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1. 发明申请

US20110160982A1 ENGINE CONTROL TECHNIQUES TO ACCOUNT FOR FUEL EFFECTS 有权
标题翻译：发动机控制技术用于燃料效应
公开(公告)号：US20110160982A1
公开(公告)日：2011-06-30
申请号：US12916872
申请日：2010-11-01
申请人： Shankar Kumar , Timothy R. Frazier , Donald W. Stanton , Yi Xu , Bruce G. Bunting , Leslie R. Wolf
发明人： Shankar Kumar , Timothy R. Frazier , Donald W. Stanton , Yi Xu , Bruce G. Bunting , Leslie R. Wolf
IPC分类号： F02D41/00
CPC分类号： F02D41/0025 , F02B3/06 , F02B29/0406 , F02D19/061 , F02D19/088 , F02D2041/1433 , F02D2200/0611 , F02M26/05 , F02M26/06 , F02M26/23 , Y02T10/36
摘要： A technique for engine control to account for fuel effects including providing an internal combustion engine and a controller to regulate operation thereof, the engine being operable to combust a fuel to produce an exhaust gas; establishing a plurality of fuel property inputs; establishing a plurality of engine performance inputs; generating engine control information as a function of the fuel property inputs and the engine performance inputs; and accessing the engine control information with the controller to regulate at least one engine operating parameter.
摘要翻译：一种用于发动机控制以解决燃料效应的技术，包括提供内燃机和控制器以调节其操作，所述发动机可操作以燃烧燃料以产生废气; 建立多个燃料特性输入; 建立多个发动机性能输入; 根据燃料属性输入和发动机性能输入产生发动机控制信息; 以及利用所述控制器访问所述发动机控制信息以调节至少一个发动机操作参数。

2. 发明授权

US08813690B2 Engine control techniques to account for fuel effects 有权
标题翻译：引擎控制技术来解释燃油效应
公开(公告)号：US08813690B2
公开(公告)日：2014-08-26
申请号：US12916872
申请日：2010-11-01
申请人： Shankar Kumar , Timothy R. Frazier , Donald W. Stanton , Yi Xu , Bruce G. Bunting , Leslie R. Wolf
发明人： Shankar Kumar , Timothy R. Frazier , Donald W. Stanton , Yi Xu , Bruce G. Bunting , Leslie R. Wolf
IPC分类号： F02B75/12
CPC分类号： F02D41/0025 , F02B3/06 , F02B29/0406 , F02D19/061 , F02D19/088 , F02D2041/1433 , F02D2200/0611 , F02M26/05 , F02M26/06 , F02M26/23 , Y02T10/36
摘要： A technique for engine control to account for fuel effects including providing an internal combustion engine and a controller to regulate operation thereof, the engine being operable to combust a fuel to produce an exhaust gas; establishing a plurality of fuel property inputs; establishing a plurality of engine performance inputs; generating engine control information as a function of the fuel property inputs and the engine performance inputs; and accessing the engine control information with the controller to regulate at least one engine operating parameter.
摘要翻译：一种用于发动机控制以解决燃料效应的技术，包括提供内燃机和控制器以调节其操作，所述发动机可操作以燃烧燃料以产生废气; 建立多个燃料特性输入; 建立多个发动机性能输入; 根据燃料属性输入和发动机性能输入产生发动机控制信息; 以及利用所述控制器访问所述发动机控制信息以调节至少一个发动机操作参数。

