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21. 发明申请

US20050163659A1 Kit for assay development and serial analysis 审中-公开
标题翻译：用于测定开发和连续分析的试剂盒
公开(公告)号：US20050163659A1
公开(公告)日：2005-07-28
申请号：US10514166
申请日：2003-05-06
申请人： Gert Duveneck , Peter Oroszlan , Michael Pawlak
发明人： Gert Duveneck , Peter Oroszlan , Michael Pawlak
IPC分类号： G01N33/543 , G01N21/00
CPC分类号： G01N33/54353 , G01N33/54366
摘要： The invention relates to a kit for assay development and for carrying out a plurality of analyses, comprising a carrier substrate and a placement body jointly forming an arrangement of a plurality of sample compartments comprising said carrier substrate as a base plate, in addition to a plurality of immobilized binding partners for the detection of one or more analytes in one or more samples in a bioaffinity assay, said binding partners being arranged and immobilized on the carrier substrate inside the sample containers always in two-dimensional arrays of discrete measuring areas, wherein always at least one measuring area of an array or a partial surface inside an array or sample compartment, respectively, is provided on the carrier substrate for referencing purposes, and the surface density of the immobilized binding partners, in relation to the surface of the measurement areas, is less than the surface density of a full, i.e. extensive, monolayer of said binding partners. The composition of the inventive kit is such that, surprisingly, it enables a full series of measurements to be carried out on an individual carrier substrate. The invention also relates to an analytical system wherein the inventive kit is used, and to analytical detection methods based thereon and the use thereof.
摘要翻译：本发明涉及用于测定开发和用于进行多个分析的试剂盒，其包括载体基底和放置体，该载体基底和放置体除了多个之外，共同形成包括所述载体基底作为基板的多个样品室的布置用于在生物亲和力测定中检测一个或多个样品中的一种或多种分析物的固定化结合配偶体，所述结合伙伴被布置和固定在样品容器内的载体基质上，总是在离散测量区域的二维阵列中，其中总是为了参考目的，在载体基底上分别提供阵列或样品室内的阵列或部分表面的至少一个测量区域，并且固定的结合物的表面密度相对于测量区域的表面小于所述结合配偶体的完整的，即广泛的单层的表面密度。本发明的试剂盒的组成使得令人惊奇的是，它使得能够在单个载体基底上进行全系列的测量。本发明还涉及其中使用本发明的试剂盒的分析系统，以及基于其的分析检测方法及其用途。

22. 发明申请

US20050019836A1 Bioanalytical reagent, method for production thereof, sensor platforms and detection methods based on use of said bioanalytical reagent 审中-公开
标题翻译：生物分析试剂，其生产方法，传感器平台和基于所述生物分析试剂的检测方法
公开(公告)号：US20050019836A1
公开(公告)日：2005-01-27
申请号：US10433823
申请日：2001-12-04
申请人： Horst Vogel , Horst Pick , Axel Preuss , Ana-Paula Tairi , Evelyne Schmid Osborne , Michael Pawlak
发明人： Horst Vogel , Horst Pick , Axel Preuss , Ana-Paula Tairi , Evelyne Schmid Osborne , Michael Pawlak
IPC分类号： G01N33/554 , G01N33/53 , C07K14/705 , C07K16/28 , G01N33/567
CPC分类号： G01N33/554
摘要： The invention relates to various embodiments of a bioanalytical reagent with at least one vesicle, generated from a living cell, comprising at least one receptor, characterized in that a mechanism of signal transduction triggered by said receptor in the cell used for vesicle generation is preserved in said vesicle, as a component of the bioanalytical reagent. The invention further relates to methods for production of the bioanalytical reagent according to the invention, to bioanalytical detection methods based on the application of said reagent, and to the use of said detection method and of the bioanalytical reagent.
摘要翻译：本发明涉及生物分析试剂的各种实施方案，其具有由活细胞产生的至少一种囊泡，其包含至少一种受体，其特征在于，用于产生囊泡的细胞中由所述受体触发的信号转导机制被保留在所述囊泡作为生物分析试剂的组分。本发明还涉及根据本发明的生物分析试剂的生产方法，基于所述试剂的应用的生物分析检测方法，以及所述检测方法和生物分析试剂的使用。

