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1. 发明授权

US06754588B2 Method of predicting three-dimensional stratigraphy using inverse optimization techniques 失效
标题翻译：使用逆优化技术预测三维地层的方法
公开(公告)号：US06754588B2
公开(公告)日：2004-06-22
申请号：US09855757
申请日：2001-05-15
申请人： Timothy A. Cross , Margaret A. Lessenger
发明人： Timothy A. Cross , Margaret A. Lessenger
IPC分类号： G01V128
CPC分类号： G01V11/00 , G01V2210/66
摘要： The invention relates generally to the field of quantitative sedimentologic and stratigraphic prediction. Specifically, geological data observed or inferred from core samples, cuttings, geophysical well logs and seismic data from locations within a sedimentary basin, in conjunction with a stratigraphic forward model and an inverse optimization technique, are used to predict sedimentologic and stratigraphic attributes at locations within the basin other than those at which data were collected. The model's output consists of a three-dimensional model of the sedimentologic and stratigraphic attributes for the specified basin volume.
摘要翻译：本发明一般涉及定量沉积学和地层学预测领域。具体来说，使用从沉积盆地内的核心样品，切屑，地球物理测井和地震数据观察或推断的地质资料，结合地层前向模型和逆优化技术，用于预测沉积盆地内部位置的沉积学和地层学特征除了收集数据之外的盆地。模型的输出由指定盆地体积的沉积学和地层学属性三维模型组成。

2. 发明授权

US07674595B1 Solid state NMR method for screening cell membrane protein binding drug candidates 有权
公开(公告)号：US07674595B1
公开(公告)日：2010-03-09
申请号：US12366173
申请日：2009-02-05
申请人： Timothy A. Cross , William W. Brey , Alexej Smirnov , Eduard Y. Chekmenev
发明人： Timothy A. Cross , William W. Brey , Alexej Smirnov , Eduard Y. Chekmenev
IPC分类号： G01N33/53
CPC分类号： G01N33/554 , G01N24/08 , G01N24/088 , G01N2500/10 , G01R33/465
摘要： Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.

3. 发明授权

US06801876B2 Method and apparatus of managing time for a processing system 失效
标题翻译：管理处理系统的时间的方法和装置
公开(公告)号：US06801876B2
公开(公告)日：2004-10-05
申请号：US09732545
申请日：2000-12-08
申请人： Dennis A. Barney , Steven V. Christensen , Timothy A. Cross , Michael R. Lyons , Ron J. Penick , Curtis V. Rocke , Christian A. Schreiner , April D. Scott , David G. Young
发明人： Dennis A. Barney , Steven V. Christensen , Timothy A. Cross , Michael R. Lyons , Ron J. Penick , Curtis V. Rocke , Christian A. Schreiner , April D. Scott , David G. Young
IPC分类号： G04F100
CPC分类号： G05B19/0421 , G05B2219/2237 , G05B2219/25047 , G05B2219/25126
摘要： The present invention includes a method and apparatus of managing time for a processing system located on a machine. The processing system includes a plurality of controllers and a communication network connecting each of the controllers. Each of the controllers has a local clock. The method includes the steps of establishing an operating characteristic of the machine, determining whether to update a local time in response to said operating characteristic, and updating said local time based upon the local clock in response to said update determination.
摘要翻译：本发明包括一种管理位于机器上的处理系统的时间的方法和装置。处理系统包括多个控制器和连接每个控制器的通信网络。每个控制器都有一个本地时钟。该方法包括以下步骤：建立机器的工作特性，响应于所述操作特性确定是否更新本地时间，以及响应于所述更新确定，基于本地时钟来更新所述本地时间。

4. 发明授权

US5345841A Elevated low idle for coasting in neutral 失效
标题翻译：升高的低空闲空档
公开(公告)号：US5345841A
公开(公告)日：1994-09-13
申请号：US955632
申请日：1992-10-02
申请人： Lorne W. Tweed , Timothy A. Cross , William M. McClure , Brian T. Rolli
发明人： Lorne W. Tweed , Timothy A. Cross , William M. McClure , Brian T. Rolli
IPC分类号： B60K26/00 , B60W10/06 , B60W30/18 , B60W50/02 , F16H59/70 , F16H61/02 , F16H61/12 , B60K41/04
CPC分类号： B60W10/06 , B60W10/04 , B60W10/11 , B60W10/115 , B60W30/18 , B60W30/1819 , B60W2050/021 , B60W2510/1005 , B60W2510/104 , B60W2520/10 , B60W2540/16 , B60W2710/0616 , B60W2710/065 , B60Y2200/14 , F16H2061/1208 , F16H59/70 , F16H61/0248 , Y10T477/68 , Y10T477/6808
摘要： The present invention provides a control which automatically elevates engine speed to a preselected value when the vehicle coasting in neutral above a preselected speed. In order to accomplish this objective, the engine controller is adapted to receive an actual gear ratio signal and a vehicle speed signal, If the vehicle is in neutral and engine speed is above a preselected threshold, the controller sets the desired engine speed to a preselected value which has been empirically determined to ensure sufficient transmission cooling and lubrication, Controlling to this speed also reduces transmission wear when the transmission is reengaged at high ground speeds.
摘要翻译：本发明提供一种当车辆在预定速度以上惯性滑行时自动将发动机转速提升到预选值的控制。为了实现该目的，发动机控制器适于接收实际齿轮比信号和车速信号。如果车辆处于空档并且发动机转速高于预选阈值，则控制器将期望的发动机转速设定为预选经验确定的值，以确保足够的传动冷却和润滑。当以高地速重新接通变速器时，以此速度控制也可降低传动磨损。

