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1. 发明申请

US20170304613A1 NERVE CUFF WITH POCKET FOR LEADLESS STIMULATOR 审中-公开
公开(公告)号：US20170304613A1
公开(公告)日：2017-10-26
申请号：US15645996
申请日：2017-07-10
申请人： Michael A. FALTYS , Roy C. MARTIN , Steven E. SCOTT , Gerald E. LOEB
发明人： Michael A. FALTYS , Roy C. MARTIN , Steven E. SCOTT , Gerald E. LOEB
IPC分类号： A61N1/05 , A61N1/372 , A61N1/36 , A61N1/375
CPC分类号： A61N1/0556 , A61N1/0558 , A61N1/36114 , A61N1/37205 , A61N1/375 , A61N1/3756
摘要： An extravascular nerve cuff that is configured to hold a leadless, integral, implantable microstimulator. The nerve cuff may include a cuff body having a pocket or pouch for removably receiving the implantable device within. The nerve cuff can be secured around the nerve such that the electrodes of the device are stably positioned relative to the nerve. Furthermore, the nerve cuff drives the majority of the current from the stimulation device into the nerve, while shielding surrounding tissues from unwanted stimulation.

2. 发明申请

US20160051813A1 NERVE CUFF WITH POCKET FOR LEADLESS STIMULATOR 有权
公开(公告)号：US20160051813A1
公开(公告)日：2016-02-25
申请号：US14931711
申请日：2015-11-03
申请人： Michael A. FALTYS , Roy C. MARTIN , Steven E. SCOTT , Gerald E. LOEB
发明人： Michael A. FALTYS , Roy C. MARTIN , Steven E. SCOTT , Gerald E. LOEB
IPC分类号： A61N1/05 , A61N1/375 , A61N1/372
CPC分类号： A61N1/0556 , A61N1/0558 , A61N1/36114 , A61N1/37205 , A61N1/375 , A61N1/3756
摘要： An extravascular nerve cuff that is configured to hold a leadless, integral, implantable microstimulator. The nerve cuff may include a cuff body having a pocket or pouch for removably receiving the implantable device within. The nerve cuff can be secured around the nerve such that the electrodes of the device are stably positioned relative to the nerve. Furthermore, the nerve cuff drives the majority of the current from the stimulation device into the nerve, while shielding surrounding tissues from unwanted stimulation.

3. 发明授权

US08181540B2 Measurement of sliding friction-induced vibrations for biomimetic tactile sensing 有权
标题翻译：用于仿生触觉感测的滑动摩擦引起的振动的测量
公开(公告)号：US08181540B2
公开(公告)日：2012-05-22
申请号：US12417532
申请日：2009-04-02
申请人： Gerald E. Loeb , Jeremy Fishel , Nicholas Wettels , Veronica J. Santos , Raymond Peck
发明人： Gerald E. Loeb , Jeremy Fishel , Nicholas Wettels , Veronica J. Santos , Raymond Peck
IPC分类号： G01L1/10 , G01L7/08 , G01L1/02 , G01L11/04
CPC分类号： G01L5/228
摘要： Tactile sensors are disclosed that mimic the human fingertip and its touch receptors. The mechanical components are similar to a fingertip, with a rigid core surrounded by a weakly conductive fluid contained within an elastomeric skin. The deformable properties of the finger pad can be used as part of a transduction process. Multiple electrodes can be mounted on the surface of the rigid core and connected to impedance measuring circuitry within the core. External forces deform the fluid path around the electrodes, resulting in a distributed pattern of impedance changes containing information about those forces and the objects that applied them. Strategies are described for extracting features related to the mechanical inputs and using this information for reflexive grip control. Controlling grip force in a prosthetic having sensory feedback information is described. Pressure transducers can provide sensory feedback by measuring micro-vibrations due to sliding friction.
摘要翻译：公开了模仿人类指尖及其触觉受体的触觉传感器。机械部件类似于指尖，刚性芯由包含在弹性体皮肤内的弱导电流体包围。指垫的可变形特性可以用作转导过程的一部分。多个电极可以安装在刚性芯的表面上并连接到芯内的阻抗测量电路。外力使电极周围的流体路径变形，导致阻抗变化的分布式图案包含关于这些力和施加它们的物体的信息。描述了用于提取与机械输入相关的特征的策略，并将该信息用于反身式握持控制。描述了在具有感觉反馈信息的假肢中控制握力。压力传感器可以通过测量由于滑动摩擦引起的微振动来提供感官反馈。

