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1. 发明授权

US07879598B2 Multianalyte determination system and methods 失效
标题翻译：多分辨率测定系统及方法
公开(公告)号：US07879598B2
公开(公告)日：2011-02-01
申请号：US10363577
申请日：2001-08-30
申请人： Wolfgang Zesch , Martin Andreas Bopp , Michael Pawlak
发明人： Wolfgang Zesch , Martin Andreas Bopp , Michael Pawlak
IPC分类号： C12M1/34
CPC分类号： G01N21/6452 , G01N21/648 , G01N21/7703 , G01N2021/6419
摘要： The invention relates to embodiments of an optical system for luminescence determination, comprising two or more excitation light sources, a sensor platform and an optical component with several discrete facets for beam deflection towards the sensor platform. Further subjects of the invention are methods for luminescence determination with an optical system according to the invention and analytical systems, as well as the use of these methods for quantitative affinity sensing and for various other applications. The aim of the present invention is to provide optical and analytical measuring devices for highly sensitive detection of one or more analytes, using a multitude of measurement areas on a common carrier.
摘要翻译：本发明涉及用于发光确定的光学系统的实施例，其包括两个或更多个激发光源，传感器平台和具有用于朝向传感器平台的光束偏转的多个离散面的光学部件。本发明的其它主题是使用根据本发明的光学系统和分析系统进行发光测定的方法，以及这些方法用于定量亲和力感测和各种其它应用的方法。本发明的目的是提供使用在公共载体上的多个测量区域对一种或多种分析物进行高灵敏度检测的光学和分析测量装置。

2. 发明申请

US20100130370A1 FLOW CELL ARRAY AND THE UTILIZATION THEREOF FOR MULTIANALYTE DETERMINATION 有权
标题翻译：流量池阵列及其多用途测定的应用
公开(公告)号：US20100130370A1
公开(公告)日：2010-05-27
申请号：US12695553
申请日：2010-01-28
申请人： Eveline Schurmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Mtthias Kresbach , Michael Pawlak , Nania Graciela Scharer-Hernandez , Eginhard Schick
发明人： Eveline Schurmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Mtthias Kresbach , Michael Pawlak , Nania Graciela Scharer-Hernandez , Eginhard Schick
IPC分类号： C40B30/00 , C40B60/12
CPC分类号： B01L3/5025 , G01N21/05 , G01N21/253 , G01N2021/0346
摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.
摘要翻译：提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置对应于样品室的（几何）布置，与基板结合。该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。一个或多个样品室的布置包括基板和与基板组合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法制造及其使用。

3. 发明授权

US08053225B2 Flow cell array and the utilization thereof for multianalyte determination 有权
标题翻译：流量池阵列及其在多分辨率测定中的应用
公开(公告)号：US08053225B2
公开(公告)日：2011-11-08
申请号：US12695553
申请日：2010-01-28
申请人： Eveline Schürmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Schärer-Hernández , Eginhard Schick
发明人： Eveline Schürmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Schärer-Hernández , Eginhard Schick
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L3/5025 , G01N21/05 , G01N21/253 , G01N2021/0346
摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.
摘要翻译：提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置对应于样品室的（几何）布置，与基板结合。该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。一个或多个样本室的布置包括基板和与基板结合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法制造及其使用。

