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11. 发明授权

US5876731A Tandem synthetic HIV-1 Peptides 失效
标题翻译：串联合成HIV-1肽
公开(公告)号：US5876731A
公开(公告)日：1999-03-02
申请号：US462507
申请日：1995-06-05
申请人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
发明人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
IPC分类号： G01N33/53 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/155 , C07K14/16 , C07K16/10 , C12N15/09 , C12N15/48 , G01N33/569 , A61K39/12 , C07K5/00 , C07K7/00
CPC分类号： C07K14/005 , G01N33/56988 , A61K39/00 , C07K2319/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16222 , Y10S977/802 , Y10S977/917 , Y10S977/92
摘要： Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.
摘要翻译：提供了新的合成肽，其是针对HIV-1的候选疫苗，并且其可用于诊断应用。肽包含HIV-1的gag蛋白的T细胞表位的氨基酸序列，特别是p24E直接与HIV-1分离物的V3环蛋白的B细胞表位的氨基酸序列连接并含有序列GPGR，和/或包含序列ELKDWA的gp41。提供了串联合成肽的多聚体形式。

12. 发明授权

US5800822A Tandem synthetic HIV-1 peptides 失效
公开(公告)号：US5800822A
公开(公告)日：1998-09-01
申请号：US465217
申请日：1995-06-05
申请人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
发明人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
IPC分类号： G01N33/53 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/155 , C07K14/16 , C07K16/10 , C12N15/09 , C12N15/48 , G01N33/569 , C07K5/00 , C07K7/00
CPC分类号： C07K14/005 , G01N33/56988 , A61K39/00 , C07K2319/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16222 , Y10S977/802 , Y10S977/917 , Y10S977/92
摘要： Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.

13. 发明授权

US5795955A Tandem synthetic HIV-1 peptides 失效
标题翻译：串联合成HIV-1肽
公开(公告)号：US5795955A
公开(公告)日：1998-08-18
申请号：US463966
申请日：1995-06-05
申请人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
发明人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
IPC分类号： G01N33/53 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/155 , C07K14/16 , C07K16/10 , C12N15/09 , C12N15/48 , G01N33/569 , A61K38/00 , A61K39/12 , C07K5/00
CPC分类号： C07K14/005 , G01N33/56988 , A61K39/00 , C07K2319/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16222 , Y10S977/802 , Y10S977/917 , Y10S977/92
摘要： Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.
摘要翻译：提供了新的合成肽，其是针对HIV-1的候选疫苗，并且其可用于诊断应用。肽包含HIV-1的gag蛋白的T细胞表位的氨基酸序列，其直接连接到HIV-1分离物的V3环蛋白的B细胞表位的氨基酸序列，并含有序列 GPGR和/或包含序列ELKDWA的gp41。提供了串联合成肽的多聚体形式。

14. 发明授权

US5639854A Tandem synthetic HIV-1 peptides 失效
标题翻译：串联合成HIV-1肽
公开(公告)号：US5639854A
公开(公告)日：1997-06-17
申请号：US257528
申请日：1994-06-09
申请人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
发明人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
IPC分类号： G01N33/53 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/155 , C07K14/16 , C07K16/10 , C12N15/09 , C12N15/48 , G01N33/569 , A61K38/00 , A61K39/12 , C07K5/00
CPC分类号： C07K14/005 , G01N33/56988 , A61K39/00 , C07K2319/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16222 , Y10S977/802 , Y10S977/917 , Y10S977/92
摘要： Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.
摘要翻译：提供了新的合成肽，其是针对HIV-1的候选疫苗，并且其可用于诊断应用。肽包含HIV-1的gag蛋白的T细胞表位的氨基酸序列，特别是p24E直接与HIV-1分离物的V3环蛋白的B细胞表位的氨基酸序列连接并含有序列GPGR，和/或包含序列ELKDWA的gp41。提供了串联合成肽的多聚体形式。

