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1. 发明授权

US06743225B2 Electrophysiologic measure of endpoints for ablation lesions created in fibrillating substrates 失效
标题翻译：在原纤化底物中产生的消融损伤终点的电生理测量
公开(公告)号：US06743225B2
公开(公告)日：2004-06-01
申请号：US09818206
申请日：2001-03-27
申请人： Javier E. Sanchez , Jeffrey A. Hall , Michael E. Benser , Raymond E. Ideker , William M. Smith
发明人： Javier E. Sanchez , Jeffrey A. Hall , Michael E. Benser , Raymond E. Ideker , William M. Smith
IPC分类号： A61B1804
CPC分类号： A61B5/0422 , A61B18/1206 , A61B2018/00839 , A61B2562/0209 , A61B2562/043
摘要： Methods, systems, and computer program products measure electrical activity of the cardiac tissue proximate the lesion site during an ablation treatment, and then compare the measurements to determine whether the lesion is clinically efficacious so as to be able to block myocardial propagation. The methods can include obtaining the measurements and performing the ablation therapy while the subject is experiencing atrial fibrillation and may measure the standard deviation of the electrogram signal.
摘要翻译：方法，系统和计算机程序产品测量在消融治疗期间靠近病变部位的心脏组织的电活动，然后比较测量值以确定病变是临床有效的，以便能够阻断心肌的传播。所述方法可以包括在受试者正在经历心房颤动时获得测量并执行消融治疗，并且可以测量电描记图信号的标准偏差。

2. 发明授权

US08116885B2 Bachmann's bundle electrode for atrial defibrillation 失效
标题翻译：巴赫曼的束电极用于心房除颤
公开(公告)号：US08116885B2
公开(公告)日：2012-02-14
申请号：US10896648
申请日：2004-07-22
申请人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
发明人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
IPC分类号： A61N1/00
CPC分类号： A61N1/0563 , A61N2001/0585
摘要： An implantable system for the defibrillation of the atria of a patient's heart comprises (a) a first catheter configured for insertion into the right atrium of the heart; a first atrial defibrillation electrode carried by the first catheter and positioned to stimulate Bachmann's bundle, or positioned at the atrial septum of the heart (i.e., an atrial septum electrode); (b) a second atrial defibrillation electrode which together with the first atrial defibrillation electrode provides a pair of atrial defibrillation electrodes that are configured for orientation in or about the patient's heart to effect atrial defibrillation, and (c) a pulse generator operatively associated with the pair of atrial defibrillation electrodes for delivering a first atrial defibrillation pulse to the heart of the patient. The second electrode may be configured for positioning through the coronary sinus ostium and in the coronary sinus or a vein on the surface of the left ventricle, such as the great vein. An additional electrode configured for positioning in the superior vena cava, right atrium (including the right atrial appendage, or the right ventricle may also be included, and the pulse generator may be configured or programmed for concurrently delivering a first defibrillation pulse through the additional electrode and the atrial septum electrode, and a second defibrillation pulse through the atrial septum electrode and the second electrode. Electrode assemblies and methods useful for carrying out the invention are also disclosed.
摘要翻译：用于对患者心脏的心房进行除颤的可植入系统包括（a）构造成用于插入心脏右心房的第一导管; 由第一导管携带并定位成刺激巴赫曼氏束或定位在心脏的心房隔膜（即心房隔膜电极）处的第一心房除颤电极; （b）第二心房除颤电极，与第一心房除颤电极一起提供一对心房除颤电极，其构造成用于在患者心脏内或周围定向以实现心房除颤，以及（c）与一对心房除颤电极，用于将第一心房除颤脉冲输送到患者的心脏。第二电极可以被配置用于定位穿过冠状窦口和冠状窦或左心室表面的静脉，例如大静脉。还可以包括配置用于定位在上腔静脉，右心房（包括右心耳或右心室）中的附加电极，并且脉冲发生器可以被配置或编程为用于同时递送第一除颤脉冲通过附加电极以及通过心房隔膜电极和第二电极的第二除颤脉冲，还公开了用于实施本发明的电极组件和方法。

