专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20080140154A1 Flexible Communication and Control Protocol for a Wireless Sensor and Microstimulator Network 有权
标题翻译：无线传感器和微型激励器网络的灵活通信和控制协议
公开(公告)号：US20080140154A1
公开(公告)日：2008-06-12
申请号：US11773322
申请日：2007-07-03
申请人： Gerald E. Loeb , Jack Weissberg , Nuria Rodriguez
发明人： Gerald E. Loeb , Jack Weissberg , Nuria Rodriguez
IPC分类号： A61N1/05 , A61N1/08
CPC分类号： A61N1/37288 , A61N1/36003 , A61N1/36057 , A61N1/36139 , A61N1/37205
摘要： A novel system and method for restoring functional movement of a paralyzed limb(s) or a prosthetic device. Stimulating one or more muscles of a patient using an implanted neuromuscular implants and sensing the response of the stimulated muscle by the implants, wherein the sensing the response is not limited to data related to patient's movement intention, the posture, muscle extension, M-Wave and EMG. A communication and control protocol to operate the system safely and efficiently, use of forward and reverse telemetry channels having a limited bandwidth capacity, and minimizing the adverse consequences caused by errors in data transmission and intermittent loss of power to the implants. Adjusting stimulation rates and phases of the stimulator in order to achieve an efficient control of muscle force while minimizing fatigue and therefore providing for smooth movements and dynamic increase of the strength in patient's muscle contraction.
摘要翻译：一种用于恢复瘫痪肢体或假体装置的功能运动的新型系统和方法。使用植入的神经肌肉植入物刺激患者的一个或多个肌肉并感测植入物对受刺激肌肉的反应，其中感测反应不限于与患者的运动意图，姿势，肌肉伸展，M波和EMG。一种用于安全有效地操作系统的通信和控制协议，使用具有有限带宽容量的正向和反向遥测通道，并且最小化由于数据传输中的错误和对植入物的间歇性功率损耗而引起的不良后果。调整刺激器的刺激速率和阶段，以便实现肌肉力量的有效控制，同时最大限度地减少疲劳，从而提供平稳运动和动态增加患者肌肉收缩的强度。

22. 发明授权

US06895279B2 Method and apparatus to treat disorders of gastrointestinal peristalsis 有权
标题翻译：治疗胃肠道蠕动障碍的方法和装置
公开(公告)号：US06895279B2
公开(公告)日：2005-05-17
申请号：US09953425
申请日：2001-09-14
申请人： Gerald E. Loeb , Frances J. R. Richmond
发明人： Gerald E. Loeb , Frances J. R. Richmond
IPC分类号： A61N1/05 , A61N1/08 , A61N1/32 , A61N1/36 , A61N1/372 , A61N1/375
CPC分类号： A61N1/36007 , A61N1/37205 , A61N1/3756
摘要： Many patients suffer from diseases and surgical damage that result in failure of the stomach and intestinal tract to contract and relax normally in order to transfer contents distally. Electrical stimulation applied to one or more sites on the surface of the gastrointestinal viscera can treat this problem by triggering or altering muscle contractility. The present invention provides such stimulation by implanting leadless microstimulators in or on the walls of the viscera that can be programmed or controlled from a source outside the body.
摘要翻译：许多患者患有疾病和手术损伤，导致胃和肠道的失败，以便正常地收缩和松弛，以便远端转运内容物。对胃肠内脏表面上的一个或多个部位施加的电刺激可以通过触发或改变肌肉收缩力来治疗这个问题。本发明通过将无引导微刺激剂植入内脏的壁中或在内脏的壁上提供这种刺激，其可以从身体外部的源被编程或控制。

23. 发明授权

US06887667B2 Method and apparatus to identify small variations of biomolecules 有权
标题翻译：识别生物分子的小变异的方法和装置
公开(公告)号：US06887667B2
公开(公告)日：2005-05-03
申请号：US10025095
申请日：2001-12-18
申请人： Gerald E. Loeb
发明人： Gerald E. Loeb
IPC分类号： C12Q1/68 , G01N27/403 , G01N33/68 , C07H21/00 , C12P19/34
CPC分类号： G01N33/6803 , C12Q1/6837 , C12Q2565/607
摘要： Many diseases are related to variations in the genetically specified structure of proteins synthesized by cells. Genetic engineering is now able to identify the structural variations and to introduce new genes to synthesize more healthful proteins, but it is difficult actually to identify the specific protein or chemical variants in bodily fluids and extracts of tissues in order to diagnose diseases and to assess the effects of treatment. This invention provides apparatuses and methods which allow a user to finely discriminate between small variations in the structure, function and levels of specific biochemicals even when admixed with other biochemicals.
摘要翻译：许多疾病与由细胞合成的蛋白质的遗传特异性结构的变化有关。遗传工程现在能够识别结构变异并引入新的基因来合成更健康的蛋白质，但实际上难以鉴定体液和组织提取物中的特定蛋白质或化学变体以诊断疾病并评估治疗效果。本发明提供了允许使用者即使在与其他生物化学物质混合时，也可以精细地区分特定生物化学物质的结构，功能和水平的小变化的装置和方法。