23. 发明授权

US06710870B1 Method and device for measuring luminescence 有权
标题翻译：用于测量发光的方法和装置
公开(公告)号：US06710870B1
公开(公告)日：2004-03-23
申请号：US09601484
申请日：2000-08-03
申请人： Gerd Marowsky , Dieter Neuschaefer , Michael Pawlak
发明人： Gerd Marowsky , Dieter Neuschaefer , Michael Pawlak
IPC分类号： G01J330
CPC分类号： G01N21/7703 , G01N21/6452 , G01N21/69 , G01N21/76
摘要： A method exites and determines a luminescence in an analyte sample which is located in contact with the waveguiding layer of an optical layer waveguide. The luminescence is generated by non-evanescent excitation in the volume of the analyte sample. Luminescence radiation generated in the immediate proximity of the surface of the waveguiding layer is conducted to a measuring device and determined after penetrating the waveguiding layer.
摘要翻译：一种方法显示和确定位于与光学层波导的波导层接触的分析物样品中的发光。通过在分析物样品的体积中的非消逝激发产生发光。在波导层的表面附近产生的发光辐射被传导到测量装置，并在穿透波导层之后确定。

24. 发明授权

US07517546B2 Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof 失效
公开(公告)号：US07517546B2
公开(公告)日：2009-04-14
申请号：US10363555
申请日：2001-08-31
申请人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
发明人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
IPC分类号： B05D3/00 , G02B6/00
CPC分类号： C23F11/1676 , A61B5/14546 , A61B5/415 , A61B17/68 , A61F2/30767 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00215 , A61F2310/00227 , A61F2310/00239 , A61F2310/00251 , A61F2310/00281 , A61F2310/00317 , A61F2310/00323 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00646 , A61F2310/00652 , A61F2310/00658 , A61F2310/00664 , A61F2310/00742 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/00778 , A61F2310/00784 , A61F2310/00874 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61F2310/00904 , A61F2310/0091 , A61F2310/00976 , A61L27/34 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C04B41/009 , C04B41/4994 , C04B41/84 , C04B2111/00836 , Y10T428/31678 , C04B35/01
摘要： The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A) Y—B—OPO3H2 (IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2 (IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more —CH2- groups. According to the invention, said precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, comprising the use of water-soluble salts of a compound of formula (IA) or (IB) for the treatment of these surfaces, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices in addition to new organophosphoric acids and organophosphonic acids themselves. The optionally substituted compounds of formulae (IA) and (IB) wherein the B and Y groups have the above-mentioned designations, i.e. optionally substituted alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetaryl, are hereinafter referred to as organophosphoric acids and organophosphonic acids.

25. 发明申请

US20090061506A1 Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof 失效
公开(公告)号：US20090061506A1
公开(公告)日：2009-03-05
申请号：US12230915
申请日：2008-09-08
申请人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schurmann-Mader , Markus Ehrat , Samuele Tosatti
发明人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schurmann-Mader , Markus Ehrat , Samuele Tosatti
IPC分类号： C12M1/34 , B05D1/18
CPC分类号： C23F11/1676 , A61B5/14546 , A61B5/415 , A61B17/68 , A61F2/30767 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00215 , A61F2310/00227 , A61F2310/00239 , A61F2310/00251 , A61F2310/00281 , A61F2310/00317 , A61F2310/00323 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00646 , A61F2310/00652 , A61F2310/00658 , A61F2310/00664 , A61F2310/00742 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/00778 , A61F2310/00784 , A61F2310/00874 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61F2310/00904 , A61F2310/0091 , A61F2310/00976 , A61L27/34 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C04B41/009 , C04B41/4994 , C04B41/84 , C04B2111/00836 , Y10T428/31678 , C04B35/01
摘要： The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A) Y—B—OPO3H2 (IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2 (IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more —CH2- groups. According to the invention, said precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, comprising the use of water-soluble salts of a compound of formula (IA) or (IB) for the treatment of these surfaces, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices in addition to new organophosphoric acids and organophosphonic acids themselves.The optionally substituted compounds of formulae (IA) and (IB) wherein the B and Y groups have the above-mentioned designations, i.e. optionally substituted alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetaryl, are hereinafter referred to as organophosphoric acids and organophosphonic acids.