4. 发明授权

US07396675B2 Kit and method for determining a plurality of analytes 有权
标题翻译：用于确定多种分析物的试剂盒和方法
公开(公告)号：US07396675B2
公开(公告)日：2008-07-08
申请号：US10296851
申请日：2001-05-25
申请人： Michael Pawlak , Eginhard Schick , Andreas Peter Abel , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Eveline Schürmann-Mader , Martin Andreas Bopp
发明人： Michael Pawlak , Eginhard Schick , Andreas Peter Abel , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Eveline Schürmann-Mader , Martin Andreas Bopp
IPC分类号： G01N33/543 , G01N33/551
CPC分类号： G01N21/6452 , B01L3/5085 , G01N21/648 , G01N33/54373 , G01N2021/6441 , G01N2021/6482 , Y10S435/808 , Y10S435/975 , Y10S436/805 , Y10S436/808
摘要： The invention is related to different embodiments of a kit for the simultaneous qualitative and/or quantitative determination of a multitude of analytes comprising a sensor platform comprising an optical thin-film waveguide with a layer (a) transparent at least at an excitation wavelength on a layer (b) with lower refractive index than layer (a), also transparent at least at said excitation wavelength, and at least one grating structure (c) modulated in said layer (a), for the incoupling of said excitation light into layer (a), at least one array of biological or biochemical or synthetic recognition elements immobilized in discrete measurement areas (d) directly or by means of an adhesion-promoting layer on layer (a), for specific recognition and/or binding of said analytes and/or for specific interaction with said analytes, means for laterally resolved referencing of the excitation light intensity available in the measurement areas, and optionally means for the calibration of one or more luminescences generated in the near-field of layer (a) as a consequence of the binding of one or more analytes or of the specific interaction with one or more analytes, wherein a liquid sample to be analyzed for said analytes is brought into contact with said measurement areas on said sensor platform either directly or after mixture with further reagents. The invention is also related to analytical systems based on a kit according to the invention and to methods for the determination of one or more analytes, based on said kit, and to use thereof.
摘要翻译：本发明涉及用于同时定性和/或定量测定大量分析物的试剂盒的不同实施方案，其包括传感器平台，所述传感器平台包括具有至少在激发波长上透明的层（a）的光学薄膜波导至少在所述激发波长下透明的至少一个光栅结构（c），用于将所述激发光转换成层（a）的至少一个光栅结构（c） a），直接或通过层（a）上的粘附促进层固定在离散测量区域（d）中的生物或生化或合成识别元件的至少一个阵列，用于特异性识别和/或结合所述分析物和 /或用于与所述分析物的特异性相互作用，用于横向分辨参考测量区域中可用的激发光强度的装置，以及可选地用于校准一个或多个由于一种或多种分析物的结合或与一种或多种分析物的特异性相互作用的结合而在层（a）的近场产生的矿物发光，其中待分析的液体样品与所述分析物接触所述测量区域在所述传感器平台上直接或与其它试剂混合之后。本发明还涉及基于根据本发明的试剂盒的分析系统和基于所述试剂盒测定一种或多种分析物的方法及其用途。

5. 发明授权

US07678565B2 Flow cell array and the utilization thereof for multianalyte determination 失效
标题翻译：流量池阵列及其在多分辨率测定中的应用
公开(公告)号：US07678565B2
公开(公告)日：2010-03-16
申请号：US12071526
申请日：2008-02-21
申请人： Eveline Schürmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Schärer-Hernández , Eginhard Schick
发明人： Eveline Schürmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Schärer-Hernández , Eginhard Schick
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L3/5025 , G01N21/05 , G01N21/253 , G01N2021/0346
摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.
摘要翻译：提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置对应于样品室的（几何）布置，与基板结合。该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。一个或多个样本室的布置包括基板和与基板结合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法制造及其使用。

6. 发明申请

US20090224173A1 Grating waveguide structure for reinforcing an excitation field and use thereof 审中-公开
标题翻译：用于加强激励场的光栅波导结构及其用途
公开(公告)号：US20090224173A1
公开(公告)日：2009-09-10
申请号：US12318568
申请日：2008-12-31
申请人： Gert Ludwig Duveneck , Martin Andreas Bopp , Michael Pawlak , Markus Ehrat , Gerd Marowsky
发明人： Gert Ludwig Duveneck , Martin Andreas Bopp , Michael Pawlak , Markus Ehrat , Gerd Marowsky
IPC分类号： G01J1/58 , G02F1/01
CPC分类号： G01N21/648 , G01N21/6428 , G01N21/774 , G01N2021/6419 , G01N2021/7786 , G02B6/124
摘要： The invention relates to a variable embodiment of a grating waveguide structure, based on a planar thin-film waveguide with a first optically transparent layer (a) on a second optically transparent layer (b) having a lower refractive index than layer (a), and a grating structure (c) modulated in layer (a), wherein the intensity of an excitation light irradiated at the resonance angle for incoupling into layer (a) is enhanced by at least a factor of 100 on layer (a) and within layer (a), at least in the region of the grating structure (c), in comparison with the intensity of said excitation light on a substrate surface without incoupling of the excitation light. The invention also relates to an optical system with an excitation light source and an embodiment of a grating waveguide structure according to the invention, and to a method for enhancing an excitation light intensity, and to the use thereof in bioanalytical detection processes, in non-linear optics or in telecommunications or communications industry.
摘要翻译：本发明涉及一种基于具有比层（a）折射率低的第二光学透明层（b）上具有第一光学透明层（a）的平面薄膜波导的光栅波导结构的可变实施例，以及在层（a）中调制的光栅结构（c），其中以共耦合角度照射到层（a）中的激发光的强度在层（a）上至少增加100倍，并且在层（a），至少在光栅结构（c）的区域中，与衬底表面上的所述激发光的强度相比较，而不会激发激发光的耦合。本发明还涉及具有激发光源和根据本发明的光栅波导结构的实施例的光学系统，以及用于增强激发光强度的方法及其在生物分析检测过程中的用途，线性光学或电信或通信行业。

