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21. 发明授权

US07678368B2 Fucoidan-containing cosmetics 失效
标题翻译：含岩藻依聚糖的化妆品
公开(公告)号：US07678368B2
公开(公告)日：2010-03-16
申请号：US11311341
申请日：2005-12-20
申请人： Shigetoshi Mizutani , Suzu Deguchi , Eiji Kobayashi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
发明人： Shigetoshi Mizutani , Suzu Deguchi , Eiji Kobayashi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K8/73 , A61P17/14
CPC分类号： A61Q19/10 , A61K8/60 , A61K8/73 , A61K8/9706 , A61K31/04 , A61K31/08 , A61K31/13 , A61K31/70 , A61K33/20 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q19/00 , A61Q19/005 , A61Q19/007 , A61Q19/08 , Y10S514/88
摘要： To find a substance which has a skin cosmeticizing effect such as prevention of skin aging, amelioriation of sensitive skin, or antipruritic action, and can serve as an effective ingredient for a hair-care product, thereby providing cosmetics comprising the effective ingredient. Concretely, there are provided cosmetics characterized in that the cosmetics comprise as an effective ingredient a compound selected from a fucoidan, a degradation product thereof, a sulfated monosaccharide or a salt thereof.
摘要翻译：为了找到具有防止皮肤老化，敏感性皮肤的改善或止痒作用的皮肤美容效果的物质，可以作为护发品的有效成分，从而提供含有效成分的化妆品。具体地，提供了化妆品，其特征在于，所述化妆品包含选自岩藻依聚糖，其降解产物，硫酸化单糖或其盐的化合物作为有效成分。

22. 发明授权

US07604962B2 α-agarase and process for producing the same 失效
标题翻译： α-琼脂糖酶及其制备方法
公开(公告)号：US07604962B2
公开(公告)日：2009-10-20
申请号：US12027738
申请日：2008-02-07
申请人： Jun Tomono , Yoshiko Nomura , Hiroaki Sagawa , Takeshi Sakai , Ikunoshin Kato
发明人： Jun Tomono , Yoshiko Nomura , Hiroaki Sagawa , Takeshi Sakai , Ikunoshin Kato
IPC分类号： C12P19/44 , C12N9/24
CPC分类号： C12Y302/01158 , C12N9/2465 , C12P19/04 , C12P19/24
摘要： A polypeptide having an α-agarase activity, a gene encoding the polypeptide, a method for producing the polypeptide by genetic engineering and a method for producing an agarooligosaccharide using the polypeptide.
摘要翻译：具有α-琼脂糖酶活性的多肽，编码该多肽的基因，通过遗传工程生产该多肽的方法以及使用该多肽制备琼脂低聚糖的方法。

23. 发明申请

US20090076136A1 THERAPEUTIC AGENT 审中-公开
标题翻译：治疗剂
公开(公告)号：US20090076136A1
公开(公告)日：2009-03-19
申请号：US12263809
申请日：2008-11-03
申请人： Tatsuji ENOKI , Eiji Kobayashi , Kinuko Ogawa , Yoko Kudo , Masashige Tanabe , Hiromu Ohnogi , Hiroaki Sagawa , Ikunoshin Kato
发明人： Tatsuji ENOKI , Eiji Kobayashi , Kinuko Ogawa , Yoko Kudo , Masashige Tanabe , Hiromu Ohnogi , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K31/343 , A61K31/225 , A61K31/19 , A61K31/192 , A61K31/11 , A61P3/04 , A61P3/10
CPC分类号： A61K31/11 , A23K20/00 , A23L33/10
摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an insulin-mimetic action agent, a food, beverage, or feed, an agent for enhancement of glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, each comprising as an effective ingredient at least one compound selected from the group consisting of specified compounds having an insulin-mimetic action, derivatives thereof, and pharmacologically acceptable salts thereof.
摘要翻译：本发明涉及一种伴随胰岛素或胰岛素反应量异常的疾病的治疗剂或预防剂，胰岛素模拟作用剂，食物，饮料或饲料，用于增强葡萄糖摄入细胞和用于诱导分化成脂肪细胞的药剂，其各自包含至少一种选自具有胰岛素模拟作用的特定化合物，其衍生物和其药理学上可接受的盐的至少一种化合物作为有效成分。

