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1. 发明申请

US20130225637A1 ISATIN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE THEREOF 有权
标题翻译： ISATIN衍生物，其药物组合物及其使用方法
公开(公告)号：US20130225637A1
公开(公告)日：2013-08-29
申请号：US13776374
申请日：2013-02-25
申请人： David A. Horne , Richard Jove , Christopher Lincoln , Sangkil Nam , Larry Overman , Jun Xie
发明人： David A. Horne , Richard Jove , Christopher Lincoln , Sangkil Nam , Larry Overman , Jun Xie
IPC分类号： C07D209/38 , C07D401/10
CPC分类号： C07D209/38 , C07D401/04 , C07D401/10
摘要： One aspect of the invention relates to novel isatin derivative compounds and the pharmaceutical composition thereof. Another aspect of the invention relates to methods of using the isatin derivative compounds disclosed herein and the pharmaceutical compositions thereof. In certain embodiments, the method is used to treat a cancer or a tumor in a subject including, without limitation, prostate cancer, melanoma, pancreatic cancer, ovarian cancer, and lymphoma. In certain embodiment, the method is used to treat a condition in a subject that can be regulated by the activation of one or more proteins such as EGFR, Erk1/2, Her2/Neu, Jak2, Src, Stat3, Akt, Cyclin B1, and Cdc25C. In certain embodiment, the method is used to treat a condition in a subject that can be regulated by the disruption of microtubule formations.
摘要翻译：本发明的一个方面涉及新颖的靛红衍生物化合物及其药物组合物。本发明的另一方面涉及使用本文公开的靛红衍生物化合物及其药物组合物的方法。在某些实施方案中，该方法用于治疗受试者中的癌症或肿瘤，包括但不限于前列腺癌，黑素瘤，胰腺癌，卵巢癌和淋巴瘤。在某些实施方案中，该方法用于治疗可以通过激活一种或多种蛋白质如EGFR，Erk1 / 2，Her2 / Neu，Jak2，Src，Stat3，Akt，细胞周期蛋白B1，和Cdc25C。在某些实施方案中，该方法用于治疗可受微管形成中断的受试者的状况。

2. 发明授权

US08722698B2 Berbamine derivatives 有权
标题翻译：伯胺衍生物
公开(公告)号：US08722698B2
公开(公告)日：2014-05-13
申请号：US12783535
申请日：2010-05-19
申请人： David Horne , Jun Xie , Angela L. Perkins Harki , Richard Jove , Sangkil Nam , Wendong Huang , Rongzhen Xu
发明人： David Horne , Jun Xie , Angela L. Perkins Harki , Richard Jove , Sangkil Nam , Wendong Huang , Rongzhen Xu
IPC分类号： C07D491/18 , A61K31/4745
CPC分类号： C07D491/147 , A61K31/4745
摘要： The invention provides novel berbamine derivatives, and compositions or pharmaceutical compositions thereof. These berbamine derivatives have shown higher potency in killing cancer/tumor cells comparing to berbamine, and can be used in cancer/tumor treatments.
摘要翻译：本发明提供新颖的柏柏胺衍生物及其组合物或药物组合物。与berbamine相比，这些berbamine衍生物在杀死癌症/肿瘤细胞方面表现出较高的效力，可用于癌症/肿瘤治疗。

3. 发明申请

US20120301400A1 MEDITOPES AND MEDITOPE-BINDING ANTIBODIES AND USES THEREOF 有权
标题翻译： MED ES。。。。。。。。。。。。。。。。。。
公开(公告)号：US20120301400A1
公开(公告)日：2012-11-29
申请号：US13443804
申请日：2012-04-10
申请人： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua Michael Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery , Jun Xie
发明人： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua Michael Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery , Jun Xie
IPC分类号： C07K16/18 , C07K7/08 , C07K1/14 , A61K39/395 , A61K49/00 , C12N5/071 , C07K7/06 , C07K2/00
CPC分类号： A61K47/6811 , A61K47/66 , A61K47/6813 , A61K47/6851 , A61K47/6877 , A61K47/6897 , A61K51/1087 , B82Y5/00 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K2299/00 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
摘要翻译：提供了与抗体结合的抗体和沉默剂，以及包含中间体和抗体的复合物，组合物和组合，以及生产，使用，测试和筛选其中的方法，包括治疗和诊断方法和用途。

