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21. 发明授权

US09075146B1 Wireless, motion and position-sensing, integrating radiation sensor for occupational and environmental dosimetry 有权
标题翻译：无线，运动和位置感应，用于职业和环境剂量测定的辐射传感器
公开(公告)号：US09075146B1
公开(公告)日：2015-07-07
申请号：US14269226
申请日：2014-05-05
申请人： LANDAUER, INC.
发明人： Daniel J. Valentino , James R. Thistlethwaite, III , R. Craig Yoder
IPC分类号： G01J1/00 , G01T7/00
CPC分类号： G01T1/02 , G01J1/0219 , G01J1/0488 , G01J1/4204 , G01P15/00 , G01T1/026 , G01T1/16 , G01T1/167 , G01T1/17 , G01T1/244 , G01T3/08 , G01T7/00 , G01V5/0083 , G01V5/025 , H04W4/02 , H04W84/18
摘要： Described is a radiation dosimeter including multiple sensor devices (including one or more passive integrating electronic radiation sensor, a MEMS accelerometers, a wireless transmitters and, optionally, a GPS, a thermistor, or other chemical, biological or EMF sensors) and a computer program for the simultaneous detection and wireless transmission of ionizing radiation, motion and global position for use in occupational and environmental dosimetry. The described dosimeter utilizes new processes and algorithms to create a self-contained, passive, integrating dosimeter. Furthermore, disclosed embodiments provide the use of MEMS and nanotechnology manufacturing techniques to encapsulate individual ionizing radiation sensor elements within a radiation attenuating material that provides a “filtration bubble” around the sensor element, the use of multiple attenuating materials (filters) around multiple sensor elements, and the use of a software algorithm to discriminate between different types of ionizing radiation and different radiation energy.
摘要翻译：描述了包括多个传感器装置（包括一个或多个无源积分电子辐射传感器，MEMS加速度计，无线发射器，以及可选地，GPS，热敏电阻或其它化学，生物或EMF传感器）和计算机程序用于电离辐射的同时检测和无线传输，用于职业和环境剂量测定的运动和全局位置。所描述的剂量计利用新的过程和算法来创建一个独立的，被动的，积分的剂量计。此外，所公开的实施例提供了MEMS和纳米技术制造技术的用途，以将单独的电离辐射传感器元件封装在辐射衰减材料内，辐射衰减材料围绕传感器元件提供“过滤气泡”，在多个传感器元件周围使用多个衰减材料，以及使用软件算法来区分不同类型的电离辐射和不同的辐射能量。

22. 发明授权

US08764695B2 Reduction of galectin-3 levels by plasmapheresis 有权
标题翻译：通过血浆去除术降低半乳凝素-3水平
公开(公告)号：US08764695B2
公开(公告)日：2014-07-01
申请号：US13629932
申请日：2012-09-28
申请人： Isaac Eliaz
发明人： Isaac Eliaz
IPC分类号： A61M1/14 , A61M1/16 , A61M1/34 , A61M1/36 , A61M1/38
CPC分类号： A61M1/3472 , A61M1/14 , A61M1/16 , A61M1/34 , A61M1/3403 , A61M1/3486 , A61M1/3496 , A61M1/36 , A61M1/3679 , A61M1/38
摘要： The invention is directed to the removal of serum gal-3 from circulation by plasmapheresis using gal-3 binding agents in either a fixed bed, or in a form easily removed, such as by being complexed with magnetic particles. This method, on its own, brings a sharp reduction and relief from the inflammation and fibroses that can be induced by circulating gal-3. The process may be combined with the administration of gal-3 binding agents, such as modified citrus pectin, to further lower unbound gal-3 levels, to the point where gal-3 in the tissues may be addressed. This method may also be combined with removal of TNF receptors to provide an effective treatment for cancer.
摘要翻译：本发明涉及通过使用gal-3结合剂在固定床中或以易于除去的形式例如通过与磁性颗粒络合的血浆去除血浆gal-3从循环中除去血清gal-3。这种方法本身就能通过循环gal-3引起的炎症和纤维的急剧减少和缓解。该方法可以与施用gal-3结合剂（例如修饰的柑橘果胶）组合以进一步降低未结合的gal-3水平，从而可以解决组织中gal-3的程度。该方法也可以与去除TNF受体相结合以提供对癌症的有效治疗。

