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    • 23. 发明授权
    • Method for synthesis of diacetylenic compounds
    • 二乙炔化合物的合成方法
    • US4867917A
    • 1989-09-19
    • US946440
    • 1986-12-24
    • Joel M. SchnurAlok Singh
    • Joel M. SchnurAlok Singh
    • C07C51/347C07C51/353
    • C07C51/347C07C51/353C07C67/343
    • A method for synthesizing a diynoic acid having the formula CH.sub.3 (CH.sub.2).sub.n --C.tbd.C--C.tbd.C--(CH.sub.2).sub.m CO.sub.2 H comprising the steps of: selecting a one-halo alkyne from the group consisting of CH.sub.3 (CH.sub.2).sub.n C.tbd.CX, where X is a selected halogen; selecting an omega-alkynoic acid having the formula, HC.tbd.C(CH.sub.2).sub.m CO.sub.2 H; dissolving the alkynoic acid in an aqueous solution of base; adding a catalytic amount of cuprous halide dissolved in an aqueous solution of alkylamine to the aqueous solution of alkynoic acid; adding a reducing agent to the solution of alkynoic acid and cuprous halide; adding the one-halo alkyne to the solution; adding as much more of the reducing agent to the solution as is necessary to maintain the cuprous ion in the cuprous state; wherein m is selected from the group of 5, 6, 7, 8, 9, 10, and 11, and n is selected from the group of 7, 8, 9, 10, 11, 12, 13, 14, 15, and 16.
    • 该方法用于合成具有式CH 3(CH 2)n C 3 CF 3 CH 3 - (CH 2)m CO 2 H的二炔酸,该方法包括以下步骤:从由CH 3(CH 2)n C 3 CFON组成的组中选择一个卤代炔,其中X 是选择的卤素; 选择具有下式的ω-炔酸:HC 3BOND C(CH2)mCO2H; 将炔烃溶于碱的水溶液中; 将溶解在烷基胺水溶液中的催化量的卤化亚铜加入到炔酸的水溶液中; 向炔丙酸和卤化亚铜的溶液中加入还原剂; 向溶液中加入单卤代炔; 向维溶液中添加更多的还原剂,以保持亚铜离子在亚铜状态; 其中m选自5,6,7,8,9,10和11组,n选自7,8,9,10,11,12,13,14,15和 16。