3. 发明申请

US20110265773A1 Composition and Method for Reducing NOx and Smoke Emissions From Diesel Engines at Minimum Fuel Consumption 审中-公开
标题翻译：减少柴油发动机NOx和烟雾排放的最小燃料消耗量的组成和方法
公开(公告)号：US20110265773A1
公开(公告)日：2011-11-03
申请号：US12915908
申请日：2010-10-29
申请人： Yi Xu , Leslie R. Wolf , Shankar Kumar , Donald W. Stanton , Timothy R. Frazier , Bruce G. Bunting
发明人： Yi Xu , Leslie R. Wolf , Shankar Kumar , Donald W. Stanton , Timothy R. Frazier , Bruce G. Bunting
IPC分类号： F02D41/00 , C10L1/04 , F02D28/00
CPC分类号： F02D41/0025 , C10L1/08 , F02D19/061 , F02D19/0649 , F02D19/087 , F02M26/23 , F02M31/13 , F02M2200/95 , Y02T10/36
摘要： A diesel fuel composition is disclosed, as well as a method for reducing NOx and smoke emissions from a diesel engine at minimum fuel consumption which comprises adding to the diesel engine at least one diesel fuel or blending component for a diesel fuel which has a combination of a low T50 in the range of from 190° C. to 280° C., a high cetane number in the range of from 31 to 60, and optionally a high distillation curve slope in the range of from 58° C. to 140° C., which combination is effective to afford a combination of the lowest NOx and smoke emissions at the lowest fuel consumption at independent engine control values for the diesel engine that are optimum to afford production of a combination of the lowest NOx and smoke emissions at the lowest fuel consumption, whereby the NOx and smoke emissions from the diesel engine are reduced by at least 10% and 15%, respectively.
摘要翻译：公开了一种柴油燃料组合物，以及用于以最小燃料消耗量从柴油发动机减少NOx和烟雾排放的方法，其包括向柴油发动机添加至少一种用于柴油燃料的柴油燃料或混合组分，在190℃至280℃的范围内的低T50，在31至60范围内的高十六烷值，以及任选的在58℃至140℃范围内的高蒸馏曲线斜率 C.这种组合在柴油机的独立发动机控制值下以最低的燃料消耗提供最低的NOx和烟雾排放的组合是有效的，其最适于提供生产最低NOx和烟雾排放的组合燃油消耗最低，柴油发动机的NOx和烟气排放量分别降低了10％和15％。

4. 发明授权

US09028830B2 Antibodies to CD122 有权
标题翻译：抗CD122抗体
公开(公告)号：US09028830B2
公开(公告)日：2015-05-12
申请号：US13082352
申请日：2011-04-07
申请人： J. Yun Tso , Naoya Tsurushita , Nicholas F. Landolfi , Shankar Kumar
发明人： J. Yun Tso , Naoya Tsurushita , Nicholas F. Landolfi , Shankar Kumar
IPC分类号： A61K39/395 , C07K16/00 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/76
摘要： The invention provides monoclonal antibodies that specifically bind to CD122, which is one component of receptors for IL-2 and IL-15. The monoclonal antibodies have the capacity for substantial inhibition of both IL-2 and IL-15 mediated functions by inhibiting binding of these cytokines to their receptors. The monoclonal antibodies can be used for inhibiting undesired immune responses or treatment of cancer, among other applications.
摘要翻译：本发明提供了特异性结合CD122的单克隆抗体，CD122是IL-2和IL-15受体的一个组分。通过抑制这些细胞因子与其受体的结合，单克隆抗体具有对IL-2和IL-15介导的功能的显着抑制的能力。除了其它应用之外，单克隆抗体可用于抑制不期望的免疫应答或癌症的治疗。

5. 发明授权

US08617829B2 Humanized antibodies specific for amino acid sequence RGD of an extracellular matrix protein and the uses thereof 有权
公开(公告)号：US08617829B2
公开(公告)日：2013-12-31
申请号：US13497692
申请日：2010-09-22
申请人： Shankar Kumar , J. Yun Tso , Naoya Tsurushita
发明人： Shankar Kumar , J. Yun Tso , Naoya Tsurushita
IPC分类号： C12Q1/68 , C07K16/00 , C07K16/46 , C07K16/24
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： The present invention provides humanized antibodies that immunospecifically recognize the RGD sequence. Some of these antibodies inhibit the biological functions of the RGD proteins, thereby exhibiting therapeutic effects on various disorders or diseases that are associated with RGD proteins, including cancer, e.g., the growth and metastasis of a cancer cell, and inflammatory diseases, e.g., rheumatoid arthritis, osteoarthritis, hepatitis, endometriosis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerative colitis and Crohn's disease), an autoimmune disease, and so forth.

