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1. 发明授权

EP3082471B1 FORTIFIED MICRONUTRIENT SALT FORMULATIONS 有权
标题翻译：强化微量盐制剂
公开(公告)号：EP3082471B1
公开(公告)日：2017-10-04
申请号：EP14824684.6
申请日：2014-12-16
申请人： Massachusetts Institute Of Technology , Tokitae LLC
发明人： JAKLENEC, Ana , XU, Xian , WOOD, Lowell L. Jr. , ECKHOFF, Philip A. , GATES, William , NIKOLIC, Boris , LANGER, Robert S.
IPC分类号： A23L33/15 , A23L33/16 , A23L5/00 , A23L27/00
CPC分类号： A61K9/5026 , A23L27/72 , A23L27/74 , A23L33/10 , A23L33/15 , A23L33/155 , A23L33/16 , A23P10/30 , A23V2002/00 , A61K9/4866 , A61K9/501 , A61K9/5073 , A61K31/07 , A61K31/23 , A61K31/295 , A61K31/375 , A61K31/519 , A61K31/593 , A61K31/714 , A61K33/18 , A61K33/26 , A61K33/30 , A61K45/06 , A61K47/26 , A61K47/36
摘要： Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.
摘要翻译：本文描述了耐潮湿和烹饪条件的盐制剂。该制剂提供微粒营养素和维生素微粒包封在耐热pH敏感的不溶于水的聚合物内，其被包装在盐壳内。 pH敏感的，水不溶性的，热稳定的材料稳定了微量营养素，特别是在高温下，例如在食物制备和烹饪过程中，并且在期望的位置如胃，小肠等释放微量营养素。优选的pH- 敏感聚合物在低pH下释放，低于胃中存在的pH。这些颗粒可以用来同时提供每日推荐剂量的微量营养素和盐，无需维生素药片。这在严重营养不良的人群中尤为重要。

2. 发明公开

EP3082471A1 FORTIFIED MICRONUTRIENT SALT FORMULATIONS 有权
标题翻译： ANGEREICHERTEMIKRONÄHRSTOFFSALZFORMULIERUNGEN
公开(公告)号：EP3082471A1
公开(公告)日：2016-10-26
申请号：EP14824684.6
申请日：2014-12-16
申请人： Massachusetts Institute Of Technology , Tokitae LLC
发明人： JAKLENEC, Ana , XU, Xian , WOOD, Lowell L. Jr. , ECKHOFF, Philip A. , GATES, William , NIKOLIC, Boris , LANGER, Robert S.
IPC分类号： A23L33/15 , A23L33/16 , A23L5/00 , A23L27/00
CPC分类号： A61K9/5026 , A23L27/72 , A23L27/74 , A23L33/10 , A23L33/15 , A23L33/155 , A23L33/16 , A23P10/30 , A23V2002/00 , A61K9/4866 , A61K9/501 , A61K9/5073 , A61K31/07 , A61K31/23 , A61K31/295 , A61K31/375 , A61K31/519 , A61K31/593 , A61K31/714 , A61K33/18 , A61K33/26 , A61K33/30 , A61K45/06 , A61K47/26 , A61K47/36
摘要： Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.
摘要翻译：本文描述了耐水分和烹饪条件的盐制剂。该制剂提供包封在耐热pH敏感性水不溶性聚合物中的微量营养素和维生素颗粒，其被包装在盐壳内。 pH敏感的水不溶性的热稳定材料稳定微量营养素，特别是在高温下，例如在食物制备和烹饪期间，并且在所需位置例如胃，小肠等释放微量营养素。优选的pH- 敏感的聚合物在低pH下释放，小于胃中存在的pH。颗粒可用于与盐同时递送每日推荐剂量的微量营养素，从而消除维生素丸的需要。这对于严重营养不良的人群尤其重要。

