录单元记录运动图像的数据和与数据相关的显微镜的观察状态。