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1. 发明授权

US07498357B2 Chalcone compounds 失效
标题翻译：查耳酮化合物
公开(公告)号：US07498357B2
公开(公告)日：2009-03-03
申请号：US10581034
申请日：2004-12-01
申请人： Hiromu Ohnogi , Katsumi Sugiyama , Tatsuji Enoki , Eiji Kobayashi , Hiroaki Sagawa , Ikunoshin Kato
发明人： Hiromu Ohnogi , Katsumi Sugiyama , Tatsuji Enoki , Eiji Kobayashi , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K31/343 , C07D307/80
CPC分类号： C07D493/08 , A23K20/121 , A23L33/10 , C07C49/835 , C07C49/84 , C07C409/08 , C07D307/80
摘要： The present invention provides a novel chalcone compound, its derivative or a salt thereof, each having a suppressive action of NO production or an inhibitory action of aldose reductase. In addition, the present invention provides a medicament, a food, a beverage or a feed having a therapeutic or prophylactic effect for a disease showing sensitivity to the compound, by utilizing the physiological actions of the compound.
摘要翻译：本发明提供了具有NO产生抑制作用或醛糖还原酶抑制作用的新型查耳酮化合物及其衍生物或其盐。此外，本发明通过利用化合物的生理作用，提供对化合物显示敏感性的疾病具有治疗或预防作用的药物，食品，饮料或饲料。

2. 发明申请

US20090053383A1 ANGELICA KEISKEI TEA 审中-公开
公开(公告)号：US20090053383A1
公开(公告)日：2009-02-26
申请号：US12176088
申请日：2008-07-18
申请人： Hiroshi ENDO , Yasushi Hattori , Hitoshi Sakakibara , Katsumi Sugiyama , Yuko Asai , Satoko Motomura , Ikunoshin Kato
发明人： Hiroshi ENDO , Yasushi Hattori , Hitoshi Sakakibara , Katsumi Sugiyama , Yuko Asai , Satoko Motomura , Ikunoshin Kato
IPC分类号： A23F3/06 , A23F3/22
CPC分类号： A23F3/34
摘要： According to the present invention, there are provided kneading-free Angelica keiskei tea leaves obtainable by a treatment comprising a step for roast-heating a dried material of Angelica keiskei; an Angelica keiskei tea beverage produced by using the kneading-free Angelica keiskei tea leaves; and a process for producing thereof. The Angelica keiskei tea leaves are preferably heated at a heating temperature of 100° C. to 150° C. in the roast-heating treatment, and the dried material of Angelica keiskei to be subjected to the roast-heating is preferably obtained by drying in a dried system after blanching and has a moisture content of 20% or less. Further, according to the present invention, there is also provided an Angelica keiskei chalcone function-formulated beverage comprising formulated Angelica keiskei chalcones that are components specific to Angelica keiskei.
摘要翻译：根据本发明，提供了通过包括用于对当归keiskei的干燥材料进行烘烤的步骤的处理而获得的无捏合当归keiskei茶叶; 通过使用揉捏的当归keiskei茶叶生产的当归keiskei茶饮料; 及其制造方法。本发明的茶叶优选在烘烤加热处理中在100℃〜150℃的加热温度下进行加热，优选通过将烘烤后的干燥物干燥，漂白后的干燥体系，水分含量为20％以下。此外，根据本发明，还提供了包含作为当归keiskei特异性成分的配方的当归keiskei chalcones的当归keiskei查耳酮功能配方饮料。

3. 发明申请

US20070092587A1 Extract from plant of japanese parsley family and process for producing the same 审中-公开
标题翻译：从日本欧芹系列植物提取物及其生产方法
公开(公告)号：US20070092587A1
公开(公告)日：2007-04-26
申请号：US10561431
申请日：2004-06-18
申请人： Hiromu Ohnogi , Katsumi Sugiyama , Nobuko Muraki , Tatsuji Enoki , Hiroaki Sagawa , Ikunoshin Kato
发明人： Hiromu Ohnogi , Katsumi Sugiyama , Nobuko Muraki , Tatsuji Enoki , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K36/232
CPC分类号： A61K36/232 , A23L2/02 , A23V2002/00 , A23V2250/21 , A23V2200/328
摘要： The present invention provides an extract obtainable by extracting a plant belonging to Umbelliferae, or a processed product thereof, with a water-containing alcohol; a process for preparing the extract; a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response and/or diabetic complications, characterized in that the therapeutic agent or prophylactic agent comprises as an effective ingredient the extract as defined above; an agent for an insulin-mimetic action, characterized in that the agent comprises as an effective ingredient the extract as defined above; a food, beverage or feed, comprising the extract as defined above; an agent for enhancing glucose uptake into a cell, characterized in that the agent comprises as an effective ingredient the extract as defined above; to an agent for inducing differentiation into an adipocyte, characterized in that the agent comprises as an effective ingredient the extract as defined above; and an inhibitory agent for aldose reductase, characterized in that the agent comprises as an effective ingredient the extract as define above.
摘要翻译：本发明提供通过用含水醇提取属于伞形赤霉属的植物或其加工产物而获得的提取物; 一种制备提取物的方法; 用于伴随胰岛素或胰岛素反应量和/或糖尿病并发症的异常的疾病的治疗剂或预防剂，其特征在于所述治疗剂或预防剂包含作为有效成分的上述提取物; 用于胰岛素模拟作用的药剂，其特征在于所述药剂包含如上所定义的提取物作为有效成分; 包含上述提取物的食品，饮料或饲料; 用于增强葡萄糖摄入细胞的药剂，其特征在于所述药剂包含如上所定义的提取物作为有效成分; 涉及诱导分化为脂肪细胞的药剂，其特征在于所述药剂包含如上所定义的提取物作为有效成分; 以及醛糖还原酶抑制剂，其特征在于，所述药剂含有作为有效成分的上述定义的提取物。

