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1. 发明授权

US09643019B2 Neurological monitoring and alerts 有权
公开(公告)号：US09643019B2
公开(公告)日：2017-05-09
申请号：US13026961
申请日：2011-02-14
申请人： Jason A. Higgins , Michael Bland , Kent W. Leyde , W. Douglas Sheffield , John F. Harris , David M. Himes
发明人： Jason A. Higgins , Michael Bland , Kent W. Leyde , W. Douglas Sheffield , John F. Harris , David M. Himes
IPC分类号： A61B5/04 , A61N1/372 , A61B5/00 , A61N1/00 , A61N1/05
CPC分类号： A61N1/37258 , A61B5/4094 , A61N1/00 , A61N1/0529 , G16H40/67
摘要： A system for providing alerts of neurological events occurring in a human subject is provided. The system includes: a monitoring module adapted to detect and sample a neurological signal; an event detection module coupled to the monitoring module for detecting one or more types of predetermined reportable events based on the detected neurological signal; and an alert module coupled to the event detection module, wherein upon the detection of a reportable event by the event detection module, said alert module selects a first alert contact from a plurality of contacts contained in a contact list, and generates a first alert communication to the first alert contact.

2. 发明授权

US08849390B2 Processing for multi-channel signals 有权
公开(公告)号：US08849390B2
公开(公告)日：2014-09-30
申请号：US12649098
申请日：2009-12-29
申请人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
发明人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
IPC分类号： A61B5/04 , A61B5/0476 , A61B5/00
CPC分类号： A61B5/0476 , A61B5/4094
摘要： Method and apparatus for improved processing for multi-channel signals. In an exemplary embodiment, an anomaly metric is computed for a multi-channel signal over a time window. The magnitude of the anomaly metric may be used to determine whether an anomaly is present in the multi-channel signal over the time window. In an exemplary embodiment, the anomaly metric may be a condition number associated with the singular values of the multi-channel signal over the time window, as further adjusted by the number of channels to produce a data condition number. Applications of the anomaly metric computation include the scrubbing of signal archives for epileptic seizure detection/prediction/counter-prediction algorithm training, pre-processing of multi-channel signals for real-time monitoring of bio-systems, and boot-up and/or adaptive self-checking of such systems during normal operation.

3. 发明授权

US08786624B2 Processing for multi-channel signals 有权
标题翻译：多通道信号处理
公开(公告)号：US08786624B2
公开(公告)日：2014-07-22
申请号：US12792582
申请日：2010-06-02
申请人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
发明人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
IPC分类号： G06T11/20 , G09G5/02 , G06F19/00 , G06F17/18
CPC分类号： A61B5/0476 , A61B5/076 , A61B5/4094 , A61B2560/0271 , G06K9/00536 , G06T11/206
摘要： Method and apparatus for improved processing for multi-channel signals. In an exemplary embodiment, an anomaly metric is computed for a multi-channel signal over a time window. The magnitude of the anomaly metric may be used to determine whether an anomaly is present in the multi-channel signal over the time window. In an exemplary embodiment, the anomaly metric may be a condition number associated with the singular values of the multi-channel signal over the time window, as further adjusted by the number of channels to produce a data condition number. Applications of the anomaly metric computation include the scrubbing of signal archives for epileptic seizure detection/prediction/counter-prediction algorithm training, pre-processing of multi-channel signals for real-time monitoring of bio-systems, and boot-up and/or adaptive self-checking of such systems during normal operation.
摘要翻译：用于改善多通道信号处理的方法和装置。在示例性实施例中，针对时间窗口上的多信道信号计算异常度量。可以使用异常度量的大小来确定在时间窗口上的多通道信号中是否存在异常。在示例性实施例中，异常度量可以是与时间窗口上的多信道信号的奇异值相关联的条件数，如通过产生数据条件数的信道数进一步调整的。异常度量计算的应用包括擦除用于癫痫发作检测/预测/反预测算法训练的信号档案，用于实时监测生物系统的多通道信号的预处理，以及启动和/或这种系统在正常运行期间的自适应自检。

