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1. 发明授权

US08581584B2 Membrane proteins, mechanisms of action and uses thereof 有权
标题翻译：膜蛋白，作用机理及其用途
公开(公告)号：US08581584B2
公开(公告)日：2013-11-12
申请号：US13067351
申请日：2011-05-26
申请人： Mukesh Sharma , Myunggi Yi , Hao Dong , Huajun Qin , David D. Busath , Huan-Xiang Zhou , Timothy A. Cross
发明人： Mukesh Sharma , Myunggi Yi , Hao Dong , Huajun Qin , David D. Busath , Huan-Xiang Zhou , Timothy A. Cross
IPC分类号： G01V3/00
CPC分类号： G01N24/088 , G01R33/4641
摘要： The invention relates to the atomistic functional understanding of the M2 protein from the influenza A virus. This acid-activated selective proton channel has been the subject of numerous conductance, structural, and computational studies. Previously, little was known at the atomic level about the heart of the functional mechanism of this tetrameric protein, a tetrad of HxxxW residues. The structure of the M2 conductance domain in a lipid bilayer is disclosed and displays the defining features of the native protein that have not been attainable from structures solubilized by detergents. A detailed mechanism for acid activation and proton conductance, involving a strong hydrogen bond between two adjacent histidines and specific interactions with the tryptophan gate, is provided and elucidates many observations on the M2 proton conductance.
摘要翻译：本发明涉及来自甲型流感病毒的M2蛋白的原子功能理解。这种酸激活的选择性质子通道已经成为许多电导，结构和计算研究的主题。以前，在原子水平上很少知道这种四聚体蛋白质的四分之一的HxxxW残基的功能机制的心脏。公开了脂质双层中的M2电导结构域的结构，并显示了通过洗涤剂溶解的结构不能获得的天然蛋白质的定义特征。提供了一个详细的酸活化和质子传导机制，涉及两个相邻组氨酸之间的强氢键和与色氨酸门的特异性相互作用，并阐明了许多对M2质子传导的观察。

2. 发明申请

US20110291652A1 Membrane proteins, mechanisms of action and uses thereof 有权
标题翻译：膜蛋白，作用机理及其用途
公开(公告)号：US20110291652A1
公开(公告)日：2011-12-01
申请号：US13067351
申请日：2011-05-26
申请人： Mukesh Sharma , Myunggi Yi , Hao Dong , Huajun Qin , David D. Busath , Huan-Xiang Zhou , Timothy A. Cross
发明人： Mukesh Sharma , Myunggi Yi , Hao Dong , Huajun Qin , David D. Busath , Huan-Xiang Zhou , Timothy A. Cross
IPC分类号： G01R33/44
CPC分类号： G01N24/088 , G01R33/4641
摘要： The invention relates to the atomistic functional understanding of the M2 protein from the influenza A virus. This acid-activated selective proton channel has been the subject of numerous conductance, structural, and computational studies. Previously, little was known at the atomic level about the heart of the functional mechanism of this tetrameric protein, a tetrad of HxxxW residues. The structure of the M2 conductance domain in a lipid bilayer is disclosed and displays the defining features of the native protein that have not been attainable from structures solubilized by detergents. A detailed mechanism for acid activation and proton conductance, involving a strong hydrogen bond between two adjacent histidines and specific interactions with the tryptophan gate, is provided and elucidates many observations on the M2 proton conductance.
摘要翻译：本发明涉及来自甲型流感病毒的M2蛋白的原子功能理解。这种酸激活的选择性质子通道已经成为许多电导，结构和计算研究的主题。以前，在原子水平上很少知道这种四聚体蛋白质的四分之一的HxxxW残基的功能机制的心脏。公开了脂质双层中的M2电导结构域的结构，并显示了通过洗涤剂溶解的结构不能获得的天然蛋白质的定义特征。提供了一个详细的酸活化和质子传导机制，涉及两个相邻组氨酸之间的强氢键和与色氨酸门的特异性相互作用，并阐明了许多对M2质子传导的观察。

