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21. 发明授权

US08543199B2 Implantable systems and methods for identifying a contra-ictal condition in a subject 有权
标题翻译：用于识别受试者的反面条件的植入式系统和方法
公开(公告)号：US08543199B2
公开(公告)日：2013-09-24
申请号：US13225241
申请日：2011-09-02
申请人： David Snyder , Kent W. Leyde , John F. Harris
发明人： David Snyder , Kent W. Leyde , John F. Harris
IPC分类号： A61B5/04
CPC分类号： A61B5/02055 , A61B5/0006 , A61B5/0031 , A61B5/01 , A61B5/0205 , A61B5/021 , A61B5/026 , A61B5/0452 , A61B5/048 , A61B5/08 , A61B5/145 , A61B5/14552 , A61B5/4094 , A61B5/7232 , A61B2560/0219
摘要： Systems and methods of monitoring a subject's neurological condition are provided. In some embodiments, the method includes the steps of analyzing a physiological signal (such as an EEG) from a subject to determine if the subject is in a contra-ictal condition; and if the subject is in a contra-ictal condition, providing an indication (e.g., to the subject and/or to a caregiver) that the subject is in the contra-ictal condition. The systems and methods may utilize a minimally invasive, leadless device to monitor the subject's condition. In some embodiments, if the subject is in a pro-ictal condition, the method includes the step of providing an indication (such as a red light) that the subject is in the pro-ictal condition.
摘要翻译：提供了监测受试者神经系统状况的系统和方法。在一些实施例中，该方法包括分析来自受试者的生理信号（例如EEG）以确定受试者是否处于对立状态的步骤; 并且如果受试者处于对立状态，则向对象提供指示（例如，对受试者和/或照顾者）对象处于对立状态。系统和方法可以利用微创无引导装置来监测受检者的状况。在一些实施例中，如果受试者处于预备状态，则该方法包括提供受试者处于预防状态的指示（例如红光）的步骤。

22. 发明申请

US20100168604A1 Processing for Multi-Channel Signals 有权
公开(公告)号：US20100168604A1
公开(公告)日：2010-07-01
申请号：US12649098
申请日：2009-12-29
申请人： Javier Ramon Echauz , David E. Snyder , Kent W. Leyde
发明人： Javier Ramon Echauz , David E. Snyder , Kent W. Leyde
IPC分类号： A61B5/0476 , G09G5/22
CPC分类号： A61B5/0476 , A61B5/4094
摘要： Method and apparatus for improved processing for multi-channel signals. In an exemplary embodiment, an anomaly metric is computed for a multi-channel signal over a time window. The magnitude of the anomaly metric may be used to determine whether an anomaly is present in the multi-channel signal over the time window. In an exemplary embodiment, the anomaly metric may be a condition number associated with the singular values of the multi-channel signal over the time window, as further adjusted by the number of channels to produce a data condition number. Applications of the anomaly metric computation include the scrubbing of signal archives for epileptic seizure detection/prediction/counter-prediction algorithm training, pre-processing of multi-channel signals for real-time monitoring of bio-systems, and boot-up and/or adaptive self-checking of such systems during normal operation.

23. 发明申请

US20100125219A1 MINIMALLY INVASIVE SYSTEM FOR SELECTING PATIENT-SPECIFIC THERAPY PARAMETERS 审中-公开
标题翻译：用于选择患者特异性治疗参数的最小入场系统
公开(公告)号：US20100125219A1
公开(公告)日：2010-05-20
申请号：US12691650
申请日：2010-01-21
申请人： John F. Harris , Kent W. Leyde , Jaideep Mavoori
发明人： John F. Harris , Kent W. Leyde , Jaideep Mavoori
IPC分类号： A61B5/0476
CPC分类号： A61N1/37229 , A61B5/0031 , A61B5/0476 , A61B5/4094 , A61B2560/0214 , A61N1/36064
摘要： The present invention provides systems and methods for ambulatory, long term monitoring of a physiological signal from a patient. At least a portion of the systems of the present invention may be implanted within the patient in a minimally invasive manner. In preferred embodiments, brain activity signals are sampled from the patient and are transmitted to a handheld patient communication device for further processing.
摘要翻译：本发明提供了用于从患者进行生理信号的长期监测的系统和方法。本发明的系统的至少一部分可以以微创方式植入患者体内。在优选实施例中，从患者采样脑活动信号，并将其发送到手持式病人通信装置以进一步处理。

