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21. 发明申请

US20130225637A1 ISATIN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE THEREOF 有权
标题翻译： ISATIN衍生物，其药物组合物及其使用方法
公开(公告)号：US20130225637A1
公开(公告)日：2013-08-29
申请号：US13776374
申请日：2013-02-25
申请人： David A. Horne , Richard Jove , Christopher Lincoln , Sangkil Nam , Larry Overman , Jun Xie
发明人： David A. Horne , Richard Jove , Christopher Lincoln , Sangkil Nam , Larry Overman , Jun Xie
IPC分类号： C07D209/38 , C07D401/10
CPC分类号： C07D209/38 , C07D401/04 , C07D401/10
摘要： One aspect of the invention relates to novel isatin derivative compounds and the pharmaceutical composition thereof. Another aspect of the invention relates to methods of using the isatin derivative compounds disclosed herein and the pharmaceutical compositions thereof. In certain embodiments, the method is used to treat a cancer or a tumor in a subject including, without limitation, prostate cancer, melanoma, pancreatic cancer, ovarian cancer, and lymphoma. In certain embodiment, the method is used to treat a condition in a subject that can be regulated by the activation of one or more proteins such as EGFR, Erk1/2, Her2/Neu, Jak2, Src, Stat3, Akt, Cyclin B1, and Cdc25C. In certain embodiment, the method is used to treat a condition in a subject that can be regulated by the disruption of microtubule formations.
摘要翻译：本发明的一个方面涉及新颖的靛红衍生物化合物及其药物组合物。本发明的另一方面涉及使用本文公开的靛红衍生物化合物及其药物组合物的方法。在某些实施方案中，该方法用于治疗受试者中的癌症或肿瘤，包括但不限于前列腺癌，黑素瘤，胰腺癌，卵巢癌和淋巴瘤。在某些实施方案中，该方法用于治疗可以通过激活一种或多种蛋白质如EGFR，Erk1 / 2，Her2 / Neu，Jak2，Src，Stat3，Akt，细胞周期蛋白B1，和Cdc25C。在某些实施方案中，该方法用于治疗可受微管形成中断的受试者的状况。

22. 发明申请

US20130101558A1 AAV-BASED TREATMENT OF CHOLESTEROL-RELATED DISORDERS 有权
标题翻译：基于AAV的治疗胆固醇相关性疾病
公开(公告)号：US20130101558A1
公开(公告)日：2013-04-25
申请号：US13642740
申请日：2011-04-22
申请人： Guangping Gao , Phillip D. Zamore , Jun Xie
发明人： Guangping Gao , Phillip D. Zamore , Jun Xie
IPC分类号： A61K48/00 , C12Q1/68
CPC分类号： C12N15/113 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2310/113 , C12N2320/32 , C12N2330/51 , C12N2750/14143 , C12N2750/14171 , C12Q1/68 , C12Q1/6897
摘要： The invention in some aspects relates to methods and compositions for assessing the effectiveness of miRNA inhibitors. In other aspects of the invention, methods and compositions for treating cholesterol related disorders are provided. In one aspect of the invention, miRNA inhibitors against miR-122 and rAAV-based compositions comprising the same are provided.
摘要翻译：本发明在某些方面涉及用于评估miRNA抑制剂有效性的方法和组合物。在本发明的其它方面，提供了治疗胆固醇相关疾病的方法和组合物。在本发明的一个方面，提供了针对miR-122和包含其的基于rAAV的组合物的miRNA抑制剂。

