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1. 发明授权

US5962430A Analog of Haemophilus Hin47 with reduced protease activity 失效
标题翻译：具有减少的蛋白酶活性的嗜血杆菌Hin47的类似物
公开(公告)号：US5962430A
公开(公告)日：1999-10-05
申请号：US801499
申请日：1997-02-18
申请人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
IPC分类号： A61K39/00 , A61P31/04 , C07K14/285 , C12N9/52 , C12N15/31 , A61K39/102 , A01N43/48 , A61K31/495
CPC分类号： C12N9/52 , C07K14/285 , A61K39/00 , C07K2319/00
摘要： An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases (caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.
摘要翻译：分离和纯化的流感嗜血杆菌Hin47蛋白的类似物具有降低的蛋白酶活性，其小于天然Hin47蛋白的约10％，优选与天然Hin47蛋白基本相同的免疫原性。可以在重组质粒中提供分离的纯化的编码Hin47类似物的核酸分子，所述重组质粒可以被引入生长以产生Hin47类似物的细胞中。包含Hin47类似物和编码核酸的免疫原性组合物可以配制为用于体内施用于宿主（包括人）的疫苗，以赋予针对疾病（由细菌病原体，包括嗜血杆菌属物种如流感嗜血杆菌引起的）的保护，产生Hin47蛋白或能够在与Hin47蛋白特异性反应的宿主中诱导抗体的蛋白质，Hin47类似物和编码核酸也可用于诊断应用。

2. 发明授权

US5939297A Analog of haemophilus HIN47 with reduced protease activity 失效
标题翻译：具有降低的蛋白酶活性的嗜血杆菌HIN47的类似物
公开(公告)号：US5939297A
公开(公告)日：1999-08-17
申请号：US296149
申请日：1994-08-26
申请人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
IPC分类号： A61K39/00 , A61P31/04 , C07K14/285 , C12N9/52 , C12N15/31 , C12N15/57
CPC分类号： C12N9/52 , C07K14/285 , A61K39/00 , C07K2319/00
摘要： An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.
摘要翻译：分离和纯化的流感嗜血杆菌Hin47蛋白的类似物具有降低的蛋白酶活性，其小于天然Hin47蛋白的约10％，优选与天然Hin47蛋白基本相同的免疫原性。可以在重组质粒中提供分离的纯化的编码Hin47类似物的核酸分子，所述重组质粒可以被引入生长以产生Hin47类似物的细胞中。包含Hin47类似物和编码核酸的免疫原性组合物可以配制成用于体内施用于宿主（包括人）的疫苗，以赋予针对由细菌病原体（例如流感嗜血杆菌）产生的细菌病原体引起的疾病的保护， Hin47蛋白或能够诱导与Hin47蛋白特异性反应的宿主中的抗体的蛋白质。 Hin47类似物和编码核酸也可用于诊断应用。

3. 发明授权

US5506139A Analog of haemophilus Hin47 with reduced protease activity 失效
公开(公告)号：US5506139A
公开(公告)日：1996-04-09
申请号：US278091
申请日：1994-07-21
申请人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
IPC分类号： A61K39/00 , A61P31/04 , C07K14/285 , C12N9/52 , C12N15/31 , C12N15/57
CPC分类号： C12N9/52 , C07K14/285 , A61K39/00 , C07K2319/00
摘要： An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.

4. 发明授权

US6147057A Analog of Haemophilus Hin47 with reduced protease activity 失效
标题翻译：具有减少的蛋白酶活性的嗜血杆菌Hin47的类似物
公开(公告)号：US6147057A
公开(公告)日：2000-11-14
申请号：US106466
申请日：1998-06-30
申请人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
IPC分类号： A61K39/00 , A61P31/04 , C07K14/285 , C12N9/52 , A01N43/04
CPC分类号： C07K14/285 , C12N9/52 , A61K2039/51 , A61K39/00 , C07K2319/00
摘要： An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.
摘要翻译：分离和纯化的流感嗜血杆菌Hin47蛋白的类似物具有降低的蛋白酶活性，其小于天然Hin47蛋白的约10％，优选与天然Hin47蛋白基本相同的免疫原性。可以在重组质粒中提供分离的纯化的编码Hin47类似物的核酸分子，所述重组质粒可以被引入生长以产生Hin47类似物的细胞中。包含Hin47类似物和编码核酸的免疫原性组合物可以配制成用于体内施用于宿主（包括人）的疫苗，以赋予针对由细菌病原体（例如流感嗜血杆菌）产生的细菌病原体引起的疾病的保护， Hin47蛋白或能够诱导与Hin47蛋白特异性反应的宿主中的抗体的蛋白质。 Hin47类似物和编码核酸也可用于诊断应用。