4. 发明授权

US08962804B2 Meditopes and meditope-binding antibodies and uses thereof 有权
标题翻译：凝胶和沉默结合抗体及其用途
公开(公告)号：US08962804B2
公开(公告)日：2015-02-24
申请号：US13443804
申请日：2012-04-10
申请人： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua Michael Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery , Jun Xie
发明人： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua Michael Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery , Jun Xie
IPC分类号： C07K16/00 , C12P21/08 , C07K1/00 , C07K17/00 , A61K47/48 , C07K16/28 , C07K16/32
CPC分类号： A61K47/6811 , A61K47/66 , A61K47/6813 , A61K47/6851 , A61K47/6877 , A61K47/6897 , A61K51/1087 , B82Y5/00 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K2299/00 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
摘要翻译：提供了与抗体结合的抗体和沉默剂，以及包含中间体和抗体的复合物，组合物和组合，以及生产，使用，测试和筛选其中的方法，包括治疗和诊断方法和用途。

5. 发明授权

US09521233B2 Method and device for recording data of terminal 有权
标题翻译：记录终端数据的方法和装置
公开(公告)号：US09521233B2
公开(公告)日：2016-12-13
申请号：US13522525
申请日：2010-09-17
申请人： Jun Xie
发明人： Jun Xie
IPC分类号： G06F15/173 , H04M1/725 , H04M1/656 , H04L12/70 , H04L12/64 , H04M3/42
CPC分类号： H04M1/72522 , H04L2012/563 , H04L2012/5636 , H04L2012/5652 , H04L2012/6443 , H04L2463/121 , H04M1/656 , H04M3/42221 , H04M2250/60
摘要： A method and device for recording data of a terminal are disclosed. The method includes: setting a relation condition list for triggering recording among function modules, and setting a corresponding random probability generator for each function module; determining whether to start recording data, and whether to end the data recording operation in accordance with the relation condition list or the random probability generator, during the operation process of each function module; and sending the respective data packets obtained by recording to a data management module for storage after the data record operation of each function module is ended. By adopting the method and device, fuzzy recording can be performed on data of the terminal, and data of different function modules can be stored centrally, and a query operation is simplified.
摘要翻译：公开了一种用于记录终端数据的方法和装置。该方法包括：设置用于在功能模块之间触发记录的关系条件列表，并为每个功能模块设置相应的随机概率发生器; 在每个功能模块的操作过程中，确定是否开始记录数据，以及是否根据关系条件列表或随机概率发生器结束数据记录操作; 并且在每个功能模块的数据记录操作结束之后将通过记录获得的各个数据包发送到数据管理模块进行存储。通过采用该方法和装置，可以对终端的数据执行模糊记录，可以集中存储不同功能模块的数据，简化查询操作。

6. 发明授权

US08734809B2 AAV's and uses thereof 有权
标题翻译： AAV及其用途
公开(公告)号：US08734809B2
公开(公告)日：2014-05-27
申请号：US13322164
申请日：2010-04-23
申请人： Guangping Gao , Terence Flotte , Jun Xie
发明人： Guangping Gao , Terence Flotte , Jun Xie
IPC分类号： A61K39/23 , A61K39/235 , A61K39/12 , C12N15/00 , C12P21/06
CPC分类号： C07K14/005 , A61K31/7088 , A61K35/76 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14145
摘要： The invention in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the invention relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the invention relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
摘要翻译：本发明在某些方面涉及具有不同组织靶向能力的重组腺相关病毒。在一些方面，本发明涉及使用重组腺相关病毒的基因转移方法。在一些方面，本发明涉及分离的AAV衣壳蛋白和编码其的分离的核酸。

7. 发明申请

US20130101558A1 AAV-BASED TREATMENT OF CHOLESTEROL-RELATED DISORDERS 有权
标题翻译：基于AAV的治疗胆固醇相关性疾病
公开(公告)号：US20130101558A1
公开(公告)日：2013-04-25
申请号：US13642740
申请日：2011-04-22
申请人： Guangping Gao , Phillip D. Zamore , Jun Xie
发明人： Guangping Gao , Phillip D. Zamore , Jun Xie
IPC分类号： A61K48/00 , C12Q1/68
CPC分类号： C12N15/113 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2310/113 , C12N2320/32 , C12N2330/51 , C12N2750/14143 , C12N2750/14171 , C12Q1/68 , C12Q1/6897
摘要： The invention in some aspects relates to methods and compositions for assessing the effectiveness of miRNA inhibitors. In other aspects of the invention, methods and compositions for treating cholesterol related disorders are provided. In one aspect of the invention, miRNA inhibitors against miR-122 and rAAV-based compositions comprising the same are provided.
摘要翻译：本发明在某些方面涉及用于评估miRNA抑制剂有效性的方法和组合物。在本发明的其它方面，提供了治疗胆固醇相关疾病的方法和组合物。在本发明的一个方面，提供了针对miR-122和包含其的基于rAAV的组合物的miRNA抑制剂。

