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21. 发明申请

US20110152913A1 TISSUE EXPANDERS AND METHODS OF USE 审中-公开
标题翻译：组织膨胀剂和使用方法
公开(公告)号：US20110152913A1
公开(公告)日：2011-06-23
申请号：US12973693
申请日：2010-12-20
申请人： Christopher S. Jones , Daniel Jacobs , F. Mark Payne , David S. Mintz , Craig A. Purdy , Ryan S. Han , Tadmor Shalon
发明人： Christopher S. Jones , Daniel Jacobs , F. Mark Payne , David S. Mintz , Craig A. Purdy , Ryan S. Han , Tadmor Shalon
IPC分类号： A61M29/00 , A61F2/12
摘要： Tissue expanders and their methods of use.
摘要翻译：组织扩张器及其使用方法。

22. 发明申请

US20090137998A1 EXPANDABLE VEIN LIGATOR CATHETER HAVING MULTIPLE ELECTRODE LEADS, AND METHOD 失效
标题翻译：具有多个电极引线的可扩展的导管引线和方法
公开(公告)号：US20090137998A1
公开(公告)日：2009-05-28
申请号：US12181277
申请日：2008-07-28
申请人： Arthur W. Zikorus , Mark P. Parker , Christopher S. Jones , Douglas M. Petty , Brian E. Farley , Joseph M. Tartaglia
发明人： Arthur W. Zikorus , Mark P. Parker , Christopher S. Jones , Douglas M. Petty , Brian E. Farley , Joseph M. Tartaglia
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2017/00084 , A61B2017/22038 , A61B2017/22051 , A61B2018/00214 , A61B2018/0022 , A61B2018/00404 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1475 , A61B2090/3782 , A61B2218/002
摘要： A catheter includes a plurality of primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that each primary lead can individually receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with an anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another. Where the hollow anatomical structure is a vein, energy is applied until the diameter of the vein is reduced to the point where the vein is occluded. In one embodiment, a secondary lead is surrounded by the primary leads, and extends beyond the primary leads. The secondary lead includes an electrode at the working end of the catheter. The secondary lead can have a polarity opposite to the polarity of the primary leads in a bipolar configuration. The polarity of the leads can be switched and the catheter can be moved during treatment to ligate an extended length of the vein. The catheter can include a lumen to accommodate a guide wire or to allow fluid delivery.
摘要翻译：导管包括多个主引线以传递用于结扎中空解剖结构的能量。每个主引线包括位于导管工作端的电极。在主引线之间保持分离，使得每个主引线可以分别接收所选极性的功率。主引线被构造成向外扩展以使电极与解剖结构相配合。可以从引线施加高频能量以在解剖结构的周围组织中产生加热效果。中空解剖结构的直径由于加热效应而降低，并且主引线的电极彼此靠近地移动。当中空解剖结构为静脉时，施加能量直到静脉的直径减小到静脉闭塞的位置。在一个实施例中，次级引线被主引线包围，并且延伸超出主引线。次级引线包括在导管的工作端的电极。次级引线可以具有与双极配置中的主引线的极性相反的极性。可以切换引线的极性，并且可以在治疗期间移动导管以连接延长的静脉长度。导管可以包括用于容纳导丝或者允许流体输送的内腔。

23. 发明申请

US20090005416A1 BENZIMIDAZOLE DERIVATIVES 有权
标题翻译：苯并咪唑衍生物
公开(公告)号：US20090005416A1
公开(公告)日：2009-01-01
申请号：US12142119
申请日：2008-06-19
申请人： Michael J. Munchhof , Lawrence A. Reiter , Susan D. La Greca , Christopher S. Jones , Qifang Li
发明人： Michael J. Munchhof , Lawrence A. Reiter , Susan D. La Greca , Christopher S. Jones , Qifang Li
IPC分类号： A61K31/4545 , C07D401/12 , A61K31/454 , A61P35/00
CPC分类号： C07D401/12 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要： The present invention relates to a compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3A, R3B, R4, R5, X, m, and n are as defined herein. Such novel benzamidazole derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中R1，R2，R3A，R3B，R4，R5，X，m和n如本文所定义。这种新型苯甲胺唑衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。

