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11. 发明授权

US5712086A Process for transfusing cell containing fractions sterilized with radiation and a quencher of type I and type II photodynamic reactions 失效
$Process for transfusing cell containing fractions sterilized with radiation and a quencher of type I and type II photodynamic reactions$
标题翻译：用于辐射灭菌的含细胞的级分和I型和II型光动力学反应的猝灭剂的方法
公开(公告)号：US5712086A
公开(公告)日：1998-01-27
申请号：US486668
申请日：1995-06-07
申请人： Bernard Horowitz , Bolanle Williams , Henrietta Margolis-Nunno , Sing N. Chin
发明人： Bernard Horowitz , Bolanle Williams , Henrietta Margolis-Nunno , Sing N. Chin
IPC分类号： A61K41/00 , A61L2/00 , C12N7/06 , A01N1/02 , A61M37/00 , C12N13/00
CPC分类号： C12N7/00 , A61K41/0019 , A61K41/0023 , A61K41/0038 , A61K41/0066 , A61L2/0011 , C12N2760/10163 , C12N2760/20263
摘要： A process is presented for transfusing cells which have been sterilized with radiation and a quencher of type I and type II photodynamic reactions. The cells are removed from a donor and exposed to virucidally effective amount of radiation in the presence of a quencher of type I and type II reactions, or a mixture of a quencher for type I reactions and a quencher of type II reactions. Subsequently, the sterilized cell containing fraction is returned to the donor.
摘要翻译：提出了一种用于输入已经用辐射灭菌的细胞和I型和II型光动力学反应的猝灭剂的方法。在I型和II型反应的猝灭剂或I型反应的猝灭剂和II型反应的猝灭剂的混合物存在下，从供体中除去细胞并暴露于病毒有效量的辐射。随后，将灭菌的含细胞的级分返回给供体。

12. 发明授权

US4556556A Vaccine for the prevention of vesicular stomatitis virus infection 失效
标题翻译：疫苗用于预防水泡性口炎病毒感染
公开(公告)号：US4556556A
公开(公告)日：1985-12-03
申请号：US592661
申请日：1984-03-23
申请人： Gary P. Wiesehahn , Richard E. Giles , David R. Stevens
发明人： Gary P. Wiesehahn , Richard E. Giles , David R. Stevens
IPC分类号： A61K39/205 , C12N7/06 , A61K39/12
CPC分类号： C12N7/00 , A61K39/12 , A61K39/205 , A61K2039/5252 , A61K2039/55505 , A61K2039/55566 , C12N2760/20234 , C12N2760/20263 , Y10S424/813
摘要： Novel vaccines for vesicular stomatitis virus are prepared by psoralen inactivation of the live virus under mild conditions in an inert atmosphere. The resulting inactivated virus can be used as a vaccine for inoculation of susceptible hosts to inhibit VSV infection.
摘要翻译：用于水泡性口炎病毒的新型疫苗通过活性病毒在惰性气氛中的温和条件下失活来制备。所得的灭活病毒可用作接种易感宿主以抑制VSV感染的疫苗。

13. 发明专利

JP5926218B2 カプリレートによるウイルスの失活有权
标题翻译：该病毒通过辛酸的失活
公开(公告)号：JP5926218B2
公开(公告)日：2016-05-25
申请号：JP2013151298
申请日：2013-07-22
申请人：グライフォルス・ス・アー
发明人：ウィトールド・レビング , ダッグ・バーンズ , ネイサン・ロス , ジョアン・ホッタ
IPC分类号： C07K1/34 , C07K14/76
CPC分类号： A01N37/02 , C07K14/76 , C12N7/00 , C12N2760/20263 , C12N2770/24363

15. 发明授权

US06413714B1 Process for the sterilization of biological compositions and the product produced thereby 失效
标题翻译：用于生物组合物的灭菌和由此产生的产品的方法
公开(公告)号：US06413714B1
公开(公告)日：2002-07-02
申请号：US09580250
申请日：2000-05-26
申请人： Henrietta Margolis-Nunno , Ehud Ben-Hur , Bernard Horowitz
发明人： Henrietta Margolis-Nunno , Ehud Ben-Hur , Bernard Horowitz
IPC分类号： A01N102
CPC分类号： A61K41/0019 , A61K41/0066 , A61L2/0011 , A61L2/10 , C12N7/00 , C12N7/06 , C12N2760/20263
摘要： The present invention concerns a process for inactivating extracellular and intracellular virus in a biological composition without incurring substantial disruption or inactivation thereof, said process comprising subjecting said composition to a virucidally effective amount of UVA1 irradiation substantially in the absence of UVA2 irradiation for a period of time sufficient to thereby inactivate said virus while retaining functionality of said composition. The biological composition is advantageously a product that contains red blood cells or platelets. The process is advantageously carried out in the presence of an irradiation sensitizer compound and/or a quencher. The present invention also concerns the product substantially identical to that produced by the inventive process.
摘要翻译：本发明涉及使生物组合物中的细胞外和细胞内病毒灭活而不引起实质性破坏或失活的方法，所述方法包括使所述组合物基本上在不存在UVA2照射的情况下对所述组合物进行病毒有效量的UVA1照射一段时间足以使所述病毒灭活同时保留所述组合物的功能。生物组合物有利地是含有红细胞或血小板的产品。该方法有利地在辐照敏化剂化合物和/或猝灭剂的存在下进行。本发明还涉及与本发明方法产生的产品基本相同的产品。

