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11. 发明申请

WO2015084701A1 TEMPERATURE-STABILIZED STORAGE SYSTEMS WITH INTEGRAL REGULATED COOLING 审中-公开
标题翻译：具有整体调节冷却的温度稳定存储系统
公开(公告)号：WO2015084701A1
公开(公告)日：2015-06-11
申请号：PCT/US2014/067863
申请日：2014-12-01
申请人： TOKITAE LLC
发明人： BLOEDOW, Jonathan , CALDERON, Ryan , FRIEND, Michael , GASPERINO, David , GATES, William , HYDE, Roderick A. , JUNG, Edward K.Y. , LIU, Shieng , MYHRVOLD, Nathan P. , PEGRAM, Nathan John , PIECH, David Keith , STONE, Shannon Weise , TEGREENE, Clarence T. , WHITMER, Charles , WOOD, Lowell L., Jr. , YILDIRIM, Ozgur Emek
IPC分类号： F28D15/02 , F25B49/00 , F25B27/02
CPC分类号： F25B21/02 , A61J1/165 , F25B23/006 , F25B2321/021 , F25D11/003 , F25D11/006 , F28D15/0275 , F28D20/021 , F28D2020/0026 , F28F1/24 , Y02E60/145
摘要： In some embodiments, a regulated thermal transfer device for a storage container includes: a phase change material unit, the phase change material unit including one or more walls surrounding a phase-change material region, and an aperture in the one or more walls; a heat pipe with a first end positioned within the phase change material unit, and a second end; a thermoelectric unit thermally connected to the second end of the heat pipe; a heat sink connected to the thermoelectric unit, and positioned to radiate heat away from the thermoelectric unit; and an electronic controller operably connected to the thermoelectric unit; wherein the regulated thermal transfer device is of a size and shape to be positioned so that the phase change material unit is within a storage region of a temperature-stabilized storage container, and the thermoelectric unit is positioned adjacent to an external surface of the temperature-stabilized storage container.
摘要翻译：在一些实施例中，用于存储容器的调节热转移装置包括：相变材料单元，所述相变材料单元包括围绕相变材料区域的一个或多个壁和所述一个或多个壁中的孔; 具有位于所述相变材料单元内的第一端的热管，以及第二端; 与热管的第二端热连接的热电单元; 连接到热电单元的散热器，并且定位成将热量从热电单元辐射出来; 以及可操作地连接到所述热电单元的电子控制器; 其特征在于，所述调节型热转印装置的尺寸和形状要被定位成使得所述相变材料单元位于温度稳定的储存容器的存储区域内，并且所述热电单元位于所述温度稳定存储容器的外表面附近，稳定的储存容器。

12. 发明申请

WO2015081058A1 REFRIGERATION DEVICES INCLUDING TEMPERATURE-CONTROLLED CONTAINER SYSTEMS 审中-公开
标题翻译：包括温度控制容器系统的制冷装置
公开(公告)号：WO2015081058A1
公开(公告)日：2015-06-04
申请号：PCT/US2014/067275
申请日：2014-11-25
申请人： TOKITAE LLC , CHOU, Fong-Li , LARUSSON, Fridrik , LIU, Shieng
发明人： CHOU, Fong-Li , LARUSSON, Fridrik , LIU, Shieng , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , GATES, William , HU, Jennifer Ezu , ISHIKAWA, Muriel Y. , MYHRVOLD, Nathan P. , PETERSON, Nels R. , TEGREENE, Clarence T. , VECCHIONE, Maurizio , WOOD, Lowell L., Jr. , WOOD, Victoria Y., H.
IPC分类号： F25D23/06 , F25D29/00 , F25B39/02
CPC分类号： F25D11/025 , F25B23/006 , F25B2500/01 , F25D11/006 , F28F3/14 , F28F2210/02 , F28F2255/18
摘要： In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to the refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned at least partially within the liquid-impermeable container; a unidirectional thermal conductor with a condensing end and an evaporative end, the condensing end positioned within the liquid-impermeable container; a first aperture in the liquid-impermeable container, the first aperture of a size, shape and position to permit the set of evaporator coils to traverse the aperture; a second aperture in the liquid-impermeable container, the second aperture including an internal surface of a size, shape and position to mate with an external surface of the unidirectional thermal conductor; and one or more walls substantially forming a storage region in thermal contact with the evaporative end of the unidirectional thermal conductor.
摘要翻译：在一些实施例中，制冷装置包括：基本上形成液体不可渗透容器的壁，其构造成在制冷装置内部保持相变材料; 至少一个主动制冷单元，其包括至少部分地定位在所述液体不可渗透容器内的一组蒸发器盘管; 具有冷凝端和蒸发端的单向热导体，冷凝端定位在液体不可渗透的容器内; 液体不可渗透容器中的第一孔，具有允许该组蒸发器盘管穿过该孔的尺寸，形状和位置的第一孔; 所述液体不可渗透容器中的第二孔，所述第二孔包括与所述单向导热体的外表面配合的尺寸，形状和位置的内表面; 以及基本上形成与单向导热体的蒸发端热接触的存储区域的一个或多个壁。