4. 发明授权

US06871936B2 Recovering apparatus for recovering a status of an ink jet recording head 失效
标题翻译：用于恢复喷墨记录头的状态的恢复装置
公开(公告)号：US06871936B2
公开(公告)日：2005-03-29
申请号：US10414071
申请日：2003-04-14
申请人： Hitoshi Fujimoto , Katsumi Sugiyama , Masataka Naito , Masatoshi Ikkatai , Tsutomu Harada , Tatsuya Fukushima , Takefumi Tamura , Tsuyoshi Mikoshiba
发明人： Hitoshi Fujimoto , Katsumi Sugiyama , Masataka Naito , Masatoshi Ikkatai , Tsutomu Harada , Tatsuya Fukushima , Takefumi Tamura , Tsuyoshi Mikoshiba
IPC分类号： B41J2/165 , B41J2/17 , B41J2/175 , B41J3/407 , B41J11/48 , B41J15/04 , B41J29/377
CPC分类号： B41J15/048 , B41J2/16547 , B41J2/16588 , B41J2/1707 , B41J2/175 , B41J3/4075 , B41J11/48 , B41J29/377
摘要： In a recovering apparatus for recovering ink ejecting ports forming a plane of an ink jet head, an ink absorbing member is disposed inward of a cap and proximate to the ink ejecting ports, facing the ink ejecting ports at a predetermined distance therefrom. Large ink droplets or water droplets adhering to the ink ejecting ports are then absorbed in the absorbing member. Thereafter, the plane of the ink jet heads with the ink ejecting ports is cleanly wiped by a wiping member, thereby preventing scattering of ink droplets or water droplets away from the ink ejecting ports. A trough is located adjacent to each head, and the recovering apparatus is disposed with respect to the trough so that a distance between the recovering apparatus and the ink jet head can be reduced, thereby permitting a compact arrangement of the recovering apparatus and the ink jet head.
摘要翻译：在用于回收形成喷墨头的平面的油墨喷射口的回收装置中，吸墨件设置在盖的内侧并靠近喷墨口，与喷墨口相对的预定距离处。附着在喷墨口上的大墨滴或水滴然后被吸收到吸收件中。此后，通过擦拭部件清洁地喷墨头与喷墨口的平面，从而防止墨滴或水滴从喷墨口散开。槽位于每个头部附近，并且回收装置相对于槽布置，使得可以减小回收装置和喷墨头之间的距离，从而允许恢复装置和喷墨头的紧凑布置头。

5. 发明授权

US6126343A Printing medium feeding apparatus using a specialized conveyor belt to control the printing medium tensioning 失效
标题翻译：印刷介质给料装置使用专用的输送带来控制打印介质张紧
公开(公告)号：US6126343A
公开(公告)日：2000-10-03
申请号：US886556
申请日：1997-07-01
申请人： Katsumi Sugiyama , Yoshihiko Kitahara , Masataka Naito , Masatoshi Ikkatai , Tsutomu Harada , Tatsuya Fukushima , Hitoshi Fujimoto , Tsuyoshi Mikoshiba , Takefumi Tamura
发明人： Katsumi Sugiyama , Yoshihiko Kitahara , Masataka Naito , Masatoshi Ikkatai , Tsutomu Harada , Tatsuya Fukushima , Hitoshi Fujimoto , Tsuyoshi Mikoshiba , Takefumi Tamura
IPC分类号： B41J15/04 , B41J2/165 , B41J3/407 , B41J11/48 , B65C9/18 , B65H16/10 , B65H19/10 , B65H29/51
CPC分类号： B41J15/048 , B41J11/48 , B41J3/4075 , B65C9/18 , B65H16/10 , B65H16/106 , B41J2/16585 , B41J2202/08
摘要： A printing medium feeding apparatus comprises a conveying belt, on which a roll-shaped printing medium is placed with the lower surface of the roll being in contact therewith to unwind the outer periphery of the roll. With the arrangement, setup of the roll to the feeding apparatus is completed easily by only placing the roll onto the conveying belt, as compared with a construction in which the center of a roll is rotatably supported. It is also possible to omit or simplify a transmission mechanism such as a train of reduction gears that is necessary for the case of central driving. Further, it is also possible to feed a constant amount of length at a constant drive speed irrespective of radius of the roll.
摘要翻译：一种打印介质输送装置，包括输送带，辊子下表面与滚筒的下表面一起放置辊状打印介质以使卷筒的外周展开。与通过将辊的中心可旋转地支撑的结构相比，通过仅将辊放置在输送带上，可以容易地完成向送料装置的辊的设置。也可以省略或简化对于中央驾驶的情况所必需的减速齿轮系的传动机构。此外，也可以以恒定的驱动速度进给恒定量的长度，而与辊的半径无关。

