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21. 发明申请

WO2010060019A2 METHODS FOR CHARACTERIZING MOLECULES 审中-公开
标题翻译：表征分子的方法
公开(公告)号：WO2010060019A2
公开(公告)日：2010-05-27
申请号：PCT/US2009/065483
申请日：2009-11-23
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann M , LAHIRI, Joydeep , TRAN, Elizabeth
发明人： FANG, Ye , FERRIE, Ann M , LAHIRI, Joydeep , TRAN, Elizabeth
IPC分类号： G01N33/543 , G01N33/50 , G06F19/00
CPC分类号： G01N33/5023 , G01N33/5041 , G01N33/54373 , G01N2800/60 , G06F19/12
摘要： Drug discovery is a complex undertaking facing many challenges, not the least of which is a high attrition rate as many promising candidates prove ineffective or toxic in the clinic owing to a poor understanding of the diseases, and thus the biological systems, they target. Therefore, it is broadly agreed that to increase the productivity of drug discovery one needs a far deeper understanding of the molecular mechanisms of diseases, taking into account the full biological context of the drug target and moving beyond individual genes and proteins. The present methods rely on the use of label-free cellular assays, particularly the DMR index, to systematically display the mode of actions, the toxicity, and the target(s) and pathway(s) of any molecules.
摘要翻译：药物发现是面临许多挑战的复杂任务，其中最重要的是高损耗率，因为许多有希望的候选人因诊断不良而对生物系统造成影响，因此在诊所中无效或有毒。因此，普遍同意，为了提高药物发现的生产力，需要更深入地了解疾病的分子机制，同时考虑到药物靶标的完整生物学背景，超越个别基因和蛋白质。本方法依赖于使用无标记细胞测定法，特别是DMR指数来系统显示任何分子的作用模式，毒性以及靶标和途径。

22. 发明申请

WO2009045524A3 SYSTEM AND METHOD FOR DUAL-DETECTION OF A CELLULAR RESPONSE 审中-公开
公开(公告)号：WO2009045524A3
公开(公告)日：2009-04-09
申请号：PCT/US2008/011485
申请日：2008-10-03
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann M. , LAHIRI, Joydeep , MUDALIAR, Deepti J. , WU, Qi
发明人： FANG, Ye , FERRIE, Ann M. , LAHIRI, Joydeep , MUDALIAR, Deepti J. , WU, Qi
IPC分类号： G01N21/77 , G01N21/64
摘要： A system and method as defined herein for dual-detection of evanescent-wave label-free light and evanescent-wave excited-fluorescent label-emitted light in an optical biosensor.

23. 发明申请

WO2009045465A1 SINGLE-CELL LABEL-FREE ASSAY 审中-公开
标题翻译：单细胞无标签测定
公开(公告)号：WO2009045465A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/011404
申请日：2008-10-02
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann, M. , WU, Qi
发明人： FANG, Ye , FERRIE, Ann, M. , WU, Qi
IPC分类号： G01N21/55 , G01N33/50
CPC分类号： G01N33/5008 , G01N21/211 , G01N21/553 , G01N21/554 , G01N33/54373
摘要： The disclosure provides a system and method for characterizing a single live-cell response to a stimulus with a biosensor imaging system having cells immobilized on the biosensor at a resolution level of a single cell, as defined herein.
摘要翻译：本公开提供了一种系统和方法，用于利用具有如本文所定义的单个细胞的分辨率水平固定在生物传感器上的细胞的生物传感器成像系统来表征对刺激的单个活细胞响应。

24. 发明申请

WO2006108183A2 LABEL FREE BIOSENSORS AND CELLS 审中-公开
标题翻译：标签免费生物传感器和细胞
公开(公告)号：WO2006108183A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/013539
申请日：2006-04-05
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann, M. , FONTAINE, Norman, H , LAHIRI, Joydeep , YUEN, Po Ki
发明人： FANG, Ye , FERRIE, Ann, M. , FONTAINE, Norman, H , LAHIRI, Joydeep , YUEN, Po Ki
IPC分类号： C12Q1/02
CPC分类号： G01N33/5008 , G01N33/54373 , G01N33/554
摘要： Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in highthough put methods and can be multiplexed.
摘要翻译：公开了使用无标签光学生物传感器进行细胞测定的组合物和方法。在某些实施方案中，所述测定可以以放置方式进行并且可以被复用。