24. 发明授权

US07676263B2 Minimally invasive system for selecting patient-specific therapy parameters 有权
标题翻译：用于选择患者特异性治疗参数的微创系统
公开(公告)号：US07676263B2
公开(公告)日：2010-03-09
申请号：US11766760
申请日：2007-06-21
申请人： John F. Harris , Kent W. Leyde , Jaideep Mavoori
发明人： John F. Harris , Kent W. Leyde , Jaideep Mavoori
IPC分类号： A61B5/00
CPC分类号： A61N1/37229 , A61B5/0031 , A61B5/0476 , A61B5/4094 , A61B2560/0214 , A61N1/36064
摘要： The present invention provides systems and methods for ambulatory, long term monitoring of a physiological signal from a patient. At least a portion of the systems of the present invention may be implanted within the patient in a minimally invasive manner. In preferred embodiments, brain activity signals are sampled from the patient and are transmitted to a handheld patient communication device for further processing.
摘要翻译：本发明提供了用于从患者进行生理信号的长期监测的系统和方法。本发明的系统的至少一部分可以以微创方式植入患者体内。在优选实施例中，从患者采样脑活动信号，并将其发送到手持式病人通信装置以进一步处理。

25. 发明申请

US20090171168A1 Systems and Method for Recording Clinical Manifestations of a Seizure 审中-公开
标题翻译：记录癫痫发作临床表现的系统和方法
公开(公告)号：US20090171168A1
公开(公告)日：2009-07-02
申请号：US12343376
申请日：2008-12-23
申请人： Kent W. Leyde , Michael Bland
发明人： Kent W. Leyde , Michael Bland
IPC分类号： A61B5/0476 , A61B5/024
CPC分类号： A61B5/4094 , A61B5/0031 , A61B5/04012 , A61B5/0478 , A61B5/048 , A61B5/11 , A61B5/7221 , A61B5/7246 , A61B5/7275 , A61N1/36082
摘要： A method of comparing a patient's neurological data to data that is indicative of the patient's clinical manifestation of a seizure. In some embodiments, the method includes the steps of monitoring neurological data from a patient indicative of the patient's propensity for having a seizure; automatically recording clinical manifestation data from the patient that may be indicative of the occurrence of a clinical seizure; and analyzing the automatically recorded clinical manifestation data and the monitored neurological data to determine if one of the clinical manifestation data and the neurological data indicates the occurrence of a seizure while the other does not. Systems are described including a monitoring device having a communication assembly for receiving neurological data transmitted external to a patient from a transmitter implanted in a patient; a processor that processes the neurological data to estimate the patient's brain state; and an assembly for automatically recording clinical manifestation data in response to a brain state estimate by the processor.
摘要翻译：将患者的神经学数据与指示患者临床表现为癫痫发作的数据进行比较的方法。在一些实施例中，该方法包括以下步骤：监测来自患者的指示患者癫痫发作倾向的神经学数据; 自动记录患者临床表现资料，可能表明临床发作的发生; 并分析自动记录的临床表现数据和所监测的神经学数据，以确定临床表现数据和神经学数据之一是否表明癫痫发作，而另一个不发生。描述了系统，其包括具有通信组件的监视设备，该通信组件用于从植入患者体内的发射器接收从患者外部传输的神经学数据; 处理器，处理神经学数据以估计患者的大脑状态; 以及用于响应于处理器的脑状态估计自动记录临床表现数据的组件。