3. 发明授权

US07020518B2 Inter-atrial septum or superior vena cava electrodes for atrial defibrillation 失效
公开(公告)号：US07020518B2
公开(公告)日：2006-03-28
申请号：US10087340
申请日：2002-03-01
申请人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
发明人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
IPC分类号： A61N1/39
CPC分类号： A61N1/0563 , A61N1/395 , A61N1/3956 , A61N2001/0585
摘要： An implantable system for the defibrillation of the atria of a patient's heart comprises (a) a first catheter configured for insertion into the right atrium of the heart, preferably without extending into the right ventricle of the heart; a first atrial defibrillation electrode carried by the first catheter and positioned at the atrial septum of the heart (i.e., an atrial septum electrode); (b) a second atrial defibrillation electrode which together with the first atrial defibrillation electrode provides a pair of atrial defibrillation electrodes that are configured for orientation in or about the patient's heart to effect atrial defibrillation, and (c) a pulse generator operatively associated with the pair of atrial defibrillation electrodes for delivering a first atrial defibrillation pulse to the heart of the patient. The second electrode may be configured for positioning through the coronary sinus ostium and in the coronary sinus or a vein on the surface of the left ventricle, such as the great vein. An additional electrode configured for positioning in the superior vena cava, right atrium (including the right atrial appendage, or the right ventricle may also be included, and the pulse generator may be configured or programmed for concurrently delivering a first defibrillation pulse through the additional electrode and the atrial septum electrode, and a second defibrillation pulse through the atrial septum electrode and the second electrode. Electrode assemblies and methods useful for carrying out the invention are also disclosed.

4. 发明授权

US08620457B2 Inter-atrial septum or superior vena cava electrodes for atrial defibrillation 失效
公开(公告)号：US08620457B2
公开(公告)日：2013-12-31
申请号：US11333503
申请日：2006-01-17
申请人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
发明人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
IPC分类号： A61N1/02
CPC分类号： A61N1/0563 , A61N1/395 , A61N1/3956 , A61N2001/0585
摘要： An implantable system for the defibrillation of the atria of a patient's heart comprises (a) a first catheter configured for insertion into the right atrium of the heart, preferably without extending into the right ventricle of the heart; a first atrial defibrillation electrode carried by the first catheter and positioned at the atrial septum of the heart (i.e., an atrial septum electrode); (b) a second atrial defibrillation electrode which together with the first atrial defibrillation electrode provides a pair of atrial defibrillation electrodes that are configured for orientation in or about the patient's heart to effect atrial defibrillation, and (c) a pulse generator operatively associated with the pair of atrial defibrillation electrodes for delivering a first atrial defibrillation pulse to the heart of the patient. The second electrode may be configured for positioning through the coronary sinus ostium and in the coronary sinus or a vein on the surface of the left ventricle, such as the great vein. An additional electrode configured for positioning in the superior vena cava, right atrium (including the right atrial appendage, or the right ventricle may also be included, and the pulse generator may be configured or programmed for concurrently delivering a first defibrillation pulse through the additional electrode and the atrial septum electrode, and a second defibrillation pulse through the atrial septum electrode and the second electrode. Electrode assemblies and methods useful for carrying out the invention are also disclosed.

5. 发明授权

US07142927B2 Method and system for the selection of cardiac defibrillation shocks based on discomfort 失效
标题翻译：基于不适的选择心脏除颤休克的方法和系统
公开(公告)号：US07142927B2
公开(公告)日：2006-11-28
申请号：US10234624
申请日：2002-09-04
申请人： Michael E. Benser , Raymond E. Ideker , Milton M. Morris
发明人： Michael E. Benser , Raymond E. Ideker , Milton M. Morris
IPC分类号： A61N1/39
CPC分类号： A61N1/3925 , A61N1/3906
摘要： Methods, systems and computer program products for selecting a shock profile for a defibrillator based on patient discomfort to a plurality of different defibrillating shocks include delivering a first defibrillating shock having an associated first shock profile to a patient, and measuring the associated physical displacement of a selected region in the patient. A second defibrillating shock having an associated second shock profile is delivered to the patient, and the associated physical displacement of the selected region in measured. One of the first or second shock profiles is selected based on which shock profile has the lesser amount of measured physical displacement.
摘要翻译：用于基于多个不同除颤冲击的患者不适来选择用于除颤器的冲击波形的方法，系统和计算机程序产品包括将具有相关联的第一冲击波形的第一除颤冲击传递给患者，以及测量相关联的物理位移患者的选定区域。具有相关联的第二冲击波形的第二除颤冲击传递给患者，并且所测量的所选区域的相关物理位移。基于哪个冲击分布具有较少量的物理位移量来选择第一或第二冲击曲线之一。

