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1. 发明专利

JP2012246240A Method for producing bi-functionalized cucurbit[7]uril 审中-公开
标题翻译：用于生产双功能碳酸钙的方法[7]
公开(公告)号：JP2012246240A
公开(公告)日：2012-12-13
申请号：JP2011118315
申请日：2011-05-26
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , Osaka Univ , 国立大学法人大阪大学
发明人： HAMAGUCHI YUZO , FUNAOKA SOHEI , INOUE YOSHIHISA , FUKUHARA MANABU
IPC分类号： C07D487/22
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a bi-functionalized cucurbit[7]uril, with which a bi-functionalized cucurbit[7]uril in which functional groups have been introduced is generated with a high yield while interaction with a guest compound is not inhibited.SOLUTION: The method for producing a bi-functionalized cucurbit[7]uril includes: a mixing step to obtain a mixed solution formed by mixing a bi-functionalized glycouril, a glycouril trimer composed of three glycouril units bonded together in a straight chain shape via methylene crosslink, a compound with an adamantane structure, a compound forming a methylene crosslink, and an acid; and a generation step to obtain a generated solution containing a bi-functionalized cucurbit[7]uril by heating the mixed solution, generating a bi-functionalized cucurbit[7]uril, and methylene-crosslinking a bi-functionalized glycouril and two glycouril trimers together.
摘要翻译：要解决的问题：提供一种生产双官能化葫芦巴[7]尿的方法，通过该方法产生其中引入了官能团的双官能化葫芦巴[7]尿素，同时产生高产率，同时相互作用与客体化合物不被抑制。解决方案：制备双功能化葫芦巴[7]尿的方法包括：混合步骤，以获得通过将双功能化的糖脲，由连接在一起的三个甘氨酸单元组成的甘氨酸三聚体通过亚甲基交联的链状形式，具有金刚烷结构的化合物，形成亚甲基交联的化合物和酸; 以及生成步骤，通过加热混合溶液获得含有双官能化葫芦巴[url]尿素的产生溶液，产生双功能化的葫芦巴[3]尿素，并将二官能化的葡萄糖和两个甘氨酸三聚体一起亚甲基交联。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2012247267A Solid-phased carrier and manufacturing method of solid-phased carrier 有权
标题翻译：固体载体的固体载体和制造方法
公开(公告)号：JP2012247267A
公开(公告)日：2012-12-13
申请号：JP2011118316
申请日：2011-05-26
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , Osaka Univ , 国立大学法人大阪大学
发明人： HAMAGUCHI YUZO , FUNAOKA SOHEI , INOUE YOSHIHISA , YANG CHENG
IPC分类号： G01N33/543 , A61K47/40 , A61K47/48 , C08B37/16
摘要： PROBLEM TO BE SOLVED: To provide a solid-phased carrier in which an indicator molecule is solid-phased stably to a carrier, and a manufacturing method of the solid-phased carrier.SOLUTION: A solid-phased carrier 1 is obtained by solid-phasing an indicator molecule 10 to a carrier 100 via a molecule complex 2. The molecule complex 2 comprises a first molecule 3, a second molecule 4 and a third molecule 5. The first molecule 3 includes a guest molecular structure 31 and a linear structure 32 bound to the guest molecular structure 31. The second molecule 4 includes a cyclodextrin structure 41 and is positioned in the middle of a length direction of the linear structure 32 while passing the linear structure 32 of the first molecule 3 through a hole that the cyclodextrin structure 41 has. The third molecule 5 includes a cucurbituril structure 51 which includes the guest molecular structure 31 within the hole and blocks the cyclodextrin structure 41 of the second molecule 4 from being separated from one terminal side of the linear structure 32 of the first molecule 3. The linear structure 32 of the first molecule 3 is bound to the carrier 100 and the cyclodextrin structure 41 of the second molecule 4 is bound to the indicator molecule 10.
摘要翻译：解决的问题：提供一种将指示剂分子稳定地固定在载体上的固相载体，以及固相载体的制造方法。解决方案：通过分子配合物2将指示剂分子10固定在载体100上，获得固相载体1.分子复合物2包含第一分子3，第二分子4和第三分子5 第一分子3包括客体分子结构31和与客体分子结构31结合的线性结构32.第二分子4包括环糊精结构41，并且在通过时位于线性结构32的长度方向的中间第一分子3的线性结构32通过环糊精结构41具有的孔。第三分子5包括葫芦素结构51，其包含孔内的客体分子结构31，并阻断第二分子4的环糊精结构41与第一分子3的直链结构32的一个末端侧分离。线性第一分子3的结构32与载体100结合，第二分子4的环糊精结构41与指示剂分子10结合。版权所有：（C）2013，JPO＆INPIT