15. 发明授权

US07105164B1 HIV-specific cytotoxic T-cell responses 失效
标题翻译： HIV特异性细胞毒性T细胞应答
公开(公告)号：US07105164B1
公开(公告)日：2006-09-12
申请号：US09647981
申请日：1999-04-07
申请人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
发明人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K38/162 , A61K39/12 , A61K39/39 , A61K2039/55516 , C07K14/005 , C12N2730/10122 , C12N2740/16034 , C12N2740/16322 , C12N2740/16334
摘要： A method of generating an HIV-specific cytotoxic T-cell response in a host involves an initial administration of a T-helper molecule to the host to prime T-helper cells of the immune system of the host and a subsequent administration to the host of a mixture of the T-helper molecule and a T-cell inducing HIV-derived molecule to generate an HIV-specific T-cell response in the host.
摘要翻译：在宿主中产生HIV-特异性细胞毒性T细胞应答的方法包括向宿主初始施用T-辅助分子以引发宿主免疫系统的T辅助细胞，并随后向宿主施用 T辅助分子和诱导HIV衍生分子的T细胞的混合物在宿主中产生HIV特异性T细胞应答。

16. 发明申请

US20060199176A1 Coronavirus S peptides 审中-公开
标题翻译：冠状病毒S肽
公开(公告)号：US20060199176A1
公开(公告)日：2006-09-07
申请号：US11181693
申请日：2005-07-14
申请人： Yeau-Ching Wang , Szu-Chia Lai , Chia-Tsui Yeh , Pele Chong , Shih-Jen Liu
发明人： Yeau-Ching Wang , Szu-Chia Lai , Chia-Tsui Yeh , Pele Chong , Shih-Jen Liu
IPC分类号： C12Q1/70 , C12N5/06 , C12N15/86 , C07K14/165 , C07K16/12
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , C07K16/10 , C07K2317/34 , C07K2317/76 , C12N2770/20022
摘要： Isolated polypeptides containing SEQ ID NO: 3 and functional equivalents thereof. Also disclosed are isolated nucleic acids encoding the polypeptides, related expression vectors, related host cells, related antibodies, and related compositions. Methods of producing the polypeptide, diagnosing infection with a coronavirus, and identifying a test compound for treating infection with a coronavirus are also disclosed.
摘要翻译：含有SEQ ID NO：3的分离的多肽及其功能等同物。还公开了编码多肽，相关表达载体，相关宿主细胞，相关抗体和相关组合物的分离的核酸。还公开了产生多肽的方法，诊断冠状病毒感染和鉴定用于治疗冠状病毒感染的测试化合物。

17. 发明授权

US06358727B1 Haemophilus transferrin receptor genes 失效
标题翻译：嗜血杆菌转铁蛋白受体基因
公开(公告)号：US06358727B1
公开(公告)日：2002-03-19
申请号：US08637654
申请日：1996-08-05
申请人： Sheena M. Loosmore , Robin E. Harkness , Anthony B. Schryvers , Pele Chong , Scott Gray-Owen , Yan-Ping Yang , Andrew D. Murdin , Michel H. Klein
发明人： Sheena M. Loosmore , Robin E. Harkness , Anthony B. Schryvers , Pele Chong , Scott Gray-Owen , Yan-Ping Yang , Andrew D. Murdin , Michel H. Klein
IPC分类号： C12N121
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/51 , C07K16/2881 , C07K2317/34 , C12N2799/021 , Y02A50/466
摘要： Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbpl or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.
摘要翻译：提供了纯化和分离的核酸，其编码嗜血杆菌菌株的转铁蛋白受体蛋白或转铁蛋白受体蛋白的片段或类似物。为了诊断和治疗的目的，核酸序列可用于产生不含通常含有Tbp1或Tbp2蛋白的细菌的不含污染物的肽。此外，核酸分子可以用于感染的诊断。还提供重组Tbpl或Tbp2及其纯化方法。提供了表达转铁蛋白受体蛋白表位的活载体用于疫苗接种。

