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21. 发明授权

US07435430B2 Natural sedative composition, process for obtaining the same and pharmaceutical formulations thereof 失效
标题翻译：天然镇静剂组合物，其获得方法和药物制剂
公开(公告)号：US07435430B2
公开(公告)日：2008-10-14
申请号：US10900203
申请日：2004-07-28
申请人： Shankar Kumar Mitra , Ekta Saxena , Marikunte Venkata Ranganna
发明人： Shankar Kumar Mitra , Ekta Saxena , Marikunte Venkata Ranganna
IPC分类号： A61K36/00
CPC分类号： A61K36/185 , A61K36/906 , A61K2300/00
摘要： Disclosed is a natural sedative composition for the treatment of insomnia, anxiety, stress and all kinds of sleep disorders, the composition comprising extract of plant Myristica fragrans and/or plant Hedychium spicatum and a pharmaceutically acceptable carrier. Also disclosed are methods for obtaining the plant extract and dosage forms.
摘要翻译：公开了用于治疗失眠，焦虑，压力和各种睡眠障碍的天然镇静组合物，所述组合物包含植物芝麻和/或植物Hedychium spicatum的提取物和药学上可接受的载体。还公开了获得植物提取物和剂型的方法。

22. 发明授权

US07223393B2 Amphiregulin antibodies and their use to treat cancer and psoriasis 有权
标题翻译：双调蛋白抗体及其用于治疗癌症和牛皮癣的用途
公开(公告)号：US07223393B2
公开(公告)日：2007-05-29
申请号：US10774076
申请日：2004-02-06
申请人： Nicholas F. Landolfi , Naoya Tsurushita , Paul R. Hinton , Shankar Kumar
发明人： Nicholas F. Landolfi , Naoya Tsurushita , Paul R. Hinton , Shankar Kumar
IPC分类号： A61K39/395
CPC分类号： G01N33/574 , A61K47/6855 , A61K2039/505 , C07K16/22 , C07K2317/73 , G01N2333/485
摘要： The present invention is directed to anti-AR antibodies, preferably humanized monoclonal antibodies having the amino acid sequences disclosed herein. The present invention includes a pharmaceutical composition comprising such antibodies. The present invention includes a method of inhibiting cancer cell growth comprising administering such antibodies into a subject. The present invention also provides a method of treating cancer or psoriasis in a subject in need of such a treatment by administering such antibodies to said subject in a pharmaceutically effective amount.
摘要翻译：本发明涉及抗AR抗体，优选具有本文公开的氨基酸序列的人源化单克隆抗体。本发明包括含有这种抗体的药物组合物。本发明包括抑制癌细胞生长的方法，其包括向受试者施用此类抗体。本发明还提供了通过以药学上有效量向所述受试者施用这种抗体来治疗需要这种治疗的受试者中的癌症或牛皮癣的方法。

23. 发明申请

US20070025912A1 Cytotoxicity mediation of cells evidencing surface expression of CD63 失效
标题翻译：证实CD63表面表达的细胞的细胞毒性调解
公开(公告)号：US20070025912A1
公开(公告)日：2007-02-01
申请号：US11362452
申请日：2006-02-24
申请人： David Young , Helen Findlay , Susan Hahn , Luis da Cruz , Daad Sayegh , Kristian Rogers , Shankar Kumar , Paul Hinton
发明人： David Young , Helen Findlay , Susan Hahn , Luis da Cruz , Daad Sayegh , Kristian Rogers , Shankar Kumar , Paul Hinton
IPC分类号： A61K51/00 , A61K39/395 , C07K16/46 , C07K16/30
CPC分类号： G01N33/57492 , A61K47/6849 , A61K47/6851 , A61K51/1027 , A61K51/1045 , A61K2039/505 , C07K16/2896 , C07K16/30 , C07K2317/24 , C07K2317/732 , C07K2317/92 , G01N33/56966 , G01N33/5743 , G01N2333/70596
摘要： This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMAB of the instant invention.
摘要翻译：本发明涉及癌症的诊断和治疗，特别涉及肿瘤细胞的细胞毒性的介导; 并且最特别地涉及使用任选与一种或多种化学治疗剂组合的癌性疾病修饰抗体（CDMAB）作为起始细胞毒性应答的手段。本发明还涉及利用本发明的CDMAB的结合测定法。