4. 发明申请

US20110213222A1 Communication Error Alerting in an Epilepsy Monitoring System 有权
标题翻译：癫痫监测系统通信错误警报
公开(公告)号：US20110213222A1
公开(公告)日：2011-09-01
申请号：US13070333
申请日：2011-03-23
申请人： Kent W. Leyde , John F. Harris
发明人： Kent W. Leyde , John F. Harris
IPC分类号： A61B5/00 , A61B5/04
CPC分类号： A61B5/0476 , A61B5/0006 , A61B5/0031 , A61B5/4094 , A61B2560/0271 , A61M5/14276 , A61N1/36082 , A61N1/37247 , A61N1/37258 , A61N1/37282 , G06F19/3418
摘要： Systems and methods for monitoring neurological signals in a patient are provided. The system includes: an implantable sensor adapted to collect neurological signals; an implantable assembly configured to sample the neurological signals collected by the sensor; and a rechargeable communication device external to the patient's body, said communication device configured to wirelessly communicate with the implantable assembly and to transmit a communication error alert to a caregiver advisory device in the event of a communication error between the implantable assembly and the communication device.
摘要翻译：提供了用于监测患者神经信号的系统和方法。该系统包括：适于收集神经信号的可植入传感器; 植入式组件，被配置为对由所述传感器收集的神经信号进行采样; 以及在患者身体外部的可充电通信设备，所述通信设备被配置为与可植入组件进行无线通信，并且在可植入组件和通信设备之间发生通信错误的情况下向通知设备发送通信错误警报。

5. 发明申请

US20110172554A1 Patient Entry Recording in an Epilepsy Monitoring System 审中-公开
标题翻译：癫痫监测系统中的患者进入记录
公开(公告)号：US20110172554A1
公开(公告)日：2011-07-14
申请号：US13070357
申请日：2011-03-23
申请人： Kent W. Leyde , John F. Harris
发明人： Kent W. Leyde , John F. Harris
IPC分类号： A61B5/048
CPC分类号： A61B5/0476 , A61B5/0006 , A61B5/0031 , A61B5/4094 , A61B2560/0271 , A61M5/14276 , A61N1/36082 , A61N1/37247 , A61N1/37258 , A61N1/37282 , G06F19/3418
摘要： Systems and methods for monitoring a patient are provided. The system includes: an implantable sensor adapted to collect neurological signals; an implantable assembly configured to sample the neurological signals collected by the sensor; and a rechargeable external assembly configured to wirelessly receive the sampled neurological signals from the implantable assembly, said external assembly being further configured to record a patient entry in response to receiving an input from the patient. The method includes: collecting neurological signals with a sensor implanted in the patient; sampling the neurological signals collected by the sensor with an implantable assembly implanted in the patient; and transmitting the sampled neurological signals from the implantable assembly to a rechargeable external assembly external to the patient; and recording a patient entry in response to receiving an input from the patient.
摘要翻译：提供了用于监测患者的系统和方法。该系统包括：适于收集神经信号的可植入传感器; 植入式组件，被配置为对由所述传感器收集的神经信号进行采样; 以及可充电外部组件，其被配置为从所述可植入组件无线地接收所述取样的神经信号，所述外部组件还被配置为响应于接收到来自所述患者的输入而记录患者入口。该方法包括：用植入患者的传感器收集神经信号; 用植入患者的可植入组件对由传感器收集的神经信号进行采样; 以及将所述取样的神经信号从所述可植入组件传输到患者外部的可再充电外部组件; 以及响应于从患者接收到输入而记录患者入口。

6. 发明申请

US20100302270A1 Processing for Multi-Channel Signals 有权
标题翻译：多通道信号处理
公开(公告)号：US20100302270A1
公开(公告)日：2010-12-02
申请号：US12792582
申请日：2010-06-02
申请人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
发明人： Javier Ramón Echauz , David E. Snyder , Kent W. Leyde
IPC分类号： G06T11/20 , G09G5/02 , G06F19/00 , G06F17/18
CPC分类号： A61B5/0476 , A61B5/076 , A61B5/4094 , A61B2560/0271 , G06K9/00536 , G06T11/206
摘要： Method and apparatus for improved processing for multi-channel signals. In an exemplary embodiment, an anomaly metric is computed for a multi-channel signal over a time window. The magnitude of the anomaly metric may be used to determine whether an anomaly is present in the multi-channel signal over the time window. In an exemplary embodiment, the anomaly metric may be a condition number associated with the singular values of the multi-channel signal over the time window, as further adjusted by the number of channels to produce a data condition number. Applications of the anomaly metric computation include the scrubbing of signal archives for epileptic seizure detection/prediction/counter-prediction algorithm training, pre-processing of multi-channel signals for real-time monitoring of bio-systems, and boot-up and/or adaptive self-checking of such systems during normal operation.
摘要翻译：用于改善多通道信号处理的方法和装置。在示例性实施例中，针对时间窗口上的多信道信号计算异常度量。可以使用异常度量的大小来确定在时间窗口上的多通道信号中是否存在异常。在示例性实施例中，异常度量可以是与时间窗口上的多信道信号的奇异值相关联的条件数，如通过产生数据条件数的信道数进一步调整的。异常度量计算的应用包括擦除用于癫痫发作检测/预测/反预测算法训练的信号档案，用于实时监测生物系统的多通道信号的预处理，以及启动和/或这种系统在正常运行期间的自适应自检。

