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1. 发明授权

US09643019B2 Neurological monitoring and alerts 有权
公开(公告)号：US09643019B2
公开(公告)日：2017-05-09
申请号：US13026961
申请日：2011-02-14
申请人： Jason A. Higgins , Michael Bland , Kent W. Leyde , W. Douglas Sheffield , John F. Harris , David M. Himes
发明人： Jason A. Higgins , Michael Bland , Kent W. Leyde , W. Douglas Sheffield , John F. Harris , David M. Himes
IPC分类号： A61B5/04 , A61N1/372 , A61B5/00 , A61N1/00 , A61N1/05
CPC分类号： A61N1/37258 , A61B5/4094 , A61N1/00 , A61N1/0529 , G16H40/67
摘要： A system for providing alerts of neurological events occurring in a human subject is provided. The system includes: a monitoring module adapted to detect and sample a neurological signal; an event detection module coupled to the monitoring module for detecting one or more types of predetermined reportable events based on the detected neurological signal; and an alert module coupled to the event detection module, wherein upon the detection of a reportable event by the event detection module, said alert module selects a first alert contact from a plurality of contacts contained in a contact list, and generates a first alert communication to the first alert contact.

2. 发明申请

US20090171168A1 Systems and Method for Recording Clinical Manifestations of a Seizure 审中-公开
标题翻译：记录癫痫发作临床表现的系统和方法
公开(公告)号：US20090171168A1
公开(公告)日：2009-07-02
申请号：US12343376
申请日：2008-12-23
申请人： Kent W. Leyde , Michael Bland
发明人： Kent W. Leyde , Michael Bland
IPC分类号： A61B5/0476 , A61B5/024
CPC分类号： A61B5/4094 , A61B5/0031 , A61B5/04012 , A61B5/0478 , A61B5/048 , A61B5/11 , A61B5/7221 , A61B5/7246 , A61B5/7275 , A61N1/36082
摘要： A method of comparing a patient's neurological data to data that is indicative of the patient's clinical manifestation of a seizure. In some embodiments, the method includes the steps of monitoring neurological data from a patient indicative of the patient's propensity for having a seizure; automatically recording clinical manifestation data from the patient that may be indicative of the occurrence of a clinical seizure; and analyzing the automatically recorded clinical manifestation data and the monitored neurological data to determine if one of the clinical manifestation data and the neurological data indicates the occurrence of a seizure while the other does not. Systems are described including a monitoring device having a communication assembly for receiving neurological data transmitted external to a patient from a transmitter implanted in a patient; a processor that processes the neurological data to estimate the patient's brain state; and an assembly for automatically recording clinical manifestation data in response to a brain state estimate by the processor.
摘要翻译：将患者的神经学数据与指示患者临床表现为癫痫发作的数据进行比较的方法。在一些实施例中，该方法包括以下步骤：监测来自患者的指示患者癫痫发作倾向的神经学数据; 自动记录患者临床表现资料，可能表明临床发作的发生; 并分析自动记录的临床表现数据和所监测的神经学数据，以确定临床表现数据和神经学数据之一是否表明癫痫发作，而另一个不发生。描述了系统，其包括具有通信组件的监视设备，该通信组件用于从植入患者体内的发射器接收从患者外部传输的神经学数据; 处理器，处理神经学数据以估计患者的大脑状态; 以及用于响应于处理器的脑状态估计自动记录临床表现数据的组件。