26. 发明授权

US07879598B2 Multianalyte determination system and methods 失效
标题翻译：多分辨率测定系统及方法
公开(公告)号：US07879598B2
公开(公告)日：2011-02-01
申请号：US10363577
申请日：2001-08-30
申请人： Wolfgang Zesch , Martin Andreas Bopp , Michael Pawlak
发明人： Wolfgang Zesch , Martin Andreas Bopp , Michael Pawlak
IPC分类号： C12M1/34
CPC分类号： G01N21/6452 , G01N21/648 , G01N21/7703 , G01N2021/6419
摘要： The invention relates to embodiments of an optical system for luminescence determination, comprising two or more excitation light sources, a sensor platform and an optical component with several discrete facets for beam deflection towards the sensor platform. Further subjects of the invention are methods for luminescence determination with an optical system according to the invention and analytical systems, as well as the use of these methods for quantitative affinity sensing and for various other applications. The aim of the present invention is to provide optical and analytical measuring devices for highly sensitive detection of one or more analytes, using a multitude of measurement areas on a common carrier.
摘要翻译：本发明涉及用于发光确定的光学系统的实施例，其包括两个或更多个激发光源，传感器平台和具有用于朝向传感器平台的光束偏转的多个离散面的光学部件。本发明的其它主题是使用根据本发明的光学系统和分析系统进行发光测定的方法，以及这些方法用于定量亲和力感测和各种其它应用的方法。本发明的目的是提供使用在公共载体上的多个测量区域对一种或多种分析物进行高灵敏度检测的光学和分析测量装置。

27. 发明申请

US20100280601A1 Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof 有权
标题翻译：除了使用有机磷酸和有机膦酸的单层和多层及其盐的沉淀方法
公开(公告)号：US20100280601A1
公开(公告)日：2010-11-04
申请号：US12662932
申请日：2010-05-12
申请人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
发明人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
IPC分类号： A61L27/10 , A61L31/16 , A61L27/54 , A61L29/16 , B32B18/00 , B32B15/04 , B32B9/04 , C40B40/00 , A61C8/00 , A61F2/38 , A61F2/32 , A61F2/30 , A61F2/44 , A61N1/36 , A61L29/02 , A61M25/10 , A61L31/02
CPC分类号： C23F11/1676 , A61B5/14546 , A61B5/415 , A61B17/68 , A61F2/30767 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00215 , A61F2310/00227 , A61F2310/00239 , A61F2310/00251 , A61F2310/00281 , A61F2310/00317 , A61F2310/00323 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00646 , A61F2310/00652 , A61F2310/00658 , A61F2310/00664 , A61F2310/00742 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/00778 , A61F2310/00784 , A61F2310/00874 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61F2310/00904 , A61F2310/0091 , A61F2310/00976 , A61L27/34 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C04B41/009 , C04B41/4994 , C04B41/84 , C04B2111/00836 , Y10T428/31678 , C04B35/01
摘要： The invention relates to a method for precipitating mono or multiple layers of a mixture of organophosphoric acids of the general formula I (A) Y—B—OPO3H2 (IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2 (IB) and the salts thereof, wherein Y and B are defined in the specification. According to the invention, precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices.
摘要翻译：本发明涉及使通式I（A）Y-B-OPO 3 H 2（IA）的有机磷酸或通式I（B）Y-B-的有机膦酸的混合物的单层或多层沉淀的方法， PO 3 H 2（IB）及其盐，其中Y和B在说明书中定义。根据本发明，在金属和半导体的纯或混合氧化物，氮化物或碳化物的基材表面上，特别是作为传感器平台，植入物和医疗附件装置的表面，发生沉淀。本发明还涉及其作为涂覆的传感器平台，植入物和医疗附件装置的一部分的用途。