23. 发明授权

US08651363B2 Joining method and device produced by this method and joining unit 有权
标题翻译：通过该方法和接合单元生产的接合方法和装置
公开(公告)号：US08651363B2
公开(公告)日：2014-02-18
申请号：US13297349
申请日：2011-11-16
申请人： Tadatomo Suga , Masuaki Okada
发明人： Tadatomo Suga , Masuaki Okada
IPC分类号： B23K31/02 , H01L21/30
CPC分类号： G02B6/4232 , B23K20/023 , B23K20/16 , B23K20/22 , B23K20/233 , B23K2101/42 , B23K2103/12 , G02B6/4214 , H01L21/67092 , H01L21/67144 , H01L24/75 , H01L24/81 , H01L24/97 , H01L25/0657 , H01L25/50 , H01L2224/0401 , H01L2224/0558 , H01L2224/05644 , H01L2224/13144 , H01L2224/13147 , H01L2224/16 , H01L2224/48463 , H01L2224/75 , H01L2224/75252 , H01L2224/75822 , H01L2224/7592 , H01L2224/81009 , H01L2224/81013 , H01L2224/81054 , H01L2224/81121 , H01L2224/81205 , H01L2224/81208 , H01L2224/81801 , H01L2224/8183 , H01L2224/81894 , H01L2224/97 , H01L2225/06513 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01018 , H01L2924/01019 , H01L2924/01023 , H01L2924/01024 , H01L2924/01029 , H01L2924/01033 , H01L2924/0105 , H01L2924/01058 , H01L2924/01068 , H01L2924/01074 , H01L2924/01075 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/12041 , H01L2924/1461 , H01L2924/19041 , H01S5/02252 , H01S5/02268 , H01S5/02272 , H01S5/02284 , H01S5/02292 , H01L2924/00014 , H01L2224/81 , H01L2924/00
摘要： A practical bonding technique is provided for solid-phase room-temperature bonding not requiring a profile irregularity of the order of several nanometers, in which a high-vacuum energy wave treatment and continuous high-vacuum bonding are not required. Since an adhering substance layer is thin immediately after a surface activating treatment using an energy wave, a bonding interface is spread by crushing the adhering substance layer to perform bonding, so that a new surface appears on a bonding surface, and objects to be bonded are bonded together. In order to crush the adhering substance layer more easily, a bonding metal of a bonding portion of the object to be bonded requires a low hardness. According to the results of various experiments conducted by the present inventors, it was found that the hardness of the bonding portion which is a Vickers hardness of 200 Hv or less is particularly effective for room-temperature bonding.
摘要翻译：提供了一种实用的接合技术，用于不需要几纳米级的不规则形状的固相室温接合，其中不需要高真空能量波处理和连续高真空接合。由于在使用能量波进行表面活化处理之后立即使粘附物质层变薄，所以通过粉碎附着物质层进行接合来扩散接合界面，从而在接合面上出现新的表面，被接合物结合在一起为了更容易地粉碎附着物质层，被接合物的接合部的接合金属需要低硬度。根据本发明人进行的各种实验的结果，发现维氏硬度为200Hv以下的接合部的硬度对于室温接合特别有效。

24. 发明授权

US08646921B2 Reflective marker being radio-opaque for MRI 有权
标题翻译：用于MRI的反射标记不透射线
公开(公告)号：US08646921B2
公开(公告)日：2014-02-11
申请号：US13408386
申请日：2012-02-29
申请人： Helen Zinreich Shafer , David Alan Zinreich , Douglas Crumb
发明人： Helen Zinreich Shafer , David Alan Zinreich , Douglas Crumb
IPC分类号： G02B5/132
CPC分类号： G01T1/105 , B65D75/327 , B65D75/36 , B65D85/58 , B65D2575/3281 , B65D2575/329 , G01T1/2014 , G02B5/134
摘要： Described is a device comprising a retro-reflective marker sphere comprising: a core ball comprising: a generally spherical body portion, a mounting base extending from one end of the body portion of the core ball, and a mounting recess having a recess opening in the mounting base and extending into the body portion of the core ball, and a retro-reflective covering on the core ball, the retro-reflective covering comprising an opening through which the mounting base of the core ball extends, wherein a flat lower surface of the mounting base is spaced proximally from a lower edge of the opening of the retro-reflective covering, and wherein the mounting recess includes an interior screw thread for engaging an exterior screw thread of a mounting post when the retro-reflective marker sphere is mounted on the mounting post.
摘要翻译：描述了一种包括回射标记球的装置，包括：芯球，包括：大体上球形的主体部分，从芯球的主体部分的一端延伸的安装基座和在其中具有凹部开口的安装凹部安装基座并延伸到芯球的主体部分中，以及在芯球上的后向反射覆盖物，所述回射覆盖物包括开口，芯球的安装基座穿过该开口延伸，其中，安装基座从后向反射覆盖物的开口的下边缘向近侧间隔开，并且其中安装凹部包括用于当将反射式标记球安装在安装座上时与安装柱的外螺纹接合的内螺纹安装柱