3. 发明申请

US20090062682A1 Patient Advisory Device 有权
标题翻译：患者咨询设备
公开(公告)号：US20090062682A1
公开(公告)日：2009-03-05
申请号：US12180996
申请日：2008-07-28
申请人： Michael Bland , Kent W. Leyde , Neil G. McIlvaine , Shan Gaw , Peter Weiss , John F. Harris
发明人： Michael Bland , Kent W. Leyde , Neil G. McIlvaine , Shan Gaw , Peter Weiss , John F. Harris
IPC分类号： A61B5/0476
CPC分类号： A61B5/0476 , A61B5/0031 , A61B5/4094
摘要： A patient advisory device (“PAD”) and its methods of use. The PAD may be configured to alert the patient about an estimated brain state of the patient. In preferred embodiments, the PAD is adapted to alert the patient of the patient's brain state, which corresponds to the patient's propensity of transitioning into an ictal brain state, e.g., having a seizure. Based on the specific type of alert, the patient will be made aware whether they are highly unlikely to have a seizure for a given period of time, an elevated propensity of having a seizure, a seizure is occurring or imminent, or the patient's brain state is unknown.
摘要翻译：患者咨询器（“PAD”）及其使用方法。 PAD可以被配置为警告患者关于患者的估计的脑状态。在优选实施例中，PAD适于警告患者患者的脑状态，其对应于患者转变为脑血管状态的倾向，例如具有癫痫发作。根据具体的警戒类型，患者将会意识到他们是否不太可能在给定的时间内癫痫发作，癫痫发作，癫痫发作或迫在眉睫的倾向，或患者的大脑状态是未知数

4. 发明申请

US20110201944A1 NEUROLOGICAL MONITORING AND ALERTS 有权
标题翻译：神经监测和警报
公开(公告)号：US20110201944A1
公开(公告)日：2011-08-18
申请号：US13026961
申请日：2011-02-14
申请人： Jason A. Higgins , Michael Bland , Kent W. Leyde , W. Douglas Sheffield , John F. Harris , David M. Himes
发明人： Jason A. Higgins , Michael Bland , Kent W. Leyde , W. Douglas Sheffield , John F. Harris , David M. Himes
IPC分类号： A61B5/0205 , A61B5/0476 , A61N1/36
CPC分类号： A61N1/37258 , A61B5/4094 , A61N1/00 , A61N1/0529 , G16H40/67
摘要： A system for providing alerts of neurological events occurring in a human subject is provided. The system includes: a monitoring module adapted to detect and sample a neurological signal; an event detection module coupled to the monitoring module for detecting one or more types of predetermined reportable events based on the detected neurological signal; and an alert module coupled to the event detection module, wherein upon the detection of a reportable event by the event detection module, said alert module selects a first alert contact from a plurality of contacts contained in a contact list, and generates a first alert communication to the first alert contact.
摘要翻译：提供了一种用于提供在人类受试者中发生的神经系统事件的警报的系统。该系统包括：适于检测和采样神经信号的监测模块; 事件检测模块，耦合到监视模块，用于基于检测到的神经信号检测一种或多种类型的预定可报告事件; 以及耦合到所述事件检测模块的警报模块，其中当所述事件检测模块检测到可报告事件时，所述警报模块从包含在联系人列表中的多个联系人中选择第一警报联系人，并且生成第一警报通信到第一个警报联系人。

5. 发明授权

US09788744B2 Systems for monitoring brain activity and patient advisory device 有权
公开(公告)号：US09788744B2
公开(公告)日：2017-10-17
申请号：US12180996
申请日：2008-07-28
申请人： Michael Bland , Kent W. Leyde , Neil G. McIlvaine , Shan Gaw , Peter Weiss , John F. Harris
发明人： Michael Bland , Kent W. Leyde , Neil G. McIlvaine , Shan Gaw , Peter Weiss , John F. Harris
IPC分类号： A61B5/04 , A61B5/0478 , A61B5/042 , A61B5/0432 , A61B5/044 , A61B5/0448 , A61B5/0476 , A61B5/0496 , A61B5/00
CPC分类号： A61B5/0476 , A61B5/0031 , A61B5/4094
摘要： A patient advisory device (“PAD”) and its methods of use. The PAD may be configured to alert the patient about an estimated brain state of the patient. In preferred embodiments, the PAD is adapted to alert the patient of the patient's brain state, which corresponds to the patient's propensity of transitioning into an ictal brain state, e.g., having a seizure. Based on the specific type of alert, the patient will be made aware whether they are highly unlikely to have a seizure for a given period of time, an elevated propensity of having a seizure, a seizure is occurring or imminent, or the patient's brain state is unknown.