7. 发明申请

US20090054263A1 Grating waveguide structure for multi-analyte determinations and the use thereof 审中-公开
标题翻译：用于多分析物测定的光栅波导结构及其用途
公开(公告)号：US20090054263A1
公开(公告)日：2009-02-26
申请号：US12222212
申请日：2008-08-05
申请人： Michael Pawlak , Markus Ehrat , Gert Ludwig Duveneck , Martin Andreas Bopp
发明人： Michael Pawlak , Markus Ehrat , Gert Ludwig Duveneck , Martin Andreas Bopp
IPC分类号： C40B30/10 , C40B60/12
CPC分类号： G01N21/7743 , G01N33/54373
摘要： The invention relates to variable embodiments of a grating waveguide structure which enables to determine locally resolved changes of the resonance conditions for the incoupling of an excitation light into the waveguiding layer (a) of a stratified optical waveguide by means of a grating structure (c) modulated in said layer (a) or for outcoupling of a light guided in layer (a). The inventive system comprises arrays of measurement areas produced on the grating waveguide structure having different immobilized biological or biochemical or synthetic recognition elements for simultaneously binding and determining one or more analytes, wherein said excitation light is simultaneously irradiated onto an entire array of measurement areas, and the degree of satisfaction of the resonance condition for the incoupling of light into the layer (a) towards said measurement areas is simultaneously measured. The invention also relates to an optical system comprising at least one excitation light source and at least one locally resolving detector and, optionally, positioning elements for altering the angle of incidence of the excitation light onto the inventive grating waveguide structure. The invention additionally relates to a corresponding measuring method and to the use thereof. Surprisingly, it has been found that the inventive method is well-suited as an imaging detection method with high local resolution and sensitivity.
摘要翻译：本发明涉及光栅波导结构的可变实施例，其能够通过光栅结构（c）确定激发光进入分层光波导的波导层（a）的谐振条件的局部解析变化，在所述层（a）中调制或者在层（a）中引导的光的外耦合。本发明的系统包括在光栅波导结构上产生的具有不同的固定的生物或生物化学或合成识别元件的测量区域的阵列，用于同时结合和确定一种或多种分析物，其中所述激发光同时照射到整个测量区域阵列上，以及同时测量对于朝向所述测量区域将光耦合到层（a）中的共振条件的满足程度。本发明还涉及一种光学系统，其包括至少一个激发光源和至少一个局部分辨检测器以及可选地用于将激发光的入射角改变到本发明的光栅波导结构上的定位元件。本发明还涉及相应的测量方法及其用途。令人惊讶的是，已经发现本发明的方法非常适合作为具有高的局部分辨率和灵敏度的成像检测方法。

8. 发明申请

US20080299008A1 Flow cell array and the utilization thereof for multianalyte determination 失效
公开(公告)号：US20080299008A1
公开(公告)日：2008-12-04
申请号：US12071526
申请日：2008-02-21
申请人： Eveline Schurmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Scharer-Hernandez , Eginhard Schick
发明人： Eveline Schurmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Scharer-Hernandez , Eginhard Schick
IPC分类号： G01N21/00 , B01L3/00 , B01J19/00 , G01N25/00 , G01N27/00 , C12M1/34
CPC分类号： B01L3/5025 , G01N21/05 , G01N21/253 , G01N2021/0346
摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.