3. 发明专利

JP2011083256A Substrate for immobilizing physiologically active substance 审中-公开
标题翻译：用于固定生理活性物质的基质
公开(公告)号：JP2011083256A
公开(公告)日：2011-04-28
申请号：JP2009240246
申请日：2009-10-19
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： FUNAOKA SOHEI
IPC分类号： C12M1/00 , C12N15/09 , G01N33/53 , G01N33/547
摘要： PROBLEM TO BE SOLVED: To provide an immobilization substrate for suppressing non-specific adsorption and binding, and simply immobilizing a physiologically active substance on the surface, and to provide a method for using the substrate.
SOLUTION: The substrate for capturing the physiologically active substance includes the substrate, a resin layer, and a biotin-binding protein disposed in the order. In the substrate for capturing the physiologically active substance, a surface of the resin layer which is opposite to the substrate has hydrophilicity. A biotin-modified physiologically active substance can be immobilized on the substrate, and adsorption and binding of unnecessary physiologically active substances or fluorescent substances to parts other than the biotin-modified physiologically active substance can be suppressed by using a solid-phase support for immobilizing the physiologically active substance.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于抑制非特异性吸附和结合的固定基材，并简单地将生理活性物质固定在表面上，并提供使用该基材的方法。解决方案：用于捕获生理活性物质的基质包括依次排列的底物，树脂层和生物素结合蛋白。在用于捕获生理活性物质的基板中，树脂层的与基板相对的表面具有亲水性。可以将生物素改性的生理活性物质固定在基材上，并且通过使用固相载体来抑制不需要的生理活性物质或荧光物质对除生物素改性的生理活性物质以外的部分的吸附和结合生理活性物质。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2013228383A Detection kit and examination method 审中-公开
标题翻译：检测套件和检查方法
公开(公告)号：JP2013228383A
公开(公告)日：2013-11-07
申请号：JP2013065369
申请日：2013-03-27
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , Fancl Corp , 株式会社ファンケル
发明人： FUNAOKA SOHEI , YASUDA TOMONAGA , ISHIWATARI SHIOJI , MATSUKUMA SACHIKO
IPC分类号： G01N33/543 , G01N33/50 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a detection kit capable of highly sensitively and quickly detecting a plurality of antigens for a skin diagnosis contained in a sample, using an antigen-antibody reaction, and an examination method capable of examining a plurality of items for the skin diagnosis using the detection kit.SOLUTION: The detection kit according to the present invention is used to detect particular antigens for a skin diagnosis contained in a sample 50. The detection kit includes: a substrate having a plurality of holes each storing the sample 50; specific antibodies for specifically recognizing antigens; and a polymer adsorbed to the inner face of each hole. A first specific antibody 41 is supported on the inner face of a first hole 11 via a first polymer 31, and a second specific antibody is supported on the inner face of a second hole via a second polymer. In the first hole 11, a first antigen 51 contained in the sample 50 is recognized by the first antibody 41, and in the second hole, a second antigen contained in the sample 50 is recognized by the second antibody.
摘要翻译：要解决的问题：提供能够高度敏感且快速地检测样品中包含的皮肤诊断的多种抗原的检测试剂盒，使用抗原 - 抗体反应，以及能够检查多种物品的检查方法使用检测试剂盒进行皮肤诊断。解决方案：根据本发明的检测试剂盒用于检测样品50中包含的皮肤诊断的特定抗原。检测试剂盒包括：具有多个孔的基材，每个孔存储样品50 ; 用于特异性识别抗原的特异性抗体; 并且吸附在每个孔的内表面上的聚合物。第一特异性抗体41经由第一聚合物31被支撑在第一孔11的内表面上，第二特异性抗体经由第二聚合物被支撑在第二孔的内表面上。在第一孔11中，样品50中包含的第一抗原51被第一抗体41识别，在第二孔中，通过第二抗体识别样品50中包含的第二抗原。

