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1. 发明申请

WO2014194022A1 TEMPERATURE-STABILIZED STORAGE SYSTEMS WITH REGULATED COOLING 审中-公开
标题翻译：温度稳定的储存系统与调节冷却
公开(公告)号：WO2014194022A1
公开(公告)日：2014-12-04
申请号：PCT/US2014/039899
申请日：2014-05-29
申请人： TOKITAE LLC
发明人： BLOEDOW, Jonathan , CALDERON, Ryan , GASPERINO, David , GATES, William , HYDE, Roderick A. , JUNG, Edward K.Y. , LIU, Shieng , MYHRVOLD, Nathan P. , PEGRAM, Nathan John , TEGREENE, Clarence T. , WHITMER, Charles , WOOD, Lowell L., Jr. , YILDIRIM, Ozgur Emek
IPC分类号： B65D81/38
CPC分类号： F25B21/02 , F25D3/06 , F25D2201/14
摘要： Regulated cooling devices are described herein that are sized, shaped and calibrated for use with a substantially thermally sealed storage container. In some embodiments, the regulated cooling devices include a cooling region, an adiabatic region, a lid region, and an electronics unit attached to the lid region.
摘要翻译：本文描述了调节冷却装置，其尺寸，形状和校准用于与基本上热密封的储存容器一起使用。在一些实施例中，调节的冷却装置包括冷却区域，绝热区域，盖子区域和附接到盖子区域的电子单元。

2. 发明申请

WO2018213118A1 MANAGEMENT OF A THERAPEUTIC OXYGEN DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2018213118A1
公开(公告)日：2018-11-22
申请号：PCT/US2018/032243
申请日：2018-05-11
申请人： TOKITAE LLC
发明人： BURKOT, Stephen Thomas Graves , CALDERON, Ryan , KUIPER, Mark K. , LIEBERMAN, Daniel Howard , NG, Chin Hei
IPC分类号： A61M16/10 , A61M16/00
摘要： Described embodiments include a therapeutic oxygen supply apparatus. The apparatus includes at least two components, including an intake manifold component configured to receive concentrated oxygen, a compressor component configured to compress concentrated oxygen, an oxygen tank component configured to store concentrated oxygen, a patient manifold component configured to supply concentrated oxygen, or a control structure component configured to route a flow of concentrated oxygen. A sensor circuit acquires data indicative of a respective operational state of the at least two components. A rule-based engine selects a next operational state of a component in response to (i) the acquired data indicative of the respective operational states of the at least two components and (ii) a rule database having at least one rule responsive to an objective providing a therapeutic flow of oxygen to the patient. A configuration manager circuit generates a control signal implementing the selected next operational state.

3. 发明申请

WO2017155883A1 TEMPERATURE STABILIZED CULTURE INCUBATOR 审中-公开
标题翻译：温度稳定培养培养箱
公开(公告)号：WO2017155883A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/020951
申请日：2017-03-06
申请人： TOKITAE LLC
发明人： CALDERON, Ryan , FRIEND, Michael , GHIONEA, Simon Jeffrey , MILLER, Andrew Kuehl , NORTON, Bryan
IPC分类号： C12M1/00 , C12M1/02 , G01N29/07 , G01N29/34
摘要： Described embodiments include a culture incubator, method, and sensor circuit. A culture incubator includes an accessible incubation compartment configured to contain a culture item at a specified incubation temperature; a phase change material having a phase transition temperature over the specified incubation temperature; and a heat transfer element in thermal communication with the phase change material and configured to transfer heat to the phase change material. A sensor circuit is configured to acquire data indicative of a phase composition state of the phase change material. A manager circuit is configured to determine a difference between the phase composition state and a target phase composition state for the phase change material. A controller circuit is configured to transfer heat to the phase change material in an amount estimated to change the phase composition state of the phase change material to the target phase composition state.
摘要翻译：所描述的实施例包括培养培养箱，方法和传感器电路。培养培养箱包括可接近的培养室，其被配置为在指定的培养温度下容纳培养物品; 相变温度超过规定温育温度的相变材料; 以及传热元件，其与相变材料热连通并被配置成将热传递至相变材料。传感器电路被配置为获取指示相变材料的相组成状态的数据。管理器电路被配置为确定相变材料的相组成状态与目标相组成状态之间的差异。控制器电路被配置成以估计的量将热量传递至相变材料，以将相变材料的相组成状态改变为目标相组成状态。