25. 发明申请

WO2006107506A2 SYSTEM AND METHOD FOR PERFORMING G PROTEIN COUPLED RECEPTOR (GPCR) CELL ASSAYS USING WAVEGUIDE-GRATING SENSORS 审中-公开
标题翻译：使用波导光栅传感器进行G蛋白偶联受体（GPCR）细胞测定的系统和方法
公开(公告)号：WO2006107506A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/008582
申请日：2006-03-10
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann, M. , FONTAINE, Norman, H. , YUEN, Po Ki , LAHIRI, Joydeep
发明人： FANG, Ye , FERRIE, Ann, M. , FONTAINE, Norman, H. , YUEN, Po Ki , LAHIRI, Joydeep
IPC分类号： G01N33/543 , G01N21/77 , G01N33/68
CPC分类号： G01N33/5041 , G01N21/4788 , G01N21/553 , G01N2333/726 , G01N2500/10
摘要： The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells based on the mass redistribution due to agonist-induced GPCR activation. In an extended embodiment, the present invention discloses different ways for self-referencing the optical LID biosensor to eliminate unwanted sensitivity to ambient temperature, pressure fluctuations, and other environmental changes. In yet another extended embodiment, the present invention discloses different ways for screening multiple GPCRs in a single type of cell or multiple GPCRs in multiple types of cells within a single medium solution. In still yet another extended embodiment, the present invention discloses different ways to confirm the physiological or pharmacological effect of a compound against a specific GPCR within living cells.
摘要翻译：本发明包括使用光学LID生物传感器来实时监测活细胞内激动剂诱导的GPCR信号传导事件的系统和方法。具体而言，本发明包括使用光学LID生物传感器基于由激动剂诱导的GPCR激活引起的质量重新分布来筛选针对活细胞内的靶GPCR的化合物的系统和方法。在扩展实施例中，本发明公开了用于自引用光学LID生物传感器以消除对周围温度，压力波动和其他环境变化的不期望的灵敏度的不同方式。在另一个扩展的实施方案中，本发明公开了用于在单一介质溶液内的多种类型的细胞中筛选单一类型的细胞中的多种GPCR或多种GPCR的不同方式。在另一个扩展的实施方案中，本发明公开了确认化合物针对活细胞内特定GPCR的生理学或药理学作用的不同方法。

26. 发明申请

WO9839446A3 70 human secreted proteins 审中-公开
标题翻译： 70种人体分泌的蛋白质
公开(公告)号：WO9839446A3
公开(公告)日：1998-12-23
申请号：PCT/US9804482
申请日：1998-03-06
申请人： HUMAN GENOME SCIENCES INC , RUBEN STEVEN M , ROSEN CRAIG A , FISCHER CARRIE L , SOPPET DANIEL R , CARTER KENNETH C , BEDNARIK DANIEL P , ENDRESS GREGORY A , YU GUO-LIANG , NI JIAN , FENG PING , YOUNG PAUL E , GREENE JOHN M , FERRIE ANN M , DUAN ROXANNE , HU JING-SHAN , GRAVES KIMBERLY A , OLSEN HENRIK S , EBNER REINHARD , BREWER LAURIE A , MOORE PAUL A , YU YANGGU , LAFLEUR DAVID W , LI YI , ZENG ZHIZHEN , KYAW HLA
发明人： RUBEN STEVEN M , ROSEN CRAIG A , FISCER DANIEL R , SOPPET DANIEL R , CARTER KENNETH C , BEDNARIK DANIEL P , ENDRESS GREGORY A , YU GUO-LIANG , NI JIAN , FENG PING , YOUNG PAUL E , GREENE JOHN M , FERRIE ANN M , DUAN ROXANNE , HU JING-SHAN , GRAVES KIMBERLY A , OLSEN HENRIK S , EBNER REINHARD , BREWER LAURIE A , MOORE PAUL A , SHI YANGGU , LAFLEUR DAVID W , LI YI , ZENG ZHIZHEN , KYAW HLA
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N5/02 , C12N15/11 , C12N15/12 , G01N33/68 , A61K38/17 , C07K16/18 , C12N5/10 , C12Q1/68 , G01N33/50 , G01N33/53
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/47 , C07K14/4718 , C12N15/11 , G01N33/68
摘要： The present invention relates to 70 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

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