25. 发明授权

US08641210B2 Retro-reflective marker including colored mounting portion 有权
标题翻译：反光标记包括彩色安装部分
公开(公告)号：US08641210B2
公开(公告)日：2014-02-04
申请号：US13408124
申请日：2012-02-29
申请人： Helen Zinreich Shafer , David Alan Zinreich , Douglas Crumb
发明人： Helen Zinreich Shafer , David Alan Zinreich , Douglas Crumb
IPC分类号： G02B5/12
CPC分类号： G01T1/105 , B65D75/327 , B65D75/36 , B65D85/58 , B65D2575/3281 , B65D2575/329 , G01T1/2014 , G02B5/134
摘要： Described is a device comprising a retro-reflective marker sphere comprising: a core ball comprising: a generally spherical body portion, a mounting base extending from one end of the body portion of the core ball, and a mounting recess having a recess opening in the mounting base and extending into the body portion of the core ball, and a retro-reflective covering on the core ball, the retro-reflective covering comprising an opening through which the mounting base of the core ball extends, wherein a flat lower surface of the mounting base is spaced proximally from a lower edge of the opening of the retro-reflective covering, and wherein the mounting recess includes an interior screw thread for engaging an exterior screw thread of a mounting post when the retro-reflective marker sphere is mounted on the mounting post.
摘要翻译：描述了一种包括回射标记球的装置，包括：芯球，包括：大体上球形的主体部分，从芯球的主体部分的一端延伸的安装基座和在其中具有凹部开口的安装凹部安装基座并延伸到芯球的主体部分中，以及在芯球上的后向反射覆盖物，所述回射覆盖物包括开口，芯球的安装基座穿过该开口延伸，其中，安装基座从后向反射覆盖物的开口的下边缘向近侧间隔开，并且其中安装凹部包括用于当将反射式标记球安装在安装座上时与安装柱的外螺纹接合的内螺纹安装柱

26. 发明授权

US08581584B2 Membrane proteins, mechanisms of action and uses thereof 有权
标题翻译：膜蛋白，作用机理及其用途
公开(公告)号：US08581584B2
公开(公告)日：2013-11-12
申请号：US13067351
申请日：2011-05-26
申请人： Mukesh Sharma , Myunggi Yi , Hao Dong , Huajun Qin , David D. Busath , Huan-Xiang Zhou , Timothy A. Cross
发明人： Mukesh Sharma , Myunggi Yi , Hao Dong , Huajun Qin , David D. Busath , Huan-Xiang Zhou , Timothy A. Cross
IPC分类号： G01V3/00
CPC分类号： G01N24/088 , G01R33/4641
摘要： The invention relates to the atomistic functional understanding of the M2 protein from the influenza A virus. This acid-activated selective proton channel has been the subject of numerous conductance, structural, and computational studies. Previously, little was known at the atomic level about the heart of the functional mechanism of this tetrameric protein, a tetrad of HxxxW residues. The structure of the M2 conductance domain in a lipid bilayer is disclosed and displays the defining features of the native protein that have not been attainable from structures solubilized by detergents. A detailed mechanism for acid activation and proton conductance, involving a strong hydrogen bond between two adjacent histidines and specific interactions with the tryptophan gate, is provided and elucidates many observations on the M2 proton conductance.
摘要翻译：本发明涉及来自甲型流感病毒的M2蛋白的原子功能理解。这种酸激活的选择性质子通道已经成为许多电导，结构和计算研究的主题。以前，在原子水平上很少知道这种四聚体蛋白质的四分之一的HxxxW残基的功能机制的心脏。公开了脂质双层中的M2电导结构域的结构，并显示了通过洗涤剂溶解的结构不能获得的天然蛋白质的定义特征。提供了一个详细的酸活化和质子传导机制，涉及两个相邻组氨酸之间的强氢键和与色氨酸门的特异性相互作用，并阐明了许多对M2质子传导的观察。

