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11. 发明专利

GB2422335B8 Chip for detection or analysis of biologically active substance 未知
公开(公告)号：GB2422335B8
公开(公告)日：2009-04-01
申请号：GB0607510
申请日：2004-09-17
申请人： SUMITOMO BAKELITE CO , KAZUHIKO ISIHARA
发明人： FUNAOKA SOHEI , YOKOYAMA KANEHISA , ISHIHARA KAZUHIKO
IPC分类号： C12Q1/00 , G01N33/53 , G01N37/00
摘要： A biochip is provided that suppresses nonspecific adsorption or bonding of a detection target substance without coating with an adsorption inhibitor and that has excellent detection sensitivity. The constitution is such that it has a macromolecular substance containing a phosphorylcholine group and an active ester group on a substrate surface of a biochip substrate.

12. 发明专利

CA2608792C HIGH MOLECULAR COMPOUND FOR MEDICAL MATERIAL, AND BIOCHIP SUBSTRATE USING SUCH HIGH MOLECULAR COMPOUND 未知
公开(公告)号：CA2608792C
公开(公告)日：2014-07-15
申请号：CA2608792
申请日：2006-05-18
申请人： SUMITOMO BAKELITE CO
发明人： MATSUMOTO TAKAYUKI , SHIBAHARA SUMIO , FUNAOKA SOHEI , MASUDA DAISUKE
IPC分类号： C08F290/06 , C08F2/38 , C09D133/00 , C09D155/00 , C09D183/04 , C12M1/00 , C12N15/09 , G01N33/53 , G01N37/00
摘要： Disclosed is a high molecular compound for medical use which is excellent in immobilization ability for physiologically active substances. This high molecular compound has adequate chemical/physical stability and thus hardly dissolves or deteriorates during a cleaning step. Furthermore, this high molecular compound can be suitably coated over the surface of a plastic base. Specifically disclosed is a high molecular compound for medical use which is a polymer containing at least a repeating unit derived from an ethylenically unsaturated polymerizable monomer (a) having a functional group for immobilizing a physiologically active substance. This high molecular compound for medical use is characterized by having a reactive functional group at at least one end of the polymer. Also specifically disclosed is a biochip substrate wherein a layer containing such a high molecular compound is formed on a substrate surface.

13. 发明专利

AU2006248394A1 High molecular compound for medical material and biochip substrate using such high molecular compound 未知
公开(公告)号：AU2006248394A1
公开(公告)日：2006-11-23
申请号：AU2006248394
申请日：2006-05-18
申请人： SUMITOMO BAKELITE CO
发明人： SHIBAHARA SUMIO , FUNAOKA SOHEI , MATSUMOTO TAKAYUKI , MASUDA DAISUKE
IPC分类号： C08F290/06 , C08F2/38 , C09D133/00 , C09D155/00 , C09D183/04 , C12M1/00 , C12N15/09 , G01N33/53 , G01N37/00
摘要： A main object of the invention is to provide a polymer compound for medicine which has an excellent capability of fixing a biologically active substance and has such chemical/physical stability that the compound is less dissolved or deteriorated in a washing step, in particular, which can be suitably applied to a plastic substrate surface. The invention provides a polymer compound for medical material which is a polymer comprising repeating units derived from an ethylenically unsaturated polymerizable monomer (a) having a functional group for fixing a biologically active substance, wherein the polymer has a reactive functional group on at least one terminal side thereof, and a biochip substrate wherein a layer containing the polymer compound is formed on a substrate surface, thereby attaining the object.

14. 发明专利

GB2422335B Chip for detection or analysis of biologically active substance 未知
公开(公告)号：GB2422335B
公开(公告)日：2008-02-13
申请号：GB0607510
申请日：2004-09-17
申请人： SUMITOMO BAKELITE CO , KAZUHIKO ISHIHARA
发明人： FUNAOKA SOHEI , YOKOYAMA KANEHISA
IPC分类号： C12Q1/00 , G01N33/53 , G01N37/00
摘要： A biochip is provided that suppresses nonspecific adsorption or bonding of a detection target substance without coating with an adsorption inhibitor and that has excellent detection sensitivity. The constitution is such that it has a macromolecular substance containing a phosphorylcholine group and an active ester group on a substrate surface of a biochip substrate.