24. 发明申请

US20050252582A1 Thermoelectric properties by high temperature annealing 失效
标题翻译：高温退火的热电性能
公开(公告)号：US20050252582A1
公开(公告)日：2005-11-17
申请号：US11100950
申请日：2005-04-06
申请人： Zhifeng Ren , Gang Chen , Shankar Kumar , Hohyun Lee
发明人： Zhifeng Ren , Gang Chen , Shankar Kumar , Hohyun Lee
IPC分类号： C22C1/00 , C22C11/00 , C22C12/00 , C22C28/00 , C22F1/00 , H01L35/14 , H01L35/16 , H01L35/22
CPC分类号： H01L35/22 , C22C1/005 , C22C11/00 , C22C12/00 , C22C28/00 , C22F1/00 , H01L35/16
摘要： The present invention generally provides methods of improving thermoelectric properties of alloys by subjecting them to one or more high temperature annealing steps, performed at temperatures at which the alloys exhibit a mixed solid/liquid phase, followed by cooling steps. For example, in one aspect, such a method of the invention can include subjecting an alloy sample to a temperature that is sufficiently elevated to cause partial melting of at least some of the grains. The sample can then be cooled so as to solidify the melted grain portions such that each solidified grain portion exhibits an average chemical composition, characterized by a relative concentration of elements forming the alloy, that is different than that of the remainder of the grain.
摘要翻译：本发明通常提供了通过使合金呈现出一种或多种高温退火步骤来提高合金的热电性能的方法，所述高温退火步骤在合金呈现混合的固相/液相的温度下进行，然后进行冷却步骤。例如，在一个方面，本发明的这种方法可以包括使合金样品经受足够升高的温度以引起至少一些晶粒的部分熔融。然后可以将样品冷却以固化熔融的颗粒部分，使得每个固化的颗粒部分显示平均化学组成，其特征在于形成合金的元素的相对浓度，其不同于其余颗粒的元素的相对浓度。

25. 发明授权

US09039907B2 Methods for improving integrated photonic device uniformity 有权
标题翻译：提高集成光子器件均匀性的方法
公开(公告)号：US09039907B2
公开(公告)日：2015-05-26
申请号：US13552506
申请日：2012-07-18
申请人： Philippe Absil , Shankar Kumar Selvaraja
发明人： Philippe Absil , Shankar Kumar Selvaraja
IPC分类号： G01L21/30 , G01N21/95 , H01L21/66
CPC分类号： G01N21/9501 , G01B2210/56 , H01L22/12 , H01L22/20
摘要： A method is described for improving the uniformity over a predetermined substrate area of a spectral response of photonic devices fabricated in a thin device layer. The method includes (i) establishing an initial device layer thickness map for the predetermined area, (ii) establishing a linewidth map for the predetermined area, and (iii) establishing an etch depth map for the predetermined area. The method further includes, based on the initial device layer thickness map, the linewidth map and the etch depth map, calculating an optimal device layer thickness map and a corresponding thickness correction map for the predetermined substrate area taking into account photonic device design data. Still further, the method includes performing a location specific corrective etch process in accordance with the thickness correction map.
摘要翻译：描述了一种用于改善在薄的器件层中制造的光子器件的光谱响应的预定衬底区域上的均匀性的方法。该方法包括（i）建立用于预定区域的初始装置层厚度图，（ii）建立预定区域的线宽图，（iii）建立预定区域的蚀刻深度图。该方法还包括基于初始器件层厚度图，线宽图和蚀刻深度图，计算最佳器件层厚度图和用于预定衬底区域的相应厚度校正图，同时考虑光子器件设计数据。此外，该方法包括根据厚度校正图进行位置特定的校正蚀刻处理。

26. 发明授权

US09006399B2 Anti-OX40 antibodies and methods of using the same 有权
标题翻译：抗OX40抗体及其使用方法
公开(公告)号：US09006399B2
公开(公告)日：2015-04-14
申请号：US13818645
申请日：2011-08-23
申请人： Yong-Jun Liu , Kui Shin Voo , Laura Bover , Naoya Tsurushita , J. Yun Tso , Shankar Kumar
发明人： Yong-Jun Liu , Kui Shin Voo , Laura Bover , Naoya Tsurushita , J. Yun Tso , Shankar Kumar
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/75
摘要： Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.
摘要翻译：公开了与人OX40特异性结合的人抗体，优选重组人抗体，人源化和嵌合。优选的抗体对OX40受体具有高亲和力，并在体外和体内激活受体。抗体可以是全长抗体或其抗原结合部分。抗体或抗体部分可用于调节受体活性，例如在患有OX40活性有害的病症的人类受试者中。提供用于表达重组人抗体的核酸，载体和宿主细胞，并提供合成重组人抗体的方法。

