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21. 发明申请

US20130204147A1 Atrial Fibrillation Detection Based On Pulmonary Artery Pressure Data 审中-公开
标题翻译：基于肺动脉压数据的心房颤动检测
公开(公告)号：US20130204147A1
公开(公告)日：2013-08-08
申请号：US13366106
申请日：2012-02-03
申请人： Andreas Blomqvist , Michael E. Benser
发明人： Andreas Blomqvist , Michael E. Benser
IPC分类号： A61B5/0215 , A61B5/021
CPC分类号： A61B5/0215 , A61B5/0002 , A61B5/02405 , A61B5/7282
摘要： Atrial fibrillation (AF) is detected based on pulmonary artery pressure (PAP) data. In some embodiments, PAP data generated by a PAP sensor device implanted in or near the pulmonary artery of a patient is processed to determine whether the patient is suffering from AF. In some aspects, detection of AF is based on identifying cycle-to-cycle variations of one or more parameters derived from the PAP data.
摘要翻译：基于肺动脉压（PAP）数据检测心房颤动（AF）。在一些实施例中，处理由植入在患者的肺动脉中或附近的PAP传感器装置生成的PAP数据，以确定患者是否患有AF。在一些方面，AF的检测基于识别从PAP数据导出的一个或多个参数的周期到周期的变化。

22. 发明申请

US20100249862A1 System and Method for Controlling Ventricular Pacing During AF Based on Underlying Ventricular Rates Using an Implantable Medical Device 有权
标题翻译：使用植入式医疗器械，在基于心室率的房颤期间控制心室起搏的系统和方法
公开(公告)号：US20100249862A1
公开(公告)日：2010-09-30
申请号：US12410386
申请日：2009-03-24
申请人： Peter Boileau , Michael E. Benser
发明人： Peter Boileau , Michael E. Benser
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61N1/3702
摘要： Techniques are provided for controlling ventricular pacing during an episode of atrial fibrillation (AF) for use by a pacemaker, implantable cardioverter-defibrillator (ICD) or other implantable medical device. In one example, upon detection of AF, the underlying intrinsic ventricular rate of the patient is determined prior to delivering any ventricular pacing. Then, a ventricular pacing procedure—such as dynamic ventricular overdrive (DVO) pacing—is activated to reduce ventricular rate variability to mitigate the adverse effects of AF. The ventricular pacing procedure employed during AF is controlled based on a maximum ventricular rate set relative to the underlying intrinsic ventricular rate so as to keep an overall ventricular rate below the maximum rate.
摘要翻译：提供技术用于在心房颤动（AF）发作期间控制心室起搏，以供起搏器，可植入式心律转复除颤器（ICD）或其他可植入医疗装置使用。在一个实例中，在检测到AF后，在递送任何心室起搏之前确定患者的潜在内在心室率。然后，启动心室起搏手术，例如动态心室超速（DVO）起搏 - 以减少心室率变异性，以减轻AF的不良反应。在AF期间使用的心室起搏过程基于相对于潜在的内部心室率设定的最大心室率进行控制，以保持总体心率低于最大速率。

23. 发明授权

US07672729B2 Multi-variable feedback control of stimulation for inspiratory facilitation 失效
标题翻译：吸气辅助刺激的多变量反馈控制
公开(公告)号：US07672729B2
公开(公告)日：2010-03-02
申请号：US11624106
申请日：2007-01-17
申请人： Steve Koh , Michael E. Benser
发明人： Steve Koh , Michael E. Benser
IPC分类号： A61N1/36
CPC分类号： A61N1/3601
摘要： An exemplary method includes delivering stimulation according to one or more stimulation parameters to cause contraction of the diaphragm, monitoring chest activity related to respiration and, in response to the monitoring, adjusting one or more of the one or more stimulation parameters during contraction of the diaphragm and continuing the delivering. Various other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括根据一个或多个刺激参数递送刺激以引起隔膜的收缩，监测与呼吸相关的胸部活动，并且响应于该监测，在隔膜收缩期间调整一个或多个刺激参数中的一个或多个并继续交付。还公开了各种其它示例性方法，装置，系统等。