5. 发明授权

US6114125A Analog of Haemophilus Hin47 with reduced protease activity 失效
标题翻译：具有减少的蛋白酶活性的嗜血杆菌Hin47的类似物
公开(公告)号：US6114125A
公开(公告)日：2000-09-05
申请号：US106468
申请日：1998-06-30
申请人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
IPC分类号： A61K39/00 , C07K14/285 , C12N9/52 , C12N15/31 , G01N33/53
CPC分类号： C07K14/285 , C12N9/52 , A61K2039/51 , A61K39/00 , C07K2319/00
摘要： An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid module encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprises the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may employed in diagnostic applications.
摘要翻译：分离和纯化的流感嗜血杆菌Hin47蛋白的类似物具有降低的蛋白酶活性，其小于天然Hin47蛋白的约10％，优选与天然Hin47蛋白基本相同的免疫原性。可以在重组质粒中提供编码Hin47类似物的分离的纯化核酸模块，其可以被引入生长以产生Hin47类似物的细胞中。免疫原性组合物包含Hin47类似物，并且编码核酸可以配制成用于体内施用于宿主（包括人）的疫苗，以赋予针对由细菌病原体（例如流感嗜血杆菌）产生的细菌病原体引起的疾病的保护， Hin47蛋白或能够诱导与Hin47蛋白特异性反应的宿主中的抗体的蛋白质。 Hin47类似物和编码核酸也可用于诊断应用。

6. 发明授权

US6020183A Analog of haemophilus Hin47 with reduced protease activity 失效
标题翻译：具有降低的蛋白酶活性的嗜血杆菌Hin47的类似物
公开(公告)号：US6020183A
公开(公告)日：2000-02-01
申请号：US74660
申请日：1998-05-08
申请人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
IPC分类号： A61K39/00 , C07K14/285 , C12N9/52 , C12N15/31 , C12N1/12 , A61K38/48 , A61K39/385 , C12P21/06 , G01N33/53
CPC分类号： C07K14/285 , C12N9/52 , A61K2039/51 , A61K39/00 , C07K2319/00
摘要： An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.
摘要翻译：分离和纯化的流感嗜血杆菌Hin47蛋白的类似物具有降低的蛋白酶活性，其小于天然Hin47蛋白的约10％，优选与天然Hin47蛋白基本相同的免疫原性。可以在重组质粒中提供分离的纯化的编码Hin47类似物的核酸分子，所述重组质粒可以被引入生长以产生Hin47类似物的细胞中。包含Hin47类似物和编码核酸的免疫原性组合物可以配制成用于体内施用于宿主（包括人）的疫苗，以赋予针对由细菌病原体（例如流感嗜血杆菌）产生的细菌病原体引起的疾病的保护， Hin47蛋白或能够诱导与Hin47蛋白特异性反应的宿主中的抗体的蛋白质。 Hin47类似物和编码核酸也可用于诊断应用。

