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1. 发明申请

US20100280601A1 Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof 有权
标题翻译：除了使用有机磷酸和有机膦酸的单层和多层及其盐的沉淀方法
公开(公告)号：US20100280601A1
公开(公告)日：2010-11-04
申请号：US12662932
申请日：2010-05-12
申请人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
发明人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
IPC分类号： A61L27/10 , A61L31/16 , A61L27/54 , A61L29/16 , B32B18/00 , B32B15/04 , B32B9/04 , C40B40/00 , A61C8/00 , A61F2/38 , A61F2/32 , A61F2/30 , A61F2/44 , A61N1/36 , A61L29/02 , A61M25/10 , A61L31/02
CPC分类号： C23F11/1676 , A61B5/14546 , A61B5/415 , A61B17/68 , A61F2/30767 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00215 , A61F2310/00227 , A61F2310/00239 , A61F2310/00251 , A61F2310/00281 , A61F2310/00317 , A61F2310/00323 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00646 , A61F2310/00652 , A61F2310/00658 , A61F2310/00664 , A61F2310/00742 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/00778 , A61F2310/00784 , A61F2310/00874 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61F2310/00904 , A61F2310/0091 , A61F2310/00976 , A61L27/34 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C04B41/009 , C04B41/4994 , C04B41/84 , C04B2111/00836 , Y10T428/31678 , C04B35/01
摘要： The invention relates to a method for precipitating mono or multiple layers of a mixture of organophosphoric acids of the general formula I (A) Y—B—OPO3H2 (IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2 (IB) and the salts thereof, wherein Y and B are defined in the specification. According to the invention, precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices.
摘要翻译：本发明涉及使通式I（A）Y-B-OPO 3 H 2（IA）的有机磷酸或通式I（B）Y-B-的有机膦酸的混合物的单层或多层沉淀的方法， PO 3 H 2（IB）及其盐，其中Y和B在说明书中定义。根据本发明，在金属和半导体的纯或混合氧化物，氮化物或碳化物的基材表面上，特别是作为传感器平台，植入物和医疗附件装置的表面，发生沉淀。本发明还涉及其作为涂覆的传感器平台，植入物和医疗附件装置的一部分的用途。

2. 发明授权

US07517546B2 Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof 失效
公开(公告)号：US07517546B2
公开(公告)日：2009-04-14
申请号：US10363555
申请日：2001-08-31
申请人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
发明人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
IPC分类号： B05D3/00 , G02B6/00
CPC分类号： C23F11/1676 , A61B5/14546 , A61B5/415 , A61B17/68 , A61F2/30767 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00215 , A61F2310/00227 , A61F2310/00239 , A61F2310/00251 , A61F2310/00281 , A61F2310/00317 , A61F2310/00323 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00646 , A61F2310/00652 , A61F2310/00658 , A61F2310/00664 , A61F2310/00742 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/00778 , A61F2310/00784 , A61F2310/00874 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61F2310/00904 , A61F2310/0091 , A61F2310/00976 , A61L27/34 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C04B41/009 , C04B41/4994 , C04B41/84 , C04B2111/00836 , Y10T428/31678 , C04B35/01
摘要： The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A) Y—B—OPO3H2 (IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2 (IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more —CH2- groups. According to the invention, said precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, comprising the use of water-soluble salts of a compound of formula (IA) or (IB) for the treatment of these surfaces, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices in addition to new organophosphoric acids and organophosphonic acids themselves. The optionally substituted compounds of formulae (IA) and (IB) wherein the B and Y groups have the above-mentioned designations, i.e. optionally substituted alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetaryl, are hereinafter referred to as organophosphoric acids and organophosphonic acids.

