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11. 发明申请

US20130012408A1 METHOD FOR DETERMINATION OF ONSET RISK OF GLAUCOMA 审中-公开
标题翻译：确定葡萄球菌风险的方法
公开(公告)号：US20130012408A1
公开(公告)日：2013-01-10
申请号：US13546674
申请日：2012-07-11
申请人： Shigeru KINOSHITA , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
发明人： Shigeru KINOSHITA , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
IPC分类号： C40B30/04 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/156
摘要： A method of determining the presence or the absence of a glaucoma risk by detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism, comparing the allele and/or the genotype detected with at least one of an allele and/or a genotype with a high-risk allele, wherein the presence of a glaucoma risk is determined in a case where the allele detected is the high-risk allele, or the presence of a glaucoma risk is determined in a case where the genotype detected is a homozygote of the genotype comprising the high-risk allele or a heterozygote when the high-risk allele complies with a dominant genetic model, or the presence of a glaucoma risk is determined in a case where the genotype detected is a homozygote of the genotype comprising the high-risk allele when the high-risk allele complies with a recessive genetic model.
摘要翻译：通过体外检测单核苷酸多态性的等位基因和/或基因型来确定青光眼存在或不存在青光眼风险的方法，比较检测到的等位基因和/或基因型与等位基因和/或具有高风险等位基因的基因型，其中在检测到的等位基因是高风险等位基因的情况下确定青光眼风险的存在，或者在检测到的基因型是纯合子的情况下确定青光眼风险的存在在高风险等位基因符合显性遗传模型的情况下，包括高风险等位基因或杂合子的基因型的基因型，或者在检测到的基因型是包含高表达的基因型的纯合子的情况下，确定青光眼风险的存在当高风险等位基因符合隐性遗传模型时，这种等位基因是错误的。

12. 发明申请

US20100196895A1 METHOD FOR DETERMINATION OF ONSET RISK OF GLAUCOMA 审中-公开
标题翻译：确定葡萄球菌风险的方法
公开(公告)号：US20100196895A1
公开(公告)日：2010-08-05
申请号：US12596258
申请日：2008-04-17
申请人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
发明人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/156
摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 514 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 514 (step B). According to the method of the present invention, the level of an onset risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention on the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
摘要翻译：一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型，其中所述碱基序列是选自SEQ ID NO：203至514所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型具有SEQ ID NO：203〜514（步骤B）所示的碱基序列中的含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。根据本发明的方法，可以通过对样品中的本发明中的单核苷酸多态性的等位基因或基因型进行分析来确定样品供体中的青光眼的发病风险水平，从而样品供体可以采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。

13. 发明授权

US07068834B1 Inspecting method, inspecting system, and method for manufacturing electronic devices 有权
标题翻译：检查方法，检查系统和电子设备制造方法
公开(公告)号：US07068834B1
公开(公告)日：2006-06-27
申请号：US09452149
申请日：1999-12-01
申请人： Yoko Ikeda , Junko Konishi , Hisafumi Iwata , Yuji Takagi , Kenji Obara , Ryo Nakagaki , Seiji Isogai , Yasuhiko Ozawa
发明人： Yoko Ikeda , Junko Konishi , Hisafumi Iwata , Yuji Takagi , Kenji Obara , Ryo Nakagaki , Seiji Isogai , Yasuhiko Ozawa
IPC分类号： G06K9/00
CPC分类号： G06F3/0486 , G06F2203/04803 , G06T7/0004 , G06T2200/24 , G06T2207/30148
摘要： The present invention has an analyzing unit including an image detection device for producing a plurality of images of a workpiece, a storage for storing detected images produced by the image detection device, and a display having a screen with a first area for displaying a plurality of detected images stored in the storage and a plurality of second areas for classifying the detected images according to features of the detected images, whereby the plurality of detected images are moved on the screen from the first area to selected second areas to classify the plurality of detected images in the second areas.
摘要翻译：本发明具有一种分析单元，包括用于产生工件的多个图像的图像检测装置，用于存储由图像检测装置产生的检测图像的存储器以及具有用于显示多个图像的第一区域的屏幕的显示器检测存储在存储器中的图像和多个第二区域，用于根据检测到的图像的特征对检测到的图像进行分类，由此多个检测图像在屏幕上从第一区域移动到选定的第二区域，以对多个检测到的图像进行分类图像在第二个区域。