24. 发明授权

US07498357B2 Chalcone compounds 失效
标题翻译：查耳酮化合物
公开(公告)号：US07498357B2
公开(公告)日：2009-03-03
申请号：US10581034
申请日：2004-12-01
申请人： Hiromu Ohnogi , Katsumi Sugiyama , Tatsuji Enoki , Eiji Kobayashi , Hiroaki Sagawa , Ikunoshin Kato
发明人： Hiromu Ohnogi , Katsumi Sugiyama , Tatsuji Enoki , Eiji Kobayashi , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K31/343 , C07D307/80
CPC分类号： C07D493/08 , A23K20/121 , A23L33/10 , C07C49/835 , C07C49/84 , C07C409/08 , C07D307/80
摘要： The present invention provides a novel chalcone compound, its derivative or a salt thereof, each having a suppressive action of NO production or an inhibitory action of aldose reductase. In addition, the present invention provides a medicament, a food, a beverage or a feed having a therapeutic or prophylactic effect for a disease showing sensitivity to the compound, by utilizing the physiological actions of the compound.
摘要翻译：本发明提供了具有NO产生抑制作用或醛糖还原酶抑制作用的新型查耳酮化合物及其衍生物或其盐。此外，本发明通过利用化合物的生理作用，提供对化合物显示敏感性的疾病具有治疗或预防作用的药物，食品，饮料或饲料。

25. 发明申请

US20080206811A1 Process For Producing Polypeptide 审中-公开
标题翻译：生产多肽的方法
公开(公告)号：US20080206811A1
公开(公告)日：2008-08-28
申请号：US11597318
申请日：2005-08-19
申请人： Toshihiro Shodai , Hiroshi Kobori , Takehiro Sagara , Hiroshi Endo , Hikaru Takakura , Jun Tomono , Hiroaki Sagawa , Hiroyuki Mukai , Ikunoshin Kato
发明人： Toshihiro Shodai , Hiroshi Kobori , Takehiro Sagara , Hiroshi Endo , Hikaru Takakura , Jun Tomono , Hiroaki Sagawa , Hiroyuki Mukai , Ikunoshin Kato
IPC分类号： C12P21/04 , C12N15/00
CPC分类号： C12N15/70 , C12N9/1276 , C12N9/22 , C12P21/02
摘要： A process for producing a target protein at low temperature, comprising inducing expression of not only a vector having introduced therein a gene coding for the target protein but also a vector having a chaperone gene introduced therein.
摘要翻译：一种在低温下生产靶蛋白的方法，包括不仅引入其中引入了编码靶蛋白的基因的载体，还诱导其中引入伴侣伴侣基因的载体。