7. 发明授权

US5869302A Analog of haemophilus hin47 with reduced protease activity 失效
标题翻译：具有减少的蛋白酶活性的嗜血杆菌hin47的类似物
公开(公告)号：US5869302A
公开(公告)日：1999-02-09
申请号：US487167
申请日：1995-06-07
申请人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
IPC分类号： A61K39/00 , A61P31/04 , C07K14/285 , C12N9/52 , C12N15/31 , C12N15/57
CPC分类号： C12N9/52 , C07K14/285 , A61K39/00 , C07K2319/00
摘要： An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.
摘要翻译：分离和纯化的流感嗜血杆菌Hin47蛋白的类似物具有降低的蛋白酶活性，其小于天然Hin47蛋白的约10％，优选与天然Hin47蛋白基本相同的免疫原性。可以在重组质粒中提供分离的纯化的编码Hin47类似物的核酸分子，所述重组质粒可以被引入生长以产生Hin47类似物的细胞中。包含Hin47类似物和编码核酸的免疫原性组合物可以配制成用于体内施用于宿主（包括人）的疫苗，以赋予针对由细菌病原体（例如流感嗜血杆菌）产生的细菌病原体引起的疾病的保护， Hin47蛋白或能够诱导与Hin47蛋白特异性反应的宿主中的抗体的蛋白质。 Hin47类似物和编码核酸也可用于诊断应用。

8. 发明授权

US5665353A Composition containing an analog of haemophilus Hin47 with reduced protease activity 失效
标题翻译：含有减少蛋白酶活性的嗜血杆菌Hin47类似物的组合物
公开(公告)号：US5665353A
公开(公告)日：1997-09-09
申请号：US472173
申请日：1995-06-07
申请人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
IPC分类号： A61K39/00 , A61P31/04 , C07K14/285 , C12N9/52 , C12N15/31 , A61K38/48
CPC分类号： C12N9/52 , C07K14/285 , A61K39/00 , C07K2319/00
摘要： An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.
摘要翻译：分离和纯化的流感嗜血杆菌Hin47蛋白的类似物具有降低的蛋白酶活性，其小于天然Hin47蛋白的约10％，优选与天然Hin47蛋白基本相同的免疫原性。可以在重组质粒中提供分离的纯化的编码Hin47类似物的核酸分子，所述重组质粒可以被引入生长以产生Hin47类似物的细胞中。包含Hin47类似物和编码核酸的免疫原性组合物可以配制成用于体内施用于宿主（包括人）的疫苗，以赋予针对由细菌病原体（例如流感嗜血杆菌）产生的细菌病原体引起的疾病的保护， Hin47蛋白或能够诱导与Hin47蛋白特异性反应的宿主中的抗体的蛋白质。 Hin47类似物和编码核酸也可用于诊断应用。

9. 发明授权

US06153580A Analog of haemophilus Hin47 with reduced protease activity 失效
公开(公告)号：US06153580A
公开(公告)日：2000-11-28
申请号：US106467
申请日：1998-06-30
申请人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
IPC分类号： A61K39/00 , A61P31/04 , C07K14/285 , C12N9/52 , A61K39/02
CPC分类号： C07K14/285 , C12N9/52 , A61K2039/51 , A61K39/00 , C07K2319/00
摘要： An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.

10. 发明授权

US5981503A Analog of Haemophilus Hin47 with reduced protease activity 失效
标题翻译：具有减少的蛋白酶活性的嗜血杆菌Hin47的类似物
公开(公告)号：US5981503A
公开(公告)日：1999-11-09
申请号：US615271
申请日：1996-06-20
申请人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
IPC分类号： A61K39/00 , C07K14/285 , C12N9/52 , C12N15/11
CPC分类号： C12N9/52 , C07K14/285 , A61K39/00 , C07K2319/00
摘要： An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10 % of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.
摘要翻译： PCT No.PCT / CA95 / 00434 Sec。 371日期：1996年6月20日 102（e）日期1996年6月20日PCT提交1995年7月21日PCT公布。公开号WO96 / 03506 日期1996年2月8日分离和纯化的流感嗜血杆菌Hin47蛋白的类似物具有降低的蛋白酶活性，其小于天然Hin47蛋白的约10％，优选与天然Hin47蛋白基本相同的免疫原性。可以在重组质粒中提供分离的纯化的编码Hin47类似物的核酸分子，所述重组质粒可以被引入生长以产生Hin47类似物的细胞中。包含Hin47类似物和编码核酸的免疫原性组合物可以配制成用于体内施用于宿主（包括人）的疫苗，以赋予针对由细菌病原体（例如流感嗜血杆菌）产生的细菌病原体引起的疾病的保护， Hin47蛋白或能够诱导与Hin47蛋白特异性反应的宿主中的抗体的蛋白质。 Hin47类似物和编码核酸也可用于诊断应用。

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