6. 发明授权

US4994605A Method of separating alpha-L-aspartyl-L-phenylalanine methyl ester through crystallization 失效
标题翻译：通过结晶分离α-L-天冬氨酰-L-苯丙氨酸甲酯的方法
公开(公告)号：US4994605A
公开(公告)日：1991-02-19
申请号：US342894
申请日：1989-04-25
申请人： Shinichi Kishimoto , Katsumi Sugiyama
发明人： Shinichi Kishimoto , Katsumi Sugiyama
IPC分类号： C07C231/00 , C07K1/14 , C07K5/072 , C07K5/075
CPC分类号： C07K5/0613
摘要： A method for crystallizing alpha-L-aspartyl-L-phenylalanine methyl ester (APM) is disclosed. The APM is crystallized from a C.sub.1 -C.sub.3 -alcohol/water solution (30-80:70-20 (v/v)). The ester crystallized by (i) concentrating the solution, (ii) cooling the solution, (iii) adjusting the water:alcohol ratio, or (iv) a combination thereof.
摘要翻译：公开了一种结晶α-L-天冬氨酰-L-苯丙氨酸甲酯（APM）的方法。 APM从C1-C3-醇/水溶液（30-80:70-20（v / v））中结晶。所述酯通过（i）浓缩溶液，（ii）冷却溶液，（iii）调节水：醇比例，或（iv）其组合来结晶。

7. 发明授权

US4824994A Method for production of N-protected-alpha-L-aspartyl-L-phenylalanine methyl ester 失效
标题翻译： N-保护-α-L-天冬氨酰基-L-苯丙氨酸甲酯的制备方法
公开(公告)号：US4824994A
公开(公告)日：1989-04-25
申请号：US650498
申请日：1984-09-14
申请人： Satoji Takahashi , Katsumi Sugiyama
发明人： Satoji Takahashi , Katsumi Sugiyama
IPC分类号： C07K1/02 , C07K5/075 , C07C101/02
CPC分类号： C07K5/0613
摘要： A method for the production of N-carbobenzoxy-.alpha.-L-aspartyl-L-phenylalanine methyl ester characterized by the reaction of L-phenylalanine methyl ester with fine N-carbobenzoxy-L-aspartic anhydride crystals, is disclosed.
摘要翻译：公开了生产N-苄氧羰基-α-天冬氨酰基-L-苯丙氨酸甲酯的方法，其特征在于L-苯丙氨酸甲酯与N-苄氧羰基-L-天冬氨酸精氨酸晶体的精细反应。

8. 发明授权

US4737503A Method for inhibiting the release of histamine 失效
标题翻译：抑制组胺释放的方法
公开(公告)号：US4737503A
公开(公告)日：1988-04-12
申请号：US916552
申请日：1986-10-08
申请人： Seizaburo Sakamoto , Katsumi Sugiyama
发明人： Seizaburo Sakamoto , Katsumi Sugiyama
IPC分类号： A61K31/47 , A61K31/44
CPC分类号： A61K31/47
摘要： The present invention deals with the inhibition of histamine release from mammalian mast cells by contacting such cells with sanguinarine, a benzophenanthridine alkaloid.
摘要翻译：本发明涉及通过使这些细胞与血根碱（benzanguantine）生物碱接触而抑制哺乳动物肥大细胞中组胺的释放。