28. 发明授权

US07767131B2 Method for production of moulded bodies, in particular optical structures and use thereof 有权
标题翻译：成型体的制造方法，特别是光学结构及其用途
公开(公告)号：US07767131B2
公开(公告)日：2010-08-03
申请号：US10487998
申请日：2002-08-26
申请人： Tilo Callenbach , Max Gmür , Heinz Lüthi , Martin Andreas Bopp , Michael Pawlak , Markus Ehrat
发明人： Tilo Callenbach , Max Gmür , Heinz Lüthi , Martin Andreas Bopp , Michael Pawlak , Markus Ehrat
IPC分类号： B29C45/16
CPC分类号： G02B6/1221 , B29C33/38 , B29C33/424 , B29C45/0001 , B29C45/37 , B29C45/372 , B29C2045/7356 , B29D11/00009 , B29K2709/08 , G02B6/13 , G02B6/34 , G02B2006/12107 , Y10T428/12597 , Y10T428/315
摘要： The present invention relates to a method for manufacture a body from a thermoplastic plastic with a three-dimensionally structured surface, wherein molding is performed directly from a master made of glass coated with metal oxide, without deposition of further coatings on a surface of the master. The invention also relates to bodies manufactured with this method from a thermoplastic featuring a three-dimensionally structured surface, as well as to planar optical structures likewise manufactured with this method for generating evanescent-field measuring platforms and to a use thereof. The invention furthermore relates to a planar optical structure for generating an evanescent-field measuring platform, comprising a first essentially optical transparent, waveguiding layer (a) with refractive index n1 and a second essentially optical transparent layer (b) with refractive index n2, where n1>n2, in a case of an embodiment of a planar optical film waveguide, or comprising a metal layer (a′) and a second layer (b), in a case of an embodiment for generating a surface plasmon resonance, wherein the second layer (b) comprises a material from a group comprising cyclo-olefin polymers and cyclo-olefin copolymers.
摘要翻译：本发明涉及一种由具有三维结构表面的热塑性塑料制造主体的方法，其中模制由直接由金属氧化物涂覆的玻璃制成的母板进行，而不会在母板的表面上沉积更多的涂层。本发明还涉及由具有三维结构化表面的热塑性材料制成的主体以及同样利用这种用于产生ev逝场测量平台的方法制造的平面光学结构及其用途。本发明还涉及一种用于产生ev逝场测量平台的平面光学结构，包括具有折射率n1的第一基本上光学透明的波导层（a）和具有折射率n2的第二基本光学透明层（b），其中 n1> n2，在平面光学膜波导的实施例的情况下，或者在用于产生表面等离子体共振的实施例的情况下，包括金属层（a'）和第二层（b），其中第二层（b）包括来自包含环烯烃聚合物和环烯烃共聚物的组的材料。