4. 发明授权

US08121701B2 System and method for displaying stimulation field generated by electrode array 有权
标题翻译：用于显示由电极阵列产生的刺激场的系统和方法
公开(公告)号：US08121701B2
公开(公告)日：2012-02-21
申请号：US12120162
申请日：2008-05-13
申请人： Carla Mann Woods , David K. L. Peterson , Paul Meadows , Gerald E. Loeb
发明人： Carla Mann Woods , David K. L. Peterson , Paul Meadows , Gerald E. Loeb
IPC分类号： A61N1/08
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/37235 , A61N1/37247
摘要： An implantable pulse generator includes a current steering capability that allows a clinician or patient to quickly determine a desired electrode stimulation pattern, including which electrodes of a group of electrodes within an electrode array should receive a stimulation current, including the amplitude, width and pulse repetition rate of such current. Movement of the selected group of electrodes is facilitated through the use of remotely generated directional signals, generated by a pointing device, such as a joystick. As movement of the selected group of electrodes occurs, current redistribution amongst the various electrode contacts takes place. The redistribution of stimulus amplitudes utilizes re-normalization of amplitudes so that the perceptual level remains fairly constant. This prevents the resulting paresthesia from falling below the perceptual threshold or above the comfort threshold.
摘要翻译：可植入脉冲发生器包括电流转向能力，其允许临床医生或患者快速确定期望的电极刺激图案，包括电极阵列内的一组电极中的哪些电极应接收刺激电流，包括振幅，宽度和脉冲重复这样的比率。所选择的电极组的移动通过使用由诸如操纵杆的指示装置产生的远程产生的方向信号来促进。随着所选择的电极组的移动发生，各种电极接触件之间的电流再分配发生。刺激幅度的再分配利用振幅的再归一化，使得感知水平保持相当恒定。这可以防止由此产生的感觉异常降低到感知阈值以下或高于舒适阈值。

5. 发明申请

US20090272201A1 ENHANCEMENTS TO IMPROVE THE FUNCTION OF A BIOMIMETIC TACTILE SENSOR 有权
标题翻译：增强生物传感器传感器的功能
公开(公告)号：US20090272201A1
公开(公告)日：2009-11-05
申请号：US12417535
申请日：2009-04-02
申请人： Gerald E. Loeb , Nicholas Wettels , Jeremy Fishel , Chia Hsien (Gary) Lin , Veronica J. Santos , Raymond Peck
发明人： Gerald E. Loeb , Nicholas Wettels , Jeremy Fishel , Chia Hsien (Gary) Lin , Veronica J. Santos , Raymond Peck
IPC分类号： G01D7/00 , G01K13/00
CPC分类号： G01L5/228
摘要： Tactile sensors are disclosed that mimic the human fingertip and its touch receptors. The mechanical components are similar to a fingertip, with a rigid core surrounded by a weakly conductive fluid contained within an elastomeric skin. The deformable properties of the finger pad can be used as part of a transduction process. Multiple electrodes can be mounted on the surface of the rigid core and connected to impedance measuring circuitry within the core. External forces deform the fluid path around the electrodes, resulting in a distributed pattern of impedance changes containing information about those forces and the objects that applied them. Strategies are described for extracting features related to the mechanical inputs and using this information for reflexive grip control. Controlling grip force in a prosthetic having sensory feedback information is described. Techniques are described for enhancing the useful force range for impedance sensors by internally texturing the elastomeric skin.
摘要翻译：公开了模仿人类指尖及其触觉受体的触觉传感器。机械部件类似于指尖，刚性芯由包含在弹性体皮肤内的弱导电流体包围。指垫的可变形特性可以用作转导过程的一部分。多个电极可以安装在刚性芯的表面上并连接到芯内的阻抗测量电路。外力使电极周围的流体路径变形，导致阻抗变化的分布式图案包含关于这些力和施加它们的物体的信息。描述了用于提取与机械输入相关的特征的策略，并将该信息用于反身式握持控制。描述了在具有感觉反馈信息的假肢中控制握力。描述了通过内部纹理弹性体皮肤来增强阻抗传感器的有用力范围的技术。