9. 发明授权

US08380020B2 Planar optical structure forming an evanescent field measuring platform that includes a layer molded by a master 失效
标题翻译：平面光学结构形成一个消逝场测量平台，其包括由主体模制的层
公开(公告)号：US08380020B2
公开(公告)日：2013-02-19
申请号：US12819598
申请日：2010-06-21
申请人： Tilo Callenbach , Max Gmür , Heinz Lüthi , Martin Andreas Bopp , Michael Pawlak , Markus Ehrat
发明人： Tilo Callenbach , Max Gmür , Heinz Lüthi , Martin Andreas Bopp , Michael Pawlak , Markus Ehrat
IPC分类号： G02B6/00 , G02B6/10 , G02B6/34
CPC分类号： G02B6/1221 , B29C33/38 , B29C33/424 , B29C45/0001 , B29C45/37 , B29C45/372 , B29C2045/7356 , B29D11/00009 , B29K2709/08 , G02B6/13 , G02B6/34 , G02B2006/12107 , Y10T428/12597 , Y10T428/315
摘要： The planar optical structure forms an evanescent-field measuring platform. A body is made from the thermoplastic plastic with a three-dimensionally structured surface, wherein molding is performed directly from a master made of glass coated with metal oxide, without deposition of further coatings on a surface of the master. The planar optical structure forming an evanescent-field measuring platform has a first essentially optically transparent, waveguiding layer (a) with a refractive index n1 and a second essentially optical transparent layer (b) with refractive index n2, where n1>n2, in a case of an embodiment of a planar optical film waveguide, or a metal layer (a′) and a second layer (b), in a case of an embodiment for generating a surface plasmon resonance, wherein the second layer (b) includes a material from a group of cyclo-olefin polymers and cyclo-olefin copolymers.
摘要翻译：平面光学结构形成消逝场测量平台。主体由具有三维结构化表面的热塑性塑料制成，其中模制由直接由金属氧化物涂覆的玻璃制成的主体进行，而不会在主体表面上沉积更多的涂层。形成ev逝场测量平台的平面光学结构具有第一基本上光学透明的波导层（a），折射率n1和第二基本光学透明层（b）具有折射率n2，其中n1> n2，在在用于产生表面等离子体共振的实施例的情况下，平面光学膜波导或金属层（a'）和第二层（b）的实施例的情况，其中第二层（b）包括材料来自一组环烯烃聚合物和环烯烃共聚物。

10. 发明申请

US20100255461A1 METHOD FOR PRODUCTION OF MOLDED BODIES, IN PARTICULAR OPTICAL STRUCTURES AND USE THEREOF 失效
标题翻译：用于生产模制体的方法，特别是光学结构及其用途
公开(公告)号：US20100255461A1
公开(公告)日：2010-10-07
申请号：US12819598
申请日：2010-06-21
申请人： Tilo CALLENBACH , Max Gmür , Heinz Lüthi , Martin Andreas Bopp , Michael Pawlak , Markus Ehrat
发明人： Tilo CALLENBACH , Max Gmür , Heinz Lüthi , Martin Andreas Bopp , Michael Pawlak , Markus Ehrat
IPC分类号： G02B6/10 , G02B6/34 , G01N21/00 , C12Q1/02 , C12Q1/70 , G01N21/55
CPC分类号： G02B6/1221 , B29C33/38 , B29C33/424 , B29C45/0001 , B29C45/37 , B29C45/372 , B29C2045/7356 , B29D11/00009 , B29K2709/08 , G02B6/13 , G02B6/34 , G02B2006/12107 , Y10T428/12597 , Y10T428/315
摘要： The present invention relates to a method for manufacture a body from a thermoplastic plastic with a three-dimensionally structured surface, wherein molding is performed directly from a master made of glass coated with metal oxide, without deposition of further coatings on a surface of the master. The invention also relates to bodies manufactured with this method from a thermoplastic featuring a three-dimensionally structured surface, as well as to planar optical structures likewise manufactured with this method for generating evanescent-field measuring platforms and to a use thereof. The invention furthermore relates to a planar optical structure for generating an evanescent-field measuring platform, comprising a first essentially optical transparent, waveguiding layer (a) with refractive index n1 and a second essentially optical transparent layer (b) with refractive index n2, where n1>n2, in a case of an embodiment of a planar optical film waveguide, or comprising a metal layer (a′) and a second layer (b), in a case of an embodiment for generating a surface plasmon resonance, wherein the second layer (b) comprises a material from a group comprising cyclo-olefin polymers and cyclo-olefin copolymers.
摘要翻译：本发明涉及一种由具有三维结构表面的热塑性塑料制造主体的方法，其中模制由直接由金属氧化物涂覆的玻璃制成的母板进行，而不会在母板的表面上沉积更多的涂层。本发明还涉及由具有三维结构化表面的热塑性材料制成的主体以及同样利用这种用于产生ev逝场测量平台的方法制造的平面光学结构及其用途。本发明还涉及一种用于产生ev逝场测量平台的平面光学结构，包括具有折射率n1的第一基本上光学透明的波导层（a）和具有折射率n2的第二基本光学透明层（b），其中 n1> n2，在平面光学膜波导的实施例的情况下，或者在用于产生表面等离子体共振的实施例的情况下，包括金属层（a'）和第二层（b），其中第二层（b）包括来自包含环烯烃聚合物和环烯烃共聚物的组的材料。

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