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1. 发明公开

EP1161261A1 APOPTOSIS INDUCING MOLECULE II AND METHODS OF USE 审中-公开
标题翻译：凋亡诱导分子II和使用方法
公开(公告)号：EP1161261A1
公开(公告)日：2001-12-12
申请号：EP00914913.9
申请日：2000-03-10
申请人： Human Genome Sciences, Inc. , Ebner, Reinhard , Yu, Guo-Liang , Ruben, Steven M. , Zhai, Yifan , Ullrich, Stephen
发明人： EBNER, Reinhard , YU, Guo-Liang , RUBEN, Steven, M. , ZHAI, Yifan , ULLRICH, Stephen
IPC分类号： A61K39/395 , A61K38/17 , C07K14/705 , A61P37/00 , A61P35/00
CPC分类号： C07K16/2875 , A61K38/00 , A61K45/06 , C07K14/4747 , C07K14/70575 , C07K16/2866 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2319/30
摘要： The present invention relates to a novel member of the TNF-Ligand superfamily. More specifically, isolated nucleic acid molecules are provided encoding a human Apoptosis Inducing Molecule II (AIM II). AIM II polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, aberrant bone development, autoimmune and other immune system deseases, graft versus host desease, rheumatoid arthritis, osteoarthritis and to inhibit neoplasia, such as tumor cell growth.

2. 发明公开

EP1187849A1 METH1 AND METH2 POLYNUCLEOTIDES AND POLYPEPTIDES 审中-公开
标题翻译： METH1和METH2多核苷酸和多肽
公开(公告)号：EP1187849A1
公开(公告)日：2002-03-20
申请号：EP00932785.9
申请日：2000-05-25
申请人： HUMAN GENOME SCIENCES, INC. , SmithKline Beecham Corporation , Beth Israel Deaconess Medical Center , Iruela-Arispe, Luisa , Hastings, Gregg A. , Ruben, Steven M. , Jonak, Zdenka L. , Trulli, Stephen H. , Fornwald, James A. , Terrett, Jonathan A.
发明人： IRUELA-ARISPE, Luisa , HASTINGS, Gregg, A. , RUBEN, Steven, M. , JONAK, Zdenka, L. , TRULLI, Stephen, H. , FORNWALD, James, A. , TERRETT, Jonathan A.
IPC分类号： C07K14/00 , C12P21/00
CPC分类号： C07K14/78 , A61K38/00
摘要： The present invention relates to novel anti-angiogenic proteins, related to thrombospondin. More specifically, isolated nucleic acid molecules are provided encoding human METH1 and METH2. METH1 and METH2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for the prognosis of cancer and therapeutic methods for treating individuals in need of an increased amount of METH1 and METH2. Also provided are methods for inhibiting angiogenesis using METH1 or METH2.

3. 发明公开

EP1499353A2 ANTIBODIES THAT SPECIFICALLY BIND TO TL5 审中-公开
标题翻译：具体至TL5结合抗体
公开(公告)号：EP1499353A2
公开(公告)日：2005-01-26
申请号：EP03728362.9
申请日：2003-04-10
申请人： Human Genome Sciences, Inc. , Rosen, Craig A. , Ruben, Steven M.
发明人： ROSEN, Craig, A. , RUBEN, Steven, M.
IPC分类号： A61K39/42 , A61K39/395 , A61K51/10 , C07K16/00 , C07K16/18 , C12N5/24
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/21 , C07K2317/622 , C07K2317/76
摘要： The present invention relates to antibodies and related molecules that specifically bind to TL5. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy. The invention also relates to nucleic acid molecules encoding antiTL5 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to TL5.

4. 发明专利

AU2002351469A1 Acrp30-like polynucleotides, polypeptides, and antibodies 未知
公开(公告)号：AU2002351469A1
公开(公告)日：2003-04-22
申请号：AU2002351469
申请日：2002-10-11
申请人： HUMAN GENOME SCIENCES INC , RUBEN STEVEN M , BLONDEL OLIVIER
发明人： RUBEN STEVEN M , BLONDEL OLIVIER
IPC分类号： C07K14/47

5. 发明专利

AU2003234706A8 Antibodies that specifically bind to tl5 未知
公开(公告)号：AU2003234706A8
公开(公告)日：2003-11-03
申请号：AU2003234706
申请日：2003-04-10
申请人： RUBEN STEVEN M , ROSEN CRAIG A , HUMAN GENOME SCIENCES INC
发明人： RUBEN STEVEN M , ROSEN CRAIG A
IPC分类号： C07K16/28 , C12N5/24 , A61K39/42 , A61K39/395 , A61K51/10 , C07K16/00 , C07K16/18