7. 发明申请

US20090171420A1 Housing for an Implantable Medical Device 有权
标题翻译：可植入医疗器械的住房
公开(公告)号：US20090171420A1
公开(公告)日：2009-07-02
申请号：US12343386
申请日：2008-12-23
申请人： David Brown , Christopher Genau , Kent W. Leyde , Shan Gaw , Jeffrey Stewart
发明人： David Brown , Christopher Genau , Kent W. Leyde , Shan Gaw , Jeffrey Stewart
IPC分类号： A61N1/05 , A61N1/08
CPC分类号： A61N1/3787 , A61N1/37223 , A61N1/375 , A61N1/3758
摘要： An implantable medical device having a concave ceramic housing component; a concave metal housing component attached to the ceramic housing component to form a hermetically sealed enclosure; and an electronic trans-housing magnetic flux component disposed within the enclosure. Another aspect of the invention provides an implantable medical device having a ceramic housing component; a metal housing component; a circumferential sealing member attached to a periphery of the ceramic housing component and to a periphery of the metal housing component to form a hermetically sealed enclosure; and an electronic trans-housing magnetic flux component disposed within the enclosure. Still another aspect of the invention provides an implantable medical device with a first metal housing component; a second metal housing component, the second metal housing component forming an opening; a ceramic housing component disposed in the opening, the first metal housing component, the second metal housing component and the ceramic housing component cooperating to form a hermetically sealed enclosure; and an electronic trans-housing magnetic flux component disposed within the enclosure.
摘要翻译：一种具有凹形陶瓷壳体部件的可植入医疗装置; 连接到陶瓷壳体部件的凹入金属壳体部件以形成密封的外壳; 以及设置在所述外壳内的电子跨壳体磁通部件。本发明的另一方面提供一种具有陶瓷壳体部件的可植入医疗装置; 金属外壳部件; 周向密封构件，其附接到陶瓷壳体部件的周边和金属壳体部件的周边，以形成密封的外壳; 以及设置在所述外壳内的电子跨壳体磁通部件。本发明的另一方面提供一种具有第一金属壳体部件的可植入医疗装置; 第二金属壳体部件，所述第二金属壳体部件形成开口; 设置在所述开口中的陶瓷壳体部件，所述第一金属壳体部件，所述第二金属壳体部件和所述陶瓷壳体部件协作以形成气密密封的壳体; 以及设置在所述外壳内的电子跨壳体磁通部件。

8. 发明申请

US20080183097A1 Methods and Systems for Measuring a Subject's Susceptibility to a Seizure 审中-公开
标题翻译：测量受试者对癫痫发作敏感性的方法和系统
公开(公告)号：US20080183097A1
公开(公告)日：2008-07-31
申请号：US12020507
申请日：2008-01-25
申请人： Kent W. Leyde , John F. Harris
发明人： Kent W. Leyde , John F. Harris
IPC分类号： A61B5/0476
CPC分类号： A61B5/0476 , A61B5/0006 , A61B5/0031 , A61B5/4094 , A61B2560/0271 , A61M5/14276 , A61N1/36082 , A61N1/37247 , A61N1/37258 , A61N1/37282 , G06F19/3418
摘要： Systems and methods for monitoring physiological signals from a subject to determine the subject's susceptibility for having a seizure. Also includes are systems and methods for activating an alert when there is a communication error between an implanted device and the external assembly. Additionally included are systems and method for long-term substantially continuous physiological signal data collection. At least a portion of the systems of the present invention may be implanted within the subject. In some embodiments, brain activity signals are sampled from the subject with implanted electrodes and are communicated to an external assembly where the brain activity signals are analyzed to determine the subject's susceptibility for having a seizure.
摘要翻译：用于监测来自受试者的生理信号的系统和方法，以确定受试者具有癫痫发作的易感性。还包括当在植入装置和外部组件之间存在通信错误时激活警报的系统和方法。另外包括用于长期基本上连续的生理信号数据收集的系统和方法。本发明的系统的至少一部分可以植入对象内。在一些实施例中，从植入电极的受试者采集脑活动信号，并将其传达到外部组件，其中分析脑活动信号以确定受试者对于发作的易感性。

