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1. 发明授权

US06961490B2 Waveguide plate and process for its production and microtitre plate 失效
标题翻译：波导板及其生产工艺及微量滴定板
公开(公告)号：US06961490B2
公开(公告)日：2005-11-01
申请号：US09916114
申请日：2001-07-27
申请人： Bernd Maisenhoelder , Johannes Edlinger , Claus Heine-Kempkens , Michael Pawlak , Gert Duveneck
发明人： Bernd Maisenhoelder , Johannes Edlinger , Claus Heine-Kempkens , Michael Pawlak , Gert Duveneck
IPC分类号： G01N21/55 , G01N21/77 , G02B6/12 , G02B6/124 , G02B6/34
CPC分类号： G01N21/7743 , G01N21/552 , G01N21/648 , G02B6/124 , G02B6/136 , G02B6/34 , G02B2006/12107 , G02B2006/12147
摘要： A waveguide plate and a process for making the waveguide plate with a plate-like glass substrate (1), carrying a waveguiding layer (2), with at least one coupling grating on the surface carrying said waveguiding layer (2), which coupling grating is formed as a grating of lines with a period between 150 nm and 1000 nm, the extension of said grating being at least 5 cm with lines parallel to one another, wherein the coupling angle () varies by not more than 0.1_/cm along a line of said grating and wherein the absolute value of the deviation of the coupling angle () on said waveguide plate, from a predefined desired value, does not exceed 0.5_. The deviation from the average value of the coupling angle does not exceed 0.3_, preferably not 0.15_ on the whole waveguide plate. The waveguide plate is suitable as part of a sensor platform and of an arrangement of sample compartments for chemo-and bioanalytical investigations in order to produce a coupling grating formed as a line grating with a grating period between 100 nm and 2500 nm
摘要翻译：波导板和用于制造具有板状玻璃基板（1）的波导板的工艺，其在承载所述波导层（2）的表面上具有带有至少一个耦合光栅的波导层（2），该耦合光栅形成为具有150nm至1000nm之间的周期的线的光栅，所述光栅的延伸至少5cm，线彼此平行，其中耦合角（）沿着所述光栅的直线比0.1_ / cm，并且其中耦合角度的偏差的绝对值（）在预定的期望值上不超过0.5_。在整个波导板上与耦合角的平均值的偏差不超过0.3_，最好不超过0.15_。波导板适合作为传感器平台的一部分和用于化学和生物分析研究的样品室的布置的一部分，以便产生形成为具有在100nm和2500nm之间的光栅周期的线光栅的耦合光栅

2. 发明申请

US20060008206A1 Waveguide plate and process for its production and microtitre plate 有权
标题翻译：波导板及其生产工艺及微量滴定板
公开(公告)号：US20060008206A1
公开(公告)日：2006-01-12
申请号：US11208765
申请日：2005-08-23
申请人： Bernd Maisenhoelder , Johannes Edlinger , Claus Heine-Kempkens , Michael Pawlak , Gert Duveneck
发明人： Bernd Maisenhoelder , Johannes Edlinger , Claus Heine-Kempkens , Michael Pawlak , Gert Duveneck
IPC分类号： G02B6/34
CPC分类号： G01N21/7743 , G01N21/552 , G01N21/648 , G02B6/124 , G02B6/136 , G02B6/34 , G02B2006/12107 , G02B2006/12147
摘要： A waveguide plate and a process for making the waveguide plate with a plate-like glass substrate (1), carrying a waveguiding layer (2), with at least one coupling grating on the surface carrying said waveguiding layer (2), which coupling grating is formed as a grating of lines with a period between 150 nm and 1000 nm, the extension of said grating being at least 5 cm with lines parallel to one another, wherein the coupling angle (θ) varies by not more than 0.1°/cm along a line of said grating and wherein the absolute value of the deviation of the coupling angle (θ) on said waveguide plate, from a predefined desired value, does not exceed 0.5°. The deviation from the average value of the coupling angle does not exceed 0.3°, preferably not 0.15° on the whole waveguide plate. The waveguide plate is suitable as part of a sensor platform and of an arrangement of sample compartments for chemo-and bioanalytical investigations in order to produce a coupling grating formed as a line grating with a grating period between 100 nm and 2500 nm.
摘要翻译：波导板和用于制造具有板状玻璃基板（1）的波导板的工艺，其在承载所述波导层（2）的表面上具有带有至少一个耦合光栅的波导层（2），该耦合光栅形成为具有150nm和1000nm之间的周期的线的光栅，所述光栅的延伸至少5cm，线彼此平行，其中耦合角（θ）变化不超过0.1°/ cm 沿着所述光栅的线，并且其中所述波导板上的耦合角（θ）与预定的期望值的偏差的绝对值不超过0.5°。与整个波导板的耦合角度的平均值的偏差不超过0.3°，最好不超过0.15°。波导板适合作为传感器平台的一部分和用于化学和生物分析研究的样品室的布置的一部分，以便产生形成为具有在100nm和2500nm之间的光栅周期的线光栅的耦合光栅。