6. 发明授权

US07555347B2 Identification of target site for implantation of a microstimulator 有权
标题翻译：识别微型刺激器植入的靶位点
公开(公告)号：US07555347B2
公开(公告)日：2009-06-30
申请号：US11103197
申请日：2005-04-11
申请人： Gerald E. Loeb
发明人： Gerald E. Loeb
IPC分类号： A61N1/08
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/08
摘要： Devices and methods for locating a target site for the electrical stimulation of muscles are disclosed. The intensity of a search stimulus is varied continuously near the threshold to evoke an M-wave recorded by EMG electrodes. A feedback signal allows the clinician to judge when the threshold is sufficiently low to warrant the implantation of the stimulation electrodes at that site.
摘要翻译：公开了用于定位用于肌肉电刺激的目标部位的装置和方法。搜索刺激的强度在阈值附近变化，以引起由EMG电极记录的M波。反馈信号允许临床医生判断阈值何时足够低，以保证在该位置植入刺激电极。

7. 发明授权

US07555346B1 Implantable pulse generator having current steering means 有权
标题翻译：具有电流转向装置的可植入式脉冲发生器
公开(公告)号：US07555346B1
公开(公告)日：2009-06-30
申请号：US11158670
申请日：2005-06-21
申请人： Carla Mann Woods , David K. L Peterson , Paul M. Meadows , Gerald E. Loeb
发明人： Carla Mann Woods , David K. L Peterson , Paul M. Meadows , Gerald E. Loeb
IPC分类号： A61N1/18
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/37235 , A61N1/37247
摘要： An implantable pulse generator includes a current steering capability that allows a clinician or patient to quickly determine a desired electrode stimulation pattern, including which electrodes of a group of electrodes within an electrode array should receive a stimulation current, including the amplitude, width and pulse repetition rate of such current. Movement of the selected group of electrodes is facilitated through the use of remotely generated directional signals, generated by a pointing device, such as a joystick. As movement of the selected group of electrodes occurs, current redistribution amongst the various electrode contacts takes place. The redistribution of stimulus amplitudes utilizes re-normalization of amplitudes so that the perceptual level remains fairly constant. This prevents the resulting paresthesia from falling below the perceptual threshold or above the comfort threshold.
摘要翻译：可植入脉冲发生器包括电流转向能力，其允许临床医生或患者快速确定期望的电极刺激图案，包括电极阵列内的一组电极中的哪些电极应接收刺激电流，包括振幅，宽度和脉冲重复这样的比率。所选择的电极组的移动通过使用由诸如操纵杆的指示装置产生的远程产生的方向信号来促进。随着所选择的电极组的移动发生，各种电极接触件之间的电流再分配发生。刺激幅度的再分配利用振幅的再归一化，使得感知水平保持相当恒定。这可以防止由此产生的感觉异常降低到感知阈值以下或高于舒适阈值。

8. 发明申请

US20080221637A1 IMPLANTABLE PULSE GENERATOR HAVING CURRENT STEERING MEANS 有权
标题翻译：具有电流转向方式的可植入脉冲发生器
公开(公告)号：US20080221637A1
公开(公告)日：2008-09-11
申请号：US12120182
申请日：2008-05-13
申请人： Carla Mann Woods , David K.L. Peterson , Paul M. Meadows , Gerald E. Loeb
发明人： Carla Mann Woods , David K.L. Peterson , Paul M. Meadows , Gerald E. Loeb
IPC分类号： A61N1/00
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/37235 , A61N1/37247
摘要： An implantable pulse generator includes a current steering capability that allows a clinician or patient to quickly determine a desired electrode stimulation pattern, including which electrodes of a group of electrodes within an electrode array should receive a stimulation current, including the amplitude, width and pulse repetition rate of such current. Movement of the selected group of electrodes is facilitated through the use of remotely generated directional signals, generated by a pointing device, such as a joystick. As movement of the selected group of electrodes occurs, current redistribution amongst the various electrode contacts takes place. The redistribution of stimulus amplitudes utilizes re-normalization of amplitudes so that the perceptual level remains fairly constant. This prevents the resulting paresthesia from falling below the perceptual threshold or above the comfort threshold.
摘要翻译：可植入脉冲发生器包括电流转向能力，其允许临床医生或患者快速确定期望的电极刺激图案，包括电极阵列内的一组电极中的哪些电极应接收刺激电流，包括振幅，宽度和脉冲重复这样的比率。所选择的电极组的移动通过使用由诸如操纵杆的指示装置产生的远程产生的方向信号来促进。随着所选择的电极组的移动发生，各种电极接触件之间的电流再分配发生。刺激幅度的再分配利用振幅的再归一化，使得感知水平保持相当恒定。这可以防止由此产生的感觉异常降低到感知阈值以下或高于舒适阈值。