26. 发明申请

US20090062682A1 Patient Advisory Device 有权
标题翻译：患者咨询设备
公开(公告)号：US20090062682A1
公开(公告)日：2009-03-05
申请号：US12180996
申请日：2008-07-28
申请人： Michael Bland , Kent W. Leyde , Neil G. McIlvaine , Shan Gaw , Peter Weiss , John F. Harris
发明人： Michael Bland , Kent W. Leyde , Neil G. McIlvaine , Shan Gaw , Peter Weiss , John F. Harris
IPC分类号： A61B5/0476
CPC分类号： A61B5/0476 , A61B5/0031 , A61B5/4094
摘要： A patient advisory device (“PAD”) and its methods of use. The PAD may be configured to alert the patient about an estimated brain state of the patient. In preferred embodiments, the PAD is adapted to alert the patient of the patient's brain state, which corresponds to the patient's propensity of transitioning into an ictal brain state, e.g., having a seizure. Based on the specific type of alert, the patient will be made aware whether they are highly unlikely to have a seizure for a given period of time, an elevated propensity of having a seizure, a seizure is occurring or imminent, or the patient's brain state is unknown.
摘要翻译：患者咨询器（“PAD”）及其使用方法。 PAD可以被配置为警告患者关于患者的估计的脑状态。在优选实施例中，PAD适于警告患者患者的脑状态，其对应于患者转变为脑血管状态的倾向，例如具有癫痫发作。根据具体的警戒类型，患者将会意识到他们是否不太可能在给定的时间内癫痫发作，癫痫发作，癫痫发作或迫在眉睫的倾向，或患者的大脑状态是未知数

27. 发明申请

US20090030403A1 Methods and Systems for Attenuating the Tolerance Response to a Drug 审中-公开
标题翻译：减轻药物耐受反应的方法和系统
公开(公告)号：US20090030403A1
公开(公告)日：2009-01-29
申请号：US11829821
申请日：2007-07-27
申请人： Kent W. Leyde
发明人： Kent W. Leyde
IPC分类号： G06F19/00
CPC分类号： G06F19/3456 , Y02A90/22 , Y02A90/26
摘要： Methods are provided for modulating a drug response comprising determining that a patient has an elevated or reduced susceptibility for a neurological event; outputting a signal that indicates to the patient to administer an acute dosage of a pharmacological agent that is sufficient to modulate the patient's susceptibility for the neurological event, wherein the drug response is modulated. Systems are also provided for treating epilepsy comprising an electrode array configured to receive a signal from a patient; a processing assembly configured to receive and process the signal to determine the patient's susceptibility for a neurological event; an output assembly configured to produce an output that indicates to the patient to administer an acute dosage of a pharmacological agent that is sufficient to reduce the patient's susceptibility for the neurological event, wherein the drug response to the pharmacological agent is attenuated.
摘要翻译：提供了用于调节药物应答的方法，包括确定患者对神经性事件的易感性升高或降低; 输出指示给患者的信号，以施用足以调节患者对神经系统事件的敏感性的药物的急性剂量，其中调节药物反应。还提供了用于治疗癫痫的系统，其包括构造成从患者接收信号的电极阵列; 配置成接收和处理信号以确定患者对神经性事件的易感性的处理组件; 输出组件，其被配置为产生输出，其向患者指示施用足以降低患者对神经系统事件的易感性的急性剂量的药理学试剂，其中对药理学试剂的药物反应减弱。

