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1. 发明公开

EP2979044A1 TEMPERATURE-CONTROLLED STORAGE SYSTEMS 有权
标题翻译： TEMPERATURGESTEUERTE AUFBEWAHRUNGSSYSTEME
公开(公告)号：EP2979044A1
公开(公告)日：2016-02-03
申请号：EP14775659.7
申请日：2014-03-27
申请人： Tokitae LLC
发明人： ECKHOFF, Philip, A. , GATES, William , HYDE, Roderick, A. , JUNG, Edward, K.Y. , MYHRVOLD, Nathan, P. , PETERSON, Nels, R. , TEGREENE, Clarence, T. , WHITMER, Charles , WOOD, Lowell, L.
IPC分类号： F25B21/00 , F25B21/02
摘要： In some embodiments, a substantially thermally sealed storage container includes an outer assembly and an evaporative cooling assembly integral to the container. In some embodiments, the outer assembly includes one or more sections of ultra efficient insulation material substantially defining at least one thermally-controlled storage region, and a single access conduit to the at least one thermally-controlled storage region. In some embodiments, the evaporative cooling assembly integral to the container includes: an evaporative cooling unit affixed to a surface of the at least one thermally-controlled storage region; a desiccant unit affixed to an external surface of the container; a vapor conduit, the vapor conduit including a first end and a second end, the first end attached to the evaporative cooling unit, the second end attached to the desiccant unit; and a vapor control unit attached to the vapor conduit.
摘要翻译：在一些实施例中，基本上热密封的储存容器包括与容器成一体的外部组件和蒸发冷却组件。在一些实施例中，外部组件包括基本上限定至少一个热控存储区域的一个或多个超高效绝缘材料部分和至少一个热控制存储区域的单个进入导管。在一些实施例中，与容器成一体的蒸发冷却组件包括：固定在至少一个热控储存区域的表面上的蒸发冷却单元; 固定在容器的外表面上的干燥剂单元; 蒸气导管，蒸气导管包括第一端和第二端，第一端连接到蒸发冷却单元，第二端连接到干燥剂单元; 以及附接到蒸汽管道的蒸汽控制单元。

2. 发明公开

EP3082852A1 MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS 无效
标题翻译： MICRO或形状3D打印机疫苗制剂PULSATING RELEASE
公开(公告)号：EP3082852A1
公开(公告)日：2016-10-26
申请号：EP14830756.4
申请日：2014-12-16
申请人： Massachusetts Institute of Technology , Tokitae LLC
发明人： JAKLENEC, Ana , GATES, William , ECKHOFF, Philip, A. , NIKOLIC, Boris , WOOD, Lowell, L. , LANGER, Robert, S. , NORMAN, James J , NGUYEN, Thanh Duc , TZENG, Stephany Yi
IPC分类号： A61K39/00 , A61K39/12
CPC分类号： A61K39/39 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/6093 , C12N2770/32634 , Y02A50/466
摘要： Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

3. 发明授权

EP2979044B1 TEMPERATURE-CONTROLLED STORAGE SYSTEMS 有权
公开(公告)号：EP2979044B1
公开(公告)日：2020-10-07
申请号：EP14775659.7
申请日：2014-03-27
申请人： Tokitae LLC
发明人： ECKHOFF, Philip, A. , GATES, William , HYDE, Roderick, A. , JUNG, Edward, K.Y. , MYHRVOLD, Nathan, P. , PETERSON, Nels, R. , TEGREENE, Clarence, T. , WHITMER, Charles , WOOD, Lowell, L.
IPC分类号： F25B21/00 , F25B21/02 , B65D81/38 , F25B17/08

4. 发明申请

WO2015191920A1 RESIDENCE STRUCTURES AND RELATED METHODS 审中-公开
标题翻译：居住结构和相关方法
公开(公告)号：WO2015191920A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035423
申请日：2015-06-11
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , TOKITAE LLC
发明人： BELLINGER, Andrew , ZHANG, Shiyi , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , MO, Stacy , GRANT, Tyler , JAFARI, Mousa , GLETTIG, Dean, Liang , DICICCIO, Angela , WOOD, Lowell, L. , ECKHOFF, Philip, A.
IPC分类号： C08F8/00 , C08G63/682
CPC分类号： A61K9/0065 , A61K9/0053 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.
摘要翻译：通常提供住宅结构，系统和相关方法。某些实施方案包括将住院结构施用（例如，口服）给对象（例如，患者），使得住院结构保持在受试者内部某一时间（例如至少约24小时）之前被释放。在一些情况下，住院结构可以是胃停留结构。在一些实施方案中，本文所述的结构和系统包含一种或多种配置用于在酸性环境中负载高活性物质（例如治疗剂），高活性物质和/或结构稳定性，内部机械柔性和强度的材料孔（例如胃腔），容易通过胃肠道直到输送到期望的内部孔（例如胃腔），和/或在生理环境（例如，肠环境）和/或对化学刺激剂的反应（例如，摄入引起快速溶解/降解的溶液）。在某些实施方案中，结构具有模块化设计，将配置用于治疗，诊断和/或增强剂的受控释放的材料与胃停留所必需的结构材料组合，但被配置用于受控和/或可调节的降解/溶解以确定保留形状完整性丧失并且结构从胃腔排出的时间。例如，在某些实施方案中，停留结构包括第一弹性组分，被配置成释放活性物质（例如治疗剂）的第二组分和任选的连接体。在一些这样的实施方案中，接头可以被配置为降解，使得停留结构在预定量的时间之后分离并且在对象内部的位置释放。