9. 发明申请

US20080215119A1 SYSTEM AND METHOD FOR DISPLAYING STIMULATION FIELD GENERATED BY ELECTRODE ARRAY 有权
标题翻译：用于显示由电极阵列产生的刺激场的系统和方法
公开(公告)号：US20080215119A1
公开(公告)日：2008-09-04
申请号：US12120162
申请日：2008-05-13
申请人： Carla Mann Woods , David K. L. Peterson , Paul M. Meadows , Gerald E. Loeb
发明人： Carla Mann Woods , David K. L. Peterson , Paul M. Meadows , Gerald E. Loeb
IPC分类号： A61N1/08
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/37235 , A61N1/37247
摘要： An implantable pulse generator includes a current steering capability that allows a clinician or patient to quickly determine a desired electrode stimulation pattern, including which electrodes of a group of electrodes within an electrode array should receive a stimulation current, including the amplitude, width and pulse repetition rate of such current. Movement of the selected group of electrodes is facilitated through the use of remotely generated directional signals, generated by a pointing device, such as a joystick. As movement of the selected group of electrodes occurs, current redistribution amongst the various electrode contacts takes place. The redistribution of stimulus amplitudes utilizes re-normalization of amplitudes so that the perceptual level remains fairly constant. This prevents the resulting paresthesia from falling below the perceptual threshold or above the comfort threshold.
摘要翻译：可植入脉冲发生器包括电流转向能力，其允许临床医生或患者快速确定期望的电极刺激图案，包括电极阵列内的一组电极中的哪些电极应接收刺激电流，包括振幅，宽度和脉冲重复这样的比率。所选择的电极组的移动通过使用由诸如操纵杆的指示装置产生的远程产生的方向信号来促进。随着所选择的电极组的移动发生，各种电极接触件之间的电流再分配发生。刺激幅度的再分配利用振幅的再归一化，使得感知水平保持相当恒定。这可以防止由此产生的感觉异常降低到感知阈值以下或高于舒适阈值。

10. 发明授权

US06909917B2 Implantable generator having current steering means 有权
标题翻译：具有电流转向装置的可植入式发电机
公开(公告)号：US06909917B2
公开(公告)日：2005-06-21
申请号：US10641905
申请日：2003-08-15
申请人： Carla Mann Woods , David K. L. Peterson , Paul M. Meadows , Gerald E. Loeb
发明人： Carla Mann Woods , David K. L. Peterson , Paul M. Meadows , Gerald E. Loeb
IPC分类号： A61N1/372 , A61N1/08
CPC分类号： A61N1/37247
摘要： An implantable pulse generator includes a current steering capability that allows a clinician or patient to quickly determine a desired electrode stimulation pattern, including which electrodes of a group of electrodes within an electrode array should receive a stimulation current, including the amplitude, width and pulse repetition rate of such current. Movement of the selected group of electrodes is facilitated through the use of remotely generated directional signals, generated by a pointing device, such as a joystick. As movement of the selected group of electrodes occurs, current redistribution amongst the various electrode contacts takes place. The redistribution of stimulus amplitudes utilizes re-normalization of amplitudes so that the perceptual level remains fairly constant. This prevents the resulting paresthesia from falling below the perceptual threshold or above the comfort threshold.
摘要翻译：可植入脉冲发生器包括电流转向能力，其允许临床医生或患者快速确定期望的电极刺激图案，包括电极阵列内的一组电极中的哪些电极应接收刺激电流，包括振幅，宽度和脉冲重复这样的比率。所选择的电极组的移动通过使用由诸如操纵杆的指示装置产生的远程产生的方向信号来促进。随着所选择的电极组的移动发生，各种电极接触件之间的电流再分配发生。刺激幅度的再分配利用振幅的再归一化，使得感知水平保持相当恒定。这可以防止由此产生的感觉异常降低到感知阈值以下或高于舒适阈值。

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