15. 发明公开

EP1882708A4 HIGH MOLECULAR COMPOUND FOR MEDICAL MATERIAL AND BIOCHIP SUBSTRATE USING SUCH HIGH MOLECULAR COMPOUND 有权
标题翻译：高相对分子连接的医疗设备与生物芯片研究衬底使用这种高分子CONNECTION
公开(公告)号：EP1882708A4
公开(公告)日：2010-12-22
申请号：EP06746605
申请日：2006-05-18
申请人： SUMITOMO BAKELITE CO
发明人： MATSUMOTO TAKAYUKI , SHIBAHARA SUMIO , FUNAOKA SOHEI , MASUDA DAISUKE
IPC分类号： C08F290/06 , C08F2/38 , C08F220/36 , C08J7/04 , C09D133/14 , C09D155/00 , G01N33/543 , G01N37/00
CPC分类号： G01N33/54393 , C08F2/38 , C08F220/36 , C08F290/06 , C08F290/062 , C08G65/3322 , C08G65/33379 , C08G65/33396 , C08G65/336 , C08L2203/02 , C09D133/00 , C09D155/005 , G01N2035/00158
摘要： A main object of the invention is to provide a polymer compound for medicine which has an excellent capability of fixing a biologically active substance and has such chemical/physical stability that the compound is less dissolved or deteriorated in a washing step, in particular, which can be suitably applied to a plastic substrate surface. The invention provides a polymer compound for medical material which is a polymer comprising repeating units derived from an ethylenically unsaturated polymerizable monomer (a) having a functional group for fixing a biologically active substance, wherein the polymer has a reactive functional group on at least one terminal side thereof, and a biochip substrate wherein a layer containing the polymer compound is formed on a substrate surface, thereby attaining the object.

16. 发明公开

EP2216406A4 CARRIER, METHOD AND REAGENT FOR OBTAINING SMALL RNA 有权
标题翻译：底物，方法和试剂OBTAINING斯尔纳
公开(公告)号：EP2216406A4
公开(公告)日：2012-01-04
申请号：EP08855276
申请日：2008-11-27
申请人： WAKO PURE CHEM IND LTD , SUMITOMO BAKELITE CO
发明人： NISHIBU TAKAHIRO , FUNAOKA SOHEI , HAMAGUCHI YUZO
IPC分类号： C12N15/09 , C12M1/00 , C12N15/10 , C12N15/11 , C12N15/113 , G01N33/53
CPC分类号： C12N15/1006 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12Q1/6813 , G01N33/5308 , C12Q2525/207

17. 发明专利

JP2012246240A Method for producing bi-functionalized cucurbit[7]uril 审中-公开
标题翻译：用于生产双功能碳酸钙的方法[7]
公开(公告)号：JP2012246240A
公开(公告)日：2012-12-13
申请号：JP2011118315
申请日：2011-05-26
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , Osaka Univ , 国立大学法人大阪大学
发明人： HAMAGUCHI YUZO , FUNAOKA SOHEI , INOUE YOSHIHISA , FUKUHARA MANABU
IPC分类号： C07D487/22
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a bi-functionalized cucurbit[7]uril, with which a bi-functionalized cucurbit[7]uril in which functional groups have been introduced is generated with a high yield while interaction with a guest compound is not inhibited.SOLUTION: The method for producing a bi-functionalized cucurbit[7]uril includes: a mixing step to obtain a mixed solution formed by mixing a bi-functionalized glycouril, a glycouril trimer composed of three glycouril units bonded together in a straight chain shape via methylene crosslink, a compound with an adamantane structure, a compound forming a methylene crosslink, and an acid; and a generation step to obtain a generated solution containing a bi-functionalized cucurbit[7]uril by heating the mixed solution, generating a bi-functionalized cucurbit[7]uril, and methylene-crosslinking a bi-functionalized glycouril and two glycouril trimers together.
摘要翻译：要解决的问题：提供一种生产双官能化葫芦巴[7]尿的方法，通过该方法产生其中引入了官能团的双官能化葫芦巴[7]尿素，同时产生高产率，同时相互作用与客体化合物不被抑制。解决方案：制备双功能化葫芦巴[7]尿的方法包括：混合步骤，以获得通过将双功能化的糖脲，由连接在一起的三个甘氨酸单元组成的甘氨酸三聚体通过亚甲基交联的链状形式，具有金刚烷结构的化合物，形成亚甲基交联的化合物和酸; 以及生成步骤，通过加热混合溶液获得含有双官能化葫芦巴[url]尿素的产生溶液，产生双功能化的葫芦巴[3]尿素，并将二官能化的葡萄糖和两个甘氨酸三聚体一起亚甲基交联。版权所有（C）2013，JPO＆INPIT