3. 发明申请

US20220410729A1 ELECTROMAGNETIC AIRBORNE HYBRID VEHICLE 有权
公开(公告)号：US20220410729A1
公开(公告)日：2022-12-29
申请号：US17446991
申请日：2021-09-07
申请人： Mukesh Sharma
发明人： Mukesh Sharma
IPC分类号： B60L50/90 , B62D21/17 , B60L50/60 , B60L8/00
摘要： An electromagnetic vehicle chassis that is configured with an upper portion and a lower portion wherein the upper portion is movable to a second position and supported therein with an electromagnetic field. The vehicle of the present invention includes a frame having the upper portion movable so as to reduce the overall vehicle weight and as such require less propulsion force resulting in reduced energy consumption. The upper portion of the frame of the present invention is moved into its second position utilizing hydraulic cylinders. Electromagnets present on both the upper portion and lower portion maintain the upper portion in its second position. A battery compartment having a plurality of batteries is operably coupled to the lower portion of the frame. The body of the vehicle includes a plurality of photovoltaic cells electrically coupled to the plurality of batteries.

4. 发明申请

US20110071287A1 PROCESS FOR THE PREPARATION OF EFAVIRENZ 审中-公开
标题翻译：制备EFAVIRENZ的方法
公开(公告)号：US20110071287A1
公开(公告)日：2011-03-24
申请号：US12990578
申请日：2009-05-01
申请人： Mukesh Kumar Madhra , Pankaj Kumar Singh , Mukesh Sharma , Chandra Has Khanduri
发明人： Mukesh Kumar Madhra , Pankaj Kumar Singh , Mukesh Sharma , Chandra Has Khanduri
IPC分类号： C07D265/24
CPC分类号： C07D265/18
摘要： The present invention relates to a process for the preparation of Efavirenz (Formula I), wherein triphosgene is used as a cyclizing agent.
摘要翻译：本发明涉及制备依法韦仑（式I）的方法，其中使用三光气作为环化剂。

5. 发明公开

US20240008711A1 HYGIENIC FOOTWEAR EQUIPMENT RACK UNIT 审中-公开
公开(公告)号：US20240008711A1
公开(公告)日：2024-01-11
申请号：US17648542
申请日：2021-06-02
申请人： Mukesh Sharma
发明人： Mukesh Sharma
IPC分类号： A47L23/20 , D06F58/10 , A43B3/26 , A61L2/10 , A61L2/18
CPC分类号： A47L23/20 , D06F58/10 , A43B3/26 , A61L2/10 , A61L2/18 , A61L2202/11 , A61L2202/14 , A47B61/04
摘要： A hygienic footwear equipment rack unit to maintain a hygienic environment of a premise and to prevent outdoor footwear handling. Slippers for indoor use are provided in various sizes. The slippers may be provided via a conveyor hanger with magnets to secure the slippers. Further provided may be a method of sanitizing outdoor shoes using UV lamps and hot air fans.

6. 发明申请

US20070129385A1 Amorphous valganciclovir hydrochloride 审中-公开
标题翻译：无定形缬更昔洛韦盐酸盐
公开(公告)号：US20070129385A1
公开(公告)日：2007-06-07
申请号：US10569615
申请日：2004-08-27
申请人： Mukesh Sharma , Yatendra Kumar , Chandra Khanduri
发明人： Mukesh Sharma , Yatendra Kumar , Chandra Khanduri
IPC分类号： A61K31/522 , C07D473/10
CPC分类号： C07D473/18
摘要： The present invention relates to an amorphous form of valganciclovir hydrochloride and the pharmaceutical compositions thereof. The amorphous form can be directly prepared by spray-drying or azeotropic distillation of reaction mass. The amorphous form is useful in treating viral infections, for example, herpes simplex and cytomegalovirus.
摘要翻译：本发明涉及无定形形式的缬羟基缬氨酸盐酸盐及其药物组合物。可以通过反应物质的喷雾干燥或共沸蒸馏直接制备无定形形式。无定形形式可用于治疗病毒感染，例如单纯疱疹病毒和巨细胞病毒。