6. 发明授权

US08017118B2 Anti-hDlk-1 antibody having an antitumor activity in vivo 有权
标题翻译：具有体内抗肿瘤活性的抗hDlk-1抗体
公开(公告)号：US08017118B2
公开(公告)日：2011-09-13
申请号：US12404419
申请日：2009-03-16
申请人： Koji Nakamura , Rie Tajima , Shankar Kumar , J. Yun Tso , Naoya Tsurushita
发明人： Koji Nakamura , Rie Tajima , Shankar Kumar , J. Yun Tso , Naoya Tsurushita
IPC分类号： C07K16/18
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92 , G01N2800/00
摘要： The present invention provides antibodies specifically against hDlk-1 and having anti-tumor activity in vivo (anti-hDlk-1 antibodies), a fragments of the antibodies, hybridomas that produce the antibodies, a complex of the antibody or antibody fragment and an agent, a pharmaceutical composition comprising the antibody and the like, a tumor therapeutic agent, a tumor angiogenesis inhibitor, a tumor diagnostic agent, a method for detecting tumor, a kit for detecting and/or diagnosing tumor, etc.
摘要翻译：本发明提供抗体特异性抗体，并具有体内抗肿瘤活性（抗hDlk-1抗体），抗体片段，产生抗体的杂交瘤，抗体或抗体片段的复合物和药剂，包含抗体等的药物组合物，肿瘤治疗剂，肿瘤血管生成抑制剂，肿瘤诊断剂，肿瘤检测方法，肿瘤检测和/或诊断用试剂盒等。

7. 发明授权

US07591913B2 Thermoelectric properties by high temperature annealing 失效
标题翻译：高温退火的热电性能
公开(公告)号：US07591913B2
公开(公告)日：2009-09-22
申请号：US11100950
申请日：2005-04-06
申请人： Zhifeng Ren , Gang Chen , Shankar Kumar , Hohyun Lee
发明人： Zhifeng Ren , Gang Chen , Shankar Kumar , Hohyun Lee
IPC分类号： C22C1/00 , H01L21/00
CPC分类号： H01L35/22 , C22C1/005 , C22C11/00 , C22C12/00 , C22C28/00 , C22F1/00 , H01L35/16
摘要： The present invention generally provides methods of improving thermoelectric properties of alloys by subjecting them to one or more high temperature annealing steps, performed at temperatures at which the alloys exhibit a mixed solid/liquid phase, followed by cooling steps. For example, in one aspect, such a method of the invention can include subjecting an alloy sample to a temperature that is sufficiently elevated to cause partial melting of at least some of the grains. The sample can then be cooled so as to solidify the melted grain portions such that each solidified grain portion exhibits an average chemical composition, characterized by a relative concentration of elements forming the alloy, that is different than that of the remainder of the grain.
摘要翻译：本发明通常提供了通过使合金呈现出一种或多种高温退火步骤来提高合金的热电性能的方法，所述高温退火步骤在合金呈现混合的固相/液相的温度下进行，然后进行冷却步骤。例如，在一个方面，本发明的这种方法可以包括使合金样品经受足够升高的温度以引起至少一些晶粒的部分熔融。然后可以将样品冷却以固化熔融的颗粒部分，使得每个固化的颗粒部分显示平均化学组成，其特征在于形成合金的元素的相对浓度，其不同于其余颗粒的元素的相对浓度。

8. 发明授权

US09163085B2 Anti-OX40 antibodies and methods of treating cancer 有权
标题翻译：抗OX40抗体及其治疗方法
公开(公告)号：US09163085B2
公开(公告)日：2015-10-20
申请号：US14240535
申请日：2012-02-09
申请人： Yong-Jun Liu , Kui Shin Voo , Laura Bover , Naoya Tsurushita , J. Yun Tso , Shankar Kumar
发明人： Yong-Jun Liu , Kui Shin Voo , Laura Bover , Naoya Tsurushita , J. Yun Tso , Shankar Kumar
IPC分类号： C07K16/28 , A61K39/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/75
摘要： Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.
摘要翻译：公开了与人OX40特异性结合的人抗体，优选重组人抗体，人源化和嵌合。优选的抗体对OX40受体具有高亲和力，并在体外和体内激活受体。抗体可以是全长抗体或其抗原结合部分。抗体或抗体部分可用于调节受体活性，例如在患有OX40活性有害的病症的人类受试者中。提供用于表达重组人抗体的核酸，载体和宿主细胞，并提供合成重组人抗体的方法。