3. 发明授权

EP3155024B1 RESIDENCE STRUCTURES AND RELATED METHODS 有权
公开(公告)号：EP3155024B1
公开(公告)日：2020-09-16
申请号：EP15806017.8
申请日：2015-06-11
申请人： Massachusetts Institute Of Technology , The Brigham and Women's Hospital, Inc.
发明人： BELLINGER, Andrew , ZHANG, Shiyi , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , MO, Stacy , GRANT, Tyler , JAFARI, Mousa , GLETTIG, Dean Liang , DICICCIO, Angela , WOOD, Lowell L. Jr. , ECKHOFF, Philip A.
IPC分类号： A61K9/00

4. 发明公开

EP3155024A1 RESIDENCE STRUCTURES AND RELATED METHODS 有权
标题翻译： WOHNUNGSSTRUKTUREN UNDZUGEHÖRIGEVERFAHREN
公开(公告)号：EP3155024A1
公开(公告)日：2017-04-19
申请号：EP15806017.8
申请日：2015-06-11
申请人： Massachusetts Institute Of Technology , The Brigham and Women's Hospital, Inc.
发明人： BELLINGER, Andrew , ZHANG, Shiyi , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , MO, Stacy , GRANT, Tyler , JAFARI, Mousa , GLETTIG, Dean Liang , DICICCIO, Angela , WOOD, Lowell L. Jr. , ECKHOFF, Philip A.
IPC分类号： C08F8/00 , C08G63/682
摘要： Described are gastric residence structures that include an active substance. The gastric residence structures may include one or more arms that include a loadable polymeric component, an elastic polymeric component, and a separate linker component. The linker may connect the one or more arms with the elastic polymeric component. The gastric residence structures may be configured to be folded and physically constrained during administration and may be configured to assume an open retention shape upon removal of a constraint. The change between the folded shape and the open retention shape may be mediated by the elastic polymeric component that undergoes elastic deformation when the residence structure is in the folded shape and recoils when the gastric residence structure assumes the open retention shape.
摘要翻译：通常提供住宅结构，系统和相关方法。某些实施方案包括将住院结构施用（例如，口服）给对象（例如，患者），使得住宿结构保持在受试者内部某一时间（例如，至少约24小时）在被释放之前。在一些情况下，住院结构可以是胃停留结构。在一些实施方案中，本文所述的结构和系统包括一种或多种配置用于在酸性环境中高水平的活性物质（例如治疗剂）负载，高活性物质和/或结构稳定性，在内部的机械柔性和强度孔（例如，胃腔），容易通过胃肠道直到输送到期望的内部孔口（例如胃腔），和/或在生理环境（例如，肠环境）中快速溶解/降解）和/或对化学刺激剂的反应（例如，摄入引起快速溶解/降解的溶液）。在某些实施方案中，该结构具有模块化设计，将配置用于控制释放治疗剂，诊断和/或增强剂的材料与胃停留所必需的结构材料组合，但被配置用于控制和/或可调节的降解/溶解以确定保留形状完整性丧失并且结构从胃腔排出的时间。例如，在某些实施方案中，宿主结构包括第一弹性组分，被配置成释放活性物质（例如治疗剂）的第二组分和任选的连接体。在一些这样的实施方案中，接头可以被配置为降解，使得停留结构在预定量的时间之后分裂并且从受试者内部的位置释放。

5. 发明申请

WO2017066412A3 TEMPERATURE-CONTROLLED PORTABLE COOLING UNITS 审中-公开
公开(公告)号：WO2017066412A3
公开(公告)日：2017-04-20
申请号：PCT/US2016/056785
申请日：2016-10-13
申请人： TOKITAE LLC
发明人： CHOU, Fong-Li , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , LIU, Shieng , MAIER-LAXHUBER, Peter K. , PETERSON, Nels R. , SCHMIDT, Ralf W. , TEGREENE, Clarence T. , WOOD, Lowell L., Jr. , WÖRZ, Reinier M. , YAGER, David J.
IPC分类号： F28C3/08 , B23P15/26
摘要： Portage storage containers including controlled evaporative cooling systems are described herein. In some embodiments, a portable container including an integral controlled evaporative cooling system includes: a storage region, an evaporative region adjacent to the storage region, a desiccant region adjacent to the outside of the container, and an insulation region positioned between the evaporative region and the desiccant region. A vapor conduit with an attached vapor control unit has a first end within the evaporative region and a second end within the desiccant region. In some embodiments, the controlled evaporative cooling systems are positioned in a radial configuration within the portable container.