5. 发明专利

JP2012052843A High molecular compound for medical material, and substrate 有权
标题翻译：医用材料高分子化合物和基材
公开(公告)号：JP2012052843A
公开(公告)日：2012-03-15
申请号：JP2010193769
申请日：2010-08-31
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： YAMANOUCHI GO , FUNAOKA SOHEI
IPC分类号： G01N33/543 , C08F220/26 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a high molecular compound for medical materials that is excellent in a fixing capability of physiological active substances when coated on a substrate, has small nonspecific adsorption to a protein, and allows the physiological active substances to be spotted in a higher density.SOLUTION: The high molecular compound for medical materials is obtained by copolymerizing an ethylene based unsaturated polymerization monomer (a) having a functional group for fixing the physiological active substances, an ethylene based unsaturated polymerization monomer (b) having an alkyl group, and an ethylene based unsaturated polymerization monomer (c) having an alkylene glycol residue. In the high molecular compound for medical materials, a composition ratio of the ethylene based unsaturated polymerization monomer (b) having an alkyl group is raised in the copolymer.
摘要翻译：待解决的问题：为了提供一种用于医疗材料的高分子化合物，其在涂覆在基材上时具有优异的生理活性物质的定影能力，对蛋白质的非特异性吸附小，并且允许生理活性物质为发现密度较高。解决方案：用于医疗材料的高分子化合物通过共聚具有用于固定生理活性物质的官能团的乙烯类不饱和聚合单体（a），具有烷基的乙烯类不饱和聚合单体（b）和具有亚烷基二醇残基的乙烯类不饱和聚合单体（c）。在医药用高分子化合物中，共聚物中具有烷基的乙烯系不饱和聚合单体（b）的组成比提高。版权所有（C）2012，JPO＆INPIT

6. 发明专利

JP2011083670A Substrate for capturing acid sugar chain 审中-公开
标题翻译：用于捕获酸奶链的基质
公开(公告)号：JP2011083670A
公开(公告)日：2011-04-28
申请号：JP2009236761
申请日：2009-10-14
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： FUNAOKA SOHEI
IPC分类号： B01J20/26 , C08B37/08 , C08B37/10 , C08F220/28 , C08F230/08
摘要： PROBLEM TO BE SOLVED: To provide a method of capturing acid sugars stably with a substrate and a substrate for the method.
SOLUTION: The method of capturing acid sugars stably with a substrate uses a substrate in which a resin layer composed of a copolymer containing a monomer having a hydrophilic group, a monomer having a functional group capable of cross-linking and a monomer having a functional group for fixing a compound capable of capturing acid sugars and a fixing layer composed of the compound capable of capturing acid sugars are laminated in order on one side. The substrate for the method is also provided.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于该方法的基板和基板稳定捕获酸性糖的方法。解决方案：用基材稳定地捕获酸性糖的方法使用其中由含有具有亲水基团的单体的共聚物构成的树脂层，具有能够交联的官能团的单体和具有在一侧依次层叠用于固定能够捕获酸性糖的化合物的官能团和由能够捕获酸性糖的化合物组成的定影层。还提供了该方法的基板。版权所有（C）2011，JPO＆INPIT

7. 发明专利

JP2013076648A Method for measuring amount of sugar chain 审中-公开
标题翻译：测量糖链量的方法
公开(公告)号：JP2013076648A
公开(公告)日：2013-04-25
申请号：JP2011217125
申请日：2011-09-30
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE HIROKI , FUNAOKA SOHEI
IPC分类号： G01N33/66
摘要： PROBLEM TO BE SOLVED: To provide a method capable of accurately measuring an amount of fixed sugar chains.SOLUTION: A method for measuring an amount of sugar chains fixed on a substrate includes: a step for oxidizing a sugar chain to form an aldehyde group; a step for bringing a labeled compound containing a primary amino group into contact with the aldehyde group to combine both components; and a step for detecting the label. The primary amino group is a hydrazide group, an oxyl amino group, or an amino group. The labeled compound containing a primary amino group is a compound containing a labeling group, the primary amino group and a linker part containing carbon atoms for connecting the labeling group and the primary amino group.
摘要翻译：待解决的问题：提供能够精确测量固定糖链的量的方法。解决方案：用于测量固定在基材上的糖链的量的方法包括：氧化糖链以形成醛基的步骤; 将含有伯氨基的标记化合物与醛基接触以使两种组分结合的步骤; 以及用于检测标签的步骤。伯氨基是酰肼基，氧基氨基或氨基。含有伯氨基的标记化合物是含有标记基团，伯氨基和含有用于连接标记基团和伯氨基的碳原子的连接部分的化合物。版权所有（C）2013，JPO＆INPIT