23. 发明申请

US20070145262A1 On-chip electrochemical flow cell 审中-公开
标题翻译：片上电化学流通池
公开(公告)号：US20070145262A1
公开(公告)日：2007-06-28
申请号：US11454364
申请日：2006-06-16
申请人： Yu-Chong Tai , Jun Xie , Darron Young
发明人： Yu-Chong Tai , Jun Xie , Darron Young
IPC分类号： H01J49/00
CPC分类号： H01J49/165 , H01J49/0018
摘要： A microfluidic device including at least one microfabricated electrochemical flow cell and method of manufacturing such a device are disclosed herein. The electrochemical cell comprising at least a substrate, wherein the substrate has a front face and a back face; a channel wall bonded to the front face of the substrate without using a spacer, wherein the wall and the substrate define a microchannel having an inlet for receiving a fluid and an outlet for transmitting the fluid; a plurality of electrodes inside the microchannel, wherein said plurality of electrodes comprises one or more working electrodes and one or more counter electrodes, wherein the fluid flows over the surface of the plurality of electrodes and wherein optionally a length of the microchannel over the one or more working electrodes is greater than a height of the microchannel over the one or more working electrodes. Other peripherals may also be included in the microfluidic device of the current invention, including an electrospray ionization (ESI) nozzle, one or more detectors, a chromatographic column, etc. each of which may be microfluidically coupled to the electrochemical flow cells to create more complicated analytic devices.
摘要翻译：本文公开了包括至少一个微加工电化学流动池的微流体装置及其制造方法。所述电化学电池至少包括衬底，其中所述衬底具有正面和背面; 通道壁，其不使用间隔件结合到所述基板的前表面，其中所述壁和所述基板限定具有用于接收流体的入口和用于传输所述流体的出口的微通道; 微通道内的多个电极，其中所述多个电极包括一个或多个工作电极和一个或多个反电极，其中所述流体流过所述多个电极的表面，并且其中可选地，所述微通道的长度在所述一个或多个更多的工作电极大于在一个或多个工作电极上的微通道的高度。其他外围设备也可以包括在本发明的微流体装置中，包括电喷雾离子化（ESI）喷嘴，一个或多个检测器，色谱柱等，其中每一个可以微流体耦合到电化学流动池以产生更多的复杂的分析设备。

24. 发明授权

US07090471B2 Integrated electrostatic peristaltic pump method and apparatus 有权
标题翻译：集成式静电蠕动泵方法及装置
公开(公告)号：US07090471B2
公开(公告)日：2006-08-15
申请号：US10757973
申请日：2004-01-13
申请人： Jun Xie , Jason Shih , Yu-Chong Tai
发明人： Jun Xie , Jason Shih , Yu-Chong Tai
IPC分类号： F04B17/03 , E03B1/00
CPC分类号： B81C1/00119 , B81B2201/036 , B81B2203/0127 , B81B2203/0338 , F04B43/043 , F04B43/082 , F04B43/12 , Y10T137/87692
摘要： An electrostatic fluid regulating device and methods. The device has a substrate. The device also has a first electrode coupled to the substrate. The device has a polymer based diaphragm. A second electrode is coupled to the diaphragm. A polymer based fluid chamber is coupled to the diaphragm. The device also has an inlet coupled to the polymer based fluid chamber and an outlet coupled to the polymer based fluid chamber.
摘要翻译：一种静电流体调节装置及方法。该装置具有基板。该器件还具有耦合到衬底的第一电极。该装置具有基于聚合物的隔膜。第二电极耦合到隔膜。基于聚合物的流体室耦合到隔膜。该装置还具有连接到基于聚合物的流体室的入口和连接到基于聚合物的流体室的出口。

25. 发明授权

US06945116B2 Integrated capacitive microfluidic sensors method and apparatus 失效
标题翻译：集成电容微流体传感器的方法和装置
公开(公告)号：US06945116B2
公开(公告)日：2005-09-20
申请号：US10802667
申请日：2004-03-16
申请人： Jun Xie , Jason Shih , Yu-Chong Tai
发明人： Jun Xie , Jason Shih , Yu-Chong Tai
IPC分类号： G01N27/22 , G01N27/447 , G01L9/12
CPC分类号： G01N27/226 , B81B7/02 , B81B2201/0292 , B81B2201/058 , G01L9/0042 , G01L9/0072
摘要： A microfluidic device and method for capacitive sensing. The device includes a fluid channel including an inlet at a first end and an outlet at a second end, a cavity region coupled to the fluid channel, and a polymer based membrane coupled between the fluid channel and the cavity region. Additionally, the device includes a first capacitor electrode coupled to the membrane, a second capacitor electrode coupled to the cavity region and physically separated from the first capacitor electrode by at least the cavity region, and an electrical power source coupled between the first capacitor electrode and the second capacitor electrode and causing an electric field at least within the cavity region. The polymer based membrane includes a polymer.
摘要翻译：用于电容感测的微流体装置和方法。该装置包括流体通道，其包括在第一端处的入口和在第二端处的出口，耦合到流体通道的空腔区域以及耦合在流体通道和腔区域之间的基于聚合物的膜。另外，该器件包括耦合到膜的第一电容器电极，耦合到空腔区域的第二电容器电极，并且至少通过腔区域与第一电容器电极物理分离;以及电源，耦合在第一电容器电极和所述第二电容器电极至少在所述腔区域内引起电场。基于聚合物的膜包括聚合物。