3. 发明授权

US07215850B2 Waveguide plate and process for its production and microtitre plate 有权
标题翻译：波导板及其生产工艺及微量滴定板
公开(公告)号：US07215850B2
公开(公告)日：2007-05-08
申请号：US11208765
申请日：2005-08-23
申请人： Bernd Maisenhoelder , Johannes Edlinger , Claus Heine , Michael Pawlak , Gert Duveneck
发明人： Bernd Maisenhoelder , Johannes Edlinger , Claus Heine , Michael Pawlak , Gert Duveneck
IPC分类号： G02B6/34
CPC分类号： G01N21/7743 , G01N21/552 , G01N21/648 , G02B6/124 , G02B6/136 , G02B6/34 , G02B2006/12107 , G02B2006/12147
摘要： A waveguide plate and a process for making the waveguide plate with a plate-like glass substrate (1), carrying a waveguiding layer (2), with at least one coupling grating on the surface carrying said waveguiding layer (2), which coupling grating is formed as a grating of lines with a period between 150 nm and 1000 nm, the extension of said grating being at least 5 cm with lines parallel to one another, wherein the coupling angle (θ) varies by not more than 0.1°/cm along a line of said grating and wherein the absolute value of the deviation of the coupling angle (θ) on said waveguide plate, from a predefined desired value, does not exceed 0.5°. The deviation from the average value of the coupling angle does not exceed 0.3°, preferably not 0.15° on the whole waveguide plate. The waveguide plate is suitable as part of a sensor platform and of an arrangement of sample compartments for chemo-and bioanalytical investigations in order to produce a coupling grating formed as a line grating with a grating period between 100 nm and 2500 nm.
摘要翻译：波导板和用于制造具有板状玻璃基板（1）的波导板的工艺，其在承载所述波导层（2）的表面上具有带有至少一个耦合光栅的波导层（2），该耦合光栅形成为具有150nm和1000nm之间的周期的线的光栅，所述光栅的延伸至少5cm，线彼此平行，其中耦合角（θ）变化不超过0.1°/ cm 沿着所述光栅的线，并且其中所述波导板上的耦合角（θ）与预定的期望值的偏差的绝对值不超过0.5°。与整个波导板的耦合角度的平均值的偏差不超过0.3°，最好不超过0.15°。波导板适合作为传感器平台的一部分和用于化学和生物分析研究的样品室的布置的一部分，以便产生形成为具有在100nm和2500nm之间的光栅周期的线光栅的耦合光栅。