29. 发明授权

US06961490B2 Waveguide plate and process for its production and microtitre plate 失效
标题翻译：波导板及其生产工艺及微量滴定板
公开(公告)号：US06961490B2
公开(公告)日：2005-11-01
申请号：US09916114
申请日：2001-07-27
申请人： Bernd Maisenhoelder , Johannes Edlinger , Claus Heine-Kempkens , Michael Pawlak , Gert Duveneck
发明人： Bernd Maisenhoelder , Johannes Edlinger , Claus Heine-Kempkens , Michael Pawlak , Gert Duveneck
IPC分类号： G01N21/55 , G01N21/77 , G02B6/12 , G02B6/124 , G02B6/34
CPC分类号： G01N21/7743 , G01N21/552 , G01N21/648 , G02B6/124 , G02B6/136 , G02B6/34 , G02B2006/12107 , G02B2006/12147
摘要： A waveguide plate and a process for making the waveguide plate with a plate-like glass substrate (1), carrying a waveguiding layer (2), with at least one coupling grating on the surface carrying said waveguiding layer (2), which coupling grating is formed as a grating of lines with a period between 150 nm and 1000 nm, the extension of said grating being at least 5 cm with lines parallel to one another, wherein the coupling angle () varies by not more than 0.1_/cm along a line of said grating and wherein the absolute value of the deviation of the coupling angle () on said waveguide plate, from a predefined desired value, does not exceed 0.5_. The deviation from the average value of the coupling angle does not exceed 0.3_, preferably not 0.15_ on the whole waveguide plate. The waveguide plate is suitable as part of a sensor platform and of an arrangement of sample compartments for chemo-and bioanalytical investigations in order to produce a coupling grating formed as a line grating with a grating period between 100 nm and 2500 nm
摘要翻译：波导板和用于制造具有板状玻璃基板（1）的波导板的工艺，其在承载所述波导层（2）的表面上具有带有至少一个耦合光栅的波导层（2），该耦合光栅形成为具有150nm至1000nm之间的周期的线的光栅，所述光栅的延伸至少5cm，线彼此平行，其中耦合角（）沿着所述光栅的直线比0.1_ / cm，并且其中耦合角度的偏差的绝对值（）在预定的期望值上不超过0.5_。在整个波导板上与耦合角的平均值的偏差不超过0.3_，最好不超过0.15_。波导板适合作为传感器平台的一部分和用于化学和生物分析研究的样品室的布置的一部分，以便产生形成为具有在100nm和2500nm之间的光栅周期的线光栅的耦合光栅

30. 发明授权

US08380020B2 Planar optical structure forming an evanescent field measuring platform that includes a layer molded by a master 失效
标题翻译：平面光学结构形成一个消逝场测量平台，其包括由主体模制的层
公开(公告)号：US08380020B2
公开(公告)日：2013-02-19
申请号：US12819598
申请日：2010-06-21
申请人： Tilo Callenbach , Max Gmür , Heinz Lüthi , Martin Andreas Bopp , Michael Pawlak , Markus Ehrat
发明人： Tilo Callenbach , Max Gmür , Heinz Lüthi , Martin Andreas Bopp , Michael Pawlak , Markus Ehrat
IPC分类号： G02B6/00 , G02B6/10 , G02B6/34
CPC分类号： G02B6/1221 , B29C33/38 , B29C33/424 , B29C45/0001 , B29C45/37 , B29C45/372 , B29C2045/7356 , B29D11/00009 , B29K2709/08 , G02B6/13 , G02B6/34 , G02B2006/12107 , Y10T428/12597 , Y10T428/315
摘要： The planar optical structure forms an evanescent-field measuring platform. A body is made from the thermoplastic plastic with a three-dimensionally structured surface, wherein molding is performed directly from a master made of glass coated with metal oxide, without deposition of further coatings on a surface of the master. The planar optical structure forming an evanescent-field measuring platform has a first essentially optically transparent, waveguiding layer (a) with a refractive index n1 and a second essentially optical transparent layer (b) with refractive index n2, where n1>n2, in a case of an embodiment of a planar optical film waveguide, or a metal layer (a′) and a second layer (b), in a case of an embodiment for generating a surface plasmon resonance, wherein the second layer (b) includes a material from a group of cyclo-olefin polymers and cyclo-olefin copolymers.
摘要翻译：平面光学结构形成消逝场测量平台。主体由具有三维结构化表面的热塑性塑料制成，其中模制由直接由金属氧化物涂覆的玻璃制成的主体进行，而不会在主体表面上沉积更多的涂层。形成ev逝场测量平台的平面光学结构具有第一基本上光学透明的波导层（a），折射率n1和第二基本光学透明层（b）具有折射率n2，其中n1> n2，在在用于产生表面等离子体共振的实施例的情况下，平面光学膜波导或金属层（a'）和第二层（b）的实施例的情况，其中第二层（b）包括材料来自一组环烯烃聚合物和环烯烃共聚物。

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