14. 发明授权

US5849797A D-.beta.-lysylmethanediamine derivatives and preparation thereof 失效
标题翻译： D-β-赖氨酰基甲二胺衍生物及其制备
公开(公告)号：US5849797A
公开(公告)日：1998-12-15
申请号：US793912
申请日：1997-02-24
申请人： Shinichi Kondo , Yoko Ikeda , Tomio Takeuchi , Rie Shinei , Shuichi Gomi , Seiji Shibahara , Hiroo Hoshino
发明人： Shinichi Kondo , Yoko Ikeda , Tomio Takeuchi , Rie Shinei , Shuichi Gomi , Seiji Shibahara , Hiroo Hoshino
IPC分类号： A61K31/16 , A61P31/12 , A61P31/18 , A61P37/04 , C07C231/02 , C07C231/12 , C07C237/10 , C07C233/05
CPC分类号： C07C237/10
摘要： Now are provided (R)-3,6-diamino-N-(.omega.-aminoalkyl)-hexanamides which are novel compounds having the general formula (I): ##STR1## wherein n stands for 2-5, and which may be for example, (R)-3,6-diamino-N-(2-aminoethyl)hexanamide (n=2) and (R)-3,6-diamino-N-(3-aminopropyl)hexanamide (n=3). Their preparation process is also provided. These novel compounds and acid addition salts thereof have activities inhibitory against Gram-positive bacteria, Gram-negative bacteria and AIDS virus, as well as tumor cells and are chemically stable. These novel compounds and their salts are useful as chemotherapeutic agents for diseases caused by these bacteria or virus and also as antitumor agent.
摘要翻译： PCT No.PCT / JP95 / 01680 Sec。 371日期1997年2月24日 102（e）1997年2月24日PCT PCT 1995年8月24日PCT公布。公开号WO96 / 06069 日期：1996年2月29日提供（R）-3,6-二氨基-N-（ω-氨基烷基） - 己酰胺，它们是具有通式（I）的新化合物：其中n代表2 -5，其可以是例如（R）-3,6-二氨基-N-（2-氨基乙基）己酰胺（n = 2）和（R）-3,6-二氨基-N-（3-氨基丙基）己酰胺（n = 3）。还提供了他们的准备过程。这些新化合物及其酸加成盐具有抑制革兰氏阳性菌，革兰氏阴性菌和艾滋病病毒以及肿瘤细胞的活性，并具有化学稳定性。这些新化合物及其盐可用作由这些细菌或病毒引起的疾病的化学治疗剂，也可用作抗肿瘤剂。

15. 发明申请

US20130275349A1 Comprehensive Glaucoma Determination Method Utilizing Glaucoma Diagnosis Chip And Deformed Proteomics Cluster Analysis 审中-公开
标题翻译：综合青光眼测定方法利用青光眼诊断芯片和变形蛋白质组学分析
公开(公告)号：US20130275349A1
公开(公告)日：2013-10-17
申请号：US13976967
申请日：2011-12-28
申请人： Kei Tashiro , Shigeru Kinoshita , Tomohito Yagi , Masakazu Nakano , Kazuhiko Mori , Yoko Ikeda , Morio Ueno , Yuichi Tokuda , Katsumi Yagi , Kengo Yoshii , Masahiro Fuwa
发明人： Kei Tashiro , Shigeru Kinoshita , Tomohito Yagi , Masakazu Nakano , Kazuhiko Mori , Yoko Ikeda , Morio Ueno , Yuichi Tokuda , Katsumi Yagi , Kengo Yoshii , Masahiro Fuwa
IPC分类号： G06N99/00
CPC分类号： G06N20/00 , C12Q1/6886 , G16B20/00 , G16B25/00 , G16B40/00
摘要： Provided is a technique for determining a physiological attribute in a mammal, including the onset or progression of human glaucoma, with high accuracy. The results of the determination of genotype date and the results of the determination of cytokine date are consolidated by a consolidated determination unit (114); comparison is made for determining as to which is larger, the number of Case determination procedures or the number of control determination procedures (S330); and it is determined as Case (glaucoma) when the number of Case determination procedures is larger and it is determined as Control (normal person) when the number of Control determination procedures is larger.
摘要翻译：提供了一种用于以高精度确定哺乳动物的生理属性，包括人类青光眼的发病或进展的技术。确定基因型日期的结果和细胞因子日期的确定结果由综合确定单位（114）合并; 比较确定哪个更大，判定程序的数量或控制确定程序的数量（S330）; 当判定判定过程的数量较多并且当控制确定过程的数量较大时被确定为控制（普通人）时被确定为病例（青光眼）。