5. 发明申请

WO2015095230A1 MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS 审中-公开
标题翻译：微型或三维印刷的流感疫苗制剂
公开(公告)号：WO2015095230A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/070664
申请日：2014-12-16
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , TOKITAE LLC
发明人： JAKLENEC, Ana , GATES, William , ECKHOFF, Philip, A. , NIKOLIC, Boris , WOOD, Lowell, L. , LANGER, Robert, S.
IPC分类号： A61K39/00 , A61K39/12
CPC分类号： A61K39/39 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/6093 , C12N2770/32634 , Y02A50/466
摘要： Emulsion-based and micromolded ("MM") or three dimensional printed ("3DP") polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
摘要翻译：已经开发了用于单次注射抗原的乳液基和微成型（“MM”）或三维印刷（“3DP”）聚合物制剂，优选在两个或更多个时间段内释放。制剂优选由生物相容的可生物降解的聚合物形成。单独或与其他抗原，佐剂，稳定剂和释放调节剂组合的包封抗原的离散区域存在于制剂中。抗原优选在给药时或赋形剂的表面存在于赋形剂中，用于立即释放，并且在初始释放抗原后10至45天，任选地以10至90天的间隔，并入引发至制剂内以释放在一个或多个额外的时间段内释放抗原。抗原可以通过使用稳定剂例如海藻糖玻璃来稳定。在用于针对脊髓灰质炎免疫的优选实施方案中，抗原在给药时释放，此后二，四和六个月释放。

6. 发明申请

WO2014160831A1 TEMPERATURE-CONTROLLED STORAGE SYSTEMS 审中-公开
标题翻译：温度控制存储系统
公开(公告)号：WO2014160831A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/031960
申请日：2014-03-27
申请人： TOKITAE LLC
发明人： ECKHOFF, Philip, A. , GATES, William , HYDE, Roderick, A. , JUNG, Edward, K.Y. , MYHRVOLD, Nathan, P. , PETERSON, Nels, R. , TEGREENE, Clarence, T. , WHITMER, Charles , WOOD, Lowell, L.
IPC分类号： F25B21/00 , F25B21/02
CPC分类号： F25B17/08 , F25B49/046
摘要： In some embodiments, a substantially thermally sealed storage container includes an outer assembly and an evaporative cooling assembly integral to the container. In some embodiments, the outer assembly includes one or more sections of ultra efficient insulation material substantially defining at least one thermally-controlled storage region, and a single access conduit to the at least one thermally-controlled storage region. In some embodiments, the evaporative cooling assembly integral to the container includes: an evaporative cooling unit affixed to a surface of the at least one thermally-controlled storage region; a desiccant unit affixed to an external surface of the container; a vapor conduit, the vapor conduit including a first end and a second end, the first end attached to the evaporative cooling unit, the second end attached to the desiccant unit; and a vapor control unit attached to the vapor conduit.
摘要翻译：在一些实施例中，基本上热密封的储存容器包括与容器成一体的外部组件和蒸发冷却组件。在一些实施例中，外部组件包括基本上限定至少一个热控存储区域的一个或多个超高效绝缘材料部分和至少一个热控制存储区域的单个进入导管。在一些实施例中，与容器成一体的蒸发冷却组件包括：固定在至少一个热控储存区域的表面上的蒸发冷却单元; 固定在容器的外表面上的干燥剂单元; 蒸气导管，蒸气导管包括第一端和第二端，第一端连接到蒸发冷却单元，第二端连接到干燥剂单元; 以及附接到蒸汽管道的蒸汽控制单元。

7. 发明申请

WO2012170926A1 HEAT STABLE VESSEL 审中-公开
标题翻译：热稳定的船只
公开(公告)号：WO2012170926A1
公开(公告)日：2012-12-13
申请号：PCT/US2012/041718
申请日：2012-06-08
申请人： TOKITAE LLC , CHAMPLIN, Cary, Richard , FOWLER, Lawrence, Morgan , GUO, Zihong , HU, Jenny , KENT, Ian, Fletcher , MURRAY, Ian , PEGRAM, Nathan, John , STONE, Shannon, Weise , WALTERS, Sarah, Patricia , WOOD, Lowell, L. , YILDIRIM, Ozgur, Emek , YOUNG, Christopher, Charles
发明人： CHAMPLIN, Cary, Richard , FOWLER, Lawrence, Morgan , GUO, Zihong , HU, Jenny , KENT, Ian, Fletcher , MURRAY, Ian , PEGRAM, Nathan, John , STONE, Shannon, Weise , WALTERS, Sarah, Patricia , WOOD, Lowell, L. , YILDIRIM, Ozgur, Emek , YOUNG, Christopher, Charles
IPC分类号： B02C25/00
CPC分类号： A23L3/003 , A23C3/023 , A23L3/16
摘要： The present disclosure relates to methods, systems, and devices that may be used to heat treat and store one or more fluids.
摘要翻译：本公开涉及可用于热处理和储存一种或多种流体的方法，系统和装置。

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