26. 发明授权

US6101972A Plasma processing system and method 有权
标题翻译：等离子体处理系统及方法
公开(公告)号：US6101972A
公开(公告)日：2000-08-15
申请号：US235943
申请日：1999-01-22
申请人： Terry Bluck , James H. Rogers , Jun Xie
发明人： Terry Bluck , James H. Rogers , Jun Xie
IPC分类号： H05H1/46 , B01J19/08 , B05C21/00 , C23C16/26 , C23C16/27 , C23C16/44 , C23C16/50 , C23C16/513 , G11B5/84 , H01J37/317 , H05H1/00
CPC分类号： H01J37/3178 , C23C16/26 , C23C16/513 , H01J2237/08 , H01J2237/0822 , H01J2237/3142
摘要： A substrate processing system includes a processing chamber, a substrate holder positioned in the chamber, a gas source for supplying a process gas to the chamber, at least one ion source located in the chamber, and a power source for energizing the ion source by positively biasing the anode and negatively biasing the cathode, the bias in each instance being relative to the chamber. The ion source ionizes the process gas producing ions for processing a substrate disposed on a substrate holder in the chamber. One embodiment includes two such ion sources. In this case, the power source energizes the first and second anodes and the cathodes in a time multiplexed manner, such that only one of the first or second ion sources is energized at any time and interactions between ion sources are eliminated.
摘要翻译：基板处理系统包括处理室，位于所述室中的基板保持器，用于向所述室提供处理气体的气体源，位于所述室中的至少一个离子源，以及用于通过正向激励所述离子源的电源偏置阳极并负偏压阴极，每种情况下的偏压相对于室。离子源电离产生离子的工艺气体，以处理设置在腔室中的衬底保持器上的衬底。一个实施例包括两个这样的离子源。在这种情况下，电源以时间复用的方式激励第一和第二阳极和阴极，使得在任何时间仅使第一或第二离子源中的仅一个被激励，并且消除离子源之间的相互作用。

27. 发明申请

US20140001337A1 SYSTEMS AND METHODS FOR PROCESSING AND IMAGING OF BIOLOGICAL SAMPLES 有权
标题翻译：用于处理和成像生物样品的系统和方法
公开(公告)号：US20140001337A1
公开(公告)日：2014-01-02
申请号：US13538898
申请日：2012-06-29
申请人： Alex David Corwin , Robert John Filkins , Jun Xie , Nannan Chen , Kashan Ali Shaikh
发明人： Alex David Corwin , Robert John Filkins , Jun Xie , Nannan Chen , Kashan Ali Shaikh
IPC分类号： H01L27/146
CPC分类号： G01N1/312
摘要： A method for processing and imaging a first and second plurality of samples, comprising processing at least one sample from the first plurality of samples, imaging the at least one sample from the first plurality of samples, while being capable of simultaneously processing at least one sample from the second plurality of samples; and imaging the at least one processed sample from the second plurality of samples.
摘要翻译：一种用于处理和成像第一和第二多个样品的方法，包括处理来自所述第一多个样品的至少一个样品，对来自所述第一多个样品的所述至少一个样品进行成像，同时能够同时处理至少一个样品从第二多个样本; 以及对来自所述第二多个样本的所述至少一个处理的样品进行成像。

28. 发明授权

US08574432B2 Integrated chromatography devices and systems for monitoring analytes in real time and methods for manufacturing the same 有权
标题翻译：用于实时监测分析物的集成色谱装置和系统及其制造方法
公开(公告)号：US08574432B2
公开(公告)日：2013-11-05
申请号：US11404496
申请日：2006-04-14
申请人： Chi-yuan Shih , Yu-Chong Tai , Jun Xie , Darron K. Young , Po-Jui Chen
发明人： Chi-yuan Shih , Yu-Chong Tai , Jun Xie , Darron K. Young , Po-Jui Chen
IPC分类号： B01D15/08 , G01N30/02 , C02F1/28
CPC分类号： B01D15/22 , G01N30/02 , G01N30/461 , G01N30/466 , G01N30/6095 , G01N30/78 , G01N30/96 , G01N2030/524 , Y10T29/49826 , B01D15/363 , B01D15/3804 , B01D15/362 , B01D15/34 , B01D15/325 , B01D15/361
摘要： Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple separation columns integrated into a single substrate. Using such a device, parallel analysis of multiple samples can be performed simultaneously and/or sequential analysis of a single sample can be performed simultaneously on a single chip or substrate. The devices and systems are well suited for use in high pressure liquid chromatography (HPLC) applications. HPLC chips and devices including embedded parylene channels can be fabricated using a single mask process.
摘要翻译：使用集成色谱系统和设备实时监测分析物的系统和方法。集成的微流体液相色谱装置和系统包括集成到单个底物中的多个分离柱。使用这样的器件，可以同时执行多个样本的并行分析和/或可以在单个芯片或衬底上同时执行单个样本的顺序分析。该装置和系统非常适用于高压液相色谱（HPLC）应用。包括嵌入式聚对二甲苯通道的HPLC芯片和器件可以使用单一掩模工艺制造。