24. 外观设计

USD574306S1 Bicycle brake 有权
标题翻译：自行车刹车
公开(公告)号：USD574306S1
公开(公告)日：2008-08-05
申请号：US29275456
申请日：2006-12-27
申请人： Christopher S. Jones
设计人： Christopher S. Jones

25. 外观设计

USD573927S1 Bicycle brake lever 有权
标题翻译：自行车制动杆
公开(公告)号：USD573927S1
公开(公告)日：2008-07-29
申请号：US29275464
申请日：2006-12-27
申请人： Christopher S. Jones
设计人： Christopher S. Jones

26. 外观设计

USD573069S1 Bicycle brake pad 有权
公开(公告)号：USD573069S1
公开(公告)日：2008-07-15
申请号：US29275461
申请日：2006-12-27
申请人： Christopher S. Jones
设计人： Christopher S. Jones

27. 发明授权

US07216220B2 Microprocessor with customer code store 有权
标题翻译：微处理器与客户代码存储
公开(公告)号：US07216220B2
公开(公告)日：2007-05-08
申请号：US10891165
申请日：2004-07-14
申请人： Gary L Brown , Christopher S. Jones , Darrell D. Boggs
发明人： Gary L Brown , Christopher S. Jones , Darrell D. Boggs
IPC分类号： G06F9/44
CPC分类号： G06F9/3017 , G06F9/26
摘要： A microprocessor including memory storage into which ISA customer code routines can be stored after having been decoded into their machine-native microinstructions. The customer code store is not subject to eviction and the like, as a cache memory would be. ISA level code can specify a routine for storage into the customer code store, at a time prior to its execution. The customer code store thus serves as a write-once execute-many library of pre-decoded routines which ISA level applications can subsequently use, permitting a system manufacturer to create a highly customized and optimized system.
摘要翻译：包括存储器存储器的微处理器，ISA客户代码程序在被解码成其机器本机微指令之后可被存储到其中。作为高速缓冲存储器，客户代码存储器不会被驱逐等等。 ISA级代码可以在执行之前指定一个用于存储到客户代码存储中的例程。因此，客户代码存储库用作可以随后使用ISA级应用程序的预先解码的例程的一次写入的多执行程序库，允许系统制造商创建高度定制和优化的系统。

28. 发明授权

US06200312B1 Expandable vein ligator catheter having multiple electrode leads 失效
标题翻译：具有多个电极引线的可扩展静脉结扎器导管
公开(公告)号：US06200312B1
公开(公告)日：2001-03-13
申请号：US08927251
申请日：1997-09-11
申请人： Arthur W. Zikorus , Mark P. Parker , Christopher S. Jones , Douglas M. Petty , Brian E. Farley , Joseph M. Tartaglia
发明人： Arthur W. Zikorus , Mark P. Parker , Christopher S. Jones , Douglas M. Petty , Brian E. Farley , Joseph M. Tartaglia
IPC分类号： A61B1738
CPC分类号： A61B18/1492 , A61B2017/00084 , A61B2017/22038 , A61B2017/22051 , A61B2018/00214 , A61B2018/0022 , A61B2018/00404 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1475 , A61B2090/3782 , A61B2218/002
摘要： A catheter includes a plurality of primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that each primary lead can individually receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with an anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another. Where the hollow anatomical structure is a vein, energy is applied until the diameter of the vein is reduced to the point where the vein is occluded. In one embodiment, a secondary lead is surrounded by the primary leads, and extends beyond the primary leads. The secondary lead includes an electrode at the working end of the catheter. The secondary lead can have a polarity opposite to the polarity of the primary leads in a bipolar configuration. The polarity of the leads can be switched and the catheter can be moved during treatment to ligate an extended length of the vein. The catheter can include a lumen to accommodate a guide wire or to allow fluid delivery.
摘要翻译：导管包括多个主引线以传递用于结扎中空解剖结构的能量。每个主引线包括位于导管工作端的电极。在主引线之间保持分离，使得每个主引线可以分别接收所选极性的功率。主引线被构造成向外扩展以使电极与解剖结构相配合。可以从引线施加高频能量以在解剖结构的周围组织中产生加热效果。中空解剖结构的直径由于加热效应而降低，并且主引线的电极彼此靠近地移动。当中空解剖结构为静脉时，施加能量直到静脉的直径减小到静脉闭塞的位置。在一个实施例中，次级引线被主引线包围，并且延伸超出主引线。次级引线包括在导管的工作端的电极。次级引线可以具有与双极配置中的主引线的极性相反的极性。可以切换引线的极性，并且可以在治疗期间移动导管以连接延长的静脉长度。导管可以包括用于容纳导丝或者允许流体输送的内腔。

