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    • 24. 发明授权
    • Sleeve reaction chamber system
    • 套筒反应室系统
    • US07578976B1
    • 2009-08-25
    • US09568618
    • 2000-05-10
    • M. Allen NorthrupBarton V. BeemanWilliam J. BenettDean R. HadleyPhoebe LandreStacy L. LehewPeter A. Krulevitch
    • M. Allen NorthrupBarton V. BeemanWilliam J. BenettDean R. HadleyPhoebe LandreStacy L. LehewPeter A. Krulevitch
    • G01N33/00
    • B01L7/52B01L2300/0838B01L2300/1822
    • A chemical reaction chamber system that combines devices such as doped polysilicon for heating, bulk silicon for convective cooling, and thermoelectric (TE) coolers to augment the heating and cooling rates of the reaction chamber or chambers. In addition the system includes non-silicon-based reaction chambers such as any high thermal conductivity material used in combination with a thermoelectric cooling mechanism (i.e., Peltier device). The heat contained in the thermally conductive part of the system can be used/reused to heat the device, thereby conserving energy and expediting the heating/cooling rates. The system combines a micromachined silicon reaction chamber, for example, with an additional module/device for augmented heating/cooling using the Peltier effect. This additional module is particularly useful in extreme environments (very hot or extremely cold) where augmented heating/cooling would be useful to speed up the thermal cycling rates. The chemical reaction chamber system has various applications for synthesis or processing of organic, inorganic, or biochemical reactions, including the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction.
    • 化学反应室系统,其组合诸如用于加热的掺杂多晶硅,对流冷却的散装硅和热电(TE)冷却器的装置,以增加反应室或室的加热和冷却速率。 此外,该系统包括非硅基反应室,例如与热电冷却机构(即珀尔帖装置)结合使用的任何高导热性材料。 系统的导热部分中所含的热量可以用于/再利用来加热装置,从而节省能量并加快加热/冷却速度。 该系统将微加工硅反应室与例如使用珀尔帖效应进行增强加热/冷却的附加模块/装置相结合。 该额外的模块在极端环境(非常热或极冷)中特别有用,其中增强的加热/冷却将有助于加快热循环速率。 化学反应室系统具有用于合成或加工有机,无机或生化反应的各种应用,包括聚合酶链式反应(PCR)和/或其他DNA反应,如连接酶链式反应。
    • 26. 发明授权
    • Microfluidic interconnects
    • 微流控互连
    • US06273478B1
    • 2001-08-14
    • US09281345
    • 1999-03-30
    • William J. BenettPeter A. Krulevitch
    • William J. BenettPeter A. Krulevitch
    • F16L2103
    • F16L19/0218F15C5/00F16L21/03
    • A miniature connector for introducing microliter quantities of solutions into microfabricated fluidic devices, and which incorporates a molded ring or seal set into a ferrule cartridge, with or without a compression screw. The fluidic connector, for example, joins standard high pressure liquid chromatography (HPLC) tubing to 1 mm diameter holes in silicon or glass, enabling ml-sized volumes of sample solutions to be merged with &mgr;l-sized devices. The connector has many features, including ease of connect and disconnect; a small footprint which enables numerous connectors to be located in a small area; low dead volume; helium leak-tight; and tubing does not twist during connection. Thus the connector enables easy and effective change of microfluidic devices and introduction of different solutions in the devices.
    • 一种微型连接器,用于将微量的溶液引入微细加工的流体装置中,并且将带有或不带有压缩螺杆的模制环或密封件组合到套圈盒中。 例如,流体连接器将标准高压液相色谱(HPLC)管道连接到硅或玻璃中的1mm直径的孔中,使得能够将大小体积的样品溶液与多种尺寸的装置合并。 连接器具有许多功能,包括易于连接和断开连接; 小的占地面积,使许多连接器位于一个小区域; 死亡体积小 氦密封; 并且管道在连接期间不扭曲。 因此,连接器能够简单有效地改变微流体装置并在装置中引入不同的解决方案。
    • 27. 发明授权
    • Microfluidic interconnects
    • 微流控互连
    • US06209928B1
    • 2001-04-03
    • US09090769
    • 1998-06-04
    • William J. BenettPeter A. Krulevitch
    • William J. BenettPeter A. Krulevitch
    • F16L3900
    • F16L37/025
    • A miniature connector for introducing microliter quantities of solutions into microfabricated fluidic devices. The fluidic connector, for example, joins standard high pressure liquid chromatography (HPLC) tubing to 1 mm diameter holes in silicon or glass, enabling ml-sized volumes of sample solutions to be merged with &mgr;l-sized devices. The connector has many features, including ease of connect and disconnect; a small footprint which enables numerous connectors to be located in a small area; low dead volume; helium leak-tight; and tubing does not twist during connection. Thus the connector enables easy and effective change of microfluidic devices and introduction of different solutions in the devices.
    • 用于将微量数量的溶液引入微制造流体装置的微型连接器。 例如,流体连接器将标准高压液相色谱(HPLC)管道连接到硅或玻璃中的1mm直径的孔中,使得能够将大小体积的样品溶液与多种尺寸的装置合并。 连接器具有许多功能,包括易于连接和断开连接; 小的占地面积,使许多连接器位于一个小区域; 死亡体积小 氦密封; 并且管道在连接期间不扭曲。 因此,连接器能够简单有效地改变微流体装置并在装置中引入不同的解决方案。