16. 发明授权

US08431345B2 Method for determination of progression risk of glaucoma 有权
标题翻译：确定青光眼进展风险的方法
公开(公告)号：US08431345B2
公开(公告)日：2013-04-30
申请号：US12596462
申请日：2008-04-17
申请人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
发明人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/156
摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
摘要翻译：一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型，其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。

17. 发明申请

US20090035785A1 IMMUNOASSAY METHOD AND REAGENT THEREFOR 有权
标题翻译：免疫方法和试剂
公开(公告)号：US20090035785A1
公开(公告)日：2009-02-05
申请号：US11817515
申请日：2006-03-02
申请人： Koji Ushizawa , Michiko Kawamoto , Shoko Yamamoto , Kumiko Yuki , Yoko Ikeda , Mitsuaki Yamamoto
发明人： Koji Ushizawa , Michiko Kawamoto , Shoko Yamamoto , Kumiko Yuki , Yoko Ikeda , Mitsuaki Yamamoto
IPC分类号： G01N33/53
CPC分类号： G01N33/581 , G01N33/5306 , G01N33/542 , G01N33/54393
摘要： The present invention provides a novel immunoassay method with high reaction specificity and high sensitivity. The present invention also provides a method for immunoassaying a target antigen utilizing reactivation of an apoenzyme, which includes simultaneously or sequentially adding a test sample to an antibody specific to the target antigen, the target antigen labeled with a coenzyme, an apo-D-amino acid oxidase, a D-amino acid, and a reagent for detecting a hydrogen peroxide produced by the oxidase.
摘要翻译：本发明提供了具有高反应特异性和高灵敏度的新型免疫测定方法。本发明还提供了使用辅酶的再活化来免疫测定靶抗原的方法，其包括同时或依次将测试样品加入到靶抗原特异性抗体中，用辅酶标记的靶抗原，载脂蛋白-D-氨基酸性氧化酶，D-氨基酸和用于检测由氧化酶产生的过氧化氢的试剂。

18. 发明申请

US20060143463A1 Keyless entry system and keyless entry method 审中-公开
标题翻译：无钥匙进入系统和无钥匙进入方法
公开(公告)号：US20060143463A1
公开(公告)日：2006-06-29
申请号：US10537491
申请日：2003-12-02
申请人： Yoko Ikeda , Yasuyuki Imai
发明人： Yoko Ikeda , Yasuyuki Imai
IPC分类号： H04L9/00
CPC分类号： B60R25/24 , B60R25/04 , B60R2325/101 , B60R2325/205 , G07C9/00309 , G07C9/00817 , G07C2009/00793 , G07C2009/00825
摘要： A keyless entry system include a key device 13 for carrying out locking and unlocking operations, a mobile terminal 14 including a mobile terminal transmitting/receiving unit 18 for transmitting user-ID number data a1 used for identifying a user of the key device 13, and a key security system 15 including a key device transmitting/receiving unit 20 for receiving the user-ID number data a1 from the mobile terminal 14. The key security system 15 includes an ID-number data comparison unit 23 for recognizing a fact that key-device ID number data a2 pre-stored in the key device 13 is identical to the user-ID number data a1 transmitted from the mobile terminal 14 and a key-device ECU 16 for receiving an unlock enable signal b and outputting a lock control signal f to the key device 13. According to the above-described configuration, when operating and activating the key device, such as a door lock device of a vehicle and a house, using a mobile terminal, such as a cell phone, which many people usually carry around with them, a keyless entry system and a keyless entry method that are reliable and convenient for users can be provided.
摘要翻译：无钥匙进入系统包括用于执行锁定和解锁操作的密钥装置13，包括用于发送用于识别密钥装置13的用户的用户ID号码数据1的移动终端发送/接收单元18的移动终端14，以及包括用于从移动终端14接收用户ID号码数据a 1的密钥装置发送/接收单元20的密钥安全系统15。密钥安全系统15包括ID号数据比较单元23，用于识别预先存储在密钥装置13中的密钥装置ID号码数据2与从移动装置发送的用户ID号数据a 1相同的事实端子14和用于接收解锁使能信号b并向锁定装置13输出锁定控制信号f的键装置ECU16。根据上述结构，当使用许多人通常携带的诸如手机的移动终端来操作和激活诸如车辆和房屋的门锁装置的钥匙装置时，可以提供对用户可靠和方便的无钥匙进入系统和无钥匙进入方法。