3. 发明授权

US08034395B2 Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof 有权
标题翻译：除了使用有机磷酸和有机膦酸的单层和多层及其盐的沉淀方法
公开(公告)号：US08034395B2
公开(公告)日：2011-10-11
申请号：US12662932
申请日：2010-05-12
申请人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
发明人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
IPC分类号： G01N1/28 , G02B6/00
CPC分类号： C23F11/1676 , A61B5/14546 , A61B5/415 , A61B17/68 , A61F2/30767 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00215 , A61F2310/00227 , A61F2310/00239 , A61F2310/00251 , A61F2310/00281 , A61F2310/00317 , A61F2310/00323 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00646 , A61F2310/00652 , A61F2310/00658 , A61F2310/00664 , A61F2310/00742 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/00778 , A61F2310/00784 , A61F2310/00874 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61F2310/00904 , A61F2310/0091 , A61F2310/00976 , A61L27/34 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C04B41/009 , C04B41/4994 , C04B41/84 , C04B2111/00836 , Y10T428/31678 , C04B35/01
摘要： The invention relates to a method for precipitating mono or multiple layers of a mixture of organophosphoric acids of the general formula I (A) Y—B—OPO3H2 (IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2 (IB) and the salts thereof, wherein Y and B are defined in the specification. According to the invention, precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices.
摘要翻译：本发明涉及使通式I（A）Y-B-OPO 3 H 2（IA）的有机磷酸或通式I（B）Y-B-的有机膦酸的混合物的单层或多层沉淀的方法， PO 3 H 2（IB）及其盐，其中Y和B在说明书中定义。根据本发明，在金属和半导体的纯或混合氧化物，氮化物或碳化物的基材表面上，特别是作为传感器平台，植入物和医疗附件装置的表面，发生沉淀。本发明还涉及其作为涂覆的传感器平台，植入物和医疗附件装置的一部分的用途。

4. 发明授权

US07740896B2 Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof 失效
公开(公告)号：US07740896B2
公开(公告)日：2010-06-22
申请号：US12230915
申请日：2008-09-08
申请人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
发明人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
IPC分类号： G01N1/28 , G02B6/00
CPC分类号： C23F11/1676 , A61B5/14546 , A61B5/415 , A61B17/68 , A61F2/30767 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00215 , A61F2310/00227 , A61F2310/00239 , A61F2310/00251 , A61F2310/00281 , A61F2310/00317 , A61F2310/00323 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00646 , A61F2310/00652 , A61F2310/00658 , A61F2310/00664 , A61F2310/00742 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/00778 , A61F2310/00784 , A61F2310/00874 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61F2310/00904 , A61F2310/0091 , A61F2310/00976 , A61L27/34 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C04B41/009 , C04B41/4994 , C04B41/84 , C04B2111/00836 , Y10T428/31678 , C04B35/01
摘要： The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A) Y—B—OPO3H2 (IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2 (IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more —CH2— groups. According to the invention, said precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, comprising the use of water-soluble salts of a compound of formula (IA) or (IB) for the treatment of these surfaces, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices in addition to new organophosphoric acids and organophosphonic acids themselves. The optionally substituted compounds of formulae (IA) and (IB) wherein the B and Y groups have the above-mentioned designations, i.e. optionally substituted alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetaryl, are hereinafter referred to as organophosphoric acids and organophosphonic acids.

5. 发明申请

US20090061506A1 Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof 失效
公开(公告)号：US20090061506A1
公开(公告)日：2009-03-05
申请号：US12230915
申请日：2008-09-08
申请人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schurmann-Mader , Markus Ehrat , Samuele Tosatti
发明人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schurmann-Mader , Markus Ehrat , Samuele Tosatti
IPC分类号： C12M1/34 , B05D1/18
CPC分类号： C23F11/1676 , A61B5/14546 , A61B5/415 , A61B17/68 , A61F2/30767 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00215 , A61F2310/00227 , A61F2310/00239 , A61F2310/00251 , A61F2310/00281 , A61F2310/00317 , A61F2310/00323 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00646 , A61F2310/00652 , A61F2310/00658 , A61F2310/00664 , A61F2310/00742 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/00778 , A61F2310/00784 , A61F2310/00874 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61F2310/00904 , A61F2310/0091 , A61F2310/00976 , A61L27/34 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C04B41/009 , C04B41/4994 , C04B41/84 , C04B2111/00836 , Y10T428/31678 , C04B35/01
摘要： The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A) Y—B—OPO3H2 (IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2 (IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more —CH2- groups. According to the invention, said precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, comprising the use of water-soluble salts of a compound of formula (IA) or (IB) for the treatment of these surfaces, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices in addition to new organophosphoric acids and organophosphonic acids themselves.The optionally substituted compounds of formulae (IA) and (IB) wherein the B and Y groups have the above-mentioned designations, i.e. optionally substituted alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetaryl, are hereinafter referred to as organophosphoric acids and organophosphonic acids.

