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1. 发明公开

EP2216406A4 CARRIER, METHOD AND REAGENT FOR OBTAINING SMALL RNA 有权
标题翻译：底物，方法和试剂OBTAINING斯尔纳
公开(公告)号：EP2216406A4
公开(公告)日：2012-01-04
申请号：EP08855276
申请日：2008-11-27
申请人： WAKO PURE CHEM IND LTD , SUMITOMO BAKELITE CO
发明人： NISHIBU TAKAHIRO , FUNAOKA SOHEI , HAMAGUCHI YUZO
IPC分类号： C12N15/09 , C12M1/00 , C12N15/10 , C12N15/11 , C12N15/113 , G01N33/53
CPC分类号： C12N15/1006 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12Q1/6813 , G01N33/5308 , C12Q2525/207

2. 发明专利

JP2009148243A Carrier, method, and reagent for obtaining small rna 有权
标题翻译：载体，方法和用于获取小RNA的试剂
公开(公告)号：JP2009148243A
公开(公告)日：2009-07-09
申请号：JP2008129068
申请日：2008-05-16
申请人： Sumitomo Bakelite Co Ltd , Wako Pure Chem Ind Ltd , 住友ベークライト株式会社 , 和光純薬工業株式会社
发明人： NISHIBE TAKAHIRO , FUNAOKA SOHEI , HAMAGUCHI YUZO
IPC分类号： C12N15/09 , C07K17/02
CPC分类号： C12N15/1006 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12Q1/6813 , G01N33/5308 , C12Q2525/207
摘要： PROBLEM TO BE SOLVED: To provide a carrier obtaining a small RNA in high yield and high purity, to provide a simple method for separating the small RNA using the carrier and/or a simple method for obtaining a nucleic acid targeted by the small RNA using the carrier, and to provide a reagent and a kit comprising the carrier. SOLUTION: There are provided: (1) the carrier for obtaining the small RNA by introducing a polymerizable functional group or a chain-transfer group onto the surface of a particle to be a nucleus, mixing the particle with a polymerizable monomer, then allowing a polymerization reaction to proceed, thereby providing a particle in which a layer containing a polymer compound is formed on the particle surface, and further immobilizing a physiologically active substance having an affinity for a small RNA-binding protein on the surface of the particle; (2) the method for obtaining the small RNA by using the carrier; (3) the reagent for obtaining the small RNA or/and the nucleic acid targeted by the small RNA, which comprises the carrier; (4) the reagent for obtaining the small RNA or/and the nucleic acid targeted by the small RNA, which comprises the reagent; and (5) the method for obtaining the nucleic acid targeted by the small RNA by using the carrier. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了提供以高产率和高纯度获得小RNA的载体，提供使用载体分离小RNA的简单方法和/或用于获得由所述载体靶向的核酸的简单方法使用载体的小RNA，并提供包含载体的试剂和试剂盒。提供：（1）通过将可聚合官能团或链转移基团引入到作为核的颗粒的表面上来获得小RNA的载体，将颗粒与可聚合单体混合，然后进行聚合反应，从而提供在颗粒表面上形成含有高分子化合物的层的颗粒，并进一步将具有对小RNA结合蛋白的亲和力的生理活性物质固定在颗粒表面上 ; （2）使用载体获得小RNA的方法; （3）用于获得小RNA的试剂或/和由小RNA靶向的核酸，其包含载体; （4）包含该试剂的小RNA获得试剂和/或小RNA靶向的核酸; 和（5）通过使用载体获得由小RNA靶向的核酸的方法。版权所有（C）2009，JPO＆INPIT