5. 发明授权

US08581584B2 Membrane proteins, mechanisms of action and uses thereof 有权
标题翻译：膜蛋白，作用机理及其用途
公开(公告)号：US08581584B2
公开(公告)日：2013-11-12
申请号：US13067351
申请日：2011-05-26
申请人： Mukesh Sharma , Myunggi Yi , Hao Dong , Huajun Qin , David D. Busath , Huan-Xiang Zhou , Timothy A. Cross
发明人： Mukesh Sharma , Myunggi Yi , Hao Dong , Huajun Qin , David D. Busath , Huan-Xiang Zhou , Timothy A. Cross
IPC分类号： G01V3/00
CPC分类号： G01N24/088 , G01R33/4641
摘要： The invention relates to the atomistic functional understanding of the M2 protein from the influenza A virus. This acid-activated selective proton channel has been the subject of numerous conductance, structural, and computational studies. Previously, little was known at the atomic level about the heart of the functional mechanism of this tetrameric protein, a tetrad of HxxxW residues. The structure of the M2 conductance domain in a lipid bilayer is disclosed and displays the defining features of the native protein that have not been attainable from structures solubilized by detergents. A detailed mechanism for acid activation and proton conductance, involving a strong hydrogen bond between two adjacent histidines and specific interactions with the tryptophan gate, is provided and elucidates many observations on the M2 proton conductance.
摘要翻译：本发明涉及来自甲型流感病毒的M2蛋白的原子功能理解。这种酸激活的选择性质子通道已经成为许多电导，结构和计算研究的主题。以前，在原子水平上很少知道这种四聚体蛋白质的四分之一的HxxxW残基的功能机制的心脏。公开了脂质双层中的M2电导结构域的结构，并显示了通过洗涤剂溶解的结构不能获得的天然蛋白质的定义特征。提供了一个详细的酸活化和质子传导机制，涉及两个相邻组氨酸之间的强氢键和与色氨酸门的特异性相互作用，并阐明了许多对M2质子传导的观察。

6. 发明申请

US20110291652A1 Membrane proteins, mechanisms of action and uses thereof 有权
标题翻译：膜蛋白，作用机理及其用途
公开(公告)号：US20110291652A1
公开(公告)日：2011-12-01
申请号：US13067351
申请日：2011-05-26
申请人： Mukesh Sharma , Myunggi Yi , Hao Dong , Huajun Qin , David D. Busath , Huan-Xiang Zhou , Timothy A. Cross
发明人： Mukesh Sharma , Myunggi Yi , Hao Dong , Huajun Qin , David D. Busath , Huan-Xiang Zhou , Timothy A. Cross
IPC分类号： G01R33/44
CPC分类号： G01N24/088 , G01R33/4641
摘要： The invention relates to the atomistic functional understanding of the M2 protein from the influenza A virus. This acid-activated selective proton channel has been the subject of numerous conductance, structural, and computational studies. Previously, little was known at the atomic level about the heart of the functional mechanism of this tetrameric protein, a tetrad of HxxxW residues. The structure of the M2 conductance domain in a lipid bilayer is disclosed and displays the defining features of the native protein that have not been attainable from structures solubilized by detergents. A detailed mechanism for acid activation and proton conductance, involving a strong hydrogen bond between two adjacent histidines and specific interactions with the tryptophan gate, is provided and elucidates many observations on the M2 proton conductance.
摘要翻译：本发明涉及来自甲型流感病毒的M2蛋白的原子功能理解。这种酸激活的选择性质子通道已经成为许多电导，结构和计算研究的主题。以前，在原子水平上很少知道这种四聚体蛋白质的四分之一的HxxxW残基的功能机制的心脏。公开了脂质双层中的M2电导结构域的结构，并显示了通过洗涤剂溶解的结构不能获得的天然蛋白质的定义特征。提供了一个详细的酸活化和质子传导机制，涉及两个相邻组氨酸之间的强氢键和与色氨酸门的特异性相互作用，并阐明了许多对M2质子传导的观察。

7. 发明授权

US06246963B1 Method for predicting stratigraphy 失效
标题翻译：地层预测方法
公开(公告)号：US06246963B1
公开(公告)日：2001-06-12
申请号：US09239634
申请日：1999-01-29
申请人： Timothy A. Cross , Margaret A. Lessenger
发明人： Timothy A. Cross , Margaret A. Lessenger
IPC分类号： G01V128
CPC分类号： G01V11/00 , G01V2210/66
摘要： The present relates generally to the field of quantitative sedimentologic and stratigraphic prediction in which errors, uncertainties, risk and accuracy are calculated. Specifically, geologic data observed or inferred from core, outcrop, well log and/or seismic data from particular locations, in conjunction with a stratigraphic forward model and an optimization technique (mathematical inverse algorithm), are used to predict stratigraphic and sedimentologic attributes at locations other than those at which data were collected. This is accomplished by inverting a stratigraphic/sedimentologic forward model with simultaneous multi-parameter inversion or other mathematical optimization technique, such that forward model predictions are forced to obtain a best match with observations. The geologic data used to constrain the inversion are a small sample set of the larger, complete, rock volume simulated by the model.
摘要翻译：本发明一般涉及计量误差，不确定性，风险和准确性的定量沉积学和地层学预测领域。具体来说，结合地层正演模型和优化技术（数学逆算法），从核心，露头，测井和/或地震数据中观察或推断出的地质资料，用于预测地理位置和地层特征除了收集数据之外。这是通过使用同时多参数反演或其他数学优化技术来反演地层/沉积学前向模型来实现的，使得前向模型预测被迫获得与观测结果的最佳匹配。用于约束反演的地质数据是由该模型模拟的较大，完整的岩石体积的小样本集。

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