6. 发明授权

US08849390B2 Processing for multi-channel signals 有权
公开(公告)号：US08849390B2
公开(公告)日：2014-09-30
申请号：US12649098
申请日：2009-12-29
申请人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
发明人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
IPC分类号： A61B5/04 , A61B5/0476 , A61B5/00
CPC分类号： A61B5/0476 , A61B5/4094
摘要： Method and apparatus for improved processing for multi-channel signals. In an exemplary embodiment, an anomaly metric is computed for a multi-channel signal over a time window. The magnitude of the anomaly metric may be used to determine whether an anomaly is present in the multi-channel signal over the time window. In an exemplary embodiment, the anomaly metric may be a condition number associated with the singular values of the multi-channel signal over the time window, as further adjusted by the number of channels to produce a data condition number. Applications of the anomaly metric computation include the scrubbing of signal archives for epileptic seizure detection/prediction/counter-prediction algorithm training, pre-processing of multi-channel signals for real-time monitoring of bio-systems, and boot-up and/or adaptive self-checking of such systems during normal operation.

7. 发明授权

US08786624B2 Processing for multi-channel signals 有权
标题翻译：多通道信号处理
公开(公告)号：US08786624B2
公开(公告)日：2014-07-22
申请号：US12792582
申请日：2010-06-02
申请人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
发明人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
IPC分类号： G06T11/20 , G09G5/02 , G06F19/00 , G06F17/18
CPC分类号： A61B5/0476 , A61B5/076 , A61B5/4094 , A61B2560/0271 , G06K9/00536 , G06T11/206
摘要： Method and apparatus for improved processing for multi-channel signals. In an exemplary embodiment, an anomaly metric is computed for a multi-channel signal over a time window. The magnitude of the anomaly metric may be used to determine whether an anomaly is present in the multi-channel signal over the time window. In an exemplary embodiment, the anomaly metric may be a condition number associated with the singular values of the multi-channel signal over the time window, as further adjusted by the number of channels to produce a data condition number. Applications of the anomaly metric computation include the scrubbing of signal archives for epileptic seizure detection/prediction/counter-prediction algorithm training, pre-processing of multi-channel signals for real-time monitoring of bio-systems, and boot-up and/or adaptive self-checking of such systems during normal operation.
摘要翻译：用于改善多通道信号处理的方法和装置。在示例性实施例中，针对时间窗口上的多信道信号计算异常度量。可以使用异常度量的大小来确定在时间窗口上的多通道信号中是否存在异常。在示例性实施例中，异常度量可以是与时间窗口上的多信道信号的奇异值相关联的条件数，如通过产生数据条件数的信道数进一步调整的。异常度量计算的应用包括擦除用于癫痫发作检测/预测/反预测算法训练的信号档案，用于实时监测生物系统的多通道信号的预处理，以及启动和/或这种系统在正常运行期间的自适应自检。

8. 发明申请

US20110213222A1 Communication Error Alerting in an Epilepsy Monitoring System 有权
标题翻译：癫痫监测系统通信错误警报
公开(公告)号：US20110213222A1
公开(公告)日：2011-09-01
申请号：US13070333
申请日：2011-03-23
申请人： Kent W. Leyde , John F. Harris
发明人： Kent W. Leyde , John F. Harris
IPC分类号： A61B5/00 , A61B5/04
CPC分类号： A61B5/0476 , A61B5/0006 , A61B5/0031 , A61B5/4094 , A61B2560/0271 , A61M5/14276 , A61N1/36082 , A61N1/37247 , A61N1/37258 , A61N1/37282 , G06F19/3418
摘要： Systems and methods for monitoring neurological signals in a patient are provided. The system includes: an implantable sensor adapted to collect neurological signals; an implantable assembly configured to sample the neurological signals collected by the sensor; and a rechargeable communication device external to the patient's body, said communication device configured to wirelessly communicate with the implantable assembly and to transmit a communication error alert to a caregiver advisory device in the event of a communication error between the implantable assembly and the communication device.
摘要翻译：提供了用于监测患者神经信号的系统和方法。该系统包括：适于收集神经信号的可植入传感器; 植入式组件，被配置为对由所述传感器收集的神经信号进行采样; 以及在患者身体外部的可充电通信设备，所述通信设备被配置为与可植入组件进行无线通信，并且在可植入组件和通信设备之间发生通信错误的情况下向通知设备发送通信错误警报。

