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1. 发明授权

US07578976B1 Sleeve reaction chamber system 失效
标题翻译：套筒反应室系统
公开(公告)号：US07578976B1
公开(公告)日：2009-08-25
申请号：US09568618
申请日：2000-05-10
申请人： M. Allen Northrup , Barton V. Beeman , William J. Benett , Dean R. Hadley , Phoebe Landre , Stacy L. Lehew , Peter A. Krulevitch
发明人： M. Allen Northrup , Barton V. Beeman , William J. Benett , Dean R. Hadley , Phoebe Landre , Stacy L. Lehew , Peter A. Krulevitch
IPC分类号： G01N33/00
CPC分类号： B01L7/52 , B01L2300/0838 , B01L2300/1822
摘要： A chemical reaction chamber system that combines devices such as doped polysilicon for heating, bulk silicon for convective cooling, and thermoelectric (TE) coolers to augment the heating and cooling rates of the reaction chamber or chambers. In addition the system includes non-silicon-based reaction chambers such as any high thermal conductivity material used in combination with a thermoelectric cooling mechanism (i.e., Peltier device). The heat contained in the thermally conductive part of the system can be used/reused to heat the device, thereby conserving energy and expediting the heating/cooling rates. The system combines a micromachined silicon reaction chamber, for example, with an additional module/device for augmented heating/cooling using the Peltier effect. This additional module is particularly useful in extreme environments (very hot or extremely cold) where augmented heating/cooling would be useful to speed up the thermal cycling rates. The chemical reaction chamber system has various applications for synthesis or processing of organic, inorganic, or biochemical reactions, including the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction.
摘要翻译：化学反应室系统，其组合诸如用于加热的掺杂多晶硅，对流冷却的散装硅和热电（TE）冷却器的装置，以增加反应室或室的加热和冷却速率。此外，该系统包括非硅基反应室，例如与热电冷却机构（即珀尔帖装置）结合使用的任何高导热性材料。系统的导热部分中所含的热量可以用于/再利用来加热装置，从而节省能量并加快加热/冷却速度。该系统将微加工硅反应室与例如使用珀尔帖效应进行增强加热/冷却的附加模块/装置相结合。该额外的模块在极端环境（非常热或极冷）中特别有用，其中增强的加热/冷却将有助于加快热循环速率。化学反应室系统具有用于合成或加工有机，无机或生化反应的各种应用，包括聚合酶链式反应（PCR）和/或其他DNA反应，如连接酶链式反应。

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