24. 发明授权

US06743225B2 Electrophysiologic measure of endpoints for ablation lesions created in fibrillating substrates 失效
标题翻译：在原纤化底物中产生的消融损伤终点的电生理测量
公开(公告)号：US06743225B2
公开(公告)日：2004-06-01
申请号：US09818206
申请日：2001-03-27
申请人： Javier E. Sanchez , Jeffrey A. Hall , Michael E. Benser , Raymond E. Ideker , William M. Smith
发明人： Javier E. Sanchez , Jeffrey A. Hall , Michael E. Benser , Raymond E. Ideker , William M. Smith
IPC分类号： A61B1804
CPC分类号： A61B5/0422 , A61B18/1206 , A61B2018/00839 , A61B2562/0209 , A61B2562/043
摘要： Methods, systems, and computer program products measure electrical activity of the cardiac tissue proximate the lesion site during an ablation treatment, and then compare the measurements to determine whether the lesion is clinically efficacious so as to be able to block myocardial propagation. The methods can include obtaining the measurements and performing the ablation therapy while the subject is experiencing atrial fibrillation and may measure the standard deviation of the electrogram signal.
摘要翻译：方法，系统和计算机程序产品测量在消融治疗期间靠近病变部位的心脏组织的电活动，然后比较测量值以确定病变是临床有效的，以便能够阻断心肌的传播。所述方法可以包括在受试者正在经历心房颤动时获得测量并执行消融治疗，并且可以测量电描记图信号的标准偏差。

25. 发明申请

US20110282226A1 CARDIAC ANALYSIS SYSTEM FOR COMPARING CLINICAL AND INDUCED VENTRICULAR TACHYCARDIA EVENTS 有权
标题翻译：用于比较临床和诱发的心室TACHYCARDIA事件的心脏分析系统
公开(公告)号：US20110282226A1
公开(公告)日：2011-11-17
申请号：US12820879
申请日：2010-06-22
申请人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
发明人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
IPC分类号： A61B5/04
CPC分类号： A61B5/0422 , A61B5/0031 , A61B5/0464 , A61B18/1492 , A61N1/3621
摘要： A cardiac analysis system is provided that includes an implantable medical device (IMD), at least one sensor, and an external device. The IMD has electrodes positioned proximate to a heart that sense first cardiac signals of the heart and associated with a clinical ventricular tachycardia (VT) event and second cardiac signals associated with an induced VT event. The sensor measures first and second cardiac parameters of the heart associated with the clinical and induced VT events, respectively. The external device is configured to receive the first and second cardiac signals associated with the clinical and the induced VT events and the first and second cardiac parameters associated with the clinical and the induced VT events. The external device compares the first and second cardiac signals and compares the first and second cardiac parameters to determine if the clinical and induced VT events are a common type of VT event.
摘要翻译：提供了包括可植入医疗装置（IMD），至少一个传感器和外部装置的心脏分析系统。 IMD具有位于心脏附近的电极，其感测心脏的第一心脏信号并与临床心室性心动过速（VT）事件和与诱导的VT事件相关联的第二心脏信号相关联。该传感器分别测量与临床和诱导VT事件相关的心脏的第一和第二心脏参数。外部设备被配置为接收与临床和诱导的VT事件相关联的第一和第二心脏信号以及与临床和诱导的VT事件相关联的第一和第二心脏参数。外部设备比较第一和第二心脏信号，并比较第一和第二心脏参数以确定临床和诱导的VT事件是否是常见类型的VT事件。