26. 发明申请

US20070092587A1 Extract from plant of japanese parsley family and process for producing the same 审中-公开
标题翻译：从日本欧芹系列植物提取物及其生产方法
公开(公告)号：US20070092587A1
公开(公告)日：2007-04-26
申请号：US10561431
申请日：2004-06-18
申请人： Hiromu Ohnogi , Katsumi Sugiyama , Nobuko Muraki , Tatsuji Enoki , Hiroaki Sagawa , Ikunoshin Kato
发明人： Hiromu Ohnogi , Katsumi Sugiyama , Nobuko Muraki , Tatsuji Enoki , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K36/232
CPC分类号： A61K36/232 , A23L2/02 , A23V2002/00 , A23V2250/21 , A23V2200/328
摘要： The present invention provides an extract obtainable by extracting a plant belonging to Umbelliferae, or a processed product thereof, with a water-containing alcohol; a process for preparing the extract; a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response and/or diabetic complications, characterized in that the therapeutic agent or prophylactic agent comprises as an effective ingredient the extract as defined above; an agent for an insulin-mimetic action, characterized in that the agent comprises as an effective ingredient the extract as defined above; a food, beverage or feed, comprising the extract as defined above; an agent for enhancing glucose uptake into a cell, characterized in that the agent comprises as an effective ingredient the extract as defined above; to an agent for inducing differentiation into an adipocyte, characterized in that the agent comprises as an effective ingredient the extract as defined above; and an inhibitory agent for aldose reductase, characterized in that the agent comprises as an effective ingredient the extract as define above.
摘要翻译：本发明提供通过用含水醇提取属于伞形赤霉属的植物或其加工产物而获得的提取物; 一种制备提取物的方法; 用于伴随胰岛素或胰岛素反应量和/或糖尿病并发症的异常的疾病的治疗剂或预防剂，其特征在于所述治疗剂或预防剂包含作为有效成分的上述提取物; 用于胰岛素模拟作用的药剂，其特征在于所述药剂包含如上所定义的提取物作为有效成分; 包含上述提取物的食品，饮料或饲料; 用于增强葡萄糖摄入细胞的药剂，其特征在于所述药剂包含如上所定义的提取物作为有效成分; 涉及诱导分化为脂肪细胞的药剂，其特征在于所述药剂包含如上所定义的提取物作为有效成分; 以及醛糖还原酶抑制剂，其特征在于，所述药剂含有作为有效成分的上述定义的提取物。

27. 发明申请

US20060216362A1 Remedy 审中-公开
标题翻译：补救
公开(公告)号：US20060216362A1
公开(公告)日：2006-09-28
申请号：US10557184
申请日：2004-05-14
申请人： Tatsuji Enoki , Kinuko Ogawa , Hiromu Ohnogi , Nobuko Muraki , Yoko Kudo , Hiroaki Sagawa , Ikunoshin Kato
发明人： Tatsuji Enoki , Kinuko Ogawa , Hiromu Ohnogi , Nobuko Muraki , Yoko Kudo , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K36/9066 , A61K36/886 , A61K36/282 , A61K36/28 , A61K36/704 , A61K36/185
CPC分类号： A61K36/896 , A23K20/10 , A23L33/105 , A61K36/185 , A61K36/28 , A61K36/282 , A61K36/287 , A61K36/70 , A61K36/704 , A61K36/886 , A61K36/906 , A61K36/9066
摘要： The present invention relates to a therapeutic agent and prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for an insulin-mimetic action, a food, beverage and feed for treating a preventing a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for enhancing glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, characterized in that each comprises as an effective ingredient a processed product derived from at least one plant selected from the group consisting of (a) a plant belonging to Tiliaceae, (b) a plant belonging to Zingiberaceae, (c) a plant belonging to Compositae, (d) a plant belonging to Liliaceae, and (e) a plant belonging to Polygonaceae.
摘要翻译：本发明涉及一种伴随胰岛素或胰岛素反应量异常的疾病的治疗剂和预防剂，用于胰岛素模拟作用的药物，用于治疗预防伴随异常的疾病的食品，饮料和饲料一定量的胰岛素或胰岛素反应，用于增强葡萄糖摄入细胞的药剂和用于诱导分化成脂肪细胞的药剂，其特征在于每种药物包含作为有效成分的来自至少一种选自以下的植物的加工产品：（a）属于尖嘴科的植物，（b）属于姜科的植物，（c）属于菊科的植物，（d）属于百合科的植物，和（e）属于Poly科的植物。