9. 发明授权

US4564471A Method for reductive elimination of protecting groups 失效
标题翻译：还原消除保护基团的方法
公开(公告)号：US4564471A
公开(公告)日：1986-01-14
申请号：US188107
申请日：1980-09-17
申请人： Katsumi Sugiyama , Hideo Takeda , Hiroko Sato , Yuji Nonaka , Kiyotaka Oyama , Masashige Kubo
发明人： Katsumi Sugiyama , Hideo Takeda , Hiroko Sato , Yuji Nonaka , Kiyotaka Oyama , Masashige Kubo
IPC分类号： C07B31/00 , C07B51/00 , C07C67/00 , C07C227/00 , C07C227/16 , C07C227/18 , C07C227/20 , C07C231/00 , C07K1/06 , C07K1/12 , C07K5/075 , C07C101/02
CPC分类号： C07K1/12 , C07K5/0613 , Y02P20/55
摘要： The invention provides a novel and efficient method for the elimination of protecting groups, e.g. benzyloxycarbonyl group, from a protected amino acid, peptide or derivative thereof having at least one functional group protected by a protecting group, e.g. a lower alkyl ester of N-benzyloxycarbonyl-.alpha.-L-aspartyl-L-phenylalanine by catalytic hydrogen reduction to produce free amino acid, peptide or derivative thereof. In contrast to the conventional procedures in which the reaction is carried out in a solvent dissolving both the starting compound and the product compound or a solvent dissolving the starting compound but not dissolving the product compound, the inventive method utilizes a binary two-phase reaction medium composed of water and an organic solvent not freely miscible with water such as toluene. The reaction takes place in the organic phase containing the starting compound dissolved and the catalyst dispersed therein whereas the reaction product which is water-soluble is smoothly and successively transferred into the aqueous phase so that advantages are obtained in the unexpectedly high yield of the product as well as in the easiness of handling the reaction mixture after completion of the reaction.
摘要翻译：本发明提供了一种用于消除保护基团的新型和有效的方法，例如，苄氧羰基，被保护的氨基酸，具有至少一个被保护基保护的官能团的肽或衍生物。 N-苄氧羰基-α-L-天冬氨酰基-L-苯丙氨酸的低级烷基酯通过催化氢还原反应产生游离氨基酸，肽或其衍生物。与在溶解起始化合物和产物化合物的溶剂或溶解起始化合物但不溶解产物化合物的溶剂中进行反应的常规方法相反，本发明的方法利用二元二相反应介质由水和不能与水如甲苯自由混溶的有机溶剂组成。反应发生在含有溶解的起始化合物和分散在其中的催化剂的有机相中，而水溶性的反应产物顺利地依次转移到水相中，从而获得了产品出乎意料的高产率的优点，以及在反应完成后容易处理反应混合物。

10. 发明授权

US5225587A Method of producing .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride 失效
标题翻译：生产α-L-天冬氨酰-L-苯丙氨酸甲酯盐酸盐的方法
公开(公告)号：US5225587A
公开(公告)日：1993-07-06
申请号：US864133
申请日：1992-04-06
申请人： Katsumi Sugiyama , Kiyo Adachi , Toshihide Yukawa
发明人： Katsumi Sugiyama , Kiyo Adachi , Toshihide Yukawa
IPC分类号： C07K5/072 , C07K5/075
CPC分类号： C07K5/0613
摘要： A method of purifying .alpha.-L-aspartyl-L-phenylalanine methyl ester as a hydrochloride salt thereof which comprises:i) contacting a mixture of .alpha.-L-aspartyl-L-phenylanaline methyl ester and .beta.-L-aspartyl-L-phenylalanine methyl ester with an aqueous medium containing (a) hydrogen chloride in an amount not more than ca. 2 mol., per liter of said aqueous medium, but not less than 1 mol., per mole of said of said mixture of .alpha.-L-aspartyl-L-phenylalanine methyl ester and .beta.-L-aspartyl-L-phenylalanine methyl ester, and (b) an inorganic chloride selected from the group consisting of NaCl, KCl, NH.sub.4 Cl, CaCl.sub.2, and ZnCl.sub.2 in an amount of at least ca. 50 g., per liter of said aqueous medium, to form crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride, andii) recovering the .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride crystals therefrom.
摘要翻译：纯化α-L-天冬氨酰基-L-苯丙氨酸甲酯盐酸盐的方法，其包括：i）使α-L-天冬氨酰基-L-苯亚胺甲酯与β-L-天冬氨酰基-L-苯丙氨酸的混合物甲酯与含有（a）氯化氢的含水介质的量不大于约每摩尔所述所述α-L-天冬氨酰基-L-苯丙氨酸甲酯和β-L-天冬氨酰-L-苯丙氨酸甲酯的混合物每升所述水性介质2摩尔，但不小于1摩尔，和（b）选自NaCl，KCl，NH 4 Cl，CaCl 2和ZnCl 2的无机氯化物，其量至少约为。 50升，每升所述水性介质中，形成α-L-天冬氨酰基-L-苯丙氨酸甲酯盐酸盐的晶体，和ii）从其中回收α-L-天冬氨酰基-L-苯丙氨酸甲酯盐酸盐晶体。

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