18. 发明授权

US06228423B1 Biodegradable targetable microparticle delivery system 有权
标题翻译：可生物降解的可靶向微粒输送系统
公开(公告)号：US06228423B1
公开(公告)日：2001-05-08
申请号：US09501373
申请日：2000-02-11
申请人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
发明人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
IPC分类号： B01J1302
CPC分类号： A61K9/1647 , A61K9/167 , A61K2039/55555 , C08G63/6852 , Y10S514/952 , Y10S530/815 , Y10S530/816 , Y10T428/2982
摘要： Copolymers designed for use as particulate carriers containing functionalizable amino acid subunits for coupling with targeting ligand are described. The copolymers are polyesters composed of &agr;-hydroxy acid subunits such as D,L-lactide and &agr;-amino acid subunits such as serine or in the preferred embodiment, terpolymers of D,L-lactide and glycolide and &agr;-amino acid subunits such as serine. Stable vaccine preparations useful as delayed release formulations containing antigen(s) or antigen(s) and co-adjuvants encapsulated within or physically mixed with polymeric microparticles are described. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral routes to produce immune responses, including antibody responses.
摘要翻译：描述了设计用作颗粒载体的共聚物，其含有用于与靶配体偶联的可官能化氨基酸亚单位。共聚物是由α-羟基酸亚基如D，L-丙交酯和α-氨基酸亚基如丝氨酸组成的聚酯，或在优选的实施方案中，D，L-丙交酯和乙交酯和α-氨基酸亚基的三元共聚物如丝氨酸描述了可用作延迟释放制剂的稳定的疫苗制剂，其含有包封在聚合物微粒内或物理混合的聚合物微粒中的抗原或抗原和辅助佐剂。颗粒载体可用于通过粘膜或肠胃外途径将药物递送至受试者的免疫系统，以产生包括抗体反应的免疫应答。

19. 发明授权

US6008326A Transferrin receptor antibodies 失效
标题翻译：转铁蛋白受体抗体
公开(公告)号：US6008326A
公开(公告)日：1999-12-28
申请号：US474671
申请日：1995-06-07
申请人： Sheena Loosmore , Robin Harkness , Anthony Schryvers , Pele Chong , Scott Gray-Owen , Yan-Ping Yang , Andrew Murdin , Michel Klein
发明人： Sheena Loosmore , Robin Harkness , Anthony Schryvers , Pele Chong , Scott Gray-Owen , Yan-Ping Yang , Andrew Murdin , Michel Klein
IPC分类号： G01N33/569 , A61K9/127 , A61K9/48 , A61K9/50 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/102 , A61K39/395 , A61K48/00 , A61P31/04 , A61P37/04 , C07H21/04 , C07K14/285 , C07K14/705 , C07K16/12 , C07K16/28 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/21
CPC分类号： C07K14/285 , C07K16/2881 , A61K2039/51 , A61K39/00 , C07K2317/34 , C12N2799/021
摘要： Isolated and purified antiserum or antibody specific for an immunogenic material is provided. Such immunogenic material may comprise purified and isolated transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein, recombinant Tbp1 or Tbp2 proteins and isolated and purified Tbp1 and Tbp2 proteins, and synthetic peptides.
摘要翻译：提供分离和纯化的抗血清或针对免疫原性物质特异性的抗体。这种免疫原性物质可以包含嗜血杆菌菌株的纯化和分离的转铁蛋白受体蛋白，或转铁蛋白受体蛋白，重组Tbp1或Tbp2蛋白和分离和纯化的Tbp1和Tbp2蛋白以及合成肽的片段或类似物。

20. 发明授权

US5962430A Analog of Haemophilus Hin47 with reduced protease activity 失效
标题翻译：具有减少的蛋白酶活性的嗜血杆菌Hin47的类似物
公开(公告)号：US5962430A
公开(公告)日：1999-10-05
申请号：US801499
申请日：1997-02-18
申请人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
IPC分类号： A61K39/00 , A61P31/04 , C07K14/285 , C12N9/52 , C12N15/31 , A61K39/102 , A01N43/48 , A61K31/495
CPC分类号： C12N9/52 , C07K14/285 , A61K39/00 , C07K2319/00
摘要： An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases (caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.
摘要翻译：分离和纯化的流感嗜血杆菌Hin47蛋白的类似物具有降低的蛋白酶活性，其小于天然Hin47蛋白的约10％，优选与天然Hin47蛋白基本相同的免疫原性。可以在重组质粒中提供分离的纯化的编码Hin47类似物的核酸分子，所述重组质粒可以被引入生长以产生Hin47类似物的细胞中。包含Hin47类似物和编码核酸的免疫原性组合物可以配制为用于体内施用于宿主（包括人）的疫苗，以赋予针对疾病（由细菌病原体，包括嗜血杆菌属物种如流感嗜血杆菌引起的）的保护，产生Hin47蛋白或能够在与Hin47蛋白特异性反应的宿主中诱导抗体的蛋白质，Hin47类似物和编码核酸也可用于诊断应用。

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