24. 发明授权

US06658301B2 Method and apparatus for conditioning muscles during sleep 有权
公开(公告)号：US06658301B2
公开(公告)日：2003-12-02
申请号：US09952950
申请日：2001-09-13
申请人： Gerald E. Loeb , Frances J. R. Richmond
发明人： Gerald E. Loeb , Frances J. R. Richmond
IPC分类号： A61N140
CPC分类号： A61N1/36003 , A61N1/36014 , A61N1/37205 , A61N1/37229 , A61N1/37252 , A61N1/3787 , A61N2/006 , A61N2/02
摘要： A method and apparatus for conditioning muscles during sleep. The apparatus includes microminiature electrical stimulators that are injected into the muscles to be exercised and a system of transmission coils located in or on the mattress of a bed. The transmission coils transmit power and command signals to the implanted electrical stimulators while the patient sleeps or rests. The implanted electrical stimulators can be programmed so as to produce the desired pattern of muscle exercise without producing cutaneous sensations that would disturb the patient.

25. 发明授权

US06181965B2 Implantable microstimulator system for prevention of disorders 有权
标题翻译：用于预防疾病的植入性微刺激系统
公开(公告)号：US06181965B2
公开(公告)日：2001-01-30
申请号：US09490920
申请日：2000-01-25
申请人： Gerald E. Loeb , Frances J. R. Richmond
发明人： Gerald E. Loeb , Frances J. R. Richmond
IPC分类号： A61N100
CPC分类号： A61N1/375 , A61N1/08 , A61N1/326 , A61N1/36003 , A61N1/3605 , A61N1/37205 , A61N1/37211 , A61N1/37235 , A61N1/3756
摘要： Improved implantable microstimulators are covered with a biocompatible polymeric coating in order to provide increased strength to the capsule and to capture fragments of the microstimulator should it become mechanically disrupted. Such coating also makes the microstimulator safer and easier to handle. The coating may include one or more diffusible chemical agents that are released in a controlled manner into the surrounding tissue. The chemical agents, such as trophic factors, antibiotics, hormones, neurotransmitters and other pharmaceutical substances, are selected to produce desired physiological effects, to aid, support or to supplement the effects of the electrical stimulation. Further, microstimulators in accordance with the invention provide systems that prevent and/or treat various disorders associated with prolonged inactivity, confinement or immobilization of one or more muscles. Such disorders include pressure ulcers, venous emboli, autonomic dysreflexia, sensorimotor spasticity and muscle atrophy. The microstimulator systems include external control for controlling the operation of the microstimulators. The control includes memory for programming preferred stimulation patterns for later activation by the patient or caregiver.
摘要翻译：改进的可植入微刺激剂被生物相容的聚合物涂层覆盖，以便为胶囊提供增强的强度，并且如果它被机械地破坏，则捕获微刺激剂的碎片。这种涂层还使微型刺激仪更安全，更易于处理。涂层可以包括以受控方式释放到周围组织中的一种或多种可扩散化学试剂。选择化学试剂，如营养因子，抗生素，激素，神经递质和其他药物，以产生所需的生理作用，以帮助，支持或补充电刺激的作用。此外，根据本发明的微刺激剂提供了预防和/或治疗与延长的不活动，限制或固定一种或多种肌肉相关的各种障碍的系统。这种疾病包括压力性溃疡，静脉栓塞，自主神经反射异常，感觉痉挛和肌肉萎缩。微型激励器系统包括用于控制微型激励器的操作的外部控制。控制器包括用于编程优选刺激模式的存储器，以供稍后由患者或看护者激活。