18. 发明专利

JP2011083256A Substrate for immobilizing physiologically active substance 审中-公开
标题翻译：用于固定生理活性物质的基质
公开(公告)号：JP2011083256A
公开(公告)日：2011-04-28
申请号：JP2009240246
申请日：2009-10-19
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： FUNAOKA SOHEI
IPC分类号： C12M1/00 , C12N15/09 , G01N33/53 , G01N33/547
摘要： PROBLEM TO BE SOLVED: To provide an immobilization substrate for suppressing non-specific adsorption and binding, and simply immobilizing a physiologically active substance on the surface, and to provide a method for using the substrate.
SOLUTION: The substrate for capturing the physiologically active substance includes the substrate, a resin layer, and a biotin-binding protein disposed in the order. In the substrate for capturing the physiologically active substance, a surface of the resin layer which is opposite to the substrate has hydrophilicity. A biotin-modified physiologically active substance can be immobilized on the substrate, and adsorption and binding of unnecessary physiologically active substances or fluorescent substances to parts other than the biotin-modified physiologically active substance can be suppressed by using a solid-phase support for immobilizing the physiologically active substance.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于抑制非特异性吸附和结合的固定基材，并简单地将生理活性物质固定在表面上，并提供使用该基材的方法。解决方案：用于捕获生理活性物质的基质包括依次排列的底物，树脂层和生物素结合蛋白。在用于捕获生理活性物质的基板中，树脂层的与基板相对的表面具有亲水性。可以将生物素改性的生理活性物质固定在基材上，并且通过使用固相载体来抑制不需要的生理活性物质或荧光物质对除生物素改性的生理活性物质以外的部分的吸附和结合生理活性物质。版权所有（C）2011，JPO＆INPIT

19. 发明专利

JP2013076648A Method for measuring amount of sugar chain 审中-公开
标题翻译：测量糖链量的方法
公开(公告)号：JP2013076648A
公开(公告)日：2013-04-25
申请号：JP2011217125
申请日：2011-09-30
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE HIROKI , FUNAOKA SOHEI
IPC分类号： G01N33/66
摘要： PROBLEM TO BE SOLVED: To provide a method capable of accurately measuring an amount of fixed sugar chains.SOLUTION: A method for measuring an amount of sugar chains fixed on a substrate includes: a step for oxidizing a sugar chain to form an aldehyde group; a step for bringing a labeled compound containing a primary amino group into contact with the aldehyde group to combine both components; and a step for detecting the label. The primary amino group is a hydrazide group, an oxyl amino group, or an amino group. The labeled compound containing a primary amino group is a compound containing a labeling group, the primary amino group and a linker part containing carbon atoms for connecting the labeling group and the primary amino group.

20. 发明专利

JP2012247267A Solid-phased carrier and manufacturing method of solid-phased carrier 有权
标题翻译：固体载体的固体载体和制造方法
公开(公告)号：JP2012247267A
公开(公告)日：2012-12-13
申请号：JP2011118316
申请日：2011-05-26
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , Osaka Univ , 国立大学法人大阪大学
发明人： HAMAGUCHI YUZO , FUNAOKA SOHEI , INOUE YOSHIHISA , YANG CHENG
IPC分类号： G01N33/543 , A61K47/40 , A61K47/48 , C08B37/16
摘要： PROBLEM TO BE SOLVED: To provide a solid-phased carrier in which an indicator molecule is solid-phased stably to a carrier, and a manufacturing method of the solid-phased carrier.SOLUTION: A solid-phased carrier 1 is obtained by solid-phasing an indicator molecule 10 to a carrier 100 via a molecule complex 2. The molecule complex 2 comprises a first molecule 3, a second molecule 4 and a third molecule 5. The first molecule 3 includes a guest molecular structure 31 and a linear structure 32 bound to the guest molecular structure 31. The second molecule 4 includes a cyclodextrin structure 41 and is positioned in the middle of a length direction of the linear structure 32 while passing the linear structure 32 of the first molecule 3 through a hole that the cyclodextrin structure 41 has. The third molecule 5 includes a cucurbituril structure 51 which includes the guest molecular structure 31 within the hole and blocks the cyclodextrin structure 41 of the second molecule 4 from being separated from one terminal side of the linear structure 32 of the first molecule 3. The linear structure 32 of the first molecule 3 is bound to the carrier 100 and the cyclodextrin structure 41 of the second molecule 4 is bound to the indicator molecule 10.
摘要翻译：解决的问题：提供一种将指示剂分子稳定地固定在载体上的固相载体，以及固相载体的制造方法。解决方案：通过分子配合物2将指示剂分子10固定在载体100上，获得固相载体1.分子复合物2包含第一分子3，第二分子4和第三分子5 第一分子3包括客体分子结构31和与客体分子结构31结合的线性结构32.第二分子4包括环糊精结构41，并且在通过时位于线性结构32的长度方向的中间第一分子3的线性结构32通过环糊精结构41具有的孔。第三分子5包括葫芦素结构51，其包含孔内的客体分子结构31，并阻断第二分子4的环糊精结构41与第一分子3的直链结构32的一个末端侧分离。线性第一分子3的结构32与载体100结合，第二分子4的环糊精结构41与指示剂分子10结合。版权所有：（C）2013，JPO＆INPIT

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