9. 发明授权

US06374137B1 Method and apparatus for reducing defibrillation energy 失效
标题翻译：降低除颤能量的方法和装置
公开(公告)号：US06374137B1
公开(公告)日：2002-04-16
申请号：US09417269
申请日：1999-10-13
申请人： Carlton B. Morgan , Bradford E. Gliner , Dawn Jorgenson , Kent W. Leyde
发明人： Carlton B. Morgan , Bradford E. Gliner , Dawn Jorgenson , Kent W. Leyde
IPC分类号： A61N139
CPC分类号： A61N1/3937 , A61N1/3931
摘要： An energy reduction unit is removably connectable to an external defibrillator to reduce the defibrillation energy delivered by the defibrillator to a patient. Use of the energy reduction unit is particularly suited to defibrillating pediatric patients (infants and children under 8) with an automatic or semi-automatic external defibrillator (AED). In one embodiment, the energy reduction unit includes an attenuator which partially dissipates energy produced by the AED. The attenuator is advantageously designed to present an impedance to the AED which, when connected to the patient, is approximately equal to the patient's impedance. The energy reduction unit may include a presence-detect function which enables the defibrillator to modify analysis of ECG signals to account for differences heart rhythms of pediatric and adult patients. In a second embodiment, the energy reduction unit includes an energy control modifier circuit which affects the charging operations performed internal to the AED. Other than being attached to the defibrillation equipment, the energy reduction unit does not otherwise change how an operator uses the equipment.
摘要翻译：能量减少单元可拆卸地连接到外部除颤器，以减少除颤器向患者传递的除颤能量。能量减少装置的使用特别适用于使用自动或半自动外部除颤器（AED）除纤维化的儿科患者（8岁以下的婴儿和8岁以下的儿童）。在一个实施例中，能量减少单元包括部分耗散由AED产生的能量的衰减器。衰减器有利地被设计成向AED呈现阻抗，其在连接到患者时大致等于患者的阻抗。能量减少单元可以包括存在检测功能，其使除颤器能够修改ECG信号的分析，以解决儿科和成人患者的心律的差异。在第二实施例中，能量减少单元包括影响在AED内部执行的充电操作的能量控制修正器电路。除了附着到除颤设备之外，能量减少单元不会改变操作者如何使用设备。

10. 发明授权

US09898656B2 Systems and methods for identifying a contra-ictal condition in a subject 有权
公开(公告)号：US09898656B2
公开(公告)日：2018-02-20
申请号：US12020450
申请日：2008-01-25
申请人： David Snyder , Kent W. Leyde , John F. Harris
发明人： David Snyder , Kent W. Leyde , John F. Harris
IPC分类号： A61B5/04 , G06K9/00 , A61B5/0482 , A61B5/0476 , G06F19/00 , G06F19/24 , A61B5/00
CPC分类号： G06K9/00496 , A61B5/0006 , A61B5/0476 , A61B5/0482 , A61B5/4094 , G06F19/00 , G06F19/24 , G06F19/30 , G06F19/3418 , G16H40/67 , G16H50/20 , G16H50/70
摘要： The invention provides a method of monitoring a subject's neurological condition. In some embodiments, the method includes the steps of analyzing a physiological signal (such as an EEG) from a subject to determine if the subject is in a contra-ictal condition; and if the subject is in a contra-ictal condition, providing an indication (e.g., to the subject and/or to a caregiver) that the subject is in the contra-ictal condition, such as by activating a green light or other visible output. In some embodiments, if the subject is in a pro-ictal condition, the method includes the step of providing an indication (such as a red light) that the subject is in the pro-ictal condition. The invention also provides neurological system monitors.

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