8. 发明专利

JP2009118773A Method for analyzing nucleic acid 审中-公开
标题翻译：分析核酸的方法
公开(公告)号：JP2009118773A
公开(公告)日：2009-06-04
申请号：JP2007296112
申请日：2007-11-14
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： SAITO SUSUMU , FUNAOKA SOHEI
IPC分类号： C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method for analyzing nucleic acid, by which a large number of specimens can treated in a simple and quick manner, and to provide a method for conducting TR-PCR.
SOLUTION: This method for analyzing nucleic acid includes steps for introducing polymerizable functional groups or chain transfer groups to the surfaces of particles which are used as nuclei; mixing the particles with a polymerizable component containing a polymerizable monomer, having a functional group for immobilizing a physiologically active substance; making the polymerization reaction advance, to form a polymer-containing layers on the surfaces of the particles; moving a sample solution containing the target nucleic acid in a reaction space, having the analysis particles to which a nucleic acid primer is immobilized via functional groups for immobilizing the physiologically active substance of the layer containing the polymer and then hybridizing the target nucleic acid with the immobilized nucleic acid primer; a step for carrying out amplification reaction with a buffer solution in the reaction space; and a step for detecting the target amplified product.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种用于分析核酸的方法，通过该方法能够以简单快速的方式处理大量标本，并提供进行TR-PCR的方法。解决方案：用于分析核酸的方法包括将可聚合官能团或链转移基团引入用作核的颗粒的表面的步骤; 将颗粒与含有可聚合单体的可聚合组分混合，具有用于固定生理活性物质的官能团; 使聚合反应进行，在颗粒表面形成含聚合物的层; 将含有靶核酸的样品溶液移动到反应空间中，其具有通过用于固定含有聚合物的层的生理活性物质的官能团固定有核酸引物的分析颗粒，然后将靶核酸与固定核酸引物; 与反应空间中的缓冲溶液进行扩增反应的步骤; 以及用于检测目标扩增产物的步骤。版权所有（C）2009，JPO＆INPIT

9. 发明专利

JP2013148484A Manufacturing method of biochip, and biochip 审中-公开
标题翻译： BIOCHIP和BIOCHIP的制造方法
公开(公告)号：JP2013148484A
公开(公告)日：2013-08-01
申请号：JP2012009519
申请日：2012-01-20
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： YAMANOUCHI GO , FUNAOKA SOHEI
IPC分类号： G01N33/543 , G01N33/547
摘要： PROBLEM TO BE SOLVED: To provide a manufacturing method of a biochip used for detection and analysis of a number of protein in a biological sample, and capable of performing highly sensitive, high-throughput detection of a physiologically active substance in which protein is immobilized at an arbitrary position on the surface of a substrate, and unnecessary adsorption and connection of a physiologically active substance is suppressed without coating an adsorption preventing agent.SOLUTION: Provided is a manufacturing method of a biochip in which protein is immobilized on the surface of a substrate, the method comprising the steps of: (1) applying a polymer having a polyethylene glycol group on the surface of a substrate; (2) performing spot application of or applying a liquid in which protein is dissolved or dispersed in a solvent on the surface of the substrate; (3) and immobilizing the protein. Also provided is a biochip manufactured by the manufacturing method.
摘要翻译：要解决的问题：提供一种用于检测和分析生物样品中的蛋白质的生物芯片的制造方法，并且能够对其中固定有蛋白质的生理活性物质进行高灵敏度，高通量检测在基材表面上的任意位置，并且抑制生物活性物质的不必要的吸附和连接而不涂覆吸附防止剂。解决方案：提供一种其中蛋白质固定在基材表面上的生物芯片的制造方法该方法包括以下步骤：（1）在基材的表面上施加具有聚乙二醇基团的聚合物; （2）将蛋白质溶解或分散在溶剂中的液体的点施用或施加于基材的表面上; （3）并固定蛋白质。还提供了通过制造方法制造的生物芯片。

10. 发明专利

JP2011141232A Substrate for immobilization of physiologically active substance and method for capturing physiologically active substance 审中-公开
标题翻译：用于固定生理活性物质的基质和用于捕获生理活性物质的方法
公开(公告)号：JP2011141232A
公开(公告)日：2011-07-21
申请号：JP2010002918
申请日：2010-01-08
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： FUNAOKA SOHEI
IPC分类号： G01N33/543 , G01N33/53 , G01N33/545 , G01N33/547
摘要： PROBLEM TO BE SOLVED: To provide a substrate for immobilization for reducing nonspecific adsorption and binding and easily immobilizing physiologically active substances to a surface and to provide a method of use thereof.
SOLUTION: The substrate for capturing a physiologically active substance is formed by arranging a substrate, a resin layer, and a biotin compound in this order. The surface of the resin layer opposite to the substrate is characteristically hydrophilic. By using a solid carrier for the immobilization of physiologically active substances, it is possible to immobilize modified physiologically active substances by a biotin-binding protein and reduce the unnecessary adsorption and binding of physiologically active substances and fluorescent substances to sections other than the section of the substrate in which the modified physiologically active substances are immobilized.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于固定以减少非特异性吸附和结合并容易地将生理活性物质固定在表面上并提供其使用方法的底物。解决方案：用于捕获生理活性物质的基材通过依次布置基材，树脂层和生物素化合物而形成。与基板相反的树脂层的表面特征为亲水性。通过使用固体载体固定生理活性物质，可以通过生物素结合蛋白固定修饰的生理活性物质，并减少生理活性物质和荧光物质不必要的吸附和结合到除其中修饰的生理活性物质被固定的底物。版权所有（C）2011，JPO＆INPIT

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