13. 发明申请

WO2014160831A1 TEMPERATURE-CONTROLLED STORAGE SYSTEMS 审中-公开
标题翻译：温度控制存储系统
公开(公告)号：WO2014160831A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/031960
申请日：2014-03-27
申请人： TOKITAE LLC
发明人： ECKHOFF, Philip, A. , GATES, William , HYDE, Roderick, A. , JUNG, Edward, K.Y. , MYHRVOLD, Nathan, P. , PETERSON, Nels, R. , TEGREENE, Clarence, T. , WHITMER, Charles , WOOD, Lowell, L.
IPC分类号： F25B21/00 , F25B21/02
CPC分类号： F25B17/08 , F25B49/046
摘要： In some embodiments, a substantially thermally sealed storage container includes an outer assembly and an evaporative cooling assembly integral to the container. In some embodiments, the outer assembly includes one or more sections of ultra efficient insulation material substantially defining at least one thermally-controlled storage region, and a single access conduit to the at least one thermally-controlled storage region. In some embodiments, the evaporative cooling assembly integral to the container includes: an evaporative cooling unit affixed to a surface of the at least one thermally-controlled storage region; a desiccant unit affixed to an external surface of the container; a vapor conduit, the vapor conduit including a first end and a second end, the first end attached to the evaporative cooling unit, the second end attached to the desiccant unit; and a vapor control unit attached to the vapor conduit.
摘要翻译：在一些实施例中，基本上热密封的储存容器包括与容器成一体的外部组件和蒸发冷却组件。在一些实施例中，外部组件包括基本上限定至少一个热控存储区域的一个或多个超高效绝缘材料部分和至少一个热控制存储区域的单个进入导管。在一些实施例中，与容器成一体的蒸发冷却组件包括：固定在至少一个热控储存区域的表面上的蒸发冷却单元; 固定在容器的外表面上的干燥剂单元; 蒸气导管，蒸气导管包括第一端和第二端，第一端连接到蒸发冷却单元，第二端连接到干燥剂单元; 以及附接到蒸汽管道的蒸汽控制单元。

15. 发明公开

EP2979044A1 TEMPERATURE-CONTROLLED STORAGE SYSTEMS 有权
标题翻译： TEMPERATURGESTEUERTE AUFBEWAHRUNGSSYSTEME
公开(公告)号：EP2979044A1
公开(公告)日：2016-02-03
申请号：EP14775659.7
申请日：2014-03-27
申请人： Tokitae LLC
发明人： ECKHOFF, Philip, A. , GATES, William , HYDE, Roderick, A. , JUNG, Edward, K.Y. , MYHRVOLD, Nathan, P. , PETERSON, Nels, R. , TEGREENE, Clarence, T. , WHITMER, Charles , WOOD, Lowell, L.
IPC分类号： F25B21/00 , F25B21/02
摘要： In some embodiments, a substantially thermally sealed storage container includes an outer assembly and an evaporative cooling assembly integral to the container. In some embodiments, the outer assembly includes one or more sections of ultra efficient insulation material substantially defining at least one thermally-controlled storage region, and a single access conduit to the at least one thermally-controlled storage region. In some embodiments, the evaporative cooling assembly integral to the container includes: an evaporative cooling unit affixed to a surface of the at least one thermally-controlled storage region; a desiccant unit affixed to an external surface of the container; a vapor conduit, the vapor conduit including a first end and a second end, the first end attached to the evaporative cooling unit, the second end attached to the desiccant unit; and a vapor control unit attached to the vapor conduit.
摘要翻译：在一些实施例中，基本上热密封的储存容器包括与容器成一体的外部组件和蒸发冷却组件。在一些实施例中，外部组件包括基本上限定至少一个热控存储区域的一个或多个超高效绝缘材料部分和至少一个热控制存储区域的单个进入导管。在一些实施例中，与容器成一体的蒸发冷却组件包括：固定在至少一个热控储存区域的表面上的蒸发冷却单元; 固定在容器的外表面上的干燥剂单元; 蒸气导管，蒸气导管包括第一端和第二端，第一端连接到蒸发冷却单元，第二端连接到干燥剂单元; 以及附接到蒸汽管道的蒸汽控制单元。