6. 发明授权

US06804553B2 Bachmann's bundle electrode for atrial defibrillation 失效
标题翻译：巴赫曼的束电极用于心房除颤
公开(公告)号：US06804553B2
公开(公告)日：2004-10-12
申请号：US09978513
申请日：2001-10-15
申请人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
发明人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
IPC分类号： A61N139
CPC分类号： A61N1/0563 , A61N1/395 , A61N1/3956 , A61N2001/0585
摘要： An implantable system for the defibrillation of the atria of a patient's heart comprises (a) a first catheter configured for insertion into the right atrium of the heart; a first atrial defibrillation electrode carried by the first catheter and positioned to stimulate Bachmann's bundle, or positioned at the atrial septum of the heart (i.e., an atrial septum electrode); (b) a second atrial defibrillation electrode which together with the first atrial defibrillation electrode provides a pair of atrial defibrillation electrodes that are configured for orientation in or about the patient's heart to effect atrial defibrillation, and (c) a pulse generator operatively associated with the pair of atrial defibrillation electrodes for delivering a first atrial defibrillation pulse to the heart of the patient. The second electrode may be configured for positioning through the coronary sinus ostium and in the coronary sinus or a vein on the surface of the left ventricle, such as the great vein. An additional electrode configured for positioning in the superior vena cava, right atrium (including the right atrial appendage, or the right ventricle may also be included, and the pulse generator may be configured or programmed for concurrently delivering a first defibrillation pulse through the additional electrode and the atrial septum electrode, and a second defibrillation pulse through the atrial septum electrode and the second electrode. Electrode assemblies and methods useful for carrying out the invention are also disclosed.
摘要翻译：用于对患者心脏的心房进行除颤的可植入系统包括（a）构造成用于插入心脏右心房的第一导管; 由第一导管携带并定位成刺激巴赫曼氏束或定位在心脏的心房隔膜（即心房隔膜电极）处的第一心房除颤电极; （b）第二心房除颤电极，与第一心房除颤电极一起提供一对心房除颤电极，其构造成用于在患者心脏内或周围定向以实现心房除颤，以及（c）与一对心房除颤电极，用于将第一心房除颤脉冲输送到患者的心脏。第二电极可以被配置用于定位穿过冠状窦口和冠状窦或左心室表面的静脉，例如大静脉。还可以包括配置用于定位在上腔静脉，右心房（包括右心耳或右心室）中的附加电极，并且脉冲发生器可以被配置或编程用于同时递送通过附加电极的第一除颤脉冲以及通过心房隔膜电极和第二电极的第二除颤脉冲，还公开了用于实施本发明的电极组件和方法。

7. 发明授权

US06662045B2 Inter-atrial septum electrode for atrial defibrillation 失效
公开(公告)号：US06662045B2
公开(公告)日：2003-12-09
申请号：US09827535
申请日：2001-04-06
申请人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
发明人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
IPC分类号： A61N139
CPC分类号： A61N1/0563 , A61N1/395 , A61N1/3956 , A61N2001/0585
摘要： An implantable system for the defibrillation of the atria of a patient's heart comprises (a) a first catheter configured for insertion into the right atrium of the heart, preferably without extending into the right ventricle of the heart; a first atrial defibrillation electrode carried by the first catheter and positioned at the atrial septum of the heart (i.e., an atrial septum electrode); (b) a second atrial defibrillation electrode which together with the first atrial defibrillation electrode provides a pair of atrial defibrillation electrodes that are configured for orientation in or about the patient's heart to effect atrial defibrillation, and (c) a pulse generator operatively associated with the pair of atrial defibrillation electrodes for delivering a first atrial defibrillation pulse to the heart of the patient. The second electrode may be configured for positioning through the coronary sinus ostium and in the coronary sinus or a vein on the surface of the left ventricle, such as the great vein. An additional electrode configured for positioning in the superior vena cava, right atrium (including the right atrial appendage, or the right ventricle may also be included, and the pulse generator may be configured or programmed for concurrently delivering a first defibrillation pulse through the additional electrode and the atrial septum electrode, and a second defibrillation pulse through the atrial septum electrode and the second electrode. Electrode assemblies and methods useful for carrying out the invention are also disclosed.