29. 发明授权

US6165172A Expandable vein ligator catheter and method of use 失效
公开(公告)号：US6165172A
公开(公告)日：2000-12-26
申请号：US958766
申请日：1997-10-26
申请人： Brian E. Farley , Dawn A. Henderson , Christopher S. Jones , Mark P. Parker , Joseph M. Tartaglia
发明人： Brian E. Farley , Dawn A. Henderson , Christopher S. Jones , Mark P. Parker , Joseph M. Tartaglia
IPC分类号： A61B17/00 , A61B17/22 , A61B18/14 , A61B18/04
CPC分类号： A61B18/1492 , A61B2017/00084 , A61B2017/22038 , A61B2017/22051 , A61B2018/00214 , A61B2018/0022 , A61B2018/00404 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1475 , A61B2090/3782 , A61B2218/002
摘要： A catheter includes a plurality of primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that each primary lead can individually receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with a hollow anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another. Where the hollow anatomical structure is a vein, energy is applied until the diameter of the vein is reduced to the point where the vein is occluded. In one embodiment, a balloon is inflated to occlude the structure before the application of energy. Where the structure is a vein, the inflated balloon obstructs blood flow and facilitates the infusion of saline, medication, or a high-impedance fluid to the vein in order to reduce the occurrence of coagulation and to improve the heating of the vein by the catheter. The catheter can include a lumen to accommodate a guide wire or to allow fluid delivery.