16. 发明授权

US06251644B1 Method for inactivating non-enveloped viral contaminants with a photosensitizer by increasing viral permeability to the photosensitizer 失效
标题翻译：通过增加光敏剂的病毒渗透性，用光敏剂灭活非包膜病毒污染物的方法
公开(公告)号：US06251644B1
公开(公告)日：2001-06-26
申请号：US08343680
申请日：1994-11-22
申请人： Samuel O. Sowemimo-Coker , Raymond P. Goodrich, Jr.
发明人： Samuel O. Sowemimo-Coker , Raymond P. Goodrich, Jr.
IPC分类号： C12N1300
CPC分类号： A61L2/0076 , A61K38/00 , A61K41/0019 , A61K41/0057 , A61L2/0011 , A61L2/0035 , A61L2/0082 , A61L2202/22 , C07K14/755 , C12N7/00 , C12N9/644 , C12N2710/16163 , C12N2710/16663 , C12N2740/16063 , C12N2760/20263 , C12N2770/36163 , C12Y304/21022
摘要： A method is presented for inactivating non-enveloped viruses that may be contaminating a biological solution or suspension by mixing the solution or suspension with a photosensitizer to form a mixture, adjusting the operating conditions of the mixture so as to increase the permeability of the viruses to the photosensitizer, and then irradiating the adjusted mixture.
摘要翻译：提出了一种用于灭活可能通过将溶液或悬浮液与光敏剂混合以形成混合物而污染生物溶液或悬浮液的非包膜病毒的方法，调节混合物的操作条件以增加病毒的渗透性光敏剂，然后照射调整后的混合物。

17. 发明授权

US06214534B1 Biological compositions containing quenchers of type I and type II photodynamic reactions 失效
标题翻译：含有I型和II型光动力学反应猝灭剂的生物组合物
公开(公告)号：US06214534B1
公开(公告)日：2001-04-10
申请号：US08653218
申请日：1996-05-24
申请人： Bernard Horowitz , Bolanle Williams , Henrietta Margolis-Nunno , Sing N. Chin
发明人： Bernard Horowitz , Bolanle Williams , Henrietta Margolis-Nunno , Sing N. Chin
IPC分类号： A01N102
CPC分类号： A61K41/0019 , A61K41/0023 , A61K41/0038 , A61K41/0066 , A61K41/0071 , A61L2/0011 , C12N7/00 , C12N2760/10163 , C12N2760/20263
摘要： The present invention concerns the product produced by inactivating extracellular or intracellular pathogenic virus in a biological composition without incurring substantial disruption or inactivation of cells and without significant loss of labile proteins or other valuable biological components also contained therein, the inactivation process comprising subjecting said composition to a virucidally effective amount of irradiation in the presence of (a) a mixture of a compound that quenches type I photodynamic reactions and a compound that quenches type II photodynamic reactions or (b) a bifunctional compound that is capable of quenching both type I and type II reactions, to thereby inactivate said virus while retaining functionality of said composition. The composition is advantageously subjected to the irradiation and the mixture of compounds or bifunctional compound in the presence of an irradiation sensitizer. Moreover, the process can be advantageously combined with a different virucidal method to enhance virus inactivation.
摘要翻译：本发明涉及通过在生物组合物中灭活细胞外或细胞内病原体病毒而产生的产物，而不会导致细胞的实质性破坏或灭活，并且没有不稳定的蛋白质或其中还含有的其它有价值的生物成分的显着损失，所述灭活过程包括将所述组合物在（a）猝灭I型光动力学反应的化合物和猝灭II型光动力学反应的化合物的混合物存在下的杀病毒有效量的照射或（b）能够淬灭I型和类型的双官能化合物 II反应，从而使所述病毒灭活同时保留所述组合物的功能。组合物有利地在照射敏化剂的存在下进行照射和化合物或双官能化合物的混合物。此外，该方法可以有利地与不同的杀病毒方法组合以增强病毒灭活。