26. 发明授权

US08634902B2 Cardiac analysis system for comparing clinical and induced ventricular tachycardia events 有权
标题翻译：用于比较临床和诱导性室性心动过速事件的心脏分析系统
公开(公告)号：US08634902B2
公开(公告)日：2014-01-21
申请号：US12820879
申请日：2010-06-22
申请人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
发明人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
IPC分类号： A61B5/04
CPC分类号： A61B5/0422 , A61B5/0031 , A61B5/0464 , A61B18/1492 , A61N1/3621
摘要： A cardiac analysis system is provided that includes an implantable medical device (IMD), at least one sensor, and an external device. The IMD has electrodes positioned proximate to a heart that sense first cardiac signals of the heart and associated with a clinical ventricular tachycardia (VT) event and second cardiac signals associated with an induced VT event. The sensor measures first and second cardiac parameters of the heart associated with the clinical and induced VT events, respectively. The external device is configured to receive the first and second cardiac signals associated with the clinical and the induced VT events and the first and second cardiac parameters associated with the clinical and the induced VT events. The external device compares the first and second cardiac signals and compares the first and second cardiac parameters to determine if the clinical and induced VT events are a common type of VT event.
摘要翻译：提供了包括可植入医疗装置（IMD），至少一个传感器和外部装置的心脏分析系统。 IMD具有位于心脏附近的电极，其感测心脏的第一心脏信号并与临床心室性心动过速（VT）事件和与诱导的VT事件相关联的第二心脏信号相关联。该传感器分别测量与临床和诱导VT事件相关的心脏的第一和第二心脏参数。外部设备被配置为接收与临床和诱导的VT事件相关联的第一和第二心脏信号以及与临床和诱导的VT事件相关联的第一和第二心脏参数。外部设备比较第一和第二心脏信号，并比较第一和第二心脏参数以确定临床和诱导的VT事件是否是常见类型的VT事件。

27. 发明授权

US08620457B2 Inter-atrial septum or superior vena cava electrodes for atrial defibrillation 失效
公开(公告)号：US08620457B2
公开(公告)日：2013-12-31
申请号：US11333503
申请日：2006-01-17
申请人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
发明人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
IPC分类号： A61N1/02
CPC分类号： A61N1/0563 , A61N1/395 , A61N1/3956 , A61N2001/0585
摘要： An implantable system for the defibrillation of the atria of a patient's heart comprises (a) a first catheter configured for insertion into the right atrium of the heart, preferably without extending into the right ventricle of the heart; a first atrial defibrillation electrode carried by the first catheter and positioned at the atrial septum of the heart (i.e., an atrial septum electrode); (b) a second atrial defibrillation electrode which together with the first atrial defibrillation electrode provides a pair of atrial defibrillation electrodes that are configured for orientation in or about the patient's heart to effect atrial defibrillation, and (c) a pulse generator operatively associated with the pair of atrial defibrillation electrodes for delivering a first atrial defibrillation pulse to the heart of the patient. The second electrode may be configured for positioning through the coronary sinus ostium and in the coronary sinus or a vein on the surface of the left ventricle, such as the great vein. An additional electrode configured for positioning in the superior vena cava, right atrium (including the right atrial appendage, or the right ventricle may also be included, and the pulse generator may be configured or programmed for concurrently delivering a first defibrillation pulse through the additional electrode and the atrial septum electrode, and a second defibrillation pulse through the atrial septum electrode and the second electrode. Electrode assemblies and methods useful for carrying out the invention are also disclosed.

28. 发明授权

US08340765B2 System and method for controlling ventricular pacing during AF based on underlying ventricular rates using an implantable medical device 有权
标题翻译：使用植入式医疗设备，根据潜在的心室率控制房颤期间心室起搏的系统和方法
公开(公告)号：US08340765B2
公开(公告)日：2012-12-25
申请号：US12410386
申请日：2009-03-24
申请人： Peter Boileau , Michael E. Benser
发明人： Peter Boileau , Michael E. Benser
IPC分类号： A61N1/36
CPC分类号： A61N1/3622 , A61N1/3702
摘要： Techniques are provided for controlling ventricular pacing during an episode of atrial fibrillation (AF) for use by a pacemaker, implantable cardioverter-defibrillator (ICD) or other implantable medical device. In one example, upon detection of AF, the underlying intrinsic ventricular rate of the patient is determined prior to delivering any ventricular pacing. Then, a ventricular pacing procedure—such as dynamic ventricular overdrive (DVO) pacing—is activated to reduce ventricular rate variability to mitigate the adverse effects of AF. The ventricular pacing procedure employed during AF is controlled based on a maximum ventricular rate set relative to the underlying intrinsic ventricular rate so as to keep an overall ventricular rate below the maximum rate.
摘要翻译：提供技术用于在心房颤动（AF）发作期间控制心室起搏，以供起搏器，可植入式心律转复除颤器（ICD）或其他可植入医疗装置使用。在一个实例中，在检测到AF后，在递送任何心室起搏之前确定患者的潜在内在心室率。然后，启动心室起搏手术，例如动态心室超速（DVO）起搏 - 以减少心室率变异性，以减轻AF的不良反应。在AF期间使用的心室起搏过程基于相对于潜在的内部心室率设定的最大心室率进行控制，以保持总体心率低于最大速率。