4. 发明授权

US06873764B2 METHOD FOR PRODUCING A GRID STRUCTURE, AN OPTICAL ELEMENT, AN EVANESCENCE FIELD SENSOR PLATE, MICROTITRE PLATE AND AN OPTICAL COMMUNICATION ENGINEERING COUPLER AS WELL AS A DEVICE FOR MONITORING A WAVELENGTH 有权
标题翻译：网格结构的生产方法，光学元件，变化现场传感器板，微型板和光通信工程耦合器，作为用于监测波长的装置
公开(公告)号：US06873764B2
公开(公告)日：2005-03-29
申请号：US10182247
申请日：2001-01-26
申请人： Bernd Maisenholder , Johannes Edlinger , Claus Heine , Michael Pawlak , Gert Duveneck
发明人： Bernd Maisenholder , Johannes Edlinger , Claus Heine , Michael Pawlak , Gert Duveneck
IPC分类号： G01N21/64 , G01N21/552 , G01N21/77 , G01N33/53 , G01N37/00 , G02B5/18 , G02B6/02 , G02B6/12 , G02B6/122 , G02B6/124 , G02B6/13 , G02B6/34
CPC分类号： G01N21/7703 , G01N21/552 , G01N21/648 , G01N21/7743 , G01N2021/7776 , G02B6/02138 , G02B6/12007 , G02B6/124 , G02B6/34 , G02B2006/12107
摘要： A coupling grating formed as a line grating with a grating period between 100 nm and 2500 nm, a substrate (1) is covered with a photoresist layer (10) and exposed for instance at the Lithrow angle (ΘL) or at 0° to a mercury-vapour lamp (11) via a folding mirror (13, 13′) through a phase mask (14) in the near field of which the photoresist layer is arranged, then structured by reactive ion etching and provided with a transparent layer by reactive DC magnetron sputtering, particularly pulsed DC sputtering or AC-superimposed DC sputtering. The phase mask (14) is structured in advance with the laser two-beam interference method. The process is particularly suited for the production of optical elements, particularly evane-scent field sensor plates and optical couplers for communications technology which can be employed in particular as filters for wavelength multiplexing in fibre-optic networks.
摘要翻译：形成为具有100nm和2500nm之间的光栅周期的线光栅的耦合光栅，衬底（1）被光致抗蚀剂层（10）覆盖并且例如以Lithrow角（ThetaL）或0°暴露于通过折射镜（13,13'）穿过其中布置光致抗蚀剂层的近场中的相位掩模（14）的汞蒸气灯（11），然后通过反应离子蚀刻构造并且通过反应性设置有透明层 DC磁控溅射，特别是脉冲DC溅射或AC叠加DC溅射。预先利用激光二光束干涉法构成相位掩模（14）。该方法特别适用于生产光学元件，特别是用于通信技术的示范性场传感器板和光耦合器，其特别可用作光纤网络中的波长复用滤波器。

5. 发明申请

US20050163659A1 Kit for assay development and serial analysis 审中-公开
标题翻译：用于测定开发和连续分析的试剂盒
公开(公告)号：US20050163659A1
公开(公告)日：2005-07-28
申请号：US10514166
申请日：2003-05-06
申请人： Gert Duveneck , Peter Oroszlan , Michael Pawlak
发明人： Gert Duveneck , Peter Oroszlan , Michael Pawlak
IPC分类号： G01N33/543 , G01N21/00
CPC分类号： G01N33/54353 , G01N33/54366
摘要： The invention relates to a kit for assay development and for carrying out a plurality of analyses, comprising a carrier substrate and a placement body jointly forming an arrangement of a plurality of sample compartments comprising said carrier substrate as a base plate, in addition to a plurality of immobilized binding partners for the detection of one or more analytes in one or more samples in a bioaffinity assay, said binding partners being arranged and immobilized on the carrier substrate inside the sample containers always in two-dimensional arrays of discrete measuring areas, wherein always at least one measuring area of an array or a partial surface inside an array or sample compartment, respectively, is provided on the carrier substrate for referencing purposes, and the surface density of the immobilized binding partners, in relation to the surface of the measurement areas, is less than the surface density of a full, i.e. extensive, monolayer of said binding partners. The composition of the inventive kit is such that, surprisingly, it enables a full series of measurements to be carried out on an individual carrier substrate. The invention also relates to an analytical system wherein the inventive kit is used, and to analytical detection methods based thereon and the use thereof.
摘要翻译：本发明涉及用于测定开发和用于进行多个分析的试剂盒，其包括载体基底和放置体，该载体基底和放置体除了多个之外，共同形成包括所述载体基底作为基板的多个样品室的布置用于在生物亲和力测定中检测一个或多个样品中的一种或多种分析物的固定化结合配偶体，所述结合伙伴被布置和固定在样品容器内的载体基质上，总是在离散测量区域的二维阵列中，其中总是为了参考目的，在载体基底上分别提供阵列或样品室内的阵列或部分表面的至少一个测量区域，并且固定的结合物的表面密度相对于测量区域的表面小于所述结合配偶体的完整的，即广泛的单层的表面密度。本发明的试剂盒的组成使得令人惊奇的是，它使得能够在单个载体基底上进行全系列的测量。本发明还涉及其中使用本发明的试剂盒的分析系统，以及基于其的分析检测方法及其用途。