9. 发明申请

US20110172554A1 Patient Entry Recording in an Epilepsy Monitoring System 审中-公开
标题翻译：癫痫监测系统中的患者进入记录
公开(公告)号：US20110172554A1
公开(公告)日：2011-07-14
申请号：US13070357
申请日：2011-03-23
申请人： Kent W. Leyde , John F. Harris
发明人： Kent W. Leyde , John F. Harris
IPC分类号： A61B5/048
CPC分类号： A61B5/0476 , A61B5/0006 , A61B5/0031 , A61B5/4094 , A61B2560/0271 , A61M5/14276 , A61N1/36082 , A61N1/37247 , A61N1/37258 , A61N1/37282 , G06F19/3418
摘要： Systems and methods for monitoring a patient are provided. The system includes: an implantable sensor adapted to collect neurological signals; an implantable assembly configured to sample the neurological signals collected by the sensor; and a rechargeable external assembly configured to wirelessly receive the sampled neurological signals from the implantable assembly, said external assembly being further configured to record a patient entry in response to receiving an input from the patient. The method includes: collecting neurological signals with a sensor implanted in the patient; sampling the neurological signals collected by the sensor with an implantable assembly implanted in the patient; and transmitting the sampled neurological signals from the implantable assembly to a rechargeable external assembly external to the patient; and recording a patient entry in response to receiving an input from the patient.
摘要翻译：提供了用于监测患者的系统和方法。该系统包括：适于收集神经信号的可植入传感器; 植入式组件，被配置为对由所述传感器收集的神经信号进行采样; 以及可充电外部组件，其被配置为从所述可植入组件无线地接收所述取样的神经信号，所述外部组件还被配置为响应于接收到来自所述患者的输入而记录患者入口。该方法包括：用植入患者的传感器收集神经信号; 用植入患者的可植入组件对由传感器收集的神经信号进行采样; 以及将所述取样的神经信号从所述可植入组件传输到患者外部的可再充电外部组件; 以及响应于从患者接收到输入而记录患者入口。

10. 发明申请

US20100302270A1 Processing for Multi-Channel Signals 有权
标题翻译：多通道信号处理
公开(公告)号：US20100302270A1
公开(公告)日：2010-12-02
申请号：US12792582
申请日：2010-06-02
申请人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
发明人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
IPC分类号： G06T11/20 , G09G5/02 , G06F19/00 , G06F17/18
CPC分类号： A61B5/0476 , A61B5/076 , A61B5/4094 , A61B2560/0271 , G06K9/00536 , G06T11/206
摘要： Method and apparatus for improved processing for multi-channel signals. In an exemplary embodiment, an anomaly metric is computed for a multi-channel signal over a time window. The magnitude of the anomaly metric may be used to determine whether an anomaly is present in the multi-channel signal over the time window. In an exemplary embodiment, the anomaly metric may be a condition number associated with the singular values of the multi-channel signal over the time window, as further adjusted by the number of channels to produce a data condition number. Applications of the anomaly metric computation include the scrubbing of signal archives for epileptic seizure detection/prediction/counter-prediction algorithm training, pre-processing of multi-channel signals for real-time monitoring of bio-systems, and boot-up and/or adaptive self-checking of such systems during normal operation.
摘要翻译：用于改善多通道信号处理的方法和装置。在示例性实施例中，针对时间窗口上的多信道信号计算异常度量。可以使用异常度量的大小来确定在时间窗口上的多通道信号中是否存在异常。在示例性实施例中，异常度量可以是与时间窗口上的多信道信号的奇异值相关联的条件数，如通过产生数据条件数的信道数进一步调整的。异常度量计算的应用包括擦除用于癫痫发作检测/预测/反预测算法训练的信号档案，用于实时监测生物系统的多通道信号的预处理，以及启动和/或这种系统在正常运行期间的自适应自检。

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