6. 发明申请

WO2016179215A1 REFRIGERATION DEVICES INCLUDING TEMPERATURE-CONTROLLED CONTAINER SYSTEMS 审中-公开
标题翻译：包括温度控制容器系统的制冷装置
公开(公告)号：WO2016179215A1
公开(公告)日：2016-11-10
申请号：PCT/US2016/030658
申请日：2016-05-04
申请人： TOKITAE LLC
发明人： CHOU, Fong-Li , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , GATES, William , HU, Jenny Ezu , ISHIKAWA, Muriel Y. , LARUSSON, Fridrik , LIU, Shieng , MYHRVOLD, Nathan P. , PAL, Brian L. , PETERSON, Nels R. , PIECH, David Keith , VECCHIONE, Maurizio , WOOD, Lowell L., Jr. , WOOD, Victoria Y.H. , YAGER, David J.
IPC分类号： F25D23/06 , F25B39/02 , F25B39/04 , F25D23/02 , F25D29/00
CPC分类号： F25D16/00 , F25B23/006 , F25D11/006
摘要： In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to a refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned within an interior of the liquid-impermeable container; walls substantially forming a storage region; and a heat transfer system including a first group of vapor-impermeable structures with a hollow interior connected to form a condenser in thermal contact with the walls substantially forming a liquid-impermeable container, a second group of vapor-impermeable structures with a hollow interior connected to form an evaporator in thermal contact with the walls substantially forming a storage region, and a connector with a hollow interior affixed to both the condenser and the evaporator, the connector forming a liquid and vapor flow path between the hollow interior of the condenser and the hollow interior of the evaporator.
摘要翻译：在一些实施例中，制冷装置包括：基本上形成液体不可渗透容器的壁，其构造成将相变材料保持在制冷装置内部; 至少一个主动制冷单元，其包括位于所述液体不可渗透容器内部的一组蒸发器盘管; 基本上形成存储区域的壁; 以及传热系统，其包括具有中空内部的第一组不透气结构，以形成基本上形成液体不可渗透容器的与所述壁热接触的冷凝器，具有中空内部连接的第二组蒸气不可渗透结构以形成与基本上形成存储区域的壁热接触的蒸发器，以及具有固定到冷凝器和蒸发器两者的中空内部的连接器，所述连接器在冷凝器的中空内部和所述冷凝器之间形成液体和蒸气流动路径中空的蒸发器内部。