26. 发明授权

US5601617A Multichannel cochlear prosthesis with flexible control of stimulus waveforms 失效
标题翻译：多通道耳蜗假体灵活控制刺激波形
公开(公告)号：US5601617A
公开(公告)日：1997-02-11
申请号：US429749
申请日：1995-04-26
申请人： Gerald E. Loeb , Michael A. Faltys
发明人： Gerald E. Loeb , Michael A. Faltys
IPC分类号： A61F11/04 , A61N1/36 , H04R25/00
CPC分类号： A61N1/36032
摘要： A method and system of readily specifying a wide range of temporospatial patterns of electrical stimulation waveforms that can be used by an implantable cochlear prosthesis. Such stimulation patterns and waveforms can thus be readily tested by an audiologist in the process of fitting the cochlear prosthesis, allowing desirable patterns of pulsatile stimuli of almost arbitrary complexity to be modulated in real-time by the acoustic signal to produce useful perceptions of sound in otherwise deaf patients. The cochlear prosthesis includes two main components: (1) an external system, and (2) an implantable system. The external system includes electronic circuitry, typically including a microprocessor, that converts sensed acoustical signals to electrical signals and processes the electrical signals in accordance with a desired speech processing strategy. The present invention facilitates the definition of complex stimulation waveforms to be used as part of the selected speech processing strategy. In a preferred embodiment, the stimulation patterns and waveforms are specified in a template table, the rows and columns of which define time intervals and stimulation sites. Alternatively, the stimulation patterns and waveforms may be specified in a list of spatial/temporal events.
摘要翻译：可以容易地指定可由可植入的耳蜗假体使用的电刺激波形的宽范围的时空空间模式的方法和系统。因此，这样的刺激模式和波形可以在拟合人工耳蜗的过程中被听力学家容易地测试，从而允许通过声学信号实时地调制几乎任意复杂的脉冲刺激的期望图案以产生有用的对声音的感知否则聋患者。耳蜗假体包括两个主要部件：（1）外部系统，和（2）可植入系统。外部系统包括通常包括微处理器的电子电路，其将感测的声学信号转换为电信号，并根据期望的语音处理策略处理电信号。本发明有助于将复杂刺激波形的定义用作所选语音处理策略的一部分。在优选实施例中，刺激模式和波形在模板表中指定，其行和列定义时间间隔和刺激位置。或者，可以在空间/时间事件的列表中指定刺激模式和波形。

27. 发明授权

US08401658B2 System and method for displaying stimulation field generated by electrode array 有权
标题翻译：用于显示由电极阵列产生的刺激场的系统和方法
公开(公告)号：US08401658B2
公开(公告)日：2013-03-19
申请号：US12948336
申请日：2010-11-17
申请人： Carla Mann Woods , David K. L. Peterson , Paul M. Meadows , Gerald E. Loeb
发明人： Carla Mann Woods , David K. L. Peterson , Paul M. Meadows , Gerald E. Loeb
IPC分类号： A61N1/08
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/37235 , A61N1/37247
摘要： An implantable pulse generator includes a current steering capability that allows a clinician or patient to quickly determine a desired electrode stimulation pattern, including which electrodes of a group of electrodes within an electrode array should receive a stimulation current, including the amplitude, width and pulse repetition rate of such current. Movement of the selected group of electrodes is facilitated through the use of remotely generated directional signals, generated by a pointing device, such as a joystick. As movement of the selected group of electrodes occurs, current redistribution amongst the various electrode contacts takes place. The redistribution of stimulus amplitudes utilizes re-normalization of amplitudes so that the perceptual level remains fairly constant. This prevents the resulting paresthesia from falling below the perceptual threshold or above the comfort threshold.
摘要翻译：可植入脉冲发生器包括电流转向能力，其允许临床医生或患者快速确定期望的电极刺激图案，包括电极阵列内的一组电极中的哪些电极应接收刺激电流，包括振幅，宽度和脉冲重复这样的比率。所选择的电极组的移动通过使用由诸如操纵杆的指示装置产生的远程产生的方向信号来促进。随着所选择的电极组的移动发生，各种电极接触件之间的电流再分配发生。刺激幅度的再分配利用振幅的再归一化，使得感知水平保持相当恒定。这可以防止由此产生的感觉异常降低到感知阈值以下或高于舒适阈值。

28. 发明授权

US08265762B2 Implantable pulse generator having current steering means 有权
标题翻译：具有电流转向装置的可植入式脉冲发生器
公开(公告)号：US08265762B2
公开(公告)日：2012-09-11
申请号：US12477019
申请日：2009-06-02
申请人： Carla Mann Woods , David K. L. Peterson , Paul M. Meadows , Gerald E. Loeb
发明人： Carla Mann Woods , David K. L. Peterson , Paul M. Meadows , Gerald E. Loeb
IPC分类号： A61N1/18
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/37235 , A61N1/37247
摘要： An implantable pulse generator includes a current steering capability that allows a clinician or patient to quickly determine a desired electrode stimulation pattern, including which electrodes of a group of electrodes within an electrode array should receive a stimulation current, including the amplitude, width and pulse repetition rate of such current. Movement of the selected group of electrodes is facilitated through the use of remotely generated directional signals, generated by a pointing device, such as a joystick. As movement of the selected group of electrodes occurs, current redistribution amongst the various electrode contacts takes place. The redistribution of stimulus amplitudes utilizes re-normalization of amplitudes so that the perceptual level remains fairly constant. This prevents the resulting paresthesia from falling below the perceptual threshold or above the comfort threshold.
摘要翻译：可植入脉冲发生器包括电流转向能力，其允许临床医生或患者快速确定期望的电极刺激图案，包括电极阵列内的一组电极中的哪些电极应接收刺激电流，包括振幅，宽度和脉冲重复这样的比率。所选择的电极组的移动通过使用由诸如操纵杆的指示装置产生的远程产生的方向信号来促进。随着所选择的电极组的移动发生，各种电极接触件之间的电流再分配发生。刺激幅度的再分配利用振幅的再归一化，使得感知水平保持相当恒定。这可以防止由此产生的感觉异常降低到感知阈值以下或高于舒适阈值。

