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1. 发明申请

US20110209531A1 DESIGN OF AN IC-PROCESSED POLYMER NANO-LIQUID CHROMATORAPHY SYSTEM ON-A-CHIP AND METHOD OF MAKING IT 有权
标题翻译： IC加工聚合物纳米液相色谱系统的设计及其制备方法
公开(公告)号：US20110209531A1
公开(公告)日：2011-09-01
申请号：US13037192
申请日：2011-02-28
申请人： Yu-Chong TAI , Qing He , Jun Xie , Changlin Pang , Terry D. Lee
发明人： Yu-Chong TAI , Qing He , Jun Xie , Changlin Pang , Terry D. Lee
IPC分类号： G01N30/02 , B01D15/22 , H05K3/28
CPC分类号： H05K3/284 , G01N30/6047 , G01N30/6095 , G01N2030/645 , G03F1/80 , G01N2030/625
摘要： Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, flits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC.
摘要翻译：根据本发明的实施方案涉及集成在片上的填充柱纳米液相色谱（nano-LC）系统及其制造和使用方法。微制造的芯片包括以常规用于形成集成电路的方法兼容的工艺制造的柱，过滤器，注射器和检测器。该柱可以填充有用于各种不同固定相的载体，以允许不同形式的纳米LC的性能，包括但不限于反相，正相，吸附，尺寸排阻，亲和力和离子色谱。交叉通道注射器在柱入口处注入纳升/皮升体积的样品塞。集成在色谱柱出口处的电化学/电导率传感器测量分离信号。自对准的通道加强技术提高了微流体系统的压力等级，使其能够承受通常用于高效液相色谱（HPLC）的高压。使用离子交换纳米LC成功地证明了在水中阴离子的混合物的片上样品注入，分离和检测。

2. 发明授权

US08323488B2 IC-processed polymer nano-liquid chromatoraphy system on-a-chip and method of making it 有权
标题翻译： IC加工聚合物纳米液体色谱体系及其制备方法
公开(公告)号：US08323488B2
公开(公告)日：2012-12-04
申请号：US13037192
申请日：2011-02-28
申请人： Yu-Chong Tai , Qing He , Jun Xie , Changlin Pang , Terry D. Lee , Damien Rodger , Matthieu Liger
发明人： Yu-Chong Tai , Qing He , Jun Xie , Changlin Pang , Terry D. Lee , Damien Rodger , Matthieu Liger
IPC分类号： B01D15/08 , B01D15/10 , B01D15/00
CPC分类号： H05K3/284 , G01N30/6047 , G01N30/6095 , G01N2030/645 , G03F1/80 , G01N2030/625
摘要： Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, flits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC.
摘要翻译：根据本发明的实施方案涉及集成在片上的填充柱纳米液相色谱（nano-LC）系统及其制造和使用方法。微制造的芯片包括以常规用于形成集成电路的方法兼容的工艺制造的柱，过滤器，注射器和检测器。该柱可以填充有用于各种不同固定相的载体，以允许不同形式的纳米LC的性能，包括但不限于反相，正相，吸附，尺寸排阻，亲和力和离子色谱。交叉通道注射器在柱入口处注入纳升/皮升体积的样品塞。集成在色谱柱出口处的电化学/电导率传感器测量分离信号。自对准的通道加强技术提高了微流体系统的压力等级，使其能够承受通常用于高效液相色谱（HPLC）的高压。使用离子交换纳米LC成功地证明了在水中阴离子的混合物的片上样品注入，分离和检测。

3. 发明授权

US07692141B2 Polymer based electrospray nozzle for mass spectrometry 失效
标题翻译：用于质谱的基于聚合物的电喷雾喷嘴
公开(公告)号：US07692141B2
公开(公告)日：2010-04-06
申请号：US11942647
申请日：2007-11-19
申请人： Yu-Chong Tai , Xuan-Qi Wang , Amish Desai , Terry D. Lee , Lawrence Licklider
发明人： Yu-Chong Tai , Xuan-Qi Wang , Amish Desai , Terry D. Lee , Lawrence Licklider
IPC分类号： H01J49/04 , H01J49/26 , B01D59/44
CPC分类号： H01J49/167 , G01N30/6095 , G01N30/7266 , H01J49/0018
摘要： A MEMS device with an overhanging ‘polymer’ capillary provides vital and significant improvements in interfacing a MEMS electrospray nozzle to an MS inlet or other macroscopic instrumentation. The fabrication methodology associated therewith is easily expanded to include built-in micro particle filters and centimeter long serpentine micro channels provided on-chip and fabricated using a low temperature process.
摘要翻译：具有突出“聚合物”毛细管的MEMS器件在将MEMS电喷雾喷嘴连接到MS入口或其他宏观仪器时提供了重要且显着的改进。与此相关的制造方法容易扩展到包括内置的微粒过滤器和片上提供的厘米长的蛇形微通道，并使用低温工艺制造。

4. 发明授权

US07297943B2 Polymer based electrospray nozzle for mass spectrometry 有权
公开(公告)号：US07297943B2
公开(公告)日：2007-11-20
申请号：US11472392
申请日：2006-06-22
申请人： Yu-Chong Tai , Xuan-Qi Wang , Amish Desai , Terry D. Lee , Lawrence Licklider
发明人： Yu-Chong Tai , Xuan-Qi Wang , Amish Desai , Terry D. Lee , Lawrence Licklider
IPC分类号： H01J49/04 , H01J49/26 , B01D15/08
CPC分类号： H01J49/167 , G01N30/6095 , G01N30/7266 , H01J49/0018
摘要： A MEMS device with an overhanging ‘polymer’ capillary provides vital and significant improvements in interfacing a MEMS electrospray nozzle to an MS inlet or other macroscopic instrumentation. The fabrication methodology associated therewith is easily expanded to include built-in micro particle filters and centimeter long serpentine micro channels provided on-chip and fabricated using a low temperature process.

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