29. 发明授权

US07142927B2 Method and system for the selection of cardiac defibrillation shocks based on discomfort 失效
标题翻译：基于不适的选择心脏除颤休克的方法和系统
公开(公告)号：US07142927B2
公开(公告)日：2006-11-28
申请号：US10234624
申请日：2002-09-04
申请人： Michael E. Benser , Raymond E. Ideker , Milton M. Morris
发明人： Michael E. Benser , Raymond E. Ideker , Milton M. Morris
IPC分类号： A61N1/39
CPC分类号： A61N1/3925 , A61N1/3906
摘要： Methods, systems and computer program products for selecting a shock profile for a defibrillator based on patient discomfort to a plurality of different defibrillating shocks include delivering a first defibrillating shock having an associated first shock profile to a patient, and measuring the associated physical displacement of a selected region in the patient. A second defibrillating shock having an associated second shock profile is delivered to the patient, and the associated physical displacement of the selected region in measured. One of the first or second shock profiles is selected based on which shock profile has the lesser amount of measured physical displacement.
摘要翻译：用于基于多个不同除颤冲击的患者不适来选择用于除颤器的冲击波形的方法，系统和计算机程序产品包括将具有相关联的第一冲击波形的第一除颤冲击传递给患者，以及测量相关联的物理位移患者的选定区域。具有相关联的第二冲击波形的第二除颤冲击传递给患者，并且所测量的所选区域的相关物理位移。基于哪个冲击分布具有较少量的物理位移量来选择第一或第二冲击曲线之一。

30. 发明授权

US06804553B2 Bachmann's bundle electrode for atrial defibrillation 失效
标题翻译：巴赫曼的束电极用于心房除颤
公开(公告)号：US06804553B2
公开(公告)日：2004-10-12
申请号：US09978513
申请日：2001-10-15
申请人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
发明人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
IPC分类号： A61N139
CPC分类号： A61N1/0563 , A61N1/395 , A61N1/3956 , A61N2001/0585
摘要： An implantable system for the defibrillation of the atria of a patient's heart comprises (a) a first catheter configured for insertion into the right atrium of the heart; a first atrial defibrillation electrode carried by the first catheter and positioned to stimulate Bachmann's bundle, or positioned at the atrial septum of the heart (i.e., an atrial septum electrode); (b) a second atrial defibrillation electrode which together with the first atrial defibrillation electrode provides a pair of atrial defibrillation electrodes that are configured for orientation in or about the patient's heart to effect atrial defibrillation, and (c) a pulse generator operatively associated with the pair of atrial defibrillation electrodes for delivering a first atrial defibrillation pulse to the heart of the patient. The second electrode may be configured for positioning through the coronary sinus ostium and in the coronary sinus or a vein on the surface of the left ventricle, such as the great vein. An additional electrode configured for positioning in the superior vena cava, right atrium (including the right atrial appendage, or the right ventricle may also be included, and the pulse generator may be configured or programmed for concurrently delivering a first defibrillation pulse through the additional electrode and the atrial septum electrode, and a second defibrillation pulse through the atrial septum electrode and the second electrode. Electrode assemblies and methods useful for carrying out the invention are also disclosed.
摘要翻译：用于对患者心脏的心房进行除颤的可植入系统包括（a）构造成用于插入心脏右心房的第一导管; 由第一导管携带并定位成刺激巴赫曼氏束或定位在心脏的心房隔膜（即心房隔膜电极）处的第一心房除颤电极; （b）第二心房除颤电极，与第一心房除颤电极一起提供一对心房除颤电极，其构造成用于在患者心脏内或周围定向以实现心房除颤，以及（c）与一对心房除颤电极，用于将第一心房除颤脉冲输送到患者的心脏。第二电极可以被配置用于定位穿过冠状窦口和冠状窦或左心室表面的静脉，例如大静脉。还可以包括配置用于定位在上腔静脉，右心房（包括右心耳或右心室）中的附加电极，并且脉冲发生器可以被配置或编程用于同时递送通过附加电极的第一除颤脉冲以及通过心房隔膜电极和第二电极的第二除颤脉冲，还公开了用于实施本发明的电极组件和方法。

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