4. 发明公开

EP3426765A1 TEMPERATURE STABILIZED CULTURE INCUBATOR 审中-公开
公开(公告)号：EP3426765A1
公开(公告)日：2019-01-16
申请号：EP17763836.8
申请日：2017-03-06
申请人： Tokitae LLC
发明人： CALDERON, Ryan , FRIEND, Michael , GHIONEA, Simon Jeffrey , MILLER, Andrew Kuehl , NORTON, Bryan
IPC分类号： C12M1/00 , C12M1/02 , G01N29/07 , G01N29/34

5. 发明申请

WO2020092254A1 SYSTEMS FOR THE CONTROL OF VALVELESS MICROFLUIDIC DEVICES USING ROTATIONAL AND PISTONING MOTION 审中-公开
公开(公告)号：WO2020092254A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058372
申请日：2019-10-28
申请人： TOKITAE LLC
发明人： ALONZO, Luis F. , CALDERON, Ryan , FRIEND, Michael , LE NY, Anne-Laure M. , MILLER, Andrew K. , NICHOLS, Kevin Paul Flood
IPC分类号： G01N35/02 , B01L3/00 , B01L9/00 , G01N35/04 , G01N35/00
摘要： Controlling a valveless microfluidic device using rotational and pistoning motion is disclosed. A system embodiment includes, but is not limited to, a stage to support a valveless microfluidic device, the stage having a bottom surface coupled with an extension, having a threaded portion, and defining an interior volume; a first motor including a powered rotating portion operable to engage with the threaded portion to induce a z-axis motion of the stage; a second motor including a powered rotating portion coupled with a slidable coupler, the slidable coupler engaging the interior volume to induce a second motion of the stage about the z-axis; a base defining an aperture to receive the stage; and a lid having a subset of the plurality of apertures corresponding to a subset of a plurality of apertures defined by the valveless microfluidic device upon positioning of the stage by the first motor and the second motor.

6. 发明申请

WO2017155560A1 THERMAL EXPANSION ACTUATORS, MICROSCOPES INCLUDING THE SAME, AND RELATED METHODS 审中-公开
标题翻译：热膨胀促动器，包括其的显微镜，以及相关方法
公开(公告)号：WO2017155560A1
公开(公告)日：2017-09-14
申请号：PCT/US2016/036160
申请日：2016-06-07
申请人： TOKITAE LLC
发明人： CALDERON, Ryan , GASPERINO, David , MCGUIRE, Shawn Keith , ROECKER, James Andrew
IPC分类号： G01N25/34 , G01N25/32
CPC分类号： G02B21/26
摘要： Embodiments disclosed herein include thermal expansion actuators, systems using the same (e.g., microscopes), and methods of using the same. The thermal expansion actuators disclosed herein can include at least one beam coupled to and extending between a plurality of support portions. The thermal expansion actuators also include at least one heating element configured to heat at least a portion of the thermal expansion actuators, such as the at least one beam. The support portions are coupled to an structure (e.g., a component of a microscope) in a manner that at least partially restrains thermal expansion or contraction of the thermal expansion actuators in at least one direction when the thermal expansion actuators are heated or cooled, respectively. Restraining the thermal expansion actuators can controllably and selectively produce relative movement in the at least one beam (e.g., deflected). For example, the thermal expansion actuators can be heated or cooled to controllably and selectively deflect the beam in 1 µm displacements or less.
摘要翻译：这里公开的实施例包括热膨胀致动器，使用其的系统（例如，显微镜）以及使用该系统的方法。本文公开的热膨胀致动器可以包括耦合到多个支撑部分并且在多个支撑部分之间延伸的至少一个梁。热膨胀致动器还包括至少一个加热元件，其构造成加热至少一部分热膨胀致动器，例如至少一个梁。支撑部分以这样的方式联接至结构（例如，显微镜的部件）：当热膨胀致动器分别被加热或冷却时，至少部分地限制热膨胀致动器在至少一个方向上的热膨胀或收缩。限制热膨胀致动器可以可控地且有选择地在至少一个梁（例如，偏转）中产生相对运动。例如，可以对热膨胀致动器进行加热或冷却，以可控制的方式选择性地偏转1微米或更小位移量的梁。