7. 发明申请

US20070106078A1 Process for the preparation of fexofenadine 审中-公开
标题翻译：非索非那定制备方法
公开(公告)号：US20070106078A1
公开(公告)日：2007-05-10
申请号：US10543517
申请日：2004-01-30
申请人： Mukesh Sharma , Chandra Khanduri , Naresh Kumar , Yatendra Kumar
发明人： Mukesh Sharma , Chandra Khanduri , Naresh Kumar , Yatendra Kumar
IPC分类号： C07D211/34
CPC分类号： C07D211/22
摘要： The invention relates to highly pure fexofenadine and a process for preparing highly pure fexofenadine. The invention also relates to pharmaceutical compositions that include the highly pure fexofenadine and use of said compositions for treating a patient for allergic reactions.
摘要翻译：本发明涉及高纯度非索非那定和制备高纯度非索非那定的方法。本发明还涉及包含高纯度非索非那定的药物组合物和所述组合物用于治疗患者过敏反应的用途。

8. 发明授权

US5812812A Method and system of implementing an early data dependency resolution mechanism in a high-performance data processing system utilizing out-of-order instruction issue 失效
标题翻译：在采用无序指令问题的高性能数据处理系统中实现早期数据依赖解析机制的方法和系统
公开(公告)号：US5812812A
公开(公告)日：1998-09-22
申请号：US740911
申请日：1996-11-04
申请人： Muhammad Nural Afsar , Romesh Mangho Jessani , Soummya Mallick , Robert Greg McDonald , Mukesh Sharma
发明人： Muhammad Nural Afsar , Romesh Mangho Jessani , Soummya Mallick , Robert Greg McDonald , Mukesh Sharma
IPC分类号： G06F9/38
CPC分类号： G06F9/3838 , G06F9/3836 , G06F9/384
摘要： A method and system of implementing an early data dependency resolution mechanism for a high-performance data processing system that utilizes out-of-order instruction issue is disclosed. In accordance with the present disclosure, an instruction cache and a register-dependency cache are provided. The instruction cache has multiple cache lines, and each of these cache lines is capable of storing multiple instructions. The register-dependency cache contains an identical number of cache lines as in the instruction cache, and each of the cache lines within the register-dependency cache is capable of storing an identical number of register-dependency units as instructions in each of the cache lines within the instruction cache. In a single processor cycle, a group of register-dependency units are fetched from the register-dependency cache. All register-dependency units that have no forward data dependency within the group of register-dependency units are identified utilizing an Instruction Dispatch Unit. Each of the identified register-dependency units is then translated to its respective instruction utilizing a corresponding cache line within the instruction cache. All of the translated instructions are issued within a next processor cycle.
摘要翻译：公开了一种利用无序指令问题的高性能数据处理系统实现早期数据依赖解析机制的方法和系统。根据本公开，提供了指令高速缓存和寄存器依赖性高速缓存。指令高速缓存具有多个高速缓存行，并且这些高速缓存行中的每一条都能够存储多个指令。寄存器依赖性高速缓存包含与指令高速缓存中相同数量的高速缓存行，并且寄存器相关高速缓存内的每个高速缓存线能够存储与每个高速缓存行中的指令相同数量的寄存器依赖单元在指令缓存中。在单个处理器周期中，从寄存器依赖性缓存中取出一组寄存器依赖单元。使用指令调度单元来识别在寄存器依赖单元组内没有转发数据依赖性的所有寄存器依赖单元。然后，使用所述指令高速缓存中的相应高速缓存行，将所识别的寄存器依赖单元中的每一个转换为其相应的指令。所有翻译的指令都是在下一个处理器周期内发出的。