9. 发明授权

US08735552B2 Generation, expression and characterization of the humanized K33N monoclonal antibody 有权
标题翻译：人源化K33N单克隆抗体的产生，表达和表征
公开(公告)号：US08735552B2
公开(公告)日：2014-05-27
申请号：US13201847
申请日：2010-03-10
申请人： Shankar Kumar , J. Yun Tso , Naoya Tsurushita , Tatsuhiro Harada
发明人： Shankar Kumar , J. Yun Tso , Naoya Tsurushita , Tatsuhiro Harada
IPC分类号： C07K16/28
CPC分类号： C07K16/2839 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6887
摘要： The present invention provides humanized antibodies that immunospecifically recognize human 9 integrin. Some of these antibodies inhibit the biological functions of the 9 integrin, thereby exhibiting therapeutic effects on various disorders or diseases that are associated with 9 integrin, including cancer, e.g., the growth and metastasis of a cancer cell, and inflammatory diseases, e.g., rheumatoid arthritis, osteoarthritis, hepatitis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerative colitis and Crohn's disease), an autoimmune disease, and so forth.
摘要翻译：本发明提供免疫特异性识别人9整联蛋白的人源化抗体。这些抗体中的一些抑制9整联蛋白的生物学功能，从而对与9种整合素（包括癌症）相关的各种疾病或疾病表现出治疗效果，例如癌细胞的生长和转移，以及炎性疾病，例如类风湿关节炎，骨关节炎，肝炎，支气管哮喘，纤维化，糖尿病，动脉硬化，多发性硬化，肉芽肿，炎性肠病（溃疡性结肠炎和克罗恩病），自身免疫性疾病等。

10. 发明授权

US08635059B2 Providing alternative translations 有权
标题翻译：提供替代翻译
公开(公告)号：US08635059B2
公开(公告)日：2014-01-21
申请号：US13046468
申请日：2011-03-11
申请人： Joshua Estelle , Shankar Kumar , Wolfgang Macherey , Franz Josef Och , Peng Xu , Awaneesh Verma
发明人： Joshua Estelle , Shankar Kumar , Wolfgang Macherey , Franz Josef Och , Peng Xu , Awaneesh Verma
IPC分类号： G06F17/28
CPC分类号： G06F17/277 , G06F17/2818
摘要： Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for presenting alternative translations. In one aspect, a method includes receiving source language text; receiving translated text corresponding to the source language text from a machine translation system; receiving segmentation data for the translated text, wherein the segmentation data includes a first segmentation of the translated text, the first segmentation dividing the translated text into two or more segments; receiving one or more alternative translations for each of the two or more segments; presenting the source text and the translated text to a user in a user interface; and in response to a user selection of a first portion of the translated text, displaying, in the user interface, one or more alternative translations for a first segment to which the first portion of translated text corresponds according to the first segmentation.
摘要翻译：方法，系统和装置，包括在计算机存储介质上编码的用于呈现替代翻译的计算机程序。一方面，一种方法包括接收源语言文本; 从机器翻译系统接收与源语言文本相对应的翻译文本; 接收所述翻译文本的分割数据，其中所述分割数据包括所述翻译文本的第一分割，所述第一分割将所述翻译文本分割成两个或多个分段; 为所述两个或更多个段中的每一个接收一个或多个替代的翻译; 在用户界面中向用户呈现源文本和翻译文本; 并且响应于用户选择所述翻译文本的第一部分，在所述用户界面中，根据所述第一分割在所述翻译文本的第一部分对应的第一片段上显示一个或多个替代翻译。

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