6. 发明申请

US20100130370A1 FLOW CELL ARRAY AND THE UTILIZATION THEREOF FOR MULTIANALYTE DETERMINATION 有权
标题翻译：流量池阵列及其多用途测定的应用
公开(公告)号：US20100130370A1
公开(公告)日：2010-05-27
申请号：US12695553
申请日：2010-01-28
申请人： Eveline Schurmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Mtthias Kresbach , Michael Pawlak , Nania Graciela Scharer-Hernandez , Eginhard Schick
发明人： Eveline Schurmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Mtthias Kresbach , Michael Pawlak , Nania Graciela Scharer-Hernandez , Eginhard Schick
IPC分类号： C40B30/00 , C40B60/12
CPC分类号： B01L3/5025 , G01N21/05 , G01N21/253 , G01N2021/0346
摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.
摘要翻译：提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置对应于样品室的（几何）布置，与基板结合。该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。一个或多个样品室的布置包括基板和与基板组合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法制造及其使用。

7. 发明申请

US20050059014A1 Analytical platform and detection method with the analytes to be determined in a sample as immobilized specific binding partners 审中-公开
标题翻译：分析平台和检测方法与样品中待测定的分析物作为固定化的特异性结合配偶体
公开(公告)号：US20050059014A1
公开(公告)日：2005-03-17
申请号：US10653386
申请日：2003-09-03
申请人： Michael Pawlak , Eginhard Schick , Peter Oroszlan
发明人： Michael Pawlak , Eginhard Schick , Peter Oroszlan
IPC分类号： G01N33/566 , C12M1/00 , C12M1/34 , C12Q1/68 , G01N21/76 , G01N33/53 , G01N33/543 , G01N33/553
CPC分类号： G01N33/54353 , G01N33/54373
摘要： The present invention is related to an analytical platform and a method performed therewith for the analysis of a multitude of “nature-identical” samples for analytes which are contained therein and are of biological relevance as binding partners in specific binding reactions, wherein said samples or dilutions of said samples of the same relative molecular composition as the original samples, with the analytes to be determined contained therein, as a first plurality of specific binding partners, are deposited in discrete measurement areas in at least one one- or two-dimensional array of measurement areas on an evanescent field sensor platform as a solid support without a change in the relative molecular composition, compared with the original relative molecular composition of the sample, one or more tracer compounds as a second plurality of specific binding partners, for the specific determination of analytes out of the first plurality of specific binding partners contained in the samples, are brought into contact with the samples deposited in said discrete measurement areas in a single step or multiple steps of a specific binding reaction, changes in opto-electronic signals, resulting from the binding of tracer compounds to analytes contained in the samples in discrete measurement areas or to specific binding partners bound to the analytes contained in the measurement areas in the evanescent field of the evanescent field sensor platform are measured laterally resolved, and the presence of the analytes to be specifically detected is determined qualitatively and/or quantitatively from the relative amount of the changes in said opto-electronic signals from the corresponding measurement areas.
摘要翻译：本发明涉及一种分析平台及其分析方法，用于分析大量与分析物相似的“自然相同”的样品，其中所含的分析物样品在其中包含并具有生物相关性，作为特异性结合反应中的结合配偶体，其中所述样品或与原始样品相同的相对分子组成的所述样品与其中包含的待测定的分析物作为第一多个特异性结合配偶体的稀释沉积在至少一个一维或二维阵列的离散测量区域中相对于样品的原始相对分子组成，作为第二多个特异性结合配偶体的一个或多个示踪剂化合物，作为固体支持物的ev逝场传感器平台上的测量区域作为固体支持物而没有相对分子组成的变化确定包含在第一个多个具体约束伙伴中的分析物在与单独的步骤或特定结合反应的多个步骤中，沉积在所述离散测量区域中的样品与示踪剂化合物与样品中包含的分析物的离散性的光电子信号的变化相接触测量区域或与消逝场传感器平台的消逝场中测量区域中包含的分析物结合的特异性结合配体进行横向分辨测定，并且特异性检测的分析物的存在是从定性和/或定量的相应测量区域的所述光电信号的相对变化量。