8. 发明申请

US20090270936A1 IMPLANTABLE MEDICAL DEVICE WITH COORDINATED VENTRICULAR OVERDRIVE AND TRIGGER MODE PACING 审中-公开
标题翻译：具有协调的心脏超声和触发模式的可植入医疗装置
公开(公告)号：US20090270936A1
公开(公告)日：2009-10-29
申请号：US12111876
申请日：2008-04-29
申请人： Michael E. Benser , Euljoon Park
发明人： Michael E. Benser , Euljoon Park
IPC分类号： A61N1/36
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/3688
摘要： A method and system are provided for providing coordinated ventricular overdrive and triggered pacing through an implantable system. A lead senses signals from a heart to obtain sensed signals representative of tachycardia occurring in at least one chamber of the heart. The lead includes an electrode. A control module detects tachycardia in at least one chamber of the heart and based thereon, initiates an overdrive pacing mode and a triggered pacing mode. The control module controls delivery of overdrive pacing pulses through the electrode to a first chamber of the heart in accordance with the overdrive pacing mode. The control module controls delivery of a triggered pacing pulse through the electrode to the first chamber of the heart in accordance with the triggered pacing mode. The triggered pacing pulse is temporally interspersed with the overdrive pacing pulses. The triggered pacing pulse may be delivered at a time that is independent of, and unrelated to, the timing of the overdrive pacing pulses.
摘要翻译：提供了一种方法和系统，用于通过可植入系统提供协调的心室过度驱动和触发起搏。引线感测来自心脏的信号以获得代表在心脏的至少一个腔室中发生的心动过速的感测信号。引线包括电极。控制模块在心脏的至少一个室中检测心动过速，并且基于此，启动过速起搏模式和触发的起搏模式。控制模块根据超速起搏模式控制过驱动起搏脉冲通过电极传递到心脏的第一腔室。控制模块根据触发的起搏模式控制触发的起搏脉冲通过电极传递到心脏的第一腔室。触发起搏脉冲在时间上散布着超速起搏脉冲。触发的起搏脉冲可以在与过速起搏脉冲的定时无关并且不相关的时间被传送。

9. 发明授权

US07435221B1 System and method for detecting abnormal respiration based on intracardiac electrogram signals using a pattern recognition device 有权
标题翻译：使用模式识别装置，基于心内电描记信号检测异常呼吸的系统和方法
公开(公告)号：US07435221B1
公开(公告)日：2008-10-14
申请号：US11558819
申请日：2006-11-10
申请人： Rupinder Bharmi , Philip de Chazal , Gene A. Bornzin , Michael E. Benser
发明人： Rupinder Bharmi , Philip de Chazal , Gene A. Bornzin , Michael E. Benser
IPC分类号： A61B5/08 , A61B5/02 , A61B5/04
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/02405 , A61B5/0472 , A61B5/08 , A61B5/0803 , A61B5/0816 , A61B5/11 , A61B5/145 , A61B5/411 , A61B5/4818 , A61B5/7267 , A61N1/3601 , A61N1/365 , A61N1/37
摘要： Techniques are provided for detecting abnormal respiration within a patient based upon intracardiac electrogram (IEGM) signals or other electrical cardiac signals. Briefly, abnormal respiration is detected using a pattern recognition trained to discriminate normal and abnormal respiration based on morphological parameters and interval-based parameters extracted from the IEGM signals. In addition, techniques are described for distinguishing among different cardiac rhythm types within the patient while using one or more pattern classifiers or other pattern recognition devices.
摘要翻译：提供了用于基于心内电描记图（IEGM）信号或其他电心脏信号来检测患者内异常呼吸的技术。简而言之，使用根据从IEGM信号提取的形态参数和基于间隔的参数来鉴别正常和异常呼吸的训练的模式识别来检测异常呼吸。此外，描述了用于在使用一个或多个模式分类器或其他模式识别装置的同时区分患者内的不同心律类型之类的技术。

10. 发明申请

US20130204147A1 Atrial Fibrillation Detection Based On Pulmonary Artery Pressure Data 审中-公开
标题翻译：基于肺动脉压数据的心房颤动检测
公开(公告)号：US20130204147A1
公开(公告)日：2013-08-08
申请号：US13366106
申请日：2012-02-03
申请人： Andreas Blomqvist , Michael E. Benser
发明人： Andreas Blomqvist , Michael E. Benser
IPC分类号： A61B5/0215 , A61B5/021
CPC分类号： A61B5/0215 , A61B5/0002 , A61B5/02405 , A61B5/7282
摘要： Atrial fibrillation (AF) is detected based on pulmonary artery pressure (PAP) data. In some embodiments, PAP data generated by a PAP sensor device implanted in or near the pulmonary artery of a patient is processed to determine whether the patient is suffering from AF. In some aspects, detection of AF is based on identifying cycle-to-cycle variations of one or more parameters derived from the PAP data.
摘要翻译：基于肺动脉压（PAP）数据检测心房颤动（AF）。在一些实施例中，处理由植入在患者的肺动脉中或附近的PAP传感器装置生成的PAP数据，以确定患者是否患有AF。在一些方面，AF的检测基于识别从PAP数据导出的一个或多个参数的周期到周期的变化。

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