18. 发明授权

US6093564A Methods and compositions for the selective modification of nucleic acids 失效
标题翻译：用于选择性修饰核酸的方法和组合物
公开(公告)号：US6093564A
公开(公告)日：2000-07-25
申请号：US5606
申请日：1998-01-12
申请人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
IPC分类号： C12N7/04 , A61K31/396 , A61K38/00 , A61K39/00 , A61K39/12 , A61L2/00 , A61P31/00 , A61P31/12 , A61P43/00 , C07D203/02 , C07D203/12 , C12N7/06 , C12N7/00
CPC分类号： C12N7/00 , A61L2/0082 , A61L2/0088 , C12N2740/16063 , C12N2760/16163 , C12N2760/20263 , C12N2770/32363 , C12N2770/32463 , C12N2795/10163
摘要： Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: ##STR1## where each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, and R.sub.8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, and R.sub.8 cannot all be H; R.sub.5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 1 and 10, inclusive are disclosed.
摘要翻译：用于选择性修饰生物组合物中核酸分子的方法和组合物，包括使组合物与具有下式的灭活剂接触：其中R1，R2，R3，R4，R6，R7和R8各自独立地为H或单价含有1至4个碳原子的烃部分（包括端值），条件是R1，R2，R3，R4，R6，R7和R8不能全部为H; R5是含有2至4个碳原子的二价烃部分，包括端值; X是药学上可接受的抗衡离子; n为1〜10的整数，包括端值。

19. 发明授权

US5789601A Method of inactivation of viral and bacterial blood contaminants 失效
公开(公告)号：US5789601A
公开(公告)日：1998-08-04
申请号：US427080
申请日：1995-04-21
申请人： Sang Chul Park , Raymond P. Goodrich, Jr. , Nagender Yerram , Samuel O. Sowemimo-Coker , Matthew S. Platz , Brian M. Aquila
发明人： Sang Chul Park , Raymond P. Goodrich, Jr. , Nagender Yerram , Samuel O. Sowemimo-Coker , Matthew S. Platz , Brian M. Aquila
IPC分类号： A61K35/14 , A61K35/16 , A61K35/18 , A61K35/19 , A61K38/00 , A61K41/00 , A61L2/00 , C07K14/755 , C12N7/06 , C12N9/64 , C07D311/08 , C07D311/12 , C07D311/14
CPC分类号： C12N7/00 , A61K35/16 , A61K35/19 , A61K41/0019 , A61K41/0057 , A61L2/0011 , A61L2/0035 , A61L2/0076 , A61L2/0082 , C07K14/755 , C12N9/644 , C12Y304/21022 , A61K38/00 , A61L2202/22 , C12N2710/16163 , C12N2710/16663 , C12N2740/16063 , C12N2760/20263 , C12N2770/36161 , C12N2770/36163
摘要： Viral and bacterial contaminants present in biological solutions are inactivated by mixing one of a novel class of photosensitizer with said solution and irradiating the mixture.

20. 发明授权

US5516629A Photoinactivation of viral and bacterial blood contaminants using halogenated coumarins 失效
标题翻译：使用卤代香豆素对病毒和细菌血液污染物进行光激活
公开(公告)号：US5516629A
公开(公告)日：1996-05-14
申请号：US311125
申请日：1994-09-22
申请人： Sang C. Park , Raymond P. Goodrich, Jr. , Nagender Yerram , Samuel O. Sowemimo-Coker , Matthew S. Platz , Brian M. Aquila
发明人： Sang C. Park , Raymond P. Goodrich, Jr. , Nagender Yerram , Samuel O. Sowemimo-Coker , Matthew S. Platz , Brian M. Aquila
IPC分类号： A61K35/14 , A61K35/16 , A61K35/18 , A61K35/19 , A61K38/00 , A61K41/00 , A61L2/00 , C07K14/755 , C12N7/06 , C12N9/64 , A01N1/02 , C12N13/00 , A61K31/37
CPC分类号： C12N7/00 , A61K35/16 , A61K35/19 , A61K41/0019 , A61K41/0057 , A61L2/0011 , A61L2/0035 , A61L2/0076 , A61L2/0082 , C07K14/755 , C12N9/644 , C12Y304/21022 , A61K38/00 , A61L2202/22 , C12N2710/16163 , C12N2710/16663 , C12N2740/16063 , C12N2760/20263 , C12N2770/36161 , C12N2770/36163
摘要： A method for photoinactivating viral and/or bacterial contaminants in blood, blood products or cell cultures is presented. The blood, blood product or cell culture is mixed with an halogenated coumarin sensitizer and irradiated with UV light to inactivate the viral and/or bacterial contaminants.
摘要翻译：提出了一种用于光激活血液，血液制品或细胞培养物中的病毒和/或细菌污染物的方法。将血液，血液制品或细胞培养物与卤化香豆素敏化剂混合并用UV光照射以灭活病毒和/或细菌污染物。

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