28. 发明授权

US06911432B2 Drugs, foods or drinks with the use of algae-derived physiologically active substances 失效
标题翻译：使用藻类来源的生理活性物质的药物，食品或饮料
公开(公告)号：US06911432B2
公开(公告)日：2005-06-28
申请号：US10228195
申请日：2002-08-27
申请人： Tatsuji Enoki , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Takeshi Sakai , Fu-Gong Yu , Katsushige Ikai , Ikunoshin Kato
发明人： Tatsuji Enoki , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Takeshi Sakai , Fu-Gong Yu , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A23L1/30 , A23L3/3472 , A23L3/3544 , A23L3/3562 , A61K31/341 , C07G99/00 , A01N43/04
CPC分类号： A01N43/04 , A23L3/3472 , A23L3/3544 , A23L3/3562 , A23L33/105 , A61K31/341 , A61K31/7048
摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose are represented by formula (I): These compositions include foods, drinks, cosmetics, etc. containing as the active ingredient at least one such compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. These compounds show an apoptosis-inducing activity, carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes them useful also as the active ingredient of antioxidants and preservatives.
摘要翻译：用于治疗，改善或预防对3,6-脱水吡喃半乳糖敏感的疾病的药物组合物由式（I）表示：这些组合物包括含有至少一种这样的化合物，其醛，其水合物和2-O-甲基化衍生物和含有上述化合物的可溶性糖化合物。这些化合物对活性氧，脂质过氧化物自由基和NO的生成表现出细胞凋亡诱导活性，制癌活性和抑制活性，这使得它们也可用作抗氧化剂和防腐剂的活性成分。

29. 发明申请

US20050124575A1 Remedies 审中-公开
标题翻译：补救措施
公开(公告)号：US20050124575A1
公开(公告)日：2005-06-09
申请号：US10507937
申请日：2003-04-14
申请人： Eiji Nishiyama , Nobuko Muraki , Hiromu Ohnogi , Hiroaki Sagawa , Ikunoshin Kato
发明人： Eiji Nishiyama , Nobuko Muraki , Hiromu Ohnogi , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A23K1/16 , A23L1/0532 , A23L1/30 , A61K31/715 , A61K31/729 , A61P29/00 , C08B37/00 , A23G3/00 , A61K47/00
CPC分类号： C08B37/0039 , A23K20/163 , A23L29/256 , A23L33/10 , A23V2002/00 , A61K31/715 , A61K31/729 , A23V2250/5024 , A23V2250/1578 , A23V2250/5108 , A23V2250/616 , A23V2250/5118
摘要： Remedies or preventives, which are characterized by containing as the active ingredient at least one member selected from the group consisting of agar, agarose, high-molecular weight digestion products originating in agar and high-molecular weight digestion products originating in agarose, for diseases sensitive to the above active ingredients.
摘要翻译：其特征在于含有选自琼脂，琼脂糖，源自琼脂的高分子量消化产物和起源于琼脂糖的高分子量消化产物中的至少一种成分为活性成分，用于疾病敏感性的补救剂或预防剂以上活性成分。

30. 发明申请

US20050119191A1 Drugs, foods or drinks with the use of algae-derived physiologically active substances 失效
标题翻译：使用藻类来源的生理活性物质的药物，食品或饮料
公开(公告)号：US20050119191A1
公开(公告)日：2005-06-02
申请号：US11034243
申请日：2005-01-13
申请人： Tatsui Enoki , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Takeshi Sakai , Fu-Gong Yu , Katsushige Ikai , Ikunoshin Kato
发明人： Tatsui Enoki , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Takeshi Sakai , Fu-Gong Yu , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A23L1/30 , A23L3/3472 , A23L3/3544 , A23L3/3562 , A61K31/341 , C07G99/00 , A61K31/70 , A61K31/335
CPC分类号： A01N43/04 , A23L3/3472 , A23L3/3544 , A23L3/3562 , A23L33/105 , A61K31/341 , A61K31/7048
摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.
摘要翻译：用于治疗，改善或预防对由式（1）表示的3,6-脱水吡喃半乳糖敏感的疾病的药物组合物：含有作为活性成分的至少一种选自上述组分的组分的食品，饮料，化妆品等，所述化合物，其醛，其水合物和2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。该化合物还显示例如细胞凋亡诱导活性，制癌活性和对活性氧，脂质过氧化物自由基和NO的产生的抑制活性，这使得它也可用作抗氧化剂和防腐剂的活性成分。

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