19. 发明授权

US06611728B1 Inspection system and method for manufacturing electronic devices using the inspection system 有权
标题翻译：使用检查系统制造电子设备的检查系统和方法
公开(公告)号：US06611728B1
公开(公告)日：2003-08-26
申请号：US09389230
申请日：1999-09-03
申请人： Natsuyo Morioka , Hisafumi Iwata , Junko Konishi , Yoko Ikeda , Kazunori Nemoto , Makoto Ono , Yasuhiro Yoshitake
发明人： Natsuyo Morioka , Hisafumi Iwata , Junko Konishi , Yoko Ikeda , Kazunori Nemoto , Makoto Ono , Yasuhiro Yoshitake
IPC分类号： G06F1900
CPC分类号： G01N21/9501 , H01L22/12 , H01L22/20
摘要： An inspection system comprises an inspection machine for inspecting a work which is processed in one of the manufacturing processes of a manufacturing line and an analysis system for outputting an inspection history list obtained by making calculations from the inspected result. The inspection history list shows a matrix of first information as the inspection processes in which the work is inspected or the manufacturing processes corresponding to the inspection processes in which the work is inspected and second information as to the works inspected by the inspection machine.
摘要翻译：检查系统包括检查机器，用于检查在生产线的一个制造过程中处理的工件和用于输出通过从检查结果进行计算而获得的检查履历表的分析系统。检查历史列表显示作为检查工作的检查过程的第一信息矩阵或与检查工作相关的检查过程对应的制造过程以及由检查机检查的工件的第二信息。

20. 发明授权

US06245734B1 Physiologically active polyoxypeptin and deoxypolyoxypeptin and anticancer drugs containing the same 失效
标题翻译：生理活性多羟脯氨酸和含有相同抗氧化素的抗癌药物
公开(公告)号：US06245734B1
公开(公告)日：2001-06-12
申请号：US09445581
申请日：1999-12-13
申请人： Tomio Takeuchi , Kazuo Umezawa , Shinichi Kondo , Yoko Ikeda , Hiroshi Naganawa , Masa Hamada
发明人： Tomio Takeuchi , Kazuo Umezawa , Shinichi Kondo , Yoko Ikeda , Hiroshi Naganawa , Masa Hamada
IPC分类号： A01N6100
CPC分类号： C12R1/465 , A61K38/00 , C07K7/06
摘要： As novel substances having an activity of inducing an apoptosis even on the apoptosis-resistant cancer cells, there are obtained polyoxypeptin and deoxypolyoxypeptin represented by the following general formula (I) wherein R denotes a hydroxyl group for polyoxypeptin, or R denotes a hydrogen atom for deoxypolyoxypeptin, by cultivation of Streptomyces sp. MK498-98F14 strain. Polyoxypeptin and deoxypolyoxypeptin are physiologically active substances which have an activity of inducing apoptosis on a human pancreatic adenocarcinoma cell, AsPC-1 cell.
摘要翻译：作为具有诱导细胞凋亡抗性的癌细胞的细胞凋亡的活性的新物质，可以举出以下通式（I）表示的多羟脯氨酸和脱氧多肽，其中R表示多羟脯氨酸的羟基，或R表示氢原子，脱氧脱氧蛋白，通过培养链霉菌 MK498-98F14菌株。多核苷酸和脱氧多肽抗氧化素是具有诱导人胰腺癌细胞AsPC-1细胞凋亡活性的生理活性物质。

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