29. 发明申请

US20120046712A1 IMPLANTABLE PULSE GENERATOR HAVING CURRENT STEERING MEANS 审中-公开
标题翻译：具有电流转向方式的可植入脉冲发生器
公开(公告)号：US20120046712A1
公开(公告)日：2012-02-23
申请号：US13280130
申请日：2011-10-24
申请人： Carla Mann Woods , David K.L. Peterson , Paul M. Meadows , Gerald E. Loeb
发明人： Carla Mann Woods , David K.L. Peterson , Paul M. Meadows , Gerald E. Loeb
IPC分类号： A61N1/36
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/37235 , A61N1/37247
摘要： An implantable pulse generator includes a current steering capability that allows a clinician or patient to quickly determine a desired electrode stimulation pattern, including which electrodes of a group of electrodes within an electrode array should receive a stimulation current, including the amplitude, width and pulse repetition rate of such current. Movement of the selected group of electrodes is facilitated through the use of remotely generated directional signals, generated by a pointing device, such as a joystick. As movement of the selected group of electrodes occurs, current redistribution amongst the various electrode contacts takes place. The redistribution of stimulus amplitudes utilizes re-normalization of amplitudes so that the perceptual level remains fairly constant. This prevents the resulting paresthesia from falling below the perceptual threshold or above the comfort threshold.
摘要翻译：可植入脉冲发生器包括电流转向能力，其允许临床医生或患者快速确定期望的电极刺激图案，包括电极阵列内的一组电极中的哪些电极应接收刺激电流，包括振幅，宽度和脉冲重复这样的比率。所选择的电极组的移动通过使用由诸如操纵杆的指示装置产生的远程产生的方向信号来促进。随着所选择的电极组的移动发生，各种电极接触件之间的电流再分配发生。刺激幅度的再分配利用振幅的再归一化，使得感知水平保持相当恒定。这可以防止由此产生的感觉异常降低到感知阈值以下或高于舒适阈值。

30. 发明申请

US20110060386A1 SYSTEM AND METHOD FOR DISPLAYING STIMULATION FIELD GENERATED BY ELECTRODE ARRAY 有权
标题翻译：用于显示由电极阵列产生的刺激场的系统和方法
公开(公告)号：US20110060386A1
公开(公告)日：2011-03-10
申请号：US12948336
申请日：2010-11-17
申请人： Carla Mann Woods , David K.L. Peterson , Paul M. Meadows , Gerald E. Loeb
发明人： Carla Mann Woods , David K.L. Peterson , Paul M. Meadows , Gerald E. Loeb
IPC分类号： A61N1/08
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/37235 , A61N1/37247
摘要： An implantable pulse generator includes a current steering capability that allows a clinician or patient to quickly determine a desired electrode stimulation pattern, including which electrodes of a group of electrodes within an electrode array should receive a stimulation current, including the amplitude, width and pulse repetition rate of such current. Movement of the selected group of electrodes is facilitated through the use of remotely generated directional signals, generated by a pointing device, such as a joystick. As movement of the selected group of electrodes occurs, current redistribution amongst the various electrode contacts takes place. The redistribution of stimulus amplitudes utilizes re-normalization of amplitudes so that the perceptual level remains fairly constant. This prevents the resulting paresthesia from falling below the perceptual threshold or above the comfort threshold.
摘要翻译：可植入脉冲发生器包括电流转向能力，其允许临床医生或患者快速确定期望的电极刺激图案，包括电极阵列内的一组电极中的哪些电极应接收刺激电流，包括振幅，宽度和脉冲重复这样的比率。所选择的电极组的移动通过使用由诸如操纵杆的指示装置产生的远程产生的方向信号来促进。随着所选择的电极组的移动发生，各种电极接触件之间的电流再分配发生。刺激幅度的再分配利用振幅的再归一化，使得感知水平保持相当恒定。这可以防止由此产生的感觉异常降低到感知阈值以下或高于舒适阈值。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式