7. 发明申请

WO2015081058A1 REFRIGERATION DEVICES INCLUDING TEMPERATURE-CONTROLLED CONTAINER SYSTEMS 审中-公开
标题翻译：包括温度控制容器系统的制冷装置
公开(公告)号：WO2015081058A1
公开(公告)日：2015-06-04
申请号：PCT/US2014/067275
申请日：2014-11-25
申请人： TOKITAE LLC , CHOU, Fong-Li , LARUSSON, Fridrik , LIU, Shieng
发明人： CHOU, Fong-Li , LARUSSON, Fridrik , LIU, Shieng , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , GATES, William , HU, Jennifer Ezu , ISHIKAWA, Muriel Y. , MYHRVOLD, Nathan P. , PETERSON, Nels R. , TEGREENE, Clarence T. , VECCHIONE, Maurizio , WOOD, Lowell L., Jr. , WOOD, Victoria Y., H.
IPC分类号： F25D23/06 , F25D29/00 , F25B39/02
CPC分类号： F25D11/025 , F25B23/006 , F25B2500/01 , F25D11/006 , F28F3/14 , F28F2210/02 , F28F2255/18
摘要： In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to the refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned at least partially within the liquid-impermeable container; a unidirectional thermal conductor with a condensing end and an evaporative end, the condensing end positioned within the liquid-impermeable container; a first aperture in the liquid-impermeable container, the first aperture of a size, shape and position to permit the set of evaporator coils to traverse the aperture; a second aperture in the liquid-impermeable container, the second aperture including an internal surface of a size, shape and position to mate with an external surface of the unidirectional thermal conductor; and one or more walls substantially forming a storage region in thermal contact with the evaporative end of the unidirectional thermal conductor.
摘要翻译：在一些实施例中，制冷装置包括：基本上形成液体不可渗透容器的壁，其构造成在制冷装置内部保持相变材料; 至少一个主动制冷单元，其包括至少部分地定位在所述液体不可渗透容器内的一组蒸发器盘管; 具有冷凝端和蒸发端的单向热导体，冷凝端定位在液体不可渗透的容器内; 液体不可渗透容器中的第一孔，具有允许该组蒸发器盘管穿过该孔的尺寸，形状和位置的第一孔; 所述液体不可渗透容器中的第二孔，所述第二孔包括与所述单向导热体的外表面配合的尺寸，形状和位置的内表面; 以及基本上形成与单向导热体的蒸发端热接触的存储区域的一个或多个壁。

8. 发明申请

WO2016200775A1 PACKAGING MULTI-MONODOSE CONTAINERS 审中-公开
标题翻译：包装多单体容器
公开(公告)号：WO2016200775A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/036157
申请日：2016-06-07
申请人： TOKITAE LLC
发明人： CHOU, Fong-Li , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , LIU, Shieng , NATARAJAN, Krishnan , PETERSON, Nels R. , WOOD, Lowell L., Jr.
IPC分类号： B65B11/50 , B65B31/02 , B65B51/10 , A61J1/05
CPC分类号： A61J1/16 , A61J1/1406 , A61J2205/30 , B65B5/045 , B65B5/06 , B65B5/067 , B65B31/00 , B65B51/10 , B65B51/146 , B65B61/04 , B65B63/04 , B65B2220/16
摘要： Methods and devices are described for packaging a multi-monodose container including covering a molded structure with a hermetically-sealable overwrap, the molded structure including a first portion and a second portion, the first portion including a row of interconnected monodose pharmaceutical vials, each of the interconnected monodose pharmaceutical vials enclosing a dose of at least one pharmaceutical agent, the second portion affixed to the first portion and including a textured surface pattern positioned to direct gas flow between the first portion and a region adjacent to the second portion; evacuating at least a portion of air from around the molded structure, the evacuated air at least partially flowing over the textured surface pattern of the second portion; forming a hermetic seal around the row of interconnected monodose pharmaceutical vials; and separating the second portion of the molded structure from the first portion of the molded structure.
摘要翻译：描述了用于包装多单体容器的方法和装置，包括用可密封的外包装覆盖模制结构，所述模制结构包括第一部分和第二部分，所述第一部分包括一排互连的单糖药物小瓶，每个所述相互连接的单糖药瓶包围剂量的至少一种药剂，所述第二部分固定在所述第一部分上，并且包括纹理表面图案，其被定位成引导所述第一部分与邻近所述第二部分的区域之间的气流; 从模制结构周围抽空至少一部分空气，抽空的空气至少部分地流过第二部分的纹理表面图案; 围绕相互连接的单糖药瓶的一排形成气密密封; 以及将模制结构的第二部分与模制结构的第一部分分开。