16. 发明公开

EP2646739A1 TEMPERATURE-STABILIZED STORAGE SYSTEMS 审中-公开
标题翻译：温度稳定存储系统
公开(公告)号：EP2646739A1
公开(公告)日：2013-10-09
申请号：EP11844442.1
申请日：2011-11-28
申请人： Tokitae LLC
发明人： CHOU, Fong-Li , DEANE, Geoffrey F. , FOWLER, Lawrence Morgan , GATES, William , HU, Jennifer Ezu , HYDE, Roderick A. , JUNG, Edward K.Y. , KARE, Jordin T. , KUIPER, Mark K. , MYHRVOLD, Nathan P. , PEGRAM, Nathan , PETERSON, Nels R. , TEGREENE, Clarence T. , VILHAUER, Michael , WHITMER, Charles , WOOD, Lowell L., Jr. , YILDIRIM, Ozgur Emek
IPC分类号： F17C11/00
CPC分类号： B65D81/3802 , B65D81/3811 , B65D81/3813 , B65D81/3823 , B65D81/3825 , B65D81/3834 , B65D81/3888 , B65D81/3897 , B65D2203/10 , F25D2201/14
摘要： Methods and apparatus described herein relate to establishing and maintaining low gas pressure within a gas-sealed device fabricated from heat sensitive materials. Methods include transferring activated getters within the interior of an apparatus from regions fabricated from heat-resistant materials to interior regions of the gas-sealed device fabricated from heat-sensitive materials.

17. 发明公开

EP3763383A1 MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS 审中-实审
公开(公告)号：EP3763383A1
公开(公告)日：2021-01-13
申请号：EP20177222.5
申请日：2014-12-16
申请人： Massachusetts Institute Of Technology , Tokitae LLC
发明人： JAKLENEC, Ana , GATES, William , WELKHOFF, Philip A , NIKOLIC, Boris , WOOD, Lowell L , LANGER, Robert S , NORMAN, James J , NGUYEN, Thanh Duc , TZENG, Stephany Yi , MCHUGH, Kevin
IPC分类号： A61K39/00 , A61K39/12
摘要： Emulsion-based and micromolded ("MM") or three dimensional printed ("3DP") polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

18. 发明公开

EP3082471A1 FORTIFIED MICRONUTRIENT SALT FORMULATIONS 有权
标题翻译： ANGEREICHERTEMIKRONÄHRSTOFFSALZFORMULIERUNGEN
公开(公告)号：EP3082471A1
公开(公告)日：2016-10-26
申请号：EP14824684.6
申请日：2014-12-16
申请人： Massachusetts Institute Of Technology , Tokitae LLC
发明人： JAKLENEC, Ana , XU, Xian , WOOD, Lowell L. Jr. , ECKHOFF, Philip A. , GATES, William , NIKOLIC, Boris , LANGER, Robert S.
IPC分类号： A23L33/15 , A23L33/16 , A23L5/00 , A23L27/00
CPC分类号： A61K9/5026 , A23L27/72 , A23L27/74 , A23L33/10 , A23L33/15 , A23L33/155 , A23L33/16 , A23P10/30 , A23V2002/00 , A61K9/4866 , A61K9/501 , A61K9/5073 , A61K31/07 , A61K31/23 , A61K31/295 , A61K31/375 , A61K31/519 , A61K31/593 , A61K31/714 , A61K33/18 , A61K33/26 , A61K33/30 , A61K45/06 , A61K47/26 , A61K47/36
摘要： Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.
摘要翻译：本文描述了耐水分和烹饪条件的盐制剂。该制剂提供包封在耐热pH敏感性水不溶性聚合物中的微量营养素和维生素颗粒，其被包装在盐壳内。 pH敏感的水不溶性的热稳定材料稳定微量营养素，特别是在高温下，例如在食物制备和烹饪期间，并且在所需位置例如胃，小肠等释放微量营养素。优选的pH- 敏感的聚合物在低pH下释放，小于胃中存在的pH。颗粒可用于与盐同时递送每日推荐剂量的微量营养素，从而消除维生素丸的需要。这对于严重营养不良的人群尤其重要。