7. 发明申请

WO2015084701A1 TEMPERATURE-STABILIZED STORAGE SYSTEMS WITH INTEGRAL REGULATED COOLING 审中-公开
标题翻译：具有整体调节冷却的温度稳定存储系统
公开(公告)号：WO2015084701A1
公开(公告)日：2015-06-11
申请号：PCT/US2014/067863
申请日：2014-12-01
申请人： TOKITAE LLC
发明人： BLOEDOW, Jonathan , CALDERON, Ryan , FRIEND, Michael , GASPERINO, David , GATES, William , HYDE, Roderick A. , JUNG, Edward K.Y. , LIU, Shieng , MYHRVOLD, Nathan P. , PEGRAM, Nathan John , PIECH, David Keith , STONE, Shannon Weise , TEGREENE, Clarence T. , WHITMER, Charles , WOOD, Lowell L., Jr. , YILDIRIM, Ozgur Emek
IPC分类号： F28D15/02 , F25B49/00 , F25B27/02
CPC分类号： F25B21/02 , A61J1/165 , F25B23/006 , F25B2321/021 , F25D11/003 , F25D11/006 , F28D15/0275 , F28D20/021 , F28D2020/0026 , F28F1/24 , Y02E60/145
摘要： In some embodiments, a regulated thermal transfer device for a storage container includes: a phase change material unit, the phase change material unit including one or more walls surrounding a phase-change material region, and an aperture in the one or more walls; a heat pipe with a first end positioned within the phase change material unit, and a second end; a thermoelectric unit thermally connected to the second end of the heat pipe; a heat sink connected to the thermoelectric unit, and positioned to radiate heat away from the thermoelectric unit; and an electronic controller operably connected to the thermoelectric unit; wherein the regulated thermal transfer device is of a size and shape to be positioned so that the phase change material unit is within a storage region of a temperature-stabilized storage container, and the thermoelectric unit is positioned adjacent to an external surface of the temperature-stabilized storage container.
摘要翻译：在一些实施例中，用于存储容器的调节热转移装置包括：相变材料单元，所述相变材料单元包括围绕相变材料区域的一个或多个壁和所述一个或多个壁中的孔; 具有位于所述相变材料单元内的第一端的热管，以及第二端; 与热管的第二端热连接的热电单元; 连接到热电单元的散热器，并且定位成将热量从热电单元辐射出来; 以及可操作地连接到所述热电单元的电子控制器; 其特征在于，所述调节型热转印装置的尺寸和形状要被定位成使得所述相变材料单元位于温度稳定的储存容器的存储区域内，并且所述热电单元位于所述温度稳定存储容器的外表面附近，稳定的储存容器。

8. 发明申请

WO2015084700A1 STORAGE APPARATUSES AND RELATED METHODS FOR STORING TEMPERATURE-SENSITIVE ITEMS 审中-公开
标题翻译：储存装置及储存温度敏感项目的相关方法
公开(公告)号：WO2015084700A1
公开(公告)日：2015-06-11
申请号：PCT/US2014/067862
申请日：2014-12-01
申请人： TOKITAE LLC
发明人： CALDERON, Ryan , CHOU, Fong-Li , FRIEND, Michael , GASPERINO, David , LIU, Shieng , ROSEN, Matthew F. , STONE, Shannon Weise , YILDIRIM, Ozgur Emek
IPC分类号： F25B49/00 , F25B30/06 , F25B21/02
CPC分类号： F25D11/006 , F25B21/02 , F25D2400/10
摘要： Embodiments disclosed herein relate to apparatuses and methods for storing temperature-sensitive items. More specifically, embodiments include a storage apparatus that may store the temperature-sensitive items. For example, the storage apparatus may include a storage compartment that may be maintained at a predetermined temperature or temperature range.
摘要翻译：本文公开的实施例涉及用于存储温度敏感物品的装置和方法。更具体地，实施例包括可以存储温度敏感项目的存储装置。例如，存储装置可以包括可以保持在预定温度或温度范围的储藏室。

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