3. 发明申请

WO2006101798A3 POLYMER COMPOUND FOR BIOMEDICAL USE AND BIOCHIP SUBSTRATE USING SUCH A POLYMER COMPOUND 审中-公开
标题翻译：用于生物医学用途的聚合物化合物和使用这种聚合物化合物的生物基质
公开(公告)号：WO2006101798A3
公开(公告)日：2007-02-01
申请号：PCT/US2006008877
申请日：2006-03-14
申请人： SUMITOMO BAKELITE CO , SOMALOGIC INC , MATSUMOTO MITSUTAKA , SHIBAHARA SUMIO , MATSUMOTO TAKAYUKI , YOKOYAMA KANEHISA , FUNAOKA SOHEI , MASUDA DAISUKE , COLEMAN MICHAEL PATRICK , ZICHI DOMINIC
发明人： MATSUMOTO MITSUTAKA , SHIBAHARA SUMIO , MATSUMOTO TAKAYUKI , YOKOYAMA KANEHISA , FUNAOKA SOHEI , MASUDA DAISUKE , COLEMAN MICHAEL PATRICK , ZICHI DOMINIC
IPC分类号： C08K5/20
CPC分类号： C08J7/047 , C08F220/28 , C08F220/30 , C08F220/36 , C08F220/38 , C08F2220/286 , C08F2220/306 , C08J2365/00 , C08J2443/00 , G01N33/54393 , Y10T428/31504 , Y10T428/31938
摘要： There is provided a biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acid and the like. The biochip substrate is for fixing a biologically active substance on a surface of a solid substrate , and characterized in that it has a layer comprising a polymer compound obtained by copolymerizing an ethylenically unsaturated polymerizable monomer having an alkylene glycol residue, an ethylenically unsaturated polymerizable monomer having a functional group for fixing a biologically active substance and an ethylenically unsaturated polymerizable monomer having a cross-linkable functional group, on the surface of the substrate.
摘要翻译：提供了一种生物芯片基板，当用于蛋白质，核酸等的检测或分析时，能够通过限制被检测物质的非特异性吸附或结合来实现高检测精度。生物芯片基板用于将生物活性物质固定在固体基材的表面上，其特征在于，其具有包含通过使具有亚烷基二醇残基的烯键式不饱和可聚合单体和具有亚烷基二醇残基的烯属不饱和可聚合单体共聚得到的聚合物，用于固定生物活性物质的官能团和具有可交联官能团的烯属不饱和可聚合单体。

4. 发明专利

CA2608792A1 HIGH MOLECULAR COMPOUND FOR MEDICAL MATERIAL AND BIOCHIP SUBSTRATE USING SUCH HIGH MOLECULAR COMPOUND 未知
公开(公告)号：CA2608792A1
公开(公告)日：2006-11-23
申请号：CA2608792
申请日：2006-05-18
申请人： SUMITOMO BAKELITE CO
发明人： SHIBAHARA SUMIO , MATSUMOTO TAKAYUKI , FUNAOKA SOHEI , MASUDA DAISUKE
IPC分类号： C08F290/06 , C08F2/38 , C09D133/00 , C09D155/00 , C09D183/04 , C12M1/00 , C12N15/09 , G01N33/53 , G01N37/00
摘要： Disclosed is a high molecular compound for medical use which is excellent in immobilization ability for physiologically active substances. This high molecular compound has adequate chemical/physical stability and thus hardly dissolves or deteriorates during a cleaning step. Furthermore, this high molecular compound can be suitably coated over the surface of a plastic base . Specifically disclosed is a high molecular compound for medical use which is a polymer containing at least a repeating unit derived from an ethylenically unsaturated polymerizable monomer (a) having a functional group for immobilizing a physiologically active substance. This high molecular compoun d for medical use is characterized by having a reactive functional group at at least one end of the polymer. Also specifically disclosed is a biochip substrate wherein a layer containing such a high molecular compound is forme d on a substrate surface.

5. 发明专利

GB2422335A Biochip 未知
公开(公告)号：GB2422335A
公开(公告)日：2006-07-26
申请号：GB0607510
申请日：2004-09-17
申请人： SUMITOMO BAKELITE CO , KAZUHIKO ISHIHARA
发明人： FUNAOKA SOHEI , YOKOYAMA KANEHISA , ISHIHARA KAZUHIKO
IPC分类号： C12Q1/00 , G01N33/53 , G01N37/00
摘要： A biochip not coated with any adsorption preventive agent, capable of suppressing nonspecific adsorption and bonding of a detection subject substance to thereby excel in detection sensitivity. There is provided a biochip comprising a biochip substrate and, applied onto the surface thereof, a polymeric substance containing a phosphorylcholine group and an active ester group.

6. 发明专利

AU2006248394B2 High molecular compound for medical material and biochip substrate using such high molecular compound 未知
公开(公告)号：AU2006248394B2
公开(公告)日：2012-11-01
申请号：AU2006248394
申请日：2006-05-18
申请人： SUMITOMO BAKELITE CO
发明人： MASUDA DAISUKE , SHIBAHARA SUMIO , MATSUMOTO TAKAYUKI , FUNAOKA SOHEI
IPC分类号： C08F290/06 , C08F2/38 , C09D133/00 , C09D155/00 , C09D183/04 , C12M1/00 , C12N15/09 , G01N33/53 , G01N37/00
摘要： Disclosed is a high molecular compound for medical use which is excellent in immobilization ability for physiologically active substances. This high molecular compound has adequate chemical/physical stability and thus hardly dissolves or deteriorates during a cleaning step. Furthermore, this high molecular compound can be suitably coated over the surface of a plastic base. Specifically disclosed is a high molecular compound for medical use which is a polymer containing at least a repeating unit derived from an ethylenically unsaturated polymerizable monomer (a) having a functional group for immobilizing a physiologically active substance. This high molecular compound for medical use is characterized by having a reactive functional group at at least one end of the polymer. Also specifically disclosed is a biochip substrate wherein a layer containing such a high molecular compound is formed on a substrate surface.