19. 发明公开

EP2534434A1 TEMPERATURE-STABILIZED STORAGE SYSTEMS 审中-公开
标题翻译： TEMPERATURSTABILISIERTE LAGERSYSTEME
公开(公告)号：EP2534434A1
公开(公告)日：2012-12-19
申请号：EP11740155.4
申请日：2011-02-08
申请人： Tokitae LLC
发明人： CHOU, Fong-Li , DEANE, Geoffrey, F. , FOWLER, Lawrence Morgan , GATES, William , GUO, Zihong , HU, Jennifer Ezu , HYDE, Roderick, A. , JUNG, Edward, K., Y. , KARE, Jordin, T. , MYHRVOLD, Nathan, P. , PEGRAM, Nathan , PETERSON, Nels, R. , TEGREENE, Clarence, T. , WHITMER, Charles , WOOD, Lowell, L., Jr.
IPC分类号： F25D3/08
CPC分类号： B65D81/3806 , A61J1/00 , A61J2200/40 , F28D20/02
摘要： A substantially thermally sealed storage container includes an outer assembly, including one or more sections of ultra efficient insulation material substantially defining at least one thermally sealed storage region, and an inner assembly, including at least one heat sink unit within the at least one thermally sealed storage region. The inner assembly may include at least one stored material dispenser unit, wherein the at least one stored material dispenser unit includes one or more interlocks. The inner assembly may include a storage structure configured for receiving and storing at least one heat sink module and at least one stored material module. Substantially thermally sealed containers including flexible connectors joining an aperture in the exterior of the container to an aperture in a substantially thermally sealed storage region within the container are described. Systems including at least one substantially thermally sealed storage container and an information system are also described.
摘要翻译：描述了基本上热密封的容器，其包括将容器的外部中的孔连接到容器内基本上热密封的储存区域中的孔的柔性连接器。柔性连接器包括在容器的外部和容器内的基本上热密封的存储区域之间形成细长的热路径的管道。柔性连接器包括与管道的每一端配合的压缩单元和连接在压缩单元之间的多个压缩股。

20. 发明公开

EP3292362A1 REFRIGERATION DEVICES INCLUDING TEMPERATURE-CONTROLLED CONTAINER SYSTEMS 审中-实审转让
标题翻译：包括温度控制容器系统的制冷设备
公开(公告)号：EP3292362A1
公开(公告)日：2018-03-14
申请号：EP16789968.1
申请日：2016-05-04
申请人： Tokitae LLC
发明人： CHOU, Fong-Li , WELKHOFF, Philip A. , FOWLER, Lawrence Morgan , GATES, William , HU, Jenny Ezu , ISHIKAWA, Muriel Y. , LARUSSON, Fridrik , LIU, Shieng , MYHRVOLD, Nathan P. , PAL, Brian L. , PETERSON, Nels R. , PIECH, David Keith , VECCHIONE, Maurizio , WOOD, Lowell L., Jr. , WOOD, Victoria Y.H. , YAGER, David J.
IPC分类号： F25D23/06 , F25B39/02 , F25B39/04 , F25D23/02 , F25D29/00
CPC分类号： F25D16/00 , F25B23/006 , F25D11/006
摘要： In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to a refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned within an interior of the liquid-impermeable container; walls substantially forming a storage region; and a heat transfer system including a first group of vapor-impermeable structures with a hollow interior connected to form a condenser in thermal contact with the walls substantially forming a liquid-impermeable container, a second group of vapor-impermeable structures with a hollow interior connected to form an evaporator in thermal contact with the walls substantially forming a storage region, and a connector with a hollow interior affixed to both the condenser and the evaporator, the connector forming a liquid and vapor flow path between the hollow interior of the condenser and the hollow interior of the evaporator.

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