27. 发明授权

US08825469B1 Techniques for translating documents including tags 有权
标题翻译：用于翻译包括标签的文档的技术
公开(公告)号：US08825469B1
公开(公告)日：2014-09-02
申请号：US13350897
申请日：2012-01-16
申请人： Sarveshwar Rao Duddu , Franz Josef Och , Eahab E. Ibrahim , Joshua James Estelle , Shankar Kumar
发明人： Sarveshwar Rao Duddu , Franz Josef Och , Eahab E. Ibrahim , Joshua James Estelle , Shankar Kumar
IPC分类号： G10L15/00
CPC分类号： G06F17/2854 , G06F17/2827 , G06F17/2836
摘要： A computer-implemented method includes receiving a document and a request to translate the document to a different language, the document including at least one tag associated with a first portion of text within the document, receiving a manual translation of the document translated by a human translator but not including the at least one tag, generating a plurality of alignments between the document and the manual translation using a statistical alignment model, selecting one of the plurality of alignments based on a likelihood that the first portion of text in the document corresponds to an aligned second portion of text within the manual translation, mapping a location of the tag in the document to a corresponding location within the manual translation based on the selected alignment, and inserting the at least one tag into the manual translation at the corresponding location to obtain a modified manual translation of the document.
摘要翻译：计算机实现的方法包括接收文档和将文档翻译成不同语言的请求，所述文档包括与文档中的文本的第一部分相关联的至少一个标签，接收由人翻译的文档的手动翻译翻译器，但不包括所述至少一个标签，使用统计对准模型在所述文档和所述手动翻译之间生成多个对齐，基于所述文档中的第一部分文本对应于的可能性来选择所述多个对齐中的一个在手动翻译中的对齐的文本的第二部分，基于所选择的对齐，将文档中的标签的位置映射到手动翻译内的对应位置，以及将至少一个标签插入到相应位置处的手动翻译获取文档的修改后的手动翻译。

28. 发明授权

US08813690B2 Engine control techniques to account for fuel effects 有权
标题翻译：引擎控制技术来解释燃油效应
公开(公告)号：US08813690B2
公开(公告)日：2014-08-26
申请号：US12916872
申请日：2010-11-01
申请人： Shankar Kumar , Timothy R. Frazier , Donald W. Stanton , Yi Xu , Bruce G. Bunting , Leslie R. Wolf
发明人： Shankar Kumar , Timothy R. Frazier , Donald W. Stanton , Yi Xu , Bruce G. Bunting , Leslie R. Wolf
IPC分类号： F02B75/12
CPC分类号： F02D41/0025 , F02B3/06 , F02B29/0406 , F02D19/061 , F02D19/088 , F02D2041/1433 , F02D2200/0611 , F02M26/05 , F02M26/06 , F02M26/23 , Y02T10/36
摘要： A technique for engine control to account for fuel effects including providing an internal combustion engine and a controller to regulate operation thereof, the engine being operable to combust a fuel to produce an exhaust gas; establishing a plurality of fuel property inputs; establishing a plurality of engine performance inputs; generating engine control information as a function of the fuel property inputs and the engine performance inputs; and accessing the engine control information with the controller to regulate at least one engine operating parameter.
摘要翻译：一种用于发动机控制以解决燃料效应的技术，包括提供内燃机和控制器以调节其操作，所述发动机可操作以燃烧燃料以产生废气; 建立多个燃料特性输入; 建立多个发动机性能输入; 根据燃料属性输入和发动机性能输入产生发动机控制信息; 以及利用所述控制器访问所述发动机控制信息以调节至少一个发动机操作参数。

29. 发明授权

US08670760B2 Converged mobile-web communications solution 有权
标题翻译：融合的移动网络通信解决方案
公开(公告)号：US08670760B2
公开(公告)日：2014-03-11
申请号：US12781566
申请日：2010-05-17
申请人： Bruce D. Lawler , Krishnakant M. Patel , Ravi Ayyasamy , Harisha M. Negalaguli , Binu Kaiparambil , Shiva K. K. Cheedella , Brahmananda R. Vempati , Ravi Shankar Kumar
发明人： Bruce D. Lawler , Krishnakant M. Patel , Ravi Ayyasamy , Harisha M. Negalaguli , Binu Kaiparambil , Shiva K. K. Cheedella , Brahmananda R. Vempati , Ravi Shankar Kumar
IPC分类号： H04W4/00
CPC分类号： H04M3/4931 , H04L51/04 , H04L51/38 , H04L65/1073 , H04L67/02 , H04M3/42365 , H04M2207/20
摘要： A converged mobile-Web communications solution interfaces to both a mobile phone network and an Internet or Intranet network, so that services that are provided to mobile phones in the mobile phone network are also provided to web clients or web widgets in the Internet or Intranet network.
摘要翻译：融合的移动Web通信解决方案与移动电话网络和因特网或内部网络网络相连接，使得提供给移动电话网络中的移动电话的服务也被提供给因特网或内部网络网络中的Web客户端或Web小部件。

30. 发明申请

US20130280275A1 ANTI-OX40 ANTIBODIES AND METHODS OF USING THE SAME 有权
公开(公告)号：US20130280275A1
公开(公告)日：2013-10-24
申请号：US13818645
申请日：2011-08-23
申请人： Yong-Jun Liu , Kui Shin Voo , Laura Bover , Naoya Tsurushita , J. Yun Tso , Shankar Kumar
发明人： Yong-Jun Liu , Kui Shin Voo , Laura Bover , Naoya Tsurushita , J. Yun Tso , Shankar Kumar
IPC分类号： C07K16/28
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/75
摘要： Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.

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