9. 发明公开

EP3074703A1 REFRIGERATION DEVICES INCLUDING TEMPERATURE-CONTROLLED CONTAINER SYSTEMS 有权
标题翻译： ÜEN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN
公开(公告)号：EP3074703A1
公开(公告)日：2016-10-05
申请号：EP14865524.4
申请日：2014-11-25
申请人： Tokitae LLC
发明人： CHOU, Fong-Li , LARUSSON, Fridrik , LIU, Shieng , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , GATES, William , HU, Jennifer Ezu , ISHIKAWA, Muriel Y. , MYHRVOLD, Nathan P. , PETERSON, Nels R. , TEGREENE, Clarence T. , VECCHIONE, Maurizio , WOOD, Lowell L., Jr. , WOOD, Victoria Y., H.
IPC分类号： F25D23/06 , F25D29/00 , F25B39/02
摘要： In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to the refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned at least partially within the liquid-impermeable container; a unidirectional thermal conductor with a condensing end and an evaporative end, the condensing end positioned within the liquid-impermeable container; a first aperture in the liquid-impermeable container, the first aperture of a size, shape and position to permit the set of evaporator coils to traverse the aperture; a second aperture in the liquid-impermeable container, the second aperture including an internal surface of a size, shape and position to mate with an external surface of the unidirectional thermal conductor; and one or more walls substantially forming a storage region in thermal contact with the evaporative end of the unidirectional thermal conductor.
摘要翻译：在一些实施例中，制冷装置包括：基本上形成液体不可渗透容器的壁，其构造成在制冷装置内部保持相变材料; 至少一个主动制冷单元，其包括至少部分地定位在所述液体不可渗透容器内的一组蒸发器盘管; 具有冷凝端和蒸发端的单向热导体，冷凝端定位在液体不可渗透的容器内; 液体不可渗透容器中的第一孔，具有允许该组蒸发器盘管穿过该孔的尺寸，形状和位置的第一孔; 所述液体不可渗透容器中的第二孔，所述第二孔包括与所述单向导热体的外表面配合的尺寸，形状和位置的内表面; 以及基本上形成与单向导热体的蒸发端热接触的存储区域的一个或多个壁。

10. 发明申请

WO2016022681A1 TEMPERATURE-CONTROLLED MEDICINAL STORAGE DEVICES 审中-公开
标题翻译：温度控制药物储存装置
公开(公告)号：WO2016022681A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/043808
申请日：2015-08-05
申请人： TOKITAE LLC
发明人： CHOU, Fong-Li , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , LARUSSON, Fridrik , LIU, Shieng , PETERSON, Nels R. , TEGREENE, Clarence T. , WOOD, Lowell L., Jr.
IPC分类号： A61J1/14 , A61J1/00
CPC分类号： F25D16/00 , A61J1/00 , F25B25/02 , F25D2400/02
摘要： In some embodiments, a medicinal storage container includes: a desiccant unit including external walls forming a gas-impermeable barrier around an interior desiccant region and including an aperture; a heating element; a controller operably attached to the heating element; a cooling unit; a compressor system including at least one evaporator coil unit, the compressor operably connected to the controller; a vapor conduit, the vapor conduit attached to a the desiccant unit at a first end, the vapor conduit attached to the evaporative cooling unit at a second end, the vapor conduit forming an internal, gas-impermeable passageway between the desiccant unit and the cooling unit; a vapor control unit attached to the vapor conduit and operably attached to the controller; and a medicinal storage unit including external walls encircling a medicinal storage region including a temperature sensor operably connected to the controller.
摘要翻译：在一些实施方案中，药物储存容器包括：干燥剂单元，其包括在内部干燥剂区域周围形成气体不可渗透屏障并包括孔的外壁; 加热元件; 可操作地连接到加热元件的控制器; 冷却单元; 压缩机系统，包括至少一个蒸发器盘管单元，所述压缩机可操作地连接到所述控制器; 蒸汽导管，在第一端处附接到干燥剂单元的蒸汽导管，在第二端处附接到蒸发冷却单元的蒸汽导管，蒸汽导管在干燥剂单元和冷却剂之间形成内部不透气通道单元; 蒸汽控制单元，其连接到蒸汽管道并可操作地附接到控制器; 以及医疗储存单元，其包括围绕包括可操作地连接到所述控制器的温度传感器的医疗储存区域的外壁。

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