27. 发明授权

US08541761B2 Portable dosimeter 有权
标题翻译：便携式剂量计
公开(公告)号：US08541761B2
公开(公告)日：2013-09-24
申请号：US12757147
申请日：2010-04-09
申请人： R. Craig Yoder , Yoshikazu Tatsumi , Tse-Min Lo , Mark S. Akselrod
发明人： R. Craig Yoder , Yoshikazu Tatsumi , Tse-Min Lo , Mark S. Akselrod
IPC分类号： G01T1/10
CPC分类号： G01T1/105 , G01T3/00
摘要： A radiation dosimeter including one or more optically stimulated luminescence (OSL) sensors.
摘要翻译：辐射剂量计包括一个或多个光学刺激的发光（OSL）传感器。

28. 发明授权

US08541749B2 Portable reader for a dosimeter 有权
标题翻译：便携式读取器
公开(公告)号：US08541749B2
公开(公告)日：2013-09-24
申请号：US12757140
申请日：2010-04-09
申请人： R. Craig Yoder , Yoshikazu Tatsumi , Tse-Min Lo , Mark S. Akselrod
发明人： R. Craig Yoder , Yoshikazu Tatsumi , Tse-Min Lo , Mark S. Akselrod
IPC分类号： H01L27/146
CPC分类号： G01T1/105 , G01T3/00
摘要： Described is a dosimeter reader for reading a plurality of optically stimulated luminescence (OSL) sensors of a dosimeter sled and for reading an RFID tag on the dosimeter sled.
摘要翻译：描述了用于读取剂量计滑板的多个光学刺激的发光（OSL）传感器并用于读取剂量计滑板上的RFID标签的剂量计读取器。

29. 发明授权

US08461111B2 Fibroblast growth factor mutants having improved functional half-life and methods of their use 有权
公开(公告)号：US08461111B2
公开(公告)日：2013-06-11
申请号：US12783005
申请日：2010-05-19
申请人： Michael Blaber , Jihun Lee
发明人： Michael Blaber , Jihun Lee
IPC分类号： A61K38/18
CPC分类号： C07K14/50 , A61K38/00 , A61K38/18 , A61K38/1825 , C07H21/00 , C07K14/501 , C07K2319/21
摘要： Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human FGF-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human FGF-1 with a tryptophan (based on the 140 amino acid numbering scheme of human FGF-1) are provided. Other amino acid mutations or substitutions may be combined. Polynucleotide sequences encoding the mutant FGF proteins and host cells containing such polynucleotide sequences are provided. Methods of administering a mutant FGF protein to an individual to treat an ischemic condition or disease or a wound or tissue injury are also provided.

30. 发明授权

US08426630B2 Method and apparatus for continuous flow synthesis of ibuprofen 有权
标题翻译：用于连续流动合成布洛芬的方法和装置
公开(公告)号：US08426630B2
公开(公告)日：2013-04-23
申请号：US12868787
申请日：2010-08-26
申请人： D. Tyler McQuade , Andrew Bogdan , Sarah Lihoa Poe
发明人： D. Tyler McQuade , Andrew Bogdan , Sarah Lihoa Poe
IPC分类号： C07C69/612
CPC分类号： B01J19/0093 , B01J2219/00867 , B01J2219/00873 , B01J2219/00889 , B01J2219/00966 , B01J2219/00984 , C07C45/46 , C07C51/09 , C07C67/27 , C07C49/76 , C07C57/30 , C07C69/612
摘要： A multi-step method for the continuous synthesis of ibuprofen or a synthetic precursor of ibuprofen is provided that does not require any intermediate purification or isolation steps and uses reagents compatible with downstream reactions. According to some embodiments, a method is provided wherein isobutylbenzene and a propionyl compound may be converted into a first product in a first Friedel Crafts acylation reaction. The first product may then be converted into a second product in a 1,2-aryl migration reaction. Finally, the second product may be converted into ibuprofen in a hydrolysis reaction. The present invention also provides a method wherein only the first and second reaction steps or only the second and third reaction steps are performed. An apparatus is also provided having two or more microreactors and two or more junctions in particular arrangements for the synthesis of ibuprofen or a synthetic precursor of ibuprofen.
摘要翻译：提供了连续合成布洛芬或布洛芬的合成前体的多步法，其不需要任何中间纯化或分离步骤，并且使用与下游反应相容的试剂。根据一些实施方案，提供了一种方法，其中在第一Friedel Crafts酰化反应中可以将异丁基苯和丙酰化合物转化为第一产物。然后可以将第一产物转化为1,2-芳基迁移反应中的第二产物。最后，第二种产物可以在水解反应中转化为布洛芬。本发明还提供了仅进行第一和第二反应步骤或仅进行第二和第三反应步骤的方法。还提供了一种装置，其具有两个或更多个微反应器和两个或多个连接点，用于合成布洛芬或布洛芬的合成前体的具体布置。

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