9. 发明公开

US20230329967A1 Foot Care Equipment 审中-公开
公开(公告)号：US20230329967A1
公开(公告)日：2023-10-19
申请号：US17905988
申请日：2021-03-09
申请人： Mukesh Sharma
发明人： Mukesh Sharma
IPC分类号： A61H35/00 , A61H33/00 , A61N5/06 , A61M35/00 , A61H9/00 , A61L2/00 , A61L2/24 , A61L2/18 , C02F1/44 , C02F1/00
CPC分类号： A61H35/006 , A61H33/0091 , A61H33/6031 , A61H33/6047 , A61N5/0624 , A61M35/00 , A61H33/6089 , A61H33/0095 , A61H9/0071 , A61L2/0088 , A61L2/0047 , A61L2/24 , A61L2/18 , C02F1/44 , C02F1/008 , A61H2033/0037 , A61H2033/0012 , A61N2005/0661 , A61N2005/0642 , A61N2005/0654 , A61H2201/105 , A61M2210/08 , A61H2201/0207 , A61H2201/169 , A61H2033/0016 , A61H2201/025 , A61H2201/0214 , A61L2202/17 , A61L2202/15 , A61L2202/11 , A61L2202/14 , A61L2202/122 , C02F2209/02
摘要： The new invention foot-care equipment unit is directly related to foot problems and cures from pain, numbness, stiffness, swelling, athlete's foot, blisters, bunios, corns, plantar fasciitis, heel spur, mallet or hammer toe, gout, ingrown toenail, nail hardening, fungal nail infection, plantar wart, stone bruise, morton neuroma, sesamoidits, poor blood circulation, crack heals, blood clots in the foot vain or excessive sweat, and or bad odours are common symptom of foot related issues or causes of poor foot health. The foot-care equipment a hands free solution for practicing random or regularly use of equipment for steaming, fermenting, massaging, cleaning and sanitizing, air blow drying, sterilizing and or scrubbing of foot or the feet's for cure or general health and hygiene as therapy or treatment. The foot-care equipment unit may comprise of semi-automatically functional in cleaning, sanitizing and sterilizing, and or drying of its equipment components for users.

10. 发明授权

US07389412B2 System and method for secure network roaming 有权
标题翻译：用于安全网络漫游的系统和方法
公开(公告)号：US07389412B2
公开(公告)日：2008-06-17
申请号：US10224226
申请日：2002-08-05
申请人： Mukesh Sharma , Christopher Skiscim , Philip Roberts , Luis Sanchez
发明人： Mukesh Sharma , Christopher Skiscim , Philip Roberts , Luis Sanchez
IPC分类号： H04L9/00
CPC分类号： H04W12/06 , H04L9/0844 , H04L9/3273 , H04L63/0272 , H04L63/0428 , H04L63/06 , H04L63/061 , H04L63/0869 , H04L63/164 , H04L2209/80 , H04W12/04 , H04W60/00 , H04W76/20 , H04W80/04 , H04W84/12 , H04W88/16 , H04W92/02
摘要： A wireless data network process and system are provided based on a network with prior network-based authentication of a connected mobile node (MN) and with a network connection to a packet gateway node (PGN). The method and system establish and use an authentication mechanism between the MN and the PGN using the network connection. An encrypted channel is then set up between the MN and the PGN based on authentication established with the authentication mechanism. Configuration data is sent from the PGN to the MN using the encrypted channel. The configuration data may then be used by the MN for communication to and from the MN with the PGN via an access point. Any network connected to the PGN via any access point may then be used.
摘要翻译：基于具有连接的移动节点（MN）的先前基于网络的认证并且与分组网关节点（PGN）的网络连接的网络来提供无线数据网络过程和系统。该方法和系统使用网络连接建立并使用MN与PGN之间的认证机制。然后，基于与认证机制建立的认证，在MN和PGN之间建立加密信道。配置数据使用加密信道从PGN发送到MN。然后，配置数据可以由MN用于经由接入点与PGN通过MN和从MN的通信。然后可以使用通过任何接入点连接到PGN的任何网络。

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