6. 发明专利

AU5045900A Meth1 and meth2 polynucleotides and polypeptides 未知
公开(公告)号：AU5045900A
公开(公告)日：2000-12-12
申请号：AU5045900
申请日：2000-05-25
申请人： BETH ISRAEL DEACONESS MEDICAL CT INC , FORNWALD JAMES A , HASTINGS GREGG A , HUMAN GENOME SCIENCES INC , IRUELA ARISPE LUISA , JONAK ZDENKA L , RUBEN STEVEN M , SMITHKLINE BEECHAM CORP , TERRETT JONATHAN A , TRULLI STEPHEN H
发明人： IRUELA-ARISPE LUISA , HASTINGS GREGG A , RUBEN STEVEN M , JONAK ZDENKA L , TRULLI STEPHEN H , FORNWALD JAMES A , TERRETT JONATHAN A
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61K48/00 , A61P1/04 , A61P9/00 , A61P9/10 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P29/00 , A61P35/00 , C07K14/47 , C07K14/78 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C07K14/00 , C12P21/00
摘要： The present invention relates to novel anti-angiogenic proteins, related to thrombospondin. More specifically, isolated nucleic acid molecules are provided encoding human METH1 and METH2. METH1 and METH2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for the prognosis of cancer and therapeutic methods for treating individuals in need of an increased amount of METH1 or METH2. Also provided are methods for inhibiting angiogenesis using METH1 or METH2.

7. 发明专利

AU2002351469A8 Acrp30-like polynucleotides, polypeptides, and antibodies 未知
公开(公告)号：AU2002351469A8
公开(公告)日：2006-11-02
申请号：AU2002351469
申请日：2002-10-11
申请人： HUMAN GENOME SCIENCES INC , RUBEN STEVEN M , BLONDEL OLIVIER
发明人： RUBEN STEVEN M , BLONDEL OLIVIER
IPC分类号： C12Q1/68 , A61K49/00 , C07K14/47 , C12N5/00 , C12N15/00

8. 发明专利

AU2003234706A1 ANTIBODIES THAT SPECIFICALLY BIND TO TL5 未知
公开(公告)号：AU2003234706A1
公开(公告)日：2003-11-03
申请号：AU2003234706
申请日：2003-04-10
申请人： ROSEN CRAIG A , RUBEN STEVEN M , HUMAN GENOME SCIENCES INC
发明人： RUBEN STEVEN M , ROSEN CRAIG A
IPC分类号： C07K16/28 , C12N5/24

9. 发明申请

WO0155313A3 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155313A3
公开(公告)日：2007-11-15
申请号：PCT/US0101323
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： C12N15/00 , A61K38/00 , A61K48/00 , C07K1/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6424 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel excretory system related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "excretory system antigens", and the use of such excretory system antigens for detecting disorders of the excretory system, particularly the presence of cancer of excretory system tissues and cancer metastases. More specifically, isolated excretory system associated nucleic acid molecules are provided encoding novel excretory system associated polypeptides. Novel excretory system polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human excretory system associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the excretory system, including cancer of excretory system tissues, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新的排泄系统相关多核苷酸和由这些多核苷酸编码的多肽本文统称为“排泄系统抗原”，以及这种排泄系统抗原用于检测排泄系统疾病，特别是排泄物癌症的存在系统组织和癌症转移。更具体地，提供了分离的排泄系统相关核酸分子，其编码新的排泄系统相关多肽。提供了与这些多肽结合的新型排泄系统多肽和抗体。还提供载体，宿主细胞，以及用于产生人排泄系统相关多核苷酸和/或多肽的重组和合成方法。本发明还涉及可用于诊断，治疗，预防和/或预测与排泄系统相关的疾病，包括排泄系统组织的癌症以及治疗这些疾病的治疗方法的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。

10. 发明申请

WO2004042000A2 157 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 157人类分泌蛋白
公开(公告)号：WO2004042000A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/015439
申请日：2003-05-16
申请人： HUMAN GENOME SCIENCES, INC. , ROSEN, Craig, A. , RUBEN, Steven, M. , OLSEN, Henrik , BAKER, Kevin, P. , FISCELLA, Michele , WEI, Ping , BIRSE, Charles, E. , KOMATSOULIS, George , CHOI, Gil, H. , MOORE, Paul, A. , GUPTA, Ram , SHI, Yanggu
发明人： ROSEN, Craig, A. , RUBEN, Steven, M. , OLSEN, Henrik , BAKER, Kevin, P. , FISCELLA, Michele , WEI, Ping , BIRSE, Charles, E. , KOMATSOULIS, George , CHOI, Gil, H. , MOORE, Paul, A. , GUPTA, Ram , SHI, Yanggu
IPC分类号： C12N
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

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