8. 发明申请

US20050019836A1 Bioanalytical reagent, method for production thereof, sensor platforms and detection methods based on use of said bioanalytical reagent 审中-公开
标题翻译：生物分析试剂，其生产方法，传感器平台和基于所述生物分析试剂的检测方法
公开(公告)号：US20050019836A1
公开(公告)日：2005-01-27
申请号：US10433823
申请日：2001-12-04
申请人： Horst Vogel , Horst Pick , Axel Preuss , Ana-Paula Tairi , Evelyne Schmid Osborne , Michael Pawlak
发明人： Horst Vogel , Horst Pick , Axel Preuss , Ana-Paula Tairi , Evelyne Schmid Osborne , Michael Pawlak
IPC分类号： G01N33/554 , G01N33/53 , C07K14/705 , C07K16/28 , G01N33/567
CPC分类号： G01N33/554
摘要： The invention relates to various embodiments of a bioanalytical reagent with at least one vesicle, generated from a living cell, comprising at least one receptor, characterized in that a mechanism of signal transduction triggered by said receptor in the cell used for vesicle generation is preserved in said vesicle, as a component of the bioanalytical reagent. The invention further relates to methods for production of the bioanalytical reagent according to the invention, to bioanalytical detection methods based on the application of said reagent, and to the use of said detection method and of the bioanalytical reagent.
摘要翻译：本发明涉及生物分析试剂的各种实施方案，其具有由活细胞产生的至少一种囊泡，其包含至少一种受体，其特征在于，用于产生囊泡的细胞中由所述受体触发的信号转导机制被保留在所述囊泡作为生物分析试剂的组分。本发明还涉及根据本发明的生物分析试剂的生产方法，基于所述试剂的应用的生物分析检测方法，以及所述检测方法和生物分析试剂的使用。

9. 发明授权

US07678565B2 Flow cell array and the utilization thereof for multianalyte determination 失效
标题翻译：流量池阵列及其在多分辨率测定中的应用
公开(公告)号：US07678565B2
公开(公告)日：2010-03-16
申请号：US12071526
申请日：2008-02-21
申请人： Eveline Schürmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Schärer-Hernández , Eginhard Schick
发明人： Eveline Schürmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Schärer-Hernández , Eginhard Schick
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L3/5025 , G01N21/05 , G01N21/253 , G01N2021/0346
摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.
摘要翻译：提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置对应于样品室的（几何）布置，与基板结合。该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。一个或多个样本室的布置包括基板和与基板结合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法制造及其使用。

10. 发明申请

US20090224173A1 Grating waveguide structure for reinforcing an excitation field and use thereof 审中-公开
标题翻译：用于加强激励场的光栅波导结构及其用途
公开(公告)号：US20090224173A1
公开(公告)日：2009-09-10
申请号：US12318568
申请日：2008-12-31
申请人： Gert Ludwig Duveneck , Martin Andreas Bopp , Michael Pawlak , Markus Ehrat , Gerd Marowsky
发明人： Gert Ludwig Duveneck , Martin Andreas Bopp , Michael Pawlak , Markus Ehrat , Gerd Marowsky
IPC分类号： G01J1/58 , G02F1/01
CPC分类号： G01N21/648 , G01N21/6428 , G01N21/774 , G01N2021/6419 , G01N2021/7786 , G02B6/124
摘要： The invention relates to a variable embodiment of a grating waveguide structure, based on a planar thin-film waveguide with a first optically transparent layer (a) on a second optically transparent layer (b) having a lower refractive index than layer (a), and a grating structure (c) modulated in layer (a), wherein the intensity of an excitation light irradiated at the resonance angle for incoupling into layer (a) is enhanced by at least a factor of 100 on layer (a) and within layer (a), at least in the region of the grating structure (c), in comparison with the intensity of said excitation light on a substrate surface without incoupling of the excitation light. The invention also relates to an optical system with an excitation light source and an embodiment of a grating waveguide structure according to the invention, and to a method for enhancing an excitation light intensity, and to the use thereof in bioanalytical detection processes, in non-linear optics or in telecommunications or communications industry.
摘要翻译：本发明涉及一种基于具有比层（a）折射率低的第二光学透明层（b）上具有第一光学透明层（a）的平面薄膜波导的光栅波导结构的可变实施例，以及在层（a）中调制的光栅结构（c），其中以共耦合角度照射到层（a）中的激发光的强度在层（a）上至少增加100倍，并且在层（a），至少在光栅结构（c）的区域中，与衬底表面上的所述激发光的强度相比较，而不会激发激发光的耦合。本发明还涉及具有激发光源和根据本发明的光栅波导结构的实施例的光学系统，以及用于增强激发光强度的方法及其在生物分析检测过程中的用途，线性光学或电信或通信行业。

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