6. 发明授权

US06884628B2 Multifunctional polymeric surface coatings in analytic and sensor devices 有权
标题翻译：分析和传感器设备中的多功能聚合物表面涂层
公开(公告)号：US06884628B2
公开(公告)日：2005-04-26
申请号：US09560472
申请日：2000-04-28
申请人： Jeffrey A. Hubbell , Marcus Textor , Donald L. Elbert , Stephanie Finken , Rolf Hofer , Nicholas D. Spencer , Laurence Ruiz-Taylor
发明人： Jeffrey A. Hubbell , Marcus Textor , Donald L. Elbert , Stephanie Finken , Rolf Hofer , Nicholas D. Spencer , Laurence Ruiz-Taylor
IPC分类号： A61L27/34 , A61L31/10 , G01N33/543 , G01N33/551 , G01N33/53
CPC分类号： B82Y30/00 , A61B5/14546 , A61B5/1459 , A61L27/34 , A61L31/10 , G01N33/54373 , G01N33/54393 , G01N33/551 , Y10S435/815 , Y10S435/961 , Y10S435/969 , Y10S436/819 , Y10S436/823
摘要： Multifunctional, polyionic copolymers with molecular architectures and properties optimized for specific applications are synthesized on/or applied to substrate surfaces for analytical and sensing purposes. The coatings are particularly useful for suppression of non-specific interaction, adsorption or attachment of molecular or ionic components present in an analyte solution. Chemical, biochemical or biological groups that are able to recognize, interact with and bind specifically to target molecules in the material containing the analyte to be detected can be coupled to, integrated into, or absorbed to the multifunctional copolymers. These multifunctional copolymer coatings are compatible with a variety of different established methods to detect, sense and quantify the target molecule in an analyte. The multifunctional copolymer coatings typically include brush copolymers based on a polycationic or polyanionic (jointly referred to herein as ‘polyionic’) backbone with side chains that control interaction with the environment, such as poly(ethylene glycol) or poly(ethylene oxide)-based side chains that decrease cellular adhesion, and analyte-specific side chains. They can be used to pattern the surfaces into non-adhesive and specifically adhesive areas by applications of known techniques such as microfluidic or contact printing techniques.
摘要翻译：具有分子结构和针对特定应用优化的性能的多功能聚异戊二烯共聚物在/或应用于基材表面进行合成，用于分析和感测目的。涂层对于抑制分析物溶液中存在的分子或离子组分的非特异性相互作用，吸附或附着是特别有用的。能够识别，相互作用并且特异性结合含有待检测分析物的物质中的靶分子的化学，生物化学或生物学基团可与多功能共聚物偶联，整合或吸收。这些多功能共聚物涂层与各种不同的已知方法兼容，以检测，感测和定量分析物中的目标分子。多功能共聚物涂层通常包括基于聚阳离子或聚阴离子（共同称为“聚阴离子”）骨架的刷共聚物，侧链具有控制与环境相互作用的侧链，例如聚（乙二醇）或聚（环氧乙烷）减少细胞粘附的侧链和分析物特异性侧链。它们可用于通过已知技术如微流体或接触印刷技术的应用将表面图案化成非粘合性和特异性粘合剂区域。

7. 发明授权

US5698660A Melt spinnable copolyamines with improved modulus of elasticity, filaments produced from them and use of such filaments 失效
标题翻译：具有改善的弹性模量的熔融可纺共聚酰胺，由它们生产的长丝和这种长丝的使用
公开(公告)号：US5698660A
公开(公告)日：1997-12-16
申请号：US649581
申请日：1996-05-28
申请人： Roland Stahlin , Rolf Hofer , Jean Coquard
发明人： Roland Stahlin , Rolf Hofer , Jean Coquard
IPC分类号： C08G69/26 , C08G69/32 , D01F6/80 , C08G73/10
CPC分类号： D01F6/80 , C08G69/265 , C08G69/32 , Y10T428/29 , Y10T428/2969
摘要： A copolyamide with an improved modulus of elasticity for the melt-spinning of filaments consists of at least 75 wt. % of a linear polyamide base polymer with a melting point of 150.degree.-320.degree. C. and at least 0.5 wt. % of a block comonomer which is incorporated into the base polymer and has a glass transition temperature (T.sub.g) between 130.degree. and 330.degree. C. and a degree of polymerization (DP) of
摘要翻译： PCT No.PCT / CH95 / 00207 Sec。 371日期：1996年5月28日 102（e）日期1996年5月28日PCT提交1995年9月19日PCT公布。公开号WO96 / 10597 日期1996年4月11日具有改善的长丝熔体纺丝的弹性模量的共聚酰胺由至少75wt。％的熔点为150-320℃的线性聚酰胺基聚合物和至少0.5wt。嵌入基础聚合物中的玻璃化转变温度（Tg）为130〜330℃，聚合度（DP）<100的嵌段共聚单体的％。由初始模量为500至1500cN / tex的改性共聚物生产的长丝适用于生产技术织物。

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