30. 发明授权

US5807309A Transurethral needle ablation device and method for the treatment of the prostate 失效
标题翻译：经尿道针消融装置及治疗前列腺的方法
公开(公告)号：US5807309A
公开(公告)日：1998-09-15
申请号：US790094
申请日：1997-01-29
申请人： Ingemar H. Lundquist , Stuart D. Edwards , James A. Baker, Jr. , Christopher S. Jones , Phillip R. Sommer , Kee S. Lee
发明人： Ingemar H. Lundquist , Stuart D. Edwards , James A. Baker, Jr. , Christopher S. Jones , Phillip R. Sommer , Kee S. Lee
IPC分类号： A61N5/02 , A61B10/00 , A61B10/02 , A61B10/06 , A61B17/00 , A61B17/22 , A61B17/24 , A61B17/28 , A61B17/34 , A61B18/00 , A61B18/08 , A61B18/14 , A61B18/18 , A61B18/22 , A61B18/24 , A61B19/00 , A61F7/00 , A61M20060101 , A61M1/00 , A61M3/02 , A61M25/00 , A61M25/01 , A61N1/06 , A61N1/40 , A61N5/04 , A61B17/20
CPC分类号： A61B18/00 , A61B10/0233 , A61B10/0275 , A61B10/06 , A61B18/1477 , A61B18/1482 , A61B18/1485 , A61B18/18 , A61B18/1815 , A61M25/0136 , A61N1/06 , A61N1/40 , A61N1/403 , A61N5/02 , A61N5/045 , A61B10/02 , A61B10/0241 , A61B18/14 , A61B18/1442 , A61B18/148 , A61B18/24 , A61B2017/00084 , A61B2017/00092 , A61B2017/00101 , A61B2017/00106 , A61B2017/00274 , A61B2017/00292 , A61B2017/003 , A61B2017/00867 , A61B2017/22072 , A61B2017/22077 , A61B2017/22082 , A61B2017/248 , A61B2017/2939 , A61B2017/3488 , A61B2018/00005 , A61B2018/00011 , A61B2018/00041 , A61B2018/00083 , A61B2018/00095 , A61B2018/00196 , A61B2018/0022 , A61B2018/00547 , A61B2018/00577 , A61B2018/00678 , A61B2018/00702 , A61B2018/00726 , A61B2018/00744 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00886 , A61B2018/0091 , A61B2018/00916 , A61B2018/00946 , A61B2018/00982 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/128 , A61B2018/1425 , A61B2018/1861 , A61B2018/2238 , A61B2090/0814 , A61B2090/3614 , A61B2090/3782 , A61B2090/3925 , A61B2217/005 , A61F2007/0054 , A61M2025/0089 , A61M2025/0091 , A61M2025/0096 , A61M2025/018 , A61M3/0279 , A61N5/04
摘要： A transurethral needle ablation device for use with the human hand for radio frequency ablation of a target volume in the tissue of a prostate of a human male having a bladder with a base and a penis with a urethra therein formed by a urethral wall extending into the base of the bladder along a longitudinal axis with the tissue of the prostate surrounding the urethra near the base of the bladder. The device comprises a bridge having proximal and distal extremities and having a passage therein extending from the proximal extremity to the distal extremity. A sheath having proximal and distal extremities is secured to the bridge and has a passageway therein in communication with the passage in the bridge. The sheath is sized so that it can enter the urethra and has a length so that when its distal extremity is in the vicinity of the prostate, the proximal extremity is outside the urethra. A disposable needle assembly having proximal and distal extremities is removably mounted in the passage in the bridge and extends through the passageway in the sheath. The needle assembly includes at least one needle electrode and an insulating sleeve coaxially disposed on the needle electrode. The proximal extremity of the needle assembly is caused to be moved sideways at an angle with respect to the longitudinal axis to face the urethral wall. A mechanism is carried by the proximal extremity of the needle assembly and the bridge for causing advancement of the needle electrode and the insulation sleeve thereon through the urethral wall and into the target volume in the tissue of the prostate with a portion of the electrode being free of the insulation but with the insulation extending through the urethral wall.
摘要翻译：一种用于人手的经尿道针消融装置，用于射线消融人体前列腺的前列腺的组织中的目标体积，所述人的男性具有膀胱与基部和阴茎，其中尿道由尿道壁形成，所述尿道壁延伸到膀胱的基部沿着纵向轴线，邻近膀胱底部的尿道周围的前列腺组织。该装置包括具有近端和远端的桥，并具有从近端至远端延伸的通道。具有近端和远端的护套固定到桥上，并且在其中具有与桥中的通道连通的通道。护套的尺寸使得其可以进入尿道并且具有长度，使得当其远端位于前列腺附近时，近端位于尿道外。具有近端和远端的一次性针组件可移除地安装在桥中的通道中并且延伸穿过护套中的通道。针组件包括至少一个针电极和同轴地设置在针电极上的绝缘套管。针组件的近端被相对于纵向轴线以一定角度侧向移动以面向尿道壁。针组件和桥的近端被携带机构，用于使针电极和绝缘套筒在其上通过尿道壁进入并进入前列腺组织中的目标体积，其中一部分电极是自由的的绝缘体，但绝缘体延伸穿过尿道壁。

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