29. 发明授权

US08147770B2 Microfluidic device including a dissolvable structure for flow control 有权
标题翻译：微流体装置包括用于流量控制的可溶解结构
公开(公告)号：US08147770B2
公开(公告)日：2012-04-03
申请号：US12954519
申请日：2010-11-24
申请人： Debjyoti Banerjee , Konrad Faulstich , Aldrich Lau , Umberto Ulmanella , Jun Xie
发明人： Debjyoti Banerjee , Konrad Faulstich , Aldrich Lau , Umberto Ulmanella , Jun Xie
IPC分类号： B01D11/04 , B01L3/00 , B01L3/02 , G01N1/10
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region, well, chamber, or other receptacle, or a retainment region such as a surface on which the material is retained. The retainment regions can include a reaction retainment region, one or more reagent retainment regions, each containing unreacted reagents, and a sample retainment region. A pressure-actuated valve can be positioned in each fluid processing passageway interconnecting the one or more reagent retainment regions with the respective intermediate retainment regions interposed between each of the one or more reagent retainment regions and the reaction retainment region. The dissolvable barrier can be a fluid flow modulator in the at least one fluid processing passageway.
摘要翻译：提供了一种诊断装置，其包括多个保持区域，其中保留区域被至少一个可溶解屏障隔开。保持区域可以通过至少一个流体处理通道相互连接。保持区域可以包括诸如保持区域，孔，腔室或其它容器的容器，或诸如保持材料的表面的保持区域。保留区域可以包括反应保留区域，一个或多个试剂保留区域，每个含有未反应的试剂和样品保留区域。压力致动阀可以定位在每个流体处理通道中，其将一个或多个试剂保留区域与插入在一个或多个试剂保留区域中的每一个和反应保留区域之间的各个中间保留区域互连。可溶解屏障可以是至少一个流体处理通道中的流体流动调节器。

30. 发明申请

US20110209531A1 DESIGN OF AN IC-PROCESSED POLYMER NANO-LIQUID CHROMATORAPHY SYSTEM ON-A-CHIP AND METHOD OF MAKING IT 有权
标题翻译： IC加工聚合物纳米液相色谱系统的设计及其制备方法
公开(公告)号：US20110209531A1
公开(公告)日：2011-09-01
申请号：US13037192
申请日：2011-02-28
申请人： Yu-Chong TAI , Qing He , Jun Xie , Changlin Pang , Terry D. Lee
发明人： Yu-Chong TAI , Qing He , Jun Xie , Changlin Pang , Terry D. Lee
IPC分类号： G01N30/02 , B01D15/22 , H05K3/28
CPC分类号： H05K3/284 , G01N30/6047 , G01N30/6095 , G01N2030/645 , G03F1/80 , G01N2030/625
摘要： Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, flits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC.
摘要翻译：根据本发明的实施方案涉及集成在片上的填充柱纳米液相色谱（nano-LC）系统及其制造和使用方法。微制造的芯片包括以常规用于形成集成电路的方法兼容的工艺制造的柱，过滤器，注射器和检测器。该柱可以填充有用于各种不同固定相的载体，以允许不同形式的纳米LC的性能，包括但不限于反相，正相，吸附，尺寸排阻，亲和力和离子色谱。交叉通道注射器在柱入口处注入纳升/皮升体积的样品塞。集成在色谱柱出口处的电化学/电导率传感器测量分离信号。自对准的通道加强技术提高了微流体系统的压力等级，使其能够承受通常用于高效液相色谱（HPLC）的高压。使用离子交换纳米LC成功地证明了在水中阴离子的混合物的片上样品注入，分离和检测。

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