28. 发明授权

US06178357B1 Electrode pad system and defibrillator electrode pad that reduces the risk of peripheral shock 有权
标题翻译：电极垫系统和除颤器电极垫，减少外围冲击的风险
公开(公告)号：US06178357B1
公开(公告)日：2001-01-23
申请号：US09143701
申请日：1998-08-28
申请人： Bradford E. Gliner , Stephen M. Dillon , Kent W. Leyde
发明人： Bradford E. Gliner , Stephen M. Dillon , Kent W. Leyde
IPC分类号： A61N105
CPC分类号： A61N1/046 , A61N1/0492
摘要： This invention is directed to a medical electrode system having a flexible substrate with two electrodes in electrical communication disposed at either end along its length. The electrode system also has one or more sensors for detecting the rate and pressure at which CPR is administered. The electrode is adjustable in length and protects the user from the potential of incidental shock when using the electrode in conjunction with a defibrillator.
摘要翻译：本发明涉及一种具有柔性基底的医疗电极系统，其中两个电极沿着其长度设置在两端。电极系统还具有一个或多个用于检测施用CPR的速率和压力的传感器。电极的长度是可调节的，并且当使用电极与除颤器一起使用时，可以保护使用者避免偶然的冲击的可能性。

29. 发明授权

US5650750A Common mode signal and circuit fault detection in differential signal detectors 失效
标题翻译：差分信号检测器中的共模信号和电路故障检测
公开(公告)号：US5650750A
公开(公告)日：1997-07-22
申请号：US398377
申请日：1995-03-03
申请人： Kent W. Leyde , Thomas D. Lyster , Daniel J. Powers
发明人： Kent W. Leyde , Thomas D. Lyster , Daniel J. Powers
IPC分类号： H03F3/45
CPC分类号： H03F3/45479 , H03F2200/261
摘要： The present invention is an apparatus and method for detecting differential mode signals in an environment where differential mode signals co-exist, and might be corrupted by, common mode signals. The most basic apparatus of the present invention essentially comprises first and second input leads through which both differential mode and common mode signals are input; a first amplifier block having a gain that is substantially one; and at least an inverting node and a non-inverting node connected to the first and second input leads. The output of the amplifier block is fed back to the input of the non-inverting node of the amplifier block in a manner to increase differential mode impedance while maintaining a low common mode impedance. Various embodiments of the basic presently claimed circuitry provides for additional methods of monitoring the level of common-mode signal introduced to the apparatus and other fault detection functions.
摘要翻译：本发明是一种用于在差分模式信号共存并可能被共模信号损坏的环境中检测差模信号的装置和方法。本发明最基本的装置基本上包括输入差模和共模信号的第一和第二输入引线; 第一放大器块，其具有实质上一个的增益; 以及至少连接到第一和第二输入引线的反相节点和非反相节点。放大器模块的输出以增加差分模式阻抗的方式反馈到放大器模块的非反相节点的输入，同时保持低共模阻抗。基本的当前要求保护的电路的各种实施例提供监视引入到该装置的共模信号的电平和其他故障检测功能的附加方法。

30. 发明授权

US08868172B2 Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders 有权
标题翻译：用于向患者推荐用于管理癫痫和其他神经障碍的适当动作的方法和系统
公开(公告)号：US08868172B2
公开(公告)日：2014-10-21
申请号：US11321897
申请日：2005-12-28
申请人： Kent W. Leyde , Daniel J. Dilorenzo
发明人： Kent W. Leyde , Daniel J. Dilorenzo
IPC分类号： A61B5/04 , A61N1/372 , A61B5/0476 , A61N1/36 , A61B5/00 , A61B5/048
CPC分类号： A61B5/4094 , A61B5/0476 , A61B5/048 , A61B5/7264 , A61B5/7275 , A61N1/36082 , A61N1/37247 , A61N1/37258 , G06F19/00
摘要： The present invention provides methods and system for managing neurological disorders such as epilepsy. In one embodiment, the method comprises measuring one or more signals from a patient and processing the one or more signals to characterize a patient's propensity for a future seizure. The characterized propensity for the seizure is thereafter used to determine an appropriate action for managing or treating the predicted seizure; and a recommendation is communicated to the patient that is indicative of the appropriate action.
摘要翻译：本发明提供了用于治疗诸如癫痫的神经障碍的方法和系统。在一个实施例中，该方法包括测量来自患者的一个或多个信号并处理一个或多个信号以表征患者将来发作的倾向。其特征是缉获倾向之后用于确定管理或治疗预期癫痫发作的适当行动; 并且向患者传达指示适当动作的建议。

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