8. 发明申请

US20100155244A1 INJECTION METHOD FOR MICROFLUIDIC CHIPS 有权
标题翻译：微流感注射液的注射方法
公开(公告)号：US20100155244A1
公开(公告)日：2010-06-24
申请号：US12341233
申请日：2008-12-22
申请人： Wei-Cheng Tian , Erin Jean Finehout , Li Zhu , Jun Xie
发明人： Wei-Cheng Tian , Erin Jean Finehout , Li Zhu , Jun Xie
IPC分类号： B01D57/02
CPC分类号： B01D57/02
摘要： Methods and systems for injecting a sample during electrophoresis, that generally comprise: loading a sieving matrix through a first end of a separation channel; having the an end of the sieving matrix at a set distance from the intersection of the separation channel and a loading channel; pressure loading a sample through the loading channel and filling an empty portion of the separation channel; applying an electric field across the separation channel while flowing a washing buffer through the loading channel; and injecting a portion of the sample into the separation channel, wherein the portion of the sample injected is of a size that is determined by a distance between the end of the sieving matrix and the intersection of the loading and separation channels.
摘要翻译：用于在电泳期间注射样品的方法和系统，其通常包括：通过分离通道的第一端装载筛分基质; 筛分矩阵的结束距离分离通道和加载通道的交点处一定距离; 通过加载通道加载样品并填充分离通道的空的部分; 在使洗涤缓冲液流过所述装载通道的同时，在所述分离通道上施加电场; 以及将所述样品的一部分注入所述分离通道中，其中所述注入的所述样品的所述部分具有由所述筛分矩阵的末端与所述加载和分离通道的交点之间的距离确定的尺寸。

9. 发明授权

US07740747B2 Injection method for microfluidic chips 失效
标题翻译：微流控芯片注射方法
公开(公告)号：US07740747B2
公开(公告)日：2010-06-22
申请号：US11965794
申请日：2007-12-28
申请人： Wei-Cheng Tian , Erin Jean Finehout , Li Zhu , Jun Xie , Shashi Thutupalli
发明人： Wei-Cheng Tian , Erin Jean Finehout , Li Zhu , Jun Xie , Shashi Thutupalli
IPC分类号： G01N27/26
CPC分类号： G01N27/44743
摘要： A microchip for capillary electrophoresis is provided. The microchip comprises an injection channel and a separation channel configured to receive a sample through a sample well disposed on a first end of the separation channel; wherein the injection channel and the separation channel intersect to form a ‘T’ junction. The microchip further comprises a first valve disposed adjacent to the ‘T’ junction and on the separation channel and a second valve disposed at the ‘T’ junction. The second valve is a two-way valve. A sample plug is injected into an area between the ‘T’ junction and a second end of the separation channel.
摘要翻译：提供了用于毛细管电泳的微芯片。微芯片包括注入通道和分离通道，其被配置为通过设置在分离通道的第一端上的样品阱接收样品; 其中注入通道和分离通道相交以形成“T”结。微芯片还包括邻近'T'结和在分离通道上设置的第一阀和设置在'T'结处的第二阀。第二个阀是一个二通阀。将样品塞注入到“T”结和分离通道的第二端之间的区域中。

10. 发明申请

US20090071832A1 MICROFLUIDIC DEVICE WITH VERTICAL INJECTION APERTURE 有权
标题翻译：具有垂直注射孔的微流体装置
公开(公告)号：US20090071832A1
公开(公告)日：2009-03-19
申请号：US11857570
申请日：2007-09-19
申请人： Jun Xie , Shashi Thutupalli , Stacey Joy Kennerly , Wei-Cheng Tian , Erin Jean Finehout , Li Zhu , Oliver Charles Boomhower
发明人： Jun Xie , Shashi Thutupalli , Stacey Joy Kennerly , Wei-Cheng Tian , Erin Jean Finehout , Li Zhu , Oliver Charles Boomhower
IPC分类号： G01N27/26
CPC分类号： G01N27/447
摘要： A microfluidic device with a vertical injection aperture is provided. The microfluidic device comprises a separation channel, an injection aperture disposed adjacent to and in fluid communication with the separation channel. The microfluidic device further comprises a semi-permeable filter disposed adjacent to the injection aperture, wherein the filter is configured to preconcentrate a sample in the injection aperture to form a preconcentrated sample plug during an injection operation, and wherein the sample plug flows downwardly from the injection aperture to the separation channel during an electrophoresis operation.
摘要翻译：提供具有垂直注射孔的微流体装置。微流体装置包括分离通道，与分离通道相邻并且与分离通道流体连通地设置的注射孔。微流体装置还包括邻近喷射孔布置的半渗透过滤器，其中过滤器构造成在注射操作期间预浓缩注入孔中的样品以形成预浓缩样品塞，并且其中样品塞从在电泳操作期间到分离通道的注射孔径。

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