7. 发明专利

GB2422335B8 Chip for detection or analysis of biologically active substance 未知
公开(公告)号：GB2422335B8
公开(公告)日：2009-04-01
申请号：GB0607510
申请日：2004-09-17
申请人： SUMITOMO BAKELITE CO , KAZUHIKO ISIHARA
发明人： FUNAOKA SOHEI , YOKOYAMA KANEHISA , ISHIHARA KAZUHIKO
IPC分类号： C12Q1/00 , G01N33/53 , G01N37/00
摘要： A biochip is provided that suppresses nonspecific adsorption or bonding of a detection target substance without coating with an adsorption inhibitor and that has excellent detection sensitivity. The constitution is such that it has a macromolecular substance containing a phosphorylcholine group and an active ester group on a substrate surface of a biochip substrate.

8. 发明专利

CA2608792C HIGH MOLECULAR COMPOUND FOR MEDICAL MATERIAL, AND BIOCHIP SUBSTRATE USING SUCH HIGH MOLECULAR COMPOUND 未知
公开(公告)号：CA2608792C
公开(公告)日：2014-07-15
申请号：CA2608792
申请日：2006-05-18
申请人： SUMITOMO BAKELITE CO
发明人： MATSUMOTO TAKAYUKI , SHIBAHARA SUMIO , FUNAOKA SOHEI , MASUDA DAISUKE
IPC分类号： C08F290/06 , C08F2/38 , C09D133/00 , C09D155/00 , C09D183/04 , C12M1/00 , C12N15/09 , G01N33/53 , G01N37/00
摘要： Disclosed is a high molecular compound for medical use which is excellent in immobilization ability for physiologically active substances. This high molecular compound has adequate chemical/physical stability and thus hardly dissolves or deteriorates during a cleaning step. Furthermore, this high molecular compound can be suitably coated over the surface of a plastic base. Specifically disclosed is a high molecular compound for medical use which is a polymer containing at least a repeating unit derived from an ethylenically unsaturated polymerizable monomer (a) having a functional group for immobilizing a physiologically active substance. This high molecular compound for medical use is characterized by having a reactive functional group at at least one end of the polymer. Also specifically disclosed is a biochip substrate wherein a layer containing such a high molecular compound is formed on a substrate surface.

9. 发明专利

CA2601432C POLYMER COMPOUND FOR BIOMEDICAL USE AND BIOCHIP SUBSTRATE USING SUCH A POLYMER COMPOUND 未知
公开(公告)号：CA2601432C
公开(公告)日：2014-07-08
申请号：CA2601432
申请日：2006-03-14
申请人： SOMALOGIC INC , SUMITOMO BAKELITE CO
发明人： MATSUMOTO MITSUTAKA , SHIBAHARA SUMIO , MATSUMOTO TAKAYUKI , YOKOYAMA KANEHISA , FUNAOKA SOHEI , MASUDA DAISUKE , COLEMAN MICHAEL PATRICK , ZICHI DOMINIC
IPC分类号： C08K5/20
摘要： There is provided a biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acid and the like. The biochip substrate is for fixing a biologically active substance on a surface of a solid substrate , and characterized in that it has a layer comprising a polymer compound obtained by copolymerizing an ethylenically unsaturated polymerizable monomer having an alkylene glycol residue, an ethylenically unsaturated polymerizable monomer having a functional group for fixing a biologically active substance and an ethylenically unsaturated polymerizable monomer having a cross-linkable functional group, on the surface of the substrate.

10. 发明专利

AU2006248394A1 High molecular compound for medical material and biochip substrate using such high molecular compound 未知
公开(公告)号：AU2006248394A1
公开(公告)日：2006-11-23
申请号：AU2006248394
申请日：2006-05-18
申请人： SUMITOMO BAKELITE CO
发明人： SHIBAHARA SUMIO , FUNAOKA SOHEI , MATSUMOTO TAKAYUKI , MASUDA DAISUKE
IPC分类号： C08F290/06 , C08F2/38 , C09D133/00 , C09D155/00 , C09D183/04 , C12M1/00 , C12N15/09 , G01N33/53 , G01N37/00
摘要： A main object of the invention is to provide a polymer compound for medicine which has an excellent capability of fixing a biologically active substance and has such chemical/physical stability that the compound is less dissolved or deteriorated in a washing step, in particular, which can be suitably applied to a plastic substrate surface. The invention provides a polymer compound for medical material which is a polymer comprising repeating units derived from an ethylenically unsaturated polymerizable monomer (a) having a functional group for fixing a biologically active substance, wherein the polymer has a reactive functional group on at least one terminal side thereof, and a biochip substrate